ISMARA results: HOXB13

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HOXB13

Z-value: 0.77

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Transcription factors associated with HOXB13

Gene Symbol	Gene ID	Gene Info
HOXB13 Ensembl NCBI GeneCards UniProt	ENSG00000159184.7	homeobox B13

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HOXB13	hg19_v2_chr17_-_46806540_46806558	0.79	3.3e-05	Click!

Activity profile of HOXB13 motif

Sorted Z-values of HOXB13 motif

No targets for HOXB13

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB13

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	2.4	GO:0007352	zygotic specification of dorsal/ventral axis(GO:0007352)
0.1	1.7	GO:1901078	negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.4	1.6	GO:0060743	epithelial cell maturation involved in prostate gland development(GO:0060743)
0.2	1.0	GO:1990414	replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.0	1.0	GO:0032728	positive regulation of interferon-beta production(GO:0032728)
0.2	0.9	GO:0090341	negative regulation of secretion of lysosomal enzymes(GO:0090341)
0.0	0.8	GO:0042776	mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.2	0.7	GO:1903225	negative regulation of endodermal cell differentiation(GO:1903225)
0.0	0.7	GO:0060965	negative regulation of gene silencing by miRNA(GO:0060965)
0.0	0.6	GO:0045648	positive regulation of erythrocyte differentiation(GO:0045648)

Showing 1 to 10 of 28 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.7	GO:0000930	gamma-tubulin complex(GO:0000930)
0.1	1.3	GO:0097197	tetraspanin-enriched microdomain(GO:0097197)
0.0	1.0	GO:0016591	DNA-directed RNA polymerase II, holoenzyme(GO:0016591)
0.0	1.0	GO:0045095	keratin filament(GO:0045095)
0.0	0.8	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.2	0.7	GO:0005588	collagen type V trimer(GO:0005588)
0.1	0.5	GO:0005683	U7 snRNP(GO:0005683)
0.0	0.5	GO:0071141	SMAD protein complex(GO:0071141)
0.0	0.4	GO:1990712	HFE-transferrin receptor complex(GO:1990712)
0.0	0.4	GO:0030008	TRAPP complex(GO:0030008)

Showing 1 to 10 of 12 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	2.4	GO:0070698	transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity(GO:0030617) type I activin receptor binding(GO:0070698)
0.0	1.7	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) gamma-tubulin binding(GO:0043015)
0.1	1.0	GO:0009378	four-way junction helicase activity(GO:0009378)
0.0	1.0	GO:0050699	WW domain binding(GO:0050699)
0.1	0.9	GO:0032810	sterol response element binding(GO:0032810)
0.0	0.8	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0	0.7	GO:0035198	miRNA binding(GO:0035198)
0.1	0.5	GO:0071209	U7 snRNA binding(GO:0071209)
0.0	0.5	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.1	0.4	GO:0017060	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity(GO:0017060)

Showing 1 to 10 of 23 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
3.3	PID BMP PATHWAY	BMP receptor signaling
1.6	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.9	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.7	NABA COLLAGENS	Genes encoding collagen proteins

Showing 1 to 4 of 4 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.3	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.0	2.1	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.5	REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0	0.2	REACTOME OPSINS	Genes involved in Opsins

Showing 1 to 4 of 4 entries

Results for HOXB13

Z-value: 0.77

Motif logo

Transcription factors associated with HOXB13

Activity-expression correlation:

Activity profile of HOXB13 motif

Sorted Z-values of HOXB13 motif

No targets for HOXB13

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB13

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: