ISMARA results: HOXD4

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HOXD4

Z-value: 0.69

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Transcription factors associated with HOXD4

Gene Symbol	Gene ID	Gene Info
HOXD4 Ensembl NCBI GeneCards UniProt	ENSG00000170166.5	homeobox D4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HOXD4	hg19_v2_chr2_+_177015950_177015950	0.81	1.6e-05	Click!

Activity profile of HOXD4 motif

Sorted Z-values of HOXD4 motif

No targets for HOXD4

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXD4

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	4.5	GO:0043152	induction of bacterial agglutination(GO:0043152)
0.1	1.9	GO:0032060	bleb assembly(GO:0032060)
0.1	1.7	GO:0034392	negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.4	1.6	GO:0048687	modulation by virus of host transcription(GO:0019056) positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026)
0.5	1.4	GO:0006663	platelet activating factor biosynthetic process(GO:0006663)
0.1	0.9	GO:0060385	axonogenesis involved in innervation(GO:0060385)
0.2	0.7	GO:0072428	signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.0	0.7	GO:0006506	GPI anchor biosynthetic process(GO:0006506)
0.1	0.6	GO:0007352	zygotic specification of dorsal/ventral axis(GO:0007352)
0.1	0.6	GO:0006627	protein processing involved in protein targeting to mitochondrion(GO:0006627)

Showing 1 to 10 of 57 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	4.5	GO:0005577	fibrinogen complex(GO:0005577)
0.1	1.7	GO:0031089	platelet dense granule lumen(GO:0031089)
0.0	1.7	GO:0005811	lipid particle(GO:0005811)
0.0	0.7	GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.2	0.6	GO:0042720	mitochondrial inner membrane peptidase complex(GO:0042720)
0.0	0.6	GO:0030314	junctional membrane complex(GO:0030314)
0.0	0.5	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	0.4	GO:1990357	terminal web(GO:1990357)
0.0	0.4	GO:0030130	clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0	0.4	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)

Showing 1 to 10 of 23 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.2	GO:0051087	chaperone binding(GO:0051087)
0.3	1.7	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
0.1	1.6	GO:0005030	neurotrophin receptor activity(GO:0005030)
0.1	1.4	GO:0047498	calcium-dependent phospholipase A2 activity(GO:0047498)
0.2	0.7	GO:0072590	N-acetyl-L-aspartate-L-glutamate ligase activity(GO:0072590)
0.0	0.7	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.2	0.6	GO:0035248	alpha-1,4-N-acetylgalactosaminyltransferase activity(GO:0035248)
0.0	0.6	GO:0015278	calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604)
0.1	0.5	GO:0035373	chondroitin sulfate proteoglycan binding(GO:0035373)
0.1	0.5	GO:0050815	phosphoserine binding(GO:0050815) phosphothreonine binding(GO:0050816)

Showing 1 to 10 of 41 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.5	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.0	1.8	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.0	1.0	PID INSULIN PATHWAY	Insulin Pathway
0.0	0.5	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events

Showing 1 to 4 of 4 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	4.5	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.1	1.4	REACTOME ACYL CHAIN REMODELLING OF PS	Genes involved in Acyl chain remodelling of PS
0.0	0.7	REACTOME G2 M DNA DAMAGE CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.0	0.5	REACTOME CD28 DEPENDENT PI3K AKT SIGNALING	Genes involved in CD28 dependent PI3K/Akt signaling
0.0	0.4	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.0	0.4	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.0	0.4	REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA	Genes involved in G beta:gamma signalling through PLC beta
0.0	0.2	REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION	Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.0	0.2	REACTOME POL SWITCHING	Genes involved in Polymerase switching

Showing 1 to 9 of 9 entries

Results for HOXD4

Z-value: 0.69

Motif logo

Transcription factors associated with HOXD4

Activity-expression correlation:

Activity profile of HOXD4 motif

Sorted Z-values of HOXD4 motif

No targets for HOXD4

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXD4

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: