ISMARA results: HOXB8

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HOXB8

Z-value: 0.89

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Transcription factors associated with HOXB8

Gene Symbol	Gene ID	Gene Info
HOXB8 Ensembl NCBI GeneCards UniProt	ENSG00000120068.5	homeobox B8

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HOXB8	hg19_v2_chr17_-_46690839_46690884	0.64	2.2e-03	Click!

Activity profile of HOXB8 motif

Sorted Z-values of HOXB8 motif

No targets for HOXB8

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB8

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	4.4	GO:0031639	plasminogen activation(GO:0031639)
0.1	2.7	GO:0043252	sodium-independent organic anion transport(GO:0043252)
0.2	1.9	GO:0071395	response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.1	1.9	GO:0044849	estrous cycle(GO:0044849)
0.0	1.8	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.1	1.3	GO:1901078	negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.2	1.2	GO:0072709	cellular response to sorbitol(GO:0072709)
0.0	1.2	GO:0070125	mitochondrial translational elongation(GO:0070125)
0.3	1.0	GO:0035283	rhombomere 3 development(GO:0021569) central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.0	1.0	GO:0035036	sperm-egg recognition(GO:0035036)

Showing 1 to 10 of 232 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	2.6	GO:0005577	fibrinogen complex(GO:0005577)
0.0	2.4	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.1	1.6	GO:0031089	platelet dense granule lumen(GO:0031089)
0.0	0.9	GO:0031941	filamentous actin(GO:0031941)
0.0	0.9	GO:0005762	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1	0.8	GO:1990726	Lsm1-7-Pat1 complex(GO:1990726)
0.1	0.8	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0	0.8	GO:0045009	melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.2	0.7	GO:0048237	rough endoplasmic reticulum lumen(GO:0048237)
0.0	0.7	GO:0009925	basal plasma membrane(GO:0009925)

Showing 1 to 10 of 79 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.4	GO:0015125	bile acid transmembrane transporter activity(GO:0015125)
0.0	1.8	GO:0004984	olfactory receptor activity(GO:0004984)
0.3	1.6	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
0.0	1.4	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0	1.3	GO:0004708	MAP kinase kinase activity(GO:0004708)
0.2	1.2	GO:0047023	androsterone dehydrogenase activity(GO:0047023)
0.1	1.1	GO:0097322	7SK snRNA binding(GO:0097322)
0.1	0.9	GO:0071933	Arp2/3 complex binding(GO:0071933)
0.2	0.7	GO:0015229	L-ascorbate:sodium symporter activity(GO:0008520) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890)
0.2	0.7	GO:0018636	phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086)

Showing 1 to 10 of 146 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.6	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.0	2.3	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.0	1.4	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.0	1.2	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.0	0.7	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.0	0.7	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.1	0.6	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway
0.0	0.6	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.0	0.5	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.0	0.3	PID CERAMIDE PATHWAY	Ceramide signaling pathway

Showing 1 to 10 of 12 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.7	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.1	2.5	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.0	1.5	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.0	1.4	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.0	1.3	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.0	1.3	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.0	1.1	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.0	1.1	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.0	1.1	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	1.1	REACTOME OLFACTORY SIGNALING PATHWAY	Genes involved in Olfactory Signaling Pathway

Showing 1 to 10 of 39 entries

Results for HOXB8

Z-value: 0.89

Motif logo

Transcription factors associated with HOXB8

Activity-expression correlation:

Activity profile of HOXB8 motif

Sorted Z-values of HOXB8 motif

No targets for HOXB8

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB8

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: