ISMARA results: IRF2_STAT2_IRF8

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for IRF2_STAT2_IRF8_IRF1

Z-value: 7.52

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Transcription factors associated with IRF2_STAT2_IRF8_IRF1

Gene Symbol	Gene ID	Gene Info
IRF2 Ensembl NCBI GeneCards UniProt	ENSG00000168310.6	interferon regulatory factor 2
STAT2 Ensembl NCBI GeneCards UniProt	ENSG00000170581.9	signal transducer and activator of transcription 2
IRF8 Ensembl NCBI GeneCards UniProt	ENSG00000140968.6	interferon regulatory factor 8
IRF1 Ensembl NCBI GeneCards UniProt	ENSG00000125347.9	interferon regulatory factor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
STAT2	hg19_v2_chr12_-_56753858_56753930	0.96	4.0e-11	Click!
IRF8	hg19_v2_chr16_+_85942594_85942635	-0.59	5.7e-03	Click!
IRF2	hg19_v2_chr4_-_185395672_185395734	0.57	8.2e-03	Click!
IRF1	hg19_v2_chr5_-_131826457_131826514	0.46	3.9e-02	Click!

Activity profile of IRF2_STAT2_IRF8_IRF1 motif

Sorted Z-values of IRF2_STAT2_IRF8_IRF1 motif

No targets for IRF2_STAT2_IRF8_IRF1

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF2_STAT2_IRF8_IRF1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	55.7	GO:0045824	negative regulation of innate immune response(GO:0045824)
5.0	54.7	GO:0018377	protein myristoylation(GO:0018377)
2.2	45.7	GO:0003373	dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
3.0	45.6	GO:0035457	cellular response to interferon-alpha(GO:0035457)
3.2	38.9	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.1	38.9	GO:0009615	response to virus(GO:0009615)
0.4	30.3	GO:0070206	protein trimerization(GO:0070206)
0.6	30.0	GO:0046825	regulation of protein export from nucleus(GO:0046825)
0.9	28.5	GO:0035456	response to interferon-beta(GO:0035456)
6.8	27.3	GO:0034343	type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)

Showing 1 to 10 of 344 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	95.1	GO:0005739	mitochondrion(GO:0005739)
0.1	53.3	GO:0016607	nuclear speck(GO:0016607)
0.4	38.3	GO:0015030	Cajal body(GO:0015030)
4.4	30.5	GO:0097179	protease inhibitor complex(GO:0097179)
0.3	29.0	GO:0035577	azurophil granule membrane(GO:0035577)
0.8	26.3	GO:0034385	very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.1	25.5	GO:0031965	nuclear membrane(GO:0031965)
0.1	22.6	GO:0045111	intermediate filament cytoskeleton(GO:0045111)
0.0	20.4	GO:0010008	endosome membrane(GO:0010008)
0.2	19.7	GO:0005811	lipid particle(GO:0005811)

Showing 1 to 10 of 155 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	59.4	GO:0005525	GTP binding(GO:0005525)
0.2	54.3	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.4	53.0	GO:0003725	double-stranded RNA binding(GO:0003725)
4.4	52.5	GO:0001730	2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.7	38.4	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.8	31.0	GO:0005521	lamin binding(GO:0005521)
0.0	30.6	GO:0008270	zinc ion binding(GO:0008270)
0.1	27.9	GO:0030674	protein binding, bridging(GO:0030674)
2.8	22.2	GO:0042289	MHC class II protein binding(GO:0042289)
0.9	21.4	GO:0008035	high-density lipoprotein particle binding(GO:0008035)

Showing 1 to 10 of 230 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	27.0	PID MYC PATHWAY	C-MYC pathway
0.5	19.6	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.1	17.6	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2	17.3	PID REG GR PATHWAY	Glucocorticoid receptor regulatory network
0.1	16.0	SIG PIP3 SIGNALING IN CARDIAC MYOCTES	Genes related to PIP3 signaling in cardiac myocytes
0.9	12.6	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.1	12.5	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.0	11.9	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	11.4	PID HDAC CLASSI PATHWAY	Signaling events mediated by HDAC Class I
0.1	10.1	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling

Showing 1 to 10 of 59 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.2	322.8	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.5	34.5	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.6	28.9	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
1.3	21.5	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway
1.0	21.1	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.4	17.0	REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS	Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.2	15.0	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.2	14.8	REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.7	13.6	REACTOME PD1 SIGNALING	Genes involved in PD-1 signaling
0.1	12.8	REACTOME O LINKED GLYCOSYLATION OF MUCINS	Genes involved in O-linked glycosylation of mucins

Showing 1 to 10 of 76 entries

Results for IRF2_STAT2_IRF8_IRF1

Z-value: 7.52

Motif logo

Transcription factors associated with IRF2_STAT2_IRF8_IRF1

Activity-expression correlation:

Activity profile of IRF2_STAT2_IRF8_IRF1 motif

Sorted Z-values of IRF2_STAT2_IRF8_IRF1 motif

No targets for IRF2_STAT2_IRF8_IRF1

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF2_STAT2_IRF8_IRF1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: