ISMARA results: HOXD10

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HOXD10

Z-value: 1.24

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Transcription factors associated with HOXD10

Gene Symbol	Gene ID	Gene Info
HOXD10 Ensembl NCBI GeneCards UniProt	ENSG00000128710.5	homeobox D10

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HOXD10	hg19_v2_chr2_+_176981307_176981307	-0.70	5.5e-04	Click!

Activity profile of HOXD10 motif

Sorted Z-values of HOXD10 motif

No targets for HOXD10

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXD10

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	6.3	GO:0030216	keratinocyte differentiation(GO:0030216)
0.1	5.3	GO:0007585	respiratory gaseous exchange(GO:0007585)
0.4	3.9	GO:0038044	transforming growth factor-beta secretion(GO:0038044)
0.1	2.7	GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.5	2.5	GO:1903285	negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470)
0.1	2.3	GO:0042481	regulation of odontogenesis(GO:0042481)
0.4	2.2	GO:0090362	positive regulation of platelet-derived growth factor production(GO:0090362)
0.5	2.1	GO:0050717	positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.0	2.1	GO:0018149	peptide cross-linking(GO:0018149)
0.5	1.9	GO:0001808	negative regulation of type IV hypersensitivity(GO:0001808)

Showing 1 to 10 of 132 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	9.2	GO:0001533	cornified envelope(GO:0001533)
1.3	3.9	GO:0034685	integrin alphav-beta6 complex(GO:0034685)
0.4	3.4	GO:0097169	AIM2 inflammasome complex(GO:0097169)
0.1	2.5	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.0	2.3	GO:0101003	ficolin-1-rich granule membrane(GO:0101003)
0.2	1.9	GO:0005955	calcineurin complex(GO:0005955)
0.0	1.9	GO:0005776	autophagosome(GO:0005776)
0.0	1.8	GO:0005790	smooth endoplasmic reticulum(GO:0005790)
0.3	1.7	GO:0000308	cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0	1.6	GO:0035578	azurophil granule lumen(GO:0035578)

Showing 1 to 10 of 49 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	6.9	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.0	4.8	GO:0001618	virus receptor activity(GO:0001618)
0.0	4.1	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.1	3.6	GO:0050700	CARD domain binding(GO:0050700)
0.1	2.7	GO:0003746	translation elongation factor activity(GO:0003746)
0.5	2.5	GO:0060961	phospholipase D inhibitor activity(GO:0060961)
0.3	1.9	GO:0042015	interleukin-20 binding(GO:0042015)
0.1	1.9	GO:0033192	calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0	1.9	GO:0070530	K63-linked polyubiquitin binding(GO:0070530)
0.0	1.9	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)

Showing 1 to 10 of 89 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.3	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	3.9	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0	2.4	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.1	2.1	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.0	1.8	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.0	1.8	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.0	1.7	PID EPHB FWD PATHWAY	EPHB forward signaling
0.0	1.5	PID MYC PATHWAY	C-MYC pathway
0.1	1.3	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.0	1.2	PID CASPASE PATHWAY	Caspase cascade in apoptosis

Showing 1 to 10 of 19 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.6	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1	2.5	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.0	1.8	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.0	1.6	REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES	Genes involved in Loss of Nlp from mitotic centrosomes
0.0	1.5	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.0	1.5	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.0	1.5	REACTOME AMYLOIDS	Genes involved in Amyloids
0.0	1.2	REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1	1.1	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
0.0	1.0	REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	Genes involved in Transport to the Golgi and subsequent modification

Showing 1 to 10 of 29 entries

Results for HOXD10

Z-value: 1.24

Motif logo

Transcription factors associated with HOXD10

Activity-expression correlation:

Activity profile of HOXD10 motif

Sorted Z-values of HOXD10 motif

No targets for HOXD10

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXD10

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: