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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HOXC11

Z-value: 1.11

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Transcription factors associated with HOXC11

Gene Symbol Gene ID Gene Info
ENSG00000123388.4 homeobox C11

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXC11hg19_v2_chr12_+_54366894_543669220.689.2e-04Click!

Activity profile of HOXC11 motif

Sorted Z-values of HOXC11 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXC11

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.2 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.8 3.1 GO:0060585 nitric oxide transport(GO:0030185) negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.5 1.6 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.5 1.4 GO:0045362 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.4 2.2 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.3 0.6 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.3 0.3 GO:0042118 endothelial cell activation(GO:0042118)
0.3 1.5 GO:0061032 cardiac right ventricle formation(GO:0003219) noradrenergic neuron differentiation(GO:0003357) visceral serous pericardium development(GO:0061032)
0.3 2.0 GO:0061113 pancreas morphogenesis(GO:0061113)
0.3 0.8 GO:0051866 general adaptation syndrome(GO:0051866)
0.2 1.0 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.2 0.7 GO:0031548 regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031548)
0.2 0.7 GO:0044205 'de novo' UMP biosynthetic process(GO:0044205)
0.2 0.8 GO:0097156 fasciculation of motor neuron axon(GO:0097156)
0.2 1.6 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.2 0.9 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.2 1.0 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.2 1.5 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.2 0.5 GO:0099543 retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by trans-synaptic complex(GO:0099545)
0.2 0.5 GO:1903718 carbamoyl phosphate metabolic process(GO:0070408) carbamoyl phosphate biosynthetic process(GO:0070409) response to ammonia(GO:1903717) cellular response to ammonia(GO:1903718)
0.2 0.6 GO:0090214 spongiotrophoblast layer developmental growth(GO:0090214)
0.1 0.4 GO:0003331 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.1 0.4 GO:0045897 positive regulation of transcription during mitosis(GO:0045897)
0.1 0.9 GO:0014807 regulation of somitogenesis(GO:0014807)
0.1 1.0 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.1 1.6 GO:0035372 protein localization to microtubule(GO:0035372)
0.1 0.5 GO:0000720 pyrimidine dimer repair by nucleotide-excision repair(GO:0000720)
0.1 0.2 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
0.1 0.5 GO:0048165 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.1 1.0 GO:0035092 sperm chromatin condensation(GO:0035092)
0.1 2.2 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.1 0.4 GO:1904207 regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.1 1.5 GO:0021516 dorsal spinal cord development(GO:0021516)
0.1 0.5 GO:0060754 positive regulation of mast cell chemotaxis(GO:0060754)
0.1 0.3 GO:0007509 mesoderm migration involved in gastrulation(GO:0007509)
0.1 0.4 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.1 0.3 GO:0090107 regulation of high-density lipoprotein particle assembly(GO:0090107)
0.1 0.3 GO:1900039 positive regulation of cellular response to hypoxia(GO:1900039)
0.0 0.2 GO:0098582 innate vocalization behavior(GO:0098582)
0.0 0.5 GO:0070307 lens fiber cell development(GO:0070307)
0.0 0.6 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.0 1.4 GO:0034389 lipid particle organization(GO:0034389)
0.0 0.7 GO:0070166 enamel mineralization(GO:0070166)
0.0 0.1 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
0.0 0.3 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.0 0.1 GO:1901857 positive regulation of cellular respiration(GO:1901857)
0.0 0.5 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.0 0.2 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
0.0 0.5 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.0 2.1 GO:0031648 protein destabilization(GO:0031648)
0.0 0.4 GO:1901299 negative regulation of hydrogen peroxide-mediated programmed cell death(GO:1901299)
0.0 0.1 GO:0002384 hepatic immune response(GO:0002384) response to prolactin(GO:1990637)
0.0 0.2 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 0.7 GO:0072321 chaperone-mediated protein transport(GO:0072321)
0.0 0.2 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.0 0.3 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
0.0 0.2 GO:0071638 negative regulation of monocyte chemotactic protein-1 production(GO:0071638)
0.0 0.2 GO:0060527 prostate glandular acinus morphogenesis(GO:0060526) prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis(GO:0060527)
0.0 0.2 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.7 GO:0003416 endochondral bone growth(GO:0003416)
0.0 0.1 GO:1901979 regulation of inward rectifier potassium channel activity(GO:1901979) regulation of cyclic nucleotide-gated ion channel activity(GO:1902159)
0.0 0.6 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 0.1 GO:1903385 regulation of homophilic cell adhesion(GO:1903385)
0.0 0.7 GO:0006825 copper ion transport(GO:0006825)
0.0 1.2 GO:0048286 lung alveolus development(GO:0048286)
0.0 0.2 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0 0.2 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.0 0.2 GO:1904970 brush border assembly(GO:1904970)
0.0 0.2 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.2 GO:0006878 cellular copper ion homeostasis(GO:0006878)
0.0 1.8 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.0 3.0 GO:0009952 anterior/posterior pattern specification(GO:0009952)
0.0 0.3 GO:0006451 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0 0.0 GO:0043438 acetoacetic acid metabolic process(GO:0043438)
0.0 0.3 GO:0007379 segment specification(GO:0007379)
0.0 0.1 GO:0098907 protein localization to T-tubule(GO:0036371) regulation of SA node cell action potential(GO:0098907)
0.0 0.0 GO:0035038 female pronucleus assembly(GO:0035038)
0.0 0.5 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.0 0.6 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 0.2 GO:0034214 protein hexamerization(GO:0034214)
0.0 0.2 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.0 0.8 GO:0048599 oocyte development(GO:0048599)
0.0 0.1 GO:0021562 vestibulocochlear nerve development(GO:0021562)
0.0 0.0 GO:0009236 cobalamin biosynthetic process(GO:0009236)
0.0 0.2 GO:0035878 nail development(GO:0035878)
0.0 0.1 GO:0070777 gamma-aminobutyric acid biosynthetic process(GO:0009449) D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 1.8 GO:0030516 regulation of axon extension(GO:0030516)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.1 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.5 1.6 GO:0005588 collagen type V trimer(GO:0005588)
0.5 1.5 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.4 1.6 GO:0008043 intracellular ferritin complex(GO:0008043) ferritin complex(GO:0070288)
0.2 1.9 GO:1990111 spermatoproteasome complex(GO:1990111)
0.2 1.2 GO:0001674 female germ cell nucleus(GO:0001674)
0.1 1.6 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.1 2.2 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 0.5 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.1 0.2 GO:0033186 CAF-1 complex(GO:0033186)
0.1 0.5 GO:0061574 ASAP complex(GO:0061574)
0.0 0.1 GO:0033011 perinuclear theca(GO:0033011)
0.0 0.2 GO:1990037 Lewy body core(GO:1990037)
0.0 0.3 GO:0044305 calyx of Held(GO:0044305)
0.0 0.5 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 0.4 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.3 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.4 GO:0033269 internode region of axon(GO:0033269)
0.0 0.6 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.1 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 0.5 GO:0032433 filopodium tip(GO:0032433)
0.0 0.2 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 1.6 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.5 GO:0000145 exocyst(GO:0000145)
0.0 0.6 GO:0000421 autophagosome membrane(GO:0000421)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.2 GO:0016211 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.7 2.2 GO:0005427 proton-dependent oligopeptide secondary active transmembrane transporter activity(GO:0005427) secondary active oligopeptide transmembrane transporter activity(GO:0015322)
0.6 3.1 GO:0031708 endothelin B receptor binding(GO:0031708)
0.5 1.4 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.4 1.8 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.3 0.9 GO:0005146 leukemia inhibitory factor receptor binding(GO:0005146)
0.3 1.2 GO:0004087 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.2 0.7 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.1 2.7 GO:0008061 chitin binding(GO:0008061)
0.1 0.4 GO:0034739 histone deacetylase activity (H4-K16 specific)(GO:0034739)
0.1 0.7 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 1.6 GO:0008199 ferric iron binding(GO:0008199)
0.1 0.5 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.1 0.5 GO:1990254 keratin filament binding(GO:1990254)
0.1 2.2 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 0.4 GO:0032558 adenyl deoxyribonucleotide binding(GO:0032558) dATP binding(GO:0032564)
0.1 0.5 GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599)
0.1 1.4 GO:0003680 AT DNA binding(GO:0003680)
0.1 1.9 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 0.3 GO:0051373 FATZ binding(GO:0051373)
0.1 1.5 GO:0071837 HMG box domain binding(GO:0071837)
0.1 0.8 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.0 0.3 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.0 5.1 GO:0098531 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0 0.2 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.5 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.5 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.0 0.3 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.0 0.1 GO:0097003 adipokinetic hormone receptor activity(GO:0097003)
0.0 0.4 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.3 GO:0005497 androgen binding(GO:0005497)
0.0 0.2 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.0 0.2 GO:0001602 pancreatic polypeptide receptor activity(GO:0001602)
0.0 0.2 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.0 0.1 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.0 0.2 GO:0070087 chromo shadow domain binding(GO:0070087)
0.0 0.1 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.0 0.1 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.0 0.9 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.4 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.3 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.2 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.0 0.5 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.2 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.6 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.5 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 2.0 GO:0008080 N-acetyltransferase activity(GO:0008080)
0.0 0.0 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.0 0.3 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.1 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.1 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.0 0.4 GO:0005520 insulin-like growth factor binding(GO:0005520)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.0 3.1 PID ENDOTHELIN PATHWAY Endothelins
0.0 0.5 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 1.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.9 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 1.3 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.1 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 0.8 PID EPHA FWDPATHWAY EPHA forward signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.1 5.2 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 1.8 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 2.3 REACTOME IRON UPTAKE AND TRANSPORT Genes involved in Iron uptake and transport
0.0 0.5 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 1.9 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 4.9 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.4 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 1.4 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.3 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.7 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 1.7 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.5 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.0 0.2 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.5 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.3 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.3 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones