ISMARA results: HSF2

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HSF2

Z-value: 1.23

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Transcription factors associated with HSF2

Gene Symbol	Gene ID	Gene Info
HSF2 Ensembl NCBI GeneCards UniProt	ENSG00000025156.8	heat shock transcription factor 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HSF2	hg19_v2_chr6_+_122720681_122720713	-0.05	8.4e-01	Click!

Activity profile of HSF2 motif

Sorted Z-values of HSF2 motif

No targets for HSF2

Network of associatons between targets according to the STRING database.

First level regulatory network of HSF2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.4	GO:0043587	tongue morphogenesis(GO:0043587)
0.1	2.4	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.0	1.2	GO:0043268	positive regulation of potassium ion transport(GO:0043268)
0.1	0.9	GO:0010193	response to ozone(GO:0010193)
0.1	0.9	GO:1903786	mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound catabolic process(GO:1901377) regulation of glutathione biosynthetic process(GO:1903786) positive regulation of glutathione biosynthetic process(GO:1903788)
0.0	0.9	GO:0035376	sterol import(GO:0035376) cholesterol import(GO:0070508)
0.1	0.8	GO:1901908	diadenosine polyphosphate catabolic process(GO:0015961) diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.1	0.8	GO:1902045	negative regulation of Fas signaling pathway(GO:1902045)
0.1	0.8	GO:0014718	positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718)
0.0	0.8	GO:0048488	synaptic vesicle endocytosis(GO:0048488)

Showing 1 to 10 of 60 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.4	GO:0045095	keratin filament(GO:0045095)
0.0	0.8	GO:0071682	endocytic vesicle lumen(GO:0071682)
0.2	0.7	GO:0016222	procollagen-proline 4-dioxygenase complex(GO:0016222)
0.1	0.7	GO:0016602	CCAAT-binding factor complex(GO:0016602)
0.0	0.6	GO:0031258	lamellipodium membrane(GO:0031258)
0.1	0.4	GO:0031838	haptoglobin-hemoglobin complex(GO:0031838)
0.1	0.4	GO:1990769	proximal neuron projection(GO:1990769)
0.1	0.4	GO:0098575	lumenal side of lysosomal membrane(GO:0098575)
0.1	0.4	GO:0005784	Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0	0.4	GO:0097512	cardiac myofibril(GO:0097512)

Showing 1 to 10 of 15 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.9	GO:0032052	bile acid binding(GO:0032052)
0.0	0.9	GO:0008391	arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.0	0.9	GO:0001671	ATPase activator activity(GO:0001671)
0.0	0.9	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1	0.8	GO:0052847	endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432) inositol diphosphate tetrakisphosphate diphosphatase activity(GO:0052840) inositol bisdiphosphate tetrakisphosphate diphosphatase activity(GO:0052841) inositol diphosphate pentakisphosphate diphosphatase activity(GO:0052842) inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity(GO:0052843) inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity(GO:0052844) inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity(GO:0052845) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity(GO:0052846) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052847) inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052848)
0.0	0.8	GO:0031432	titin binding(GO:0031432)
0.0	0.8	GO:0005123	death receptor binding(GO:0005123)
0.1	0.7	GO:0070728	leucine binding(GO:0070728)
0.1	0.7	GO:0019798	procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.0	0.6	GO:0043225	anion transmembrane-transporting ATPase activity(GO:0043225)

Showing 1 to 10 of 42 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.0	PID WNT NONCANONICAL PATHWAY	Noncanonical Wnt signaling pathway
0.0	0.5	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway

Showing 1 to 2 of 2 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.1	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0	0.9	REACTOME XENOBIOTICS	Genes involved in Xenobiotics
0.0	0.9	REACTOME STEROID HORMONES	Genes involved in Steroid hormones
0.0	0.7	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.0	0.6	REACTOME HYALURONAN METABOLISM	Genes involved in Hyaluronan metabolism
0.0	0.5	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.0	0.5	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.0	0.4	REACTOME SEMA3A PAK DEPENDENT AXON REPULSION	Genes involved in Sema3A PAK dependent Axon repulsion
0.0	0.4	REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS	Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0	0.1	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism

Showing 1 to 10 of 10 entries

Results for HSF2

Z-value: 1.23

Motif logo

Transcription factors associated with HSF2

Activity-expression correlation:

Activity profile of HSF2 motif

Sorted Z-values of HSF2 motif

No targets for HSF2

Network of associatons between targets according to the STRING database.

First level regulatory network of HSF2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: