ISMARA results: HOXD1

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HOXD1

Z-value: 0.91

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Transcription factors associated with HOXD1

Gene Symbol	Gene ID	Gene Info
HOXD1 Ensembl NCBI GeneCards UniProt	ENSG00000128645.11	homeobox D1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HOXD1	hg19_v2_chr2_+_177053307_177053402	-0.58	6.7e-03	Click!

Activity profile of HOXD1 motif

Sorted Z-values of HOXD1 motif

No targets for HOXD1

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXD1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.5	4.5	GO:0070563	negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.9	2.7	GO:0061713	neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713)
0.1	2.5	GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.1	2.3	GO:0042420	dopamine catabolic process(GO:0042420)
0.4	2.0	GO:0007070	negative regulation of transcription during mitosis(GO:0007068) negative regulation of transcription from RNA polymerase II promoter during mitosis(GO:0007070)
0.0	2.0	GO:0035728	response to hepatocyte growth factor(GO:0035728)
0.0	1.8	GO:0030574	collagen catabolic process(GO:0030574)
0.4	1.7	GO:1901994	negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.0	1.6	GO:0016266	O-glycan processing(GO:0016266)
0.1	0.9	GO:1903575	cornified envelope assembly(GO:1903575)

Showing 1 to 10 of 24 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.3	GO:0043209	myelin sheath(GO:0043209)
0.1	2.7	GO:0031362	anchored component of external side of plasma membrane(GO:0031362)
0.1	2.0	GO:0071564	npBAF complex(GO:0071564)
0.0	1.6	GO:0005796	Golgi lumen(GO:0005796)
0.3	0.8	GO:1990032	parallel fiber(GO:1990032)
0.0	0.7	GO:0031258	lamellipodium membrane(GO:0031258)
0.1	0.6	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.0	0.6	GO:0030127	COPII vesicle coat(GO:0030127)
0.0	0.4	GO:1990578	perinuclear endoplasmic reticulum membrane(GO:1990578)
0.0	0.4	GO:0014701	junctional sarcoplasmic reticulum membrane(GO:0014701)

Showing 1 to 10 of 11 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	6.2	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.7	2.7	GO:0061714	folic acid receptor activity(GO:0061714)
0.1	2.5	GO:0001608	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.3	2.3	GO:0008131	primary amine oxidase activity(GO:0008131)
0.0	2.3	GO:0016303	1-phosphatidylinositol-3-kinase activity(GO:0016303)
0.1	2.0	GO:0030957	Tat protein binding(GO:0030957)
0.0	1.8	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.1	0.8	GO:0035662	Toll-like receptor 4 binding(GO:0035662)
0.0	0.8	GO:0019707	protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0	0.7	GO:0005385	zinc ion transmembrane transporter activity(GO:0005385)

Showing 1 to 10 of 18 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	6.8	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1	2.0	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.0	0.8	PID RAS PATHWAY	Regulation of Ras family activation

Showing 1 to 3 of 3 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.3	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0	2.3	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR
0.1	1.8	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.0	1.6	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.0	0.7	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.0	0.6	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Showing 1 to 6 of 6 entries

Results for HOXD1

Z-value: 0.91

Motif logo

Transcription factors associated with HOXD1

Activity-expression correlation:

Activity profile of HOXD1 motif

Sorted Z-values of HOXD1 motif

No targets for HOXD1

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXD1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: