ISMARA results: HOXC10

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HOXC10_HOXD13

Z-value: 2.97

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Transcription factors associated with HOXC10_HOXD13

Gene Symbol	Gene ID	Gene Info
HOXC10 Ensembl NCBI GeneCards UniProt	ENSG00000180818.4	homeobox C10
HOXD13 Ensembl NCBI GeneCards UniProt	ENSG00000128714.5	homeobox D13

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HOXC10	hg19_v2_chr12_+_54378923_54378970	-0.97	5.4e-13	Click!
HOXD13	hg19_v2_chr2_+_176957619_176957619	-0.73	2.8e-04	Click!

Activity profile of HOXC10_HOXD13 motif

Sorted Z-values of HOXC10_HOXD13 motif

No targets for HOXC10_HOXD13

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXC10_HOXD13

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	21.4	GO:0010107	potassium ion import(GO:0010107)
5.5	16.4	GO:0070563	negative regulation of vitamin D receptor signaling pathway(GO:0070563)
4.6	13.8	GO:0070175	positive regulation of enamel mineralization(GO:0070175)
0.2	13.5	GO:0006120	mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.2	12.8	GO:0018149	peptide cross-linking(GO:0018149)
0.1	12.5	GO:0016266	O-glycan processing(GO:0016266)
0.6	8.6	GO:1904352	positive regulation of protein catabolic process in the vacuole(GO:1904352)
0.0	8.4	GO:0006906	vesicle fusion(GO:0006906)
0.3	7.8	GO:0006704	glucocorticoid biosynthetic process(GO:0006704)
1.1	7.6	GO:0010046	response to mycotoxin(GO:0010046)

Showing 1 to 10 of 242 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	30.0	GO:0000790	nuclear chromatin(GO:0000790)
0.4	21.6	GO:0005605	basal lamina(GO:0005605)
0.2	13.9	GO:0001533	cornified envelope(GO:0001533)
0.6	9.7	GO:0030478	actin cap(GO:0030478)
0.0	9.4	GO:0005770	late endosome(GO:0005770)
0.1	7.9	GO:0030964	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.9	7.6	GO:0097442	CA3 pyramidal cell dendrite(GO:0097442)
0.0	7.0	GO:0005913	cell-cell adherens junction(GO:0005913)
0.1	6.7	GO:0043034	costamere(GO:0043034)
0.1	6.4	GO:0005604	basement membrane(GO:0005604)

Showing 1 to 10 of 114 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	22.1	GO:0015467	G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1	16.6	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.0	15.2	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)
0.2	14.0	GO:0050136	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1	13.3	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0	10.5	GO:0030674	protein binding, bridging(GO:0030674)
0.3	9.5	GO:0005523	tropomyosin binding(GO:0005523)
0.3	9.4	GO:0001871	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.1	8.9	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
2.7	8.0	GO:0003845	11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)

Showing 1 to 10 of 174 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	30.4	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.1	26.5	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.1	21.2	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	13.2	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.1	9.5	PID NOTCH PATHWAY	Notch signaling pathway
0.1	8.3	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.0	8.3	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	8.2	PID FOXO PATHWAY	FoxO family signaling
0.1	7.5	PID LKB1 PATHWAY	LKB1 signaling events
0.1	7.4	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Showing 1 to 10 of 50 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	21.9	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1	12.5	REACTOME O LINKED GLYCOSYLATION OF MUCINS	Genes involved in O-linked glycosylation of mucins
0.1	10.0	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.2	8.0	REACTOME STEROID HORMONES	Genes involved in Steroid hormones
0.1	6.4	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.3	6.0	REACTOME XENOBIOTICS	Genes involved in Xenobiotics
0.3	5.7	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.5	5.0	REACTOME GLYCOPROTEIN HORMONES	Genes involved in Glycoprotein hormones
0.1	4.3	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.1	3.7	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling

Showing 1 to 10 of 67 entries

Results for HOXC10_HOXD13

Z-value: 2.97

Motif logo

Transcription factors associated with HOXC10_HOXD13

Activity-expression correlation:

Activity profile of HOXC10_HOXD13 motif

Sorted Z-values of HOXC10_HOXD13 motif

No targets for HOXC10_HOXD13

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXC10_HOXD13

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: