ISMARA results: HOXC6

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HOXC6_HOXA7

Z-value: 0.49

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Transcription factors associated with HOXC6_HOXA7

Gene Symbol	Gene ID	Gene Info
HOXC6 Ensembl NCBI GeneCards UniProt	ENSG00000197757.7	homeobox C6
HOXA7 Ensembl NCBI GeneCards UniProt	ENSG00000122592.6	homeobox A7

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HOXC6	hg19_v2_chr12_+_54384370_54384408	-0.67	1.2e-03	Click!
HOXA7	hg19_v2_chr7_-_27196267_27196311	-0.61	4.6e-03	Click!

Activity profile of HOXC6_HOXA7 motif

Sorted Z-values of HOXC6_HOXA7 motif

No targets for HOXC6_HOXA7

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXC6_HOXA7

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.8	GO:0034314	Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.1	0.7	GO:0071279	cellular response to cobalt ion(GO:0071279)
0.1	0.6	GO:1900623	regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.2	0.5	GO:0060489	orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.1	0.5	GO:0035425	autocrine signaling(GO:0035425)
0.0	0.5	GO:0042420	dopamine catabolic process(GO:0042420)
0.0	0.5	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.1	0.4	GO:1903674	regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
0.1	0.4	GO:0010133	proline catabolic process to glutamate(GO:0010133)
0.0	0.4	GO:0043152	induction of bacterial agglutination(GO:0043152)

Showing 1 to 10 of 32 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.8	GO:0005885	Arp2/3 protein complex(GO:0005885)
0.0	0.7	GO:0043203	axon hillock(GO:0043203)
0.1	0.6	GO:0035692	macrophage migration inhibitory factor receptor complex(GO:0035692)
0.1	0.5	GO:0060187	cell pole(GO:0060187)
0.0	0.4	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.4	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.0	0.3	GO:0097129	cyclin D2-CDK4 complex(GO:0097129)
0.0	0.3	GO:0097169	AIM2 inflammasome complex(GO:0097169)
0.1	0.2	GO:0005608	laminin-3 complex(GO:0005608)
0.0	0.2	GO:0005742	mitochondrial outer membrane translocase complex(GO:0005742)

Showing 1 to 10 of 12 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	GO:0008131	primary amine oxidase activity(GO:0008131)
0.0	0.5	GO:0005540	hyaluronic acid binding(GO:0005540)
0.1	0.4	GO:0004657	proline dehydrogenase activity(GO:0004657)
0.1	0.4	GO:0071074	eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0	0.3	GO:0008417	fucosyltransferase activity(GO:0008417)
0.0	0.3	GO:0050700	CARD domain binding(GO:0050700)
0.0	0.2	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.0	0.2	GO:0047894	flavonol 3-sulfotransferase activity(GO:0047894) steroid sulfotransferase activity(GO:0050294)
0.0	0.2	GO:0016909	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0	0.2	GO:0097016	L27 domain binding(GO:0097016)

Showing 1 to 10 of 23 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.6	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Showing 1 to 1 of 1 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Total log-likelihood	Term	Description
0.6	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.5	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.4	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.4	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.4	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac

Showing 1 to 5 of 5 entries

Results for HOXC6_HOXA7

Z-value: 0.49

Motif logo

Transcription factors associated with HOXC6_HOXA7

Activity-expression correlation:

Activity profile of HOXC6_HOXA7 motif

Sorted Z-values of HOXC6_HOXA7 motif

No targets for HOXC6_HOXA7

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXC6_HOXA7

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: