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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for HOXA9
Z-value: 1.22
Motif logo
Transcription factors associated with HOXA9
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
HOXA9
|
ENSG00000078399.11 | homeobox A9 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXA9 | hg19_v2_chr7_-_27205136_27205164 | -0.65 | 1.8e-03 | Click! |
Activity profile of HOXA9 motif
Sorted Z-values of HOXA9 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXA9
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 3.2 | GO:1903045 | neural crest cell migration involved in sympathetic nervous system development(GO:1903045) |
| 0.6 | 1.8 | GO:0048627 | myoblast development(GO:0048627) |
| 0.6 | 1.7 | GO:1902173 | negative regulation of keratinocyte apoptotic process(GO:1902173) |
| 0.4 | 3.8 | GO:0043415 | positive regulation of skeletal muscle tissue regeneration(GO:0043415) |
| 0.4 | 1.1 | GO:0070175 | positive regulation of enamel mineralization(GO:0070175) |
| 0.4 | 1.1 | GO:1903674 | regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676) |
| 0.4 | 8.8 | GO:0090179 | planar cell polarity pathway involved in neural tube closure(GO:0090179) |
| 0.4 | 1.5 | GO:0050717 | positive regulation of interleukin-1 alpha secretion(GO:0050717) |
| 0.4 | 1.4 | GO:1905205 | positive regulation of connective tissue replacement(GO:1905205) |
| 0.4 | 1.4 | GO:1904501 | glial cell fate determination(GO:0007403) canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation(GO:0061324) regulation of chromatin-mediated maintenance of transcription(GO:1904499) positive regulation of chromatin-mediated maintenance of transcription(GO:1904501) regulation of euchromatin binding(GO:1904793) |
| 0.4 | 1.8 | GO:0045658 | regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659) |
| 0.3 | 1.0 | GO:0015728 | mevalonate transport(GO:0015728) behavioral response to nutrient(GO:0051780) |
| 0.3 | 3.4 | GO:0071847 | TNFSF11-mediated signaling pathway(GO:0071847) |
| 0.3 | 2.2 | GO:0010609 | mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164) |
| 0.3 | 1.2 | GO:0043006 | activation of phospholipase A2 activity by calcium-mediated signaling(GO:0043006) |
| 0.3 | 1.2 | GO:0046110 | xanthine metabolic process(GO:0046110) |
| 0.3 | 0.5 | GO:0031587 | positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031587) |
| 0.3 | 1.8 | GO:0044861 | protein transport into plasma membrane raft(GO:0044861) |
| 0.2 | 1.2 | GO:0039534 | negative regulation of MDA-5 signaling pathway(GO:0039534) |
| 0.2 | 0.7 | GO:0001544 | initiation of primordial ovarian follicle growth(GO:0001544) |
| 0.2 | 0.7 | GO:0021503 | neural fold bending(GO:0021503) |
| 0.2 | 0.7 | GO:0003245 | cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245) |
| 0.2 | 0.6 | GO:2000393 | negative regulation of lamellipodium morphogenesis(GO:2000393) |
| 0.2 | 0.8 | GO:2000097 | regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
| 0.2 | 0.5 | GO:0006059 | hexitol metabolic process(GO:0006059) |
| 0.2 | 0.5 | GO:0072684 | mitochondrial tRNA 3'-trailer cleavage, endonucleolytic(GO:0072684) |
| 0.2 | 0.9 | GO:0002378 | immunoglobulin biosynthetic process(GO:0002378) |
| 0.2 | 1.5 | GO:0051013 | microtubule severing(GO:0051013) |
| 0.1 | 1.0 | GO:1904381 | Golgi apparatus mannose trimming(GO:1904381) |
| 0.1 | 2.1 | GO:0008090 | retrograde axonal transport(GO:0008090) |
| 0.1 | 0.5 | GO:0039533 | regulation of MDA-5 signaling pathway(GO:0039533) positive regulation of MDA-5 signaling pathway(GO:1900245) |
| 0.1 | 0.9 | GO:0051012 | microtubule sliding(GO:0051012) |
| 0.1 | 1.1 | GO:0019255 | glucose 1-phosphate metabolic process(GO:0019255) |
| 0.1 | 0.3 | GO:1990709 | maintenance of synapse structure(GO:0099558) presynaptic active zone organization(GO:1990709) |
| 0.1 | 1.1 | GO:1903764 | regulation of potassium ion export across plasma membrane(GO:1903764) |
| 0.1 | 0.8 | GO:1905150 | regulation of voltage-gated sodium channel activity(GO:1905150) |
| 0.1 | 1.6 | GO:0097264 | self proteolysis(GO:0097264) |
| 0.1 | 1.3 | GO:0006477 | protein sulfation(GO:0006477) |
| 0.1 | 0.4 | GO:0010430 | fatty acid omega-oxidation(GO:0010430) |
| 0.1 | 0.6 | GO:0051684 | maintenance of Golgi location(GO:0051684) |
| 0.1 | 0.9 | GO:0033183 | negative regulation of histone ubiquitination(GO:0033183) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) |
| 0.1 | 0.5 | GO:0001692 | histamine metabolic process(GO:0001692) |
| 0.1 | 0.3 | GO:1904017 | cellular response to Thyroglobulin triiodothyronine(GO:1904017) |
| 0.1 | 0.7 | GO:0051122 | hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122) |
| 0.1 | 1.4 | GO:0014067 | negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067) |
| 0.1 | 0.7 | GO:0040038 | polar body extrusion after meiotic divisions(GO:0040038) formin-nucleated actin cable assembly(GO:0070649) |
| 0.1 | 1.0 | GO:0035562 | negative regulation of chromatin binding(GO:0035562) |
| 0.1 | 1.2 | GO:1902902 | negative regulation of autophagosome assembly(GO:1902902) |
| 0.1 | 0.2 | GO:0021912 | regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) |
| 0.1 | 0.9 | GO:0034720 | histone H3-K4 demethylation(GO:0034720) |
| 0.1 | 0.4 | GO:0006172 | ADP biosynthetic process(GO:0006172) |
| 0.1 | 0.7 | GO:0071492 | cellular response to UV-A(GO:0071492) |
| 0.1 | 1.2 | GO:0051451 | myoblast migration(GO:0051451) |
| 0.1 | 0.8 | GO:0034201 | response to oleic acid(GO:0034201) |
| 0.1 | 1.0 | GO:0015693 | magnesium ion transport(GO:0015693) |
| 0.1 | 0.3 | GO:0038018 | Wnt receptor catabolic process(GO:0038018) |
| 0.1 | 1.2 | GO:0021957 | corticospinal tract morphogenesis(GO:0021957) |
| 0.1 | 0.6 | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) positive regulation of glycogen (starch) synthase activity(GO:2000467) |
| 0.1 | 1.0 | GO:0044341 | sodium-dependent phosphate transport(GO:0044341) |
| 0.1 | 0.2 | GO:0033861 | negative regulation of NAD(P)H oxidase activity(GO:0033861) |
| 0.1 | 0.7 | GO:0045329 | carnitine biosynthetic process(GO:0045329) |
| 0.1 | 1.4 | GO:0003334 | keratinocyte development(GO:0003334) |
| 0.1 | 0.2 | GO:0033685 | negative regulation of luteinizing hormone secretion(GO:0033685) |
| 0.0 | 0.2 | GO:0006566 | threonine metabolic process(GO:0006566) |
| 0.0 | 0.4 | GO:0051725 | protein de-ADP-ribosylation(GO:0051725) |
| 0.0 | 0.4 | GO:1901189 | positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068) |
| 0.0 | 0.3 | GO:1901525 | negative regulation of macromitophagy(GO:1901525) |
| 0.0 | 0.9 | GO:1902373 | negative regulation of mRNA catabolic process(GO:1902373) |
| 0.0 | 0.7 | GO:0043249 | erythrocyte maturation(GO:0043249) |
| 0.0 | 0.4 | GO:0007288 | sperm axoneme assembly(GO:0007288) |
| 0.0 | 0.4 | GO:0017062 | respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033) |
| 0.0 | 0.5 | GO:0042373 | vitamin K metabolic process(GO:0042373) |
| 0.0 | 0.4 | GO:0070269 | ectopic germ cell programmed cell death(GO:0035234) pyroptosis(GO:0070269) |
| 0.0 | 0.2 | GO:0043605 | cellular amide catabolic process(GO:0043605) |
| 0.0 | 2.0 | GO:0030262 | apoptotic nuclear changes(GO:0030262) |
| 0.0 | 0.4 | GO:0098881 | exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967) |
| 0.0 | 0.7 | GO:0007097 | nuclear migration(GO:0007097) |
| 0.0 | 0.6 | GO:2000096 | positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096) |
| 0.0 | 0.2 | GO:0002018 | renin-angiotensin regulation of aldosterone production(GO:0002018) |
| 0.0 | 0.3 | GO:0006398 | mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398) |
| 0.0 | 0.2 | GO:0045229 | cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229) |
| 0.0 | 0.5 | GO:0090091 | positive regulation of extracellular matrix disassembly(GO:0090091) negative regulation of wound healing, spreading of epidermal cells(GO:1903690) |
| 0.0 | 0.5 | GO:0034058 | endosomal vesicle fusion(GO:0034058) positive regulation of early endosome to late endosome transport(GO:2000643) |
| 0.0 | 1.2 | GO:0045589 | regulation of regulatory T cell differentiation(GO:0045589) |
| 0.0 | 2.1 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 0.0 | 1.5 | GO:0045747 | positive regulation of Notch signaling pathway(GO:0045747) |
| 0.0 | 1.0 | GO:0002385 | mucosal immune response(GO:0002385) |
| 0.0 | 0.1 | GO:2000078 | glandular epithelial cell maturation(GO:0002071) type B pancreatic cell maturation(GO:0072560) positive regulation of type B pancreatic cell development(GO:2000078) |
| 0.0 | 0.5 | GO:0001514 | selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451) |
| 0.0 | 0.6 | GO:0090110 | cargo loading into COPII-coated vesicle(GO:0090110) |
| 0.0 | 0.2 | GO:0044026 | DNA hypermethylation(GO:0044026) |
| 0.0 | 0.4 | GO:1904355 | regulation of telomere capping(GO:1904353) positive regulation of telomere capping(GO:1904355) |
| 0.0 | 0.5 | GO:0046520 | sphingoid biosynthetic process(GO:0046520) |
| 0.0 | 1.0 | GO:0001573 | ganglioside metabolic process(GO:0001573) |
| 0.0 | 0.2 | GO:0055011 | atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014) |
| 0.0 | 0.2 | GO:0010819 | regulation of T cell chemotaxis(GO:0010819) |
| 0.0 | 0.7 | GO:0006490 | oligosaccharide-lipid intermediate biosynthetic process(GO:0006490) |
| 0.0 | 0.2 | GO:1904550 | chemotaxis to arachidonic acid(GO:0034670) response to arachidonic acid(GO:1904550) |
| 0.0 | 0.7 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.0 | 0.1 | GO:2000768 | glomerular parietal epithelial cell differentiation(GO:0072139) positive regulation of epithelial cell differentiation involved in kidney development(GO:2000698) positive regulation of nephron tubule epithelial cell differentiation(GO:2000768) |
| 0.0 | 0.3 | GO:0070779 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
| 0.0 | 0.1 | GO:0018032 | protein amidation(GO:0018032) |
| 0.0 | 0.6 | GO:0015937 | coenzyme A biosynthetic process(GO:0015937) |
| 0.0 | 0.3 | GO:0090204 | protein localization to nuclear pore(GO:0090204) |
| 0.0 | 0.6 | GO:0045109 | intermediate filament organization(GO:0045109) |
| 0.0 | 0.2 | GO:0038165 | oncostatin-M-mediated signaling pathway(GO:0038165) |
| 0.0 | 0.2 | GO:0002326 | B cell lineage commitment(GO:0002326) immunoglobulin V(D)J recombination(GO:0033152) |
| 0.0 | 0.5 | GO:0098719 | sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118) |
| 0.0 | 0.3 | GO:2000400 | positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400) |
| 0.0 | 0.1 | GO:0070343 | white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350) |
| 0.0 | 0.2 | GO:1902177 | positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902177) |
| 0.0 | 0.3 | GO:0001833 | inner cell mass cell proliferation(GO:0001833) |
| 0.0 | 0.1 | GO:0016480 | negative regulation of transcription from RNA polymerase III promoter(GO:0016480) |
| 0.0 | 0.4 | GO:0097094 | craniofacial suture morphogenesis(GO:0097094) |
| 0.0 | 0.1 | GO:1901475 | pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475) |
| 0.0 | 0.1 | GO:0009236 | cobalamin biosynthetic process(GO:0009236) |
| 0.0 | 0.7 | GO:0035338 | long-chain fatty-acyl-CoA biosynthetic process(GO:0035338) |
| 0.0 | 0.0 | GO:2000296 | negative regulation of hydrogen peroxide catabolic process(GO:2000296) |
| 0.0 | 0.1 | GO:0006642 | triglyceride mobilization(GO:0006642) |
| 0.0 | 0.6 | GO:0090162 | establishment of epithelial cell polarity(GO:0090162) |
| 0.0 | 0.7 | GO:0006622 | protein targeting to lysosome(GO:0006622) |
| 0.0 | 0.5 | GO:0035635 | entry of bacterium into host cell(GO:0035635) |
| 0.0 | 0.3 | GO:0007191 | adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191) |
| 0.0 | 0.5 | GO:0010800 | positive regulation of peptidyl-threonine phosphorylation(GO:0010800) |
| 0.0 | 0.1 | GO:1902527 | positive regulation of protein monoubiquitination(GO:1902527) |
| 0.0 | 0.1 | GO:0071231 | thymidylate synthase biosynthetic process(GO:0050757) regulation of thymidylate synthase biosynthetic process(GO:0050758) cellular response to folic acid(GO:0071231) |
| 0.0 | 0.8 | GO:0006699 | bile acid biosynthetic process(GO:0006699) |
| 0.0 | 0.5 | GO:0050832 | defense response to fungus(GO:0050832) |
| 0.0 | 0.1 | GO:0048341 | paraxial mesoderm formation(GO:0048341) |
| 0.0 | 0.2 | GO:0045103 | intermediate filament-based process(GO:0045103) |
| 0.0 | 0.4 | GO:0060325 | face morphogenesis(GO:0060325) |
| 0.0 | 0.1 | GO:0030916 | otic vesicle formation(GO:0030916) otic vesicle morphogenesis(GO:0071600) |
| 0.0 | 0.2 | GO:0034356 | NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356) |
| 0.0 | 0.3 | GO:0052695 | cellular glucuronidation(GO:0052695) |
| 0.0 | 0.5 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.0 | 0.4 | GO:0042359 | vitamin D metabolic process(GO:0042359) |
| 0.0 | 0.1 | GO:0042427 | serotonin biosynthetic process(GO:0042427) |
| 0.0 | 1.9 | GO:0048706 | embryonic skeletal system development(GO:0048706) |
| 0.0 | 0.5 | GO:0030866 | cortical actin cytoskeleton organization(GO:0030866) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 2.5 | GO:0031673 | H zone(GO:0031673) |
| 0.4 | 1.2 | GO:0097489 | multivesicular body, internal vesicle lumen(GO:0097489) |
| 0.3 | 1.0 | GO:0034686 | integrin alphav-beta8 complex(GO:0034686) |
| 0.3 | 1.0 | GO:0032002 | interleukin-28 receptor complex(GO:0032002) |
| 0.3 | 0.8 | GO:0036457 | keratohyalin granule(GO:0036457) |
| 0.3 | 1.8 | GO:0072558 | NLRP1 inflammasome complex(GO:0072558) |
| 0.2 | 1.4 | GO:0070369 | Scrib-APC-beta-catenin complex(GO:0034750) beta-catenin-TCF7L2 complex(GO:0070369) |
| 0.2 | 1.8 | GO:0044354 | pinosome(GO:0044352) macropinosome(GO:0044354) |
| 0.1 | 1.4 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.1 | 0.5 | GO:0031592 | centrosomal corona(GO:0031592) |
| 0.1 | 1.2 | GO:0030688 | preribosome, small subunit precursor(GO:0030688) |
| 0.1 | 0.4 | GO:1990796 | photoreceptor cell terminal bouton(GO:1990796) |
| 0.1 | 0.4 | GO:0035370 | UBC13-UEV1A complex(GO:0035370) |
| 0.1 | 1.1 | GO:0097025 | lateral loop(GO:0043219) MPP7-DLG1-LIN7 complex(GO:0097025) |
| 0.1 | 0.2 | GO:0005900 | oncostatin-M receptor complex(GO:0005900) |
| 0.1 | 1.1 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.0 | 0.4 | GO:0002177 | manchette(GO:0002177) |
| 0.0 | 0.3 | GO:0032589 | axolemma(GO:0030673) neuron projection membrane(GO:0032589) |
| 0.0 | 1.0 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
| 0.0 | 0.5 | GO:0031211 | serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211) |
| 0.0 | 0.7 | GO:0044754 | autolysosome(GO:0044754) |
| 0.0 | 0.3 | GO:0005587 | collagen type IV trimer(GO:0005587) |
| 0.0 | 0.3 | GO:0060201 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.0 | 1.2 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
| 0.0 | 0.4 | GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex(GO:0002193) |
| 0.0 | 4.0 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 0.0 | 2.3 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 0.4 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 0.0 | 0.7 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.0 | 0.2 | GO:0035032 | phosphatidylinositol 3-kinase complex, class III(GO:0035032) |
| 0.0 | 1.1 | GO:0005605 | basal lamina(GO:0005605) |
| 0.0 | 0.5 | GO:0005915 | zonula adherens(GO:0005915) |
| 0.0 | 1.2 | GO:0090544 | BAF-type complex(GO:0090544) |
| 0.0 | 0.5 | GO:0008091 | spectrin(GO:0008091) |
| 0.0 | 0.4 | GO:0000124 | SAGA complex(GO:0000124) STAGA complex(GO:0030914) |
| 0.0 | 0.5 | GO:0030897 | HOPS complex(GO:0030897) |
| 0.0 | 0.2 | GO:1990589 | ATF4-CREB1 transcription factor complex(GO:1990589) |
| 0.0 | 0.5 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.0 | 4.1 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 0.3 | GO:0005869 | dynactin complex(GO:0005869) |
| 0.0 | 2.6 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 0.4 | GO:0000786 | nucleosome(GO:0000786) |
| 0.0 | 0.8 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
| 0.0 | 0.0 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.0 | 1.4 | GO:0030425 | dendrite(GO:0030425) |
| 0.0 | 1.1 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.0 | 0.9 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 5.6 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.0 | 2.6 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 0.6 | GO:0005865 | striated muscle thin filament(GO:0005865) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.0 | GO:0015130 | mevalonate transmembrane transporter activity(GO:0015130) |
| 0.3 | 1.0 | GO:1990430 | extracellular matrix protein binding(GO:1990430) |
| 0.2 | 1.2 | GO:0005006 | epidermal growth factor-activated receptor activity(GO:0005006) |
| 0.2 | 1.8 | GO:0016314 | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314) |
| 0.2 | 1.1 | GO:0071074 | eukaryotic initiation factor eIF2 binding(GO:0071074) |
| 0.2 | 2.4 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
| 0.2 | 1.3 | GO:0050119 | N-acetylglucosamine deacetylase activity(GO:0050119) |
| 0.2 | 0.7 | GO:0008336 | gamma-butyrobetaine dioxygenase activity(GO:0008336) |
| 0.2 | 0.7 | GO:0000026 | alpha-1,2-mannosyltransferase activity(GO:0000026) |
| 0.2 | 1.5 | GO:0015319 | sodium:inorganic phosphate symporter activity(GO:0015319) |
| 0.2 | 1.1 | GO:0051748 | UTP:glucose-1-phosphate uridylyltransferase activity(GO:0003983) UTP-monosaccharide-1-phosphate uridylyltransferase activity(GO:0051748) |
| 0.1 | 3.2 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.1 | 4.2 | GO:0036041 | long-chain fatty acid binding(GO:0036041) |
| 0.1 | 0.4 | GO:1902271 | D3 vitamins binding(GO:1902271) |
| 0.1 | 1.5 | GO:0008568 | microtubule-severing ATPase activity(GO:0008568) |
| 0.1 | 2.2 | GO:0016018 | cyclosporin A binding(GO:0016018) |
| 0.1 | 0.7 | GO:0051120 | hepoxilin A3 synthase activity(GO:0051120) |
| 0.1 | 2.1 | GO:0016861 | intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861) |
| 0.1 | 1.2 | GO:0043546 | molybdopterin cofactor binding(GO:0043546) |
| 0.1 | 1.0 | GO:0070137 | ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139) |
| 0.1 | 0.4 | GO:0004031 | aldehyde oxidase activity(GO:0004031) |
| 0.1 | 0.5 | GO:0042781 | 3'-tRNA processing endoribonuclease activity(GO:0042781) |
| 0.1 | 0.9 | GO:0034648 | histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648) |
| 0.1 | 0.3 | GO:0008441 | 3'(2'),5'-bisphosphate nucleotidase activity(GO:0008441) |
| 0.1 | 0.3 | GO:0005128 | erythropoietin receptor binding(GO:0005128) |
| 0.1 | 4.8 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.1 | 0.5 | GO:0047057 | oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor(GO:0016900) vitamin-K-epoxide reductase (warfarin-sensitive) activity(GO:0047057) |
| 0.1 | 1.2 | GO:0089720 | caspase binding(GO:0089720) |
| 0.1 | 1.1 | GO:0097016 | L27 domain binding(GO:0097016) |
| 0.1 | 0.6 | GO:0004594 | pantothenate kinase activity(GO:0004594) |
| 0.1 | 1.5 | GO:0050700 | CARD domain binding(GO:0050700) |
| 0.1 | 0.2 | GO:0047280 | nicotinamide phosphoribosyltransferase activity(GO:0047280) |
| 0.1 | 0.2 | GO:0070644 | vitamin D response element binding(GO:0070644) |
| 0.1 | 0.4 | GO:0003875 | ADP-ribosylarginine hydrolase activity(GO:0003875) |
| 0.1 | 3.4 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 0.1 | 0.8 | GO:0071532 | ankyrin repeat binding(GO:0071532) |
| 0.1 | 1.0 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
| 0.1 | 0.5 | GO:0004758 | serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454) |
| 0.1 | 0.5 | GO:0035368 | selenocysteine insertion sequence binding(GO:0035368) |
| 0.1 | 0.3 | GO:0010861 | thyroid hormone receptor activator activity(GO:0010861) thyroid hormone receptor coactivator activity(GO:0030375) |
| 0.1 | 0.9 | GO:0005221 | intracellular cyclic nucleotide activated cation channel activity(GO:0005221) cyclic nucleotide-gated ion channel activity(GO:0043855) |
| 0.1 | 9.4 | GO:0031490 | chromatin DNA binding(GO:0031490) |
| 0.1 | 1.4 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.1 | 0.2 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 0.1 | 1.5 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
| 0.1 | 0.2 | GO:0004995 | tachykinin receptor activity(GO:0004995) |
| 0.1 | 0.7 | GO:0038036 | sphingosine-1-phosphate receptor activity(GO:0038036) |
| 0.1 | 0.4 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 0.0 | 0.6 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |
| 0.0 | 0.3 | GO:0017159 | pantetheine hydrolase activity(GO:0017159) |
| 0.0 | 0.6 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
| 0.0 | 0.2 | GO:0004906 | interferon-gamma receptor activity(GO:0004906) |
| 0.0 | 0.5 | GO:0042731 | PH domain binding(GO:0042731) |
| 0.0 | 0.1 | GO:0005477 | pyruvate secondary active transmembrane transporter activity(GO:0005477) |
| 0.0 | 5.0 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 0.9 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.0 | 0.5 | GO:0034452 | dynactin binding(GO:0034452) |
| 0.0 | 0.5 | GO:0015386 | potassium:proton antiporter activity(GO:0015386) |
| 0.0 | 0.2 | GO:0004924 | oncostatin-M receptor activity(GO:0004924) |
| 0.0 | 0.3 | GO:0004465 | lipoprotein lipase activity(GO:0004465) |
| 0.0 | 0.2 | GO:0016453 | C-acetyltransferase activity(GO:0016453) |
| 0.0 | 0.1 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
| 0.0 | 4.3 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 1.2 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.0 | 0.3 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.0 | 0.6 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.0 | 0.4 | GO:0015035 | protein disulfide oxidoreductase activity(GO:0015035) |
| 0.0 | 0.5 | GO:0008494 | translation activator activity(GO:0008494) |
| 0.0 | 0.1 | GO:0004598 | peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598) |
| 0.0 | 0.9 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.0 | 0.4 | GO:0000150 | recombinase activity(GO:0000150) |
| 0.0 | 0.7 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.0 | 0.2 | GO:1990763 | arrestin family protein binding(GO:1990763) |
| 0.0 | 2.5 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.0 | 0.4 | GO:0004017 | adenylate kinase activity(GO:0004017) |
| 0.0 | 0.1 | GO:0070915 | lysophosphatidic acid receptor activity(GO:0070915) |
| 0.0 | 0.3 | GO:0030548 | acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602) |
| 0.0 | 0.9 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
| 0.0 | 0.1 | GO:0004510 | tryptophan 5-monooxygenase activity(GO:0004510) |
| 0.0 | 0.1 | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575) |
| 0.0 | 0.8 | GO:0015485 | cholesterol binding(GO:0015485) |
| 0.0 | 0.1 | GO:0008195 | phosphatidate phosphatase activity(GO:0008195) |
| 0.0 | 0.4 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
| 0.0 | 1.8 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.0 | 0.1 | GO:0061714 | folic acid receptor activity(GO:0061714) |
| 0.0 | 0.5 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.0 | 0.4 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.0 | 0.5 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.0 | 0.1 | GO:0001016 | RNA polymerase III regulatory region DNA binding(GO:0001016) thioredoxin peroxidase activity(GO:0008379) |
| 0.0 | 0.9 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 0.0 | 0.4 | GO:0019706 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.0 | 0.4 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.8 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 3.2 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.0 | 3.9 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.0 | 3.4 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 1.1 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 1.0 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 1.4 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 1.6 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 1.1 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 1.4 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 0.3 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.0 | 2.5 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 0.3 | PID ERBB2 ERBB3 PATHWAY | ErbB2/ErbB3 signaling events |
| 0.0 | 3.5 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 1.1 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 1.4 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.0 | 0.2 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
| 0.0 | 0.4 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.0 | 0.4 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.0 | 0.4 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 4.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 1.0 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.0 | 1.9 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.0 | 1.3 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.0 | 0.7 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.8 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.1 | 3.2 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.1 | 1.5 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.1 | 1.2 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |
| 0.1 | 1.2 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.0 | 1.1 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.0 | 1.5 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.0 | 1.1 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.0 | 1.1 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.0 | 1.0 | REACTOME SHC1 EVENTS IN EGFR SIGNALING | Genes involved in SHC1 events in EGFR signaling |
| 0.0 | 1.8 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 0.2 | REACTOME SHC RELATED EVENTS | Genes involved in SHC-related events |
| 0.0 | 0.6 | REACTOME VITAMIN B5 PANTOTHENATE METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.0 | 1.3 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.0 | 0.4 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.0 | 1.3 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 0.2 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.0 | 0.6 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 1.4 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 0.7 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.0 | 2.4 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 0.4 | REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY | Genes involved in Adenylate cyclase activating pathway |
| 0.0 | 0.7 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.0 | 1.6 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.0 | 0.7 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.0 | 0.4 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.0 | 0.3 | REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
| 0.0 | 0.4 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.0 | 1.7 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 0.4 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.0 | 0.4 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.0 | 0.5 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |