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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for HOXB3
Z-value: 2.51
Motif logo
Transcription factors associated with HOXB3
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
HOXB3
|
ENSG00000120093.7 | homeobox B3 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXB3 | hg19_v2_chr17_-_46667628_46667642 | -0.84 | 3.8e-06 | Click! |
Activity profile of HOXB3 motif
Sorted Z-values of HOXB3 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXB3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.3 | 15.9 | GO:0070563 | negative regulation of vitamin D receptor signaling pathway(GO:0070563) |
| 2.3 | 11.4 | GO:0015688 | iron chelate transport(GO:0015688) siderophore transport(GO:0015891) |
| 1.4 | 8.6 | GO:0033031 | positive regulation of neutrophil apoptotic process(GO:0033031) |
| 1.0 | 4.2 | GO:1901994 | negative regulation of meiotic cell cycle phase transition(GO:1901994) |
| 1.0 | 7.9 | GO:0010836 | negative regulation of protein ADP-ribosylation(GO:0010836) |
| 1.0 | 3.8 | GO:0061357 | positive regulation of Wnt protein secretion(GO:0061357) |
| 0.9 | 4.6 | GO:0007070 | negative regulation of transcription during mitosis(GO:0007068) negative regulation of transcription from RNA polymerase II promoter during mitosis(GO:0007070) |
| 0.9 | 3.6 | GO:0050717 | positive regulation of interleukin-1 alpha secretion(GO:0050717) |
| 0.8 | 2.4 | GO:0002644 | negative regulation of tolerance induction(GO:0002644) positive regulation of interleukin-4 biosynthetic process(GO:0045404) |
| 0.8 | 2.3 | GO:0060489 | orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490) |
| 0.6 | 4.9 | GO:1902714 | antifungal humoral response(GO:0019732) negative regulation of interferon-gamma secretion(GO:1902714) |
| 0.5 | 2.7 | GO:0071874 | cellular response to norepinephrine stimulus(GO:0071874) |
| 0.4 | 2.1 | GO:0043553 | vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324) negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) |
| 0.4 | 2.4 | GO:0001692 | histamine metabolic process(GO:0001692) |
| 0.4 | 2.4 | GO:0010936 | negative regulation of macrophage cytokine production(GO:0010936) |
| 0.4 | 1.2 | GO:2000393 | negative regulation of lamellipodium morphogenesis(GO:2000393) |
| 0.4 | 1.6 | GO:0030718 | germ-line stem cell population maintenance(GO:0030718) |
| 0.4 | 1.2 | GO:0030327 | prenylated protein catabolic process(GO:0030327) |
| 0.4 | 1.9 | GO:0002528 | regulation of vascular permeability involved in acute inflammatory response(GO:0002528) |
| 0.4 | 3.4 | GO:1903265 | positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265) |
| 0.4 | 4.1 | GO:0070777 | gamma-aminobutyric acid biosynthetic process(GO:0009449) D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
| 0.3 | 2.4 | GO:1903575 | cornified envelope assembly(GO:1903575) |
| 0.3 | 2.3 | GO:2000538 | regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538) |
| 0.3 | 1.9 | GO:2001288 | positive regulation of caveolin-mediated endocytosis(GO:2001288) |
| 0.3 | 6.0 | GO:0031268 | pseudopodium organization(GO:0031268) |
| 0.3 | 3.0 | GO:0060770 | negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770) |
| 0.3 | 0.8 | GO:2000744 | anterior head development(GO:0097065) regulation of anterior head development(GO:2000742) positive regulation of anterior head development(GO:2000744) |
| 0.3 | 1.0 | GO:1905205 | positive regulation of connective tissue replacement(GO:1905205) |
| 0.2 | 6.1 | GO:0035589 | G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589) |
| 0.2 | 11.1 | GO:0042730 | fibrinolysis(GO:0042730) |
| 0.2 | 3.7 | GO:0042420 | dopamine catabolic process(GO:0042420) |
| 0.2 | 0.9 | GO:0046946 | hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947) |
| 0.2 | 2.6 | GO:0006689 | ganglioside catabolic process(GO:0006689) |
| 0.2 | 0.8 | GO:0043456 | regulation of pentose-phosphate shunt(GO:0043456) |
| 0.2 | 0.6 | GO:1900126 | negative regulation of hyaluronan biosynthetic process(GO:1900126) |
| 0.2 | 2.9 | GO:0016127 | cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127) |
| 0.2 | 1.9 | GO:0034350 | regulation of glial cell apoptotic process(GO:0034350) negative regulation of glial cell apoptotic process(GO:0034351) |
| 0.2 | 1.5 | GO:1902261 | positive regulation of delayed rectifier potassium channel activity(GO:1902261) |
| 0.2 | 2.6 | GO:0060613 | fat pad development(GO:0060613) |
| 0.2 | 7.6 | GO:0048012 | hepatocyte growth factor receptor signaling pathway(GO:0048012) |
| 0.2 | 0.6 | GO:2000435 | regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435) |
| 0.2 | 2.1 | GO:0002051 | osteoblast fate commitment(GO:0002051) |
| 0.2 | 4.4 | GO:0009312 | oligosaccharide biosynthetic process(GO:0009312) |
| 0.1 | 2.1 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
| 0.1 | 1.4 | GO:0097475 | motor neuron migration(GO:0097475) |
| 0.1 | 0.8 | GO:0015722 | canalicular bile acid transport(GO:0015722) |
| 0.1 | 1.9 | GO:0034058 | endosomal vesicle fusion(GO:0034058) |
| 0.1 | 1.1 | GO:0010898 | positive regulation of triglyceride catabolic process(GO:0010898) |
| 0.1 | 0.4 | GO:1902948 | regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246) |
| 0.1 | 3.2 | GO:0035728 | response to hepatocyte growth factor(GO:0035728) |
| 0.1 | 2.7 | GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity(GO:0007175) |
| 0.1 | 0.5 | GO:0060584 | detection of peptidoglycan(GO:0032499) activation of MAPK activity involved in innate immune response(GO:0035419) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585) positive regulation of protein K63-linked ubiquitination(GO:1902523) |
| 0.1 | 0.8 | GO:0033133 | positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301) |
| 0.1 | 1.2 | GO:0036091 | positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091) |
| 0.1 | 0.5 | GO:0030311 | poly-N-acetyllactosamine biosynthetic process(GO:0030311) |
| 0.1 | 2.2 | GO:1902018 | negative regulation of cilium assembly(GO:1902018) |
| 0.1 | 0.7 | GO:0051684 | maintenance of Golgi location(GO:0051684) |
| 0.1 | 1.3 | GO:0007258 | JUN phosphorylation(GO:0007258) |
| 0.1 | 0.7 | GO:2001034 | positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034) |
| 0.1 | 2.0 | GO:0006068 | ethanol catabolic process(GO:0006068) |
| 0.1 | 6.0 | GO:0045824 | negative regulation of innate immune response(GO:0045824) |
| 0.1 | 1.4 | GO:0043249 | erythrocyte maturation(GO:0043249) |
| 0.1 | 0.7 | GO:0006741 | NADP biosynthetic process(GO:0006741) |
| 0.1 | 0.8 | GO:0032534 | regulation of microvillus assembly(GO:0032534) |
| 0.1 | 0.7 | GO:0030579 | ubiquitin-dependent SMAD protein catabolic process(GO:0030579) |
| 0.1 | 1.6 | GO:0033623 | regulation of integrin activation(GO:0033623) |
| 0.1 | 1.2 | GO:1990440 | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440) |
| 0.1 | 1.2 | GO:0060252 | positive regulation of glial cell proliferation(GO:0060252) |
| 0.1 | 0.4 | GO:0007525 | somatic muscle development(GO:0007525) |
| 0.1 | 0.7 | GO:0046887 | positive regulation of hormone secretion(GO:0046887) |
| 0.1 | 3.8 | GO:0055078 | sodium ion homeostasis(GO:0055078) |
| 0.1 | 0.7 | GO:2000767 | peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183) positive regulation of cytoplasmic translation(GO:2000767) |
| 0.1 | 0.6 | GO:0031572 | G2 DNA damage checkpoint(GO:0031572) |
| 0.1 | 0.9 | GO:0033089 | positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400) |
| 0.1 | 0.6 | GO:0014809 | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809) |
| 0.1 | 0.5 | GO:0006868 | glutamine transport(GO:0006868) |
| 0.1 | 0.6 | GO:0006657 | CDP-choline pathway(GO:0006657) |
| 0.1 | 0.3 | GO:0046292 | formaldehyde metabolic process(GO:0046292) |
| 0.0 | 0.3 | GO:0015692 | lead ion transport(GO:0015692) |
| 0.0 | 0.5 | GO:1900119 | positive regulation of execution phase of apoptosis(GO:1900119) |
| 0.0 | 0.9 | GO:0098719 | sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118) |
| 0.0 | 0.2 | GO:2000078 | glandular epithelial cell maturation(GO:0002071) type B pancreatic cell maturation(GO:0072560) positive regulation of type B pancreatic cell development(GO:2000078) |
| 0.0 | 3.9 | GO:0070206 | protein trimerization(GO:0070206) |
| 0.0 | 5.3 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.0 | 3.3 | GO:0031529 | ruffle organization(GO:0031529) |
| 0.0 | 0.8 | GO:0045741 | positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) |
| 0.0 | 0.7 | GO:0070070 | proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072) |
| 0.0 | 0.4 | GO:0051005 | negative regulation of lipoprotein lipase activity(GO:0051005) |
| 0.0 | 0.1 | GO:0048241 | epinephrine transport(GO:0048241) |
| 0.0 | 5.4 | GO:0043647 | inositol phosphate metabolic process(GO:0043647) |
| 0.0 | 0.3 | GO:2000628 | regulation of miRNA metabolic process(GO:2000628) |
| 0.0 | 0.1 | GO:0036058 | filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060) |
| 0.0 | 3.4 | GO:0045540 | regulation of cholesterol biosynthetic process(GO:0045540) |
| 0.0 | 8.5 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.0 | 0.2 | GO:0021784 | postganglionic parasympathetic fiber development(GO:0021784) |
| 0.0 | 3.0 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 0.0 | 1.7 | GO:0006699 | bile acid biosynthetic process(GO:0006699) |
| 0.0 | 0.5 | GO:0097094 | craniofacial suture morphogenesis(GO:0097094) |
| 0.0 | 0.5 | GO:0006307 | DNA dealkylation involved in DNA repair(GO:0006307) |
| 0.0 | 4.6 | GO:1900181 | negative regulation of protein localization to nucleus(GO:1900181) |
| 0.0 | 1.0 | GO:0007130 | synaptonemal complex assembly(GO:0007130) |
| 0.0 | 0.5 | GO:0019371 | cyclooxygenase pathway(GO:0019371) |
| 0.0 | 0.8 | GO:0001829 | trophectodermal cell differentiation(GO:0001829) |
| 0.0 | 0.1 | GO:0042214 | terpene metabolic process(GO:0042214) |
| 0.0 | 0.9 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 0.0 | 1.2 | GO:0010107 | potassium ion import(GO:0010107) |
| 0.0 | 3.0 | GO:0042035 | regulation of cytokine biosynthetic process(GO:0042035) |
| 0.0 | 0.4 | GO:0006067 | ethanol metabolic process(GO:0006067) ethanol oxidation(GO:0006069) |
| 0.0 | 1.7 | GO:0009311 | oligosaccharide metabolic process(GO:0009311) |
| 0.0 | 2.6 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
| 0.0 | 0.4 | GO:0034063 | stress granule assembly(GO:0034063) |
| 0.0 | 0.2 | GO:0060087 | relaxation of vascular smooth muscle(GO:0060087) negative regulation of platelet aggregation(GO:0090331) |
| 0.0 | 0.6 | GO:0000042 | protein targeting to Golgi(GO:0000042) |
| 0.0 | 0.2 | GO:0008627 | intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627) |
| 0.0 | 0.7 | GO:0032201 | telomere maintenance via semi-conservative replication(GO:0032201) |
| 0.0 | 0.3 | GO:2000096 | positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096) |
| 0.0 | 0.7 | GO:0051491 | positive regulation of filopodium assembly(GO:0051491) |
| 0.0 | 0.3 | GO:0005513 | detection of calcium ion(GO:0005513) |
| 0.0 | 0.6 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
| 0.0 | 0.2 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.0 | 0.4 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
| 0.0 | 0.2 | GO:0048312 | intracellular distribution of mitochondria(GO:0048312) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 9.5 | GO:0010370 | perinucleolar chromocenter(GO:0010370) |
| 0.8 | 7.0 | GO:0097169 | AIM2 inflammasome complex(GO:0097169) |
| 0.7 | 2.1 | GO:1990032 | parallel fiber(GO:1990032) |
| 0.7 | 2.6 | GO:0005889 | hydrogen:potassium-exchanging ATPase complex(GO:0005889) |
| 0.6 | 2.3 | GO:0060187 | cell pole(GO:0060187) |
| 0.3 | 2.7 | GO:1990812 | growth cone filopodium(GO:1990812) |
| 0.2 | 7.6 | GO:0031528 | microvillus membrane(GO:0031528) |
| 0.2 | 6.0 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.2 | 5.6 | GO:0071565 | nBAF complex(GO:0071565) |
| 0.2 | 1.2 | GO:0008282 | ATP-sensitive potassium channel complex(GO:0008282) |
| 0.1 | 3.0 | GO:0043203 | axon hillock(GO:0043203) |
| 0.1 | 3.9 | GO:0034706 | sodium channel complex(GO:0034706) |
| 0.1 | 1.0 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.1 | 3.8 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.1 | 1.0 | GO:0000801 | central element(GO:0000801) |
| 0.1 | 0.7 | GO:0008622 | epsilon DNA polymerase complex(GO:0008622) |
| 0.1 | 0.6 | GO:0014802 | terminal cisterna(GO:0014802) |
| 0.1 | 1.9 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
| 0.1 | 0.5 | GO:0034388 | Pwp2p-containing subcomplex of 90S preribosome(GO:0034388) |
| 0.1 | 1.5 | GO:0014701 | junctional sarcoplasmic reticulum membrane(GO:0014701) |
| 0.1 | 9.4 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.1 | 0.7 | GO:0000220 | vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) |
| 0.1 | 1.8 | GO:0044232 | organelle membrane contact site(GO:0044232) |
| 0.1 | 0.8 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.1 | 2.3 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.1 | 0.7 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 0.1 | 0.7 | GO:0061689 | tricellular tight junction(GO:0061689) |
| 0.1 | 0.8 | GO:0030015 | CCR4-NOT core complex(GO:0030015) |
| 0.1 | 0.7 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 0.0 | 0.3 | GO:0070826 | paraferritin complex(GO:0070826) |
| 0.0 | 4.0 | GO:0015030 | Cajal body(GO:0015030) |
| 0.0 | 5.1 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.0 | 1.2 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.0 | 0.4 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.0 | 0.6 | GO:0030130 | clathrin coat of trans-Golgi network vesicle(GO:0030130) |
| 0.0 | 5.0 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.0 | 0.4 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.0 | 0.6 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.0 | 1.9 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.0 | 2.6 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 14.6 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.0 | 4.1 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.0 | 0.8 | GO:0031083 | BLOC-1 complex(GO:0031083) |
| 0.0 | 0.8 | GO:0097228 | sperm principal piece(GO:0097228) |
| 0.0 | 0.9 | GO:0030867 | rough endoplasmic reticulum membrane(GO:0030867) |
| 0.0 | 0.3 | GO:0017119 | Golgi transport complex(GO:0017119) |
| 0.0 | 9.9 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 2.2 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.0 | 0.7 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.0 | 0.5 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.0 | 0.5 | GO:0098827 | endoplasmic reticulum subcompartment(GO:0098827) |
| 0.0 | 0.4 | GO:0002080 | acrosomal membrane(GO:0002080) |
| 0.0 | 1.7 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.0 | 1.2 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 1.5 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 2.4 | GO:0098857 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 0.0 | 0.9 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.0 | 1.2 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 1.1 | GO:0005811 | lipid particle(GO:0005811) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 5.4 | GO:0052829 | inositol-1,4-bisphosphate 1-phosphatase activity(GO:0004441) inositol-1,3,4-trisphosphate 1-phosphatase activity(GO:0052829) |
| 1.1 | 4.2 | GO:0047273 | galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity(GO:0047273) |
| 1.0 | 4.9 | GO:0005152 | interleukin-1 receptor antagonist activity(GO:0005152) |
| 0.8 | 3.4 | GO:0008431 | vitamin E binding(GO:0008431) |
| 0.4 | 1.7 | GO:0050698 | proteoglycan sulfotransferase activity(GO:0050698) |
| 0.4 | 3.7 | GO:0008131 | primary amine oxidase activity(GO:0008131) |
| 0.4 | 4.1 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.4 | 2.3 | GO:0043423 | 3-phosphoinositide-dependent protein kinase binding(GO:0043423) |
| 0.4 | 2.9 | GO:0004771 | sterol esterase activity(GO:0004771) |
| 0.3 | 1.6 | GO:0034584 | piRNA binding(GO:0034584) |
| 0.3 | 1.2 | GO:0008281 | sulfonylurea receptor activity(GO:0008281) |
| 0.3 | 2.1 | GO:0035662 | Toll-like receptor 4 binding(GO:0035662) |
| 0.3 | 7.5 | GO:0050700 | CARD domain binding(GO:0050700) |
| 0.3 | 2.0 | GO:0047894 | flavonol 3-sulfotransferase activity(GO:0047894) steroid sulfotransferase activity(GO:0050294) |
| 0.3 | 2.6 | GO:0004563 | beta-N-acetylhexosaminidase activity(GO:0004563) |
| 0.3 | 0.8 | GO:0015432 | bile acid-exporting ATPase activity(GO:0015432) |
| 0.3 | 1.9 | GO:0004699 | calcium-independent protein kinase C activity(GO:0004699) |
| 0.2 | 0.7 | GO:0070506 | high-density lipoprotein particle receptor activity(GO:0070506) |
| 0.2 | 6.1 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.2 | 4.6 | GO:0030957 | Tat protein binding(GO:0030957) |
| 0.2 | 0.9 | GO:0033823 | procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823) procollagen galactosyltransferase activity(GO:0050211) |
| 0.2 | 3.8 | GO:0031852 | mu-type opioid receptor binding(GO:0031852) |
| 0.2 | 0.8 | GO:0004619 | bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538) |
| 0.2 | 3.8 | GO:0015280 | ligand-gated sodium channel activity(GO:0015280) |
| 0.2 | 2.7 | GO:0051425 | PTB domain binding(GO:0051425) |
| 0.2 | 0.7 | GO:0032184 | SUMO polymer binding(GO:0032184) |
| 0.1 | 0.9 | GO:0017159 | pantetheine hydrolase activity(GO:0017159) |
| 0.1 | 1.2 | GO:0016670 | oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670) |
| 0.1 | 0.6 | GO:0004105 | choline-phosphate cytidylyltransferase activity(GO:0004105) |
| 0.1 | 4.1 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.1 | 1.9 | GO:0019870 | potassium channel inhibitor activity(GO:0019870) |
| 0.1 | 7.9 | GO:0042162 | telomeric DNA binding(GO:0042162) |
| 0.1 | 1.3 | GO:0004705 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
| 0.1 | 0.5 | GO:0008532 | N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532) |
| 0.1 | 4.4 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.1 | 0.5 | GO:0004666 | prostaglandin-endoperoxide synthase activity(GO:0004666) |
| 0.1 | 0.8 | GO:0004331 | 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331) |
| 0.1 | 14.1 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 0.4 | GO:0010465 | nerve growth factor receptor activity(GO:0010465) |
| 0.1 | 21.6 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.1 | 1.7 | GO:0036312 | phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312) |
| 0.1 | 1.3 | GO:0008097 | 5S rRNA binding(GO:0008097) |
| 0.1 | 3.7 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
| 0.1 | 1.5 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.1 | 1.0 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
| 0.1 | 0.2 | GO:0047275 | glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275) |
| 0.1 | 1.9 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.1 | 0.4 | GO:0070181 | small ribosomal subunit rRNA binding(GO:0070181) |
| 0.1 | 0.9 | GO:0015386 | potassium:proton antiporter activity(GO:0015386) |
| 0.1 | 0.5 | GO:0015186 | L-glutamine transmembrane transporter activity(GO:0015186) |
| 0.1 | 1.6 | GO:0031005 | filamin binding(GO:0031005) |
| 0.1 | 3.4 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.0 | 11.4 | GO:0005506 | iron ion binding(GO:0005506) |
| 0.0 | 0.3 | GO:0015086 | cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639) |
| 0.0 | 3.4 | GO:0016303 | 1-phosphatidylinositol-3-kinase activity(GO:0016303) |
| 0.0 | 0.2 | GO:0004692 | cGMP-dependent protein kinase activity(GO:0004692) |
| 0.0 | 2.5 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.0 | 1.2 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.0 | 0.4 | GO:0004024 | alcohol dehydrogenase activity, zinc-dependent(GO:0004024) |
| 0.0 | 0.8 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
| 0.0 | 0.7 | GO:0032454 | histone demethylase activity (H3-K9 specific)(GO:0032454) |
| 0.0 | 0.6 | GO:0004579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 0.0 | 1.1 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.0 | 2.1 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
| 0.0 | 1.7 | GO:0015248 | sterol transporter activity(GO:0015248) |
| 0.0 | 0.1 | GO:0005277 | acetylcholine transmembrane transporter activity(GO:0005277) secondary active organic cation transmembrane transporter activity(GO:0008513) acetate ester transmembrane transporter activity(GO:1901375) |
| 0.0 | 1.9 | GO:0015026 | coreceptor activity(GO:0015026) |
| 0.0 | 3.8 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.0 | 0.2 | GO:0003998 | acylphosphatase activity(GO:0003998) |
| 0.0 | 16.0 | GO:0004930 | G-protein coupled receptor activity(GO:0004930) |
| 0.0 | 1.2 | GO:0001221 | transcription cofactor binding(GO:0001221) |
| 0.0 | 0.7 | GO:0046961 | proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
| 0.0 | 0.2 | GO:0004064 | arylesterase activity(GO:0004064) |
| 0.0 | 5.7 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 0.6 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.0 | 0.7 | GO:0003951 | NAD+ kinase activity(GO:0003951) |
| 0.0 | 2.4 | GO:0008170 | N-methyltransferase activity(GO:0008170) |
| 0.0 | 0.8 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.0 | 0.1 | GO:0031386 | protein tag(GO:0031386) |
| 0.0 | 0.1 | GO:0008079 | translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079) |
| 0.0 | 0.8 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.0 | 4.4 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 0.1 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
| 0.0 | 0.3 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.0 | 0.7 | GO:0005080 | protein kinase C binding(GO:0005080) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.6 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.2 | 19.3 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.1 | 3.6 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.1 | 2.3 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.1 | 3.4 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 7.9 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 3.0 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.1 | 4.2 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.1 | 18.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 7.5 | PID MET PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| 0.0 | 2.4 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.0 | 3.4 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 1.7 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.0 | 2.1 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 3.3 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 3.2 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 3.1 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.0 | 1.1 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 2.1 | PID TXA2PATHWAY | Thromboxane A2 receptor signaling |
| 0.0 | 6.3 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 0.3 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.0 | 2.2 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 0.5 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 6.3 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.2 | 3.7 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.1 | 5.3 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.1 | 1.9 | REACTOME G ALPHA Z SIGNALLING EVENTS | Genes involved in G alpha (z) signalling events |
| 0.1 | 6.9 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.1 | 2.1 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.1 | 4.7 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.1 | 1.3 | REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 | Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| 0.1 | 2.4 | REACTOME CD28 DEPENDENT VAV1 PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
| 0.1 | 3.0 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.1 | 3.2 | REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR | Genes involved in Signaling by constitutively active EGFR |
| 0.1 | 2.0 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.1 | 16.1 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.1 | 2.7 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.1 | 3.9 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.1 | 2.2 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.0 | 0.8 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.0 | 1.6 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.0 | 1.2 | REACTOME INWARDLY RECTIFYING K CHANNELS | Genes involved in Inwardly rectifying K+ channels |
| 0.0 | 1.5 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.0 | 1.1 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 0.5 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.0 | 0.6 | REACTOME RETROGRADE NEUROTROPHIN SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
| 0.0 | 0.3 | REACTOME DESTABILIZATION OF MRNA BY KSRP | Genes involved in Destabilization of mRNA by KSRP |
| 0.0 | 0.6 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.0 | 0.8 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 0.8 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 0.7 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 3.6 | REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES | Genes involved in Transmission across Chemical Synapses |
| 0.0 | 8.4 | REACTOME HEMOSTASIS | Genes involved in Hemostasis |
| 0.0 | 1.7 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.0 | 0.6 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 1.0 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 0.2 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.0 | 0.9 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |