ISMARA results: HOXC12

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HOXC12_HOXD12

Z-value: 1.44

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Transcription factors associated with HOXC12_HOXD12

Gene Symbol	Gene ID	Gene Info
HOXC12 Ensembl NCBI GeneCards UniProt	ENSG00000123407.3	homeobox C12
HOXD12 Ensembl NCBI GeneCards UniProt	ENSG00000170178.5	homeobox D12

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HOXC12	hg19_v2_chr12_+_54348618_54348693	0.12	6.2e-01	Click!
HOXD12	hg19_v2_chr2_+_176964458_176964540	-0.08	7.5e-01	Click!

Activity profile of HOXC12_HOXD12 motif

Sorted Z-values of HOXC12_HOXD12 motif

No targets for HOXC12_HOXD12

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXC12_HOXD12

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	3.9	GO:0006433	glutamyl-tRNA aminoacylation(GO:0006424) prolyl-tRNA aminoacylation(GO:0006433)
0.1	2.9	GO:0007026	negative regulation of microtubule depolymerization(GO:0007026)
0.7	2.7	GO:0001732	formation of cytoplasmic translation initiation complex(GO:0001732)
0.1	2.7	GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.1	1.5	GO:0034501	protein localization to kinetochore(GO:0034501)
0.0	1.3	GO:0032755	positive regulation of interleukin-6 production(GO:0032755)
0.0	1.0	GO:0070987	error-free translesion synthesis(GO:0070987)
0.1	0.9	GO:0010032	meiotic chromosome condensation(GO:0010032)
0.0	0.9	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	0.8	GO:1904871	regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871)

Showing 1 to 10 of 108 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	3.9	GO:0097452	GAIT complex(GO:0097452)
0.0	3.1	GO:0005881	cytoplasmic microtubule(GO:0005881)
0.2	2.7	GO:0071541	eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.6	2.4	GO:0005967	mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.1	1.7	GO:0000940	condensed chromosome outer kinetochore(GO:0000940)
0.2	1.6	GO:0005663	DNA replication factor C complex(GO:0005663)
0.2	0.9	GO:0000799	nuclear condensin complex(GO:0000799)
0.0	0.9	GO:0002102	podosome(GO:0002102)
0.2	0.8	GO:1990423	RZZ complex(GO:1990423)
0.1	0.8	GO:1990316	ATG1/ULK1 kinase complex(GO:1990316)

Showing 1 to 10 of 51 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	3.9	GO:0004827	glutamate-tRNA ligase activity(GO:0004818) proline-tRNA ligase activity(GO:0004827)
0.7	2.7	GO:0098808	mRNA cap binding(GO:0098808)
0.8	2.4	GO:0016418	S-acetyltransferase activity(GO:0016418)
0.2	1.7	GO:0043515	kinetochore binding(GO:0043515)
0.2	1.6	GO:0003689	DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0	1.2	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	1.0	GO:0005154	epidermal growth factor receptor binding(GO:0005154)
0.0	0.8	GO:0035612	AP-2 adaptor complex binding(GO:0035612)
0.2	0.7	GO:0003918	DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0	0.7	GO:0035374	chondroitin sulfate binding(GO:0035374)

Showing 1 to 10 of 70 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
1.4	PID AURORA B PATHWAY	Aurora B signaling
1.0	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.9	PID ATR PATHWAY	ATR signaling pathway
0.8	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.7	PID REELIN PATHWAY	Reelin signaling pathway
0.5	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.4	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.4	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.3	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway

Showing 1 to 9 of 9 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.9	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.1	2.7	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0	1.5	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0	1.1	REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0	0.9	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.8	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.0	0.8	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.0	0.7	REACTOME POL SWITCHING	Genes involved in Polymerase switching
0.0	0.7	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.0	0.6	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network

Showing 1 to 10 of 20 entries

Results for HOXC12_HOXD12

Z-value: 1.44

Motif logo

Transcription factors associated with HOXC12_HOXD12

Activity-expression correlation:

Activity profile of HOXC12_HOXD12 motif

Sorted Z-values of HOXC12_HOXD12 motif

No targets for HOXC12_HOXD12

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXC12_HOXD12

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: