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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for IRF2_STAT2_IRF8_IRF1

Z-value: 7.52

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Transcription factors associated with IRF2_STAT2_IRF8_IRF1

Gene Symbol Gene ID Gene Info
ENSG00000168310.6 interferon regulatory factor 2
ENSG00000170581.9 signal transducer and activator of transcription 2
ENSG00000140968.6 interferon regulatory factor 8
ENSG00000125347.9 interferon regulatory factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
STAT2hg19_v2_chr12_-_56753858_567539300.964.0e-11Click!
IRF8hg19_v2_chr16_+_85942594_85942635-0.595.7e-03Click!
IRF2hg19_v2_chr4_-_185395672_1853957340.578.2e-03Click!
IRF1hg19_v2_chr5_-_131826457_1318265140.463.9e-02Click!

Activity profile of IRF2_STAT2_IRF8_IRF1 motif

Sorted Z-values of IRF2_STAT2_IRF8_IRF1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF2_STAT2_IRF8_IRF1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
6.8 27.3 GO:0034343 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
5.2 20.9 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
5.0 54.7 GO:0018377 protein myristoylation(GO:0018377)
4.7 14.2 GO:0002731 negative regulation of dendritic cell cytokine production(GO:0002731) negative regulation of intracellular transport of viral material(GO:1901253)
4.2 25.3 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
4.1 16.5 GO:0051097 negative regulation of helicase activity(GO:0051097)
4.1 20.5 GO:2000110 negative regulation of macrophage apoptotic process(GO:2000110)
3.9 11.8 GO:0010847 regulation of chromatin assembly(GO:0010847)
3.4 20.3 GO:0034165 positive regulation of toll-like receptor 9 signaling pathway(GO:0034165)
3.2 38.9 GO:0032020 ISG15-protein conjugation(GO:0032020)
3.0 45.6 GO:0035457 cellular response to interferon-alpha(GO:0035457)
2.7 10.8 GO:0009138 pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
2.4 9.5 GO:0002428 antigen processing and presentation of peptide antigen via MHC class Ib(GO:0002428)
2.2 6.7 GO:1902173 negative regulation of keratinocyte apoptotic process(GO:1902173)
2.2 45.7 GO:0003373 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
2.1 21.2 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
2.0 9.9 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
1.9 15.5 GO:0030578 PML body organization(GO:0030578)
1.9 5.8 GO:0002519 natural killer cell tolerance induction(GO:0002519) positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
1.9 7.5 GO:0036269 swimming behavior(GO:0036269)
1.8 1.8 GO:0002859 negative regulation of response to tumor cell(GO:0002835) negative regulation of immune response to tumor cell(GO:0002838) negative regulation of natural killer cell mediated immune response to tumor cell(GO:0002856) negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002859)
1.7 10.1 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
1.7 11.8 GO:1902162 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
1.6 26.4 GO:0035455 response to interferon-alpha(GO:0035455)
1.6 13.1 GO:0018242 protein O-linked glycosylation via serine(GO:0018242)
1.5 3.1 GO:0046967 cytosol to ER transport(GO:0046967)
1.4 8.5 GO:1904274 tricellular tight junction assembly(GO:1904274)
1.4 11.2 GO:0071494 cellular response to UV-C(GO:0071494)
1.4 1.4 GO:0002590 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590)
1.3 3.8 GO:1901252 regulation of intracellular transport of viral material(GO:1901252)
1.2 9.5 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
1.2 3.5 GO:0048633 negative regulation of auditory receptor cell differentiation(GO:0045608) positive regulation of skeletal muscle tissue growth(GO:0048633)
1.2 1.2 GO:0060545 positive regulation of necroptotic process(GO:0060545)
1.1 6.9 GO:0030421 defecation(GO:0030421)
1.1 8.7 GO:0045591 positive regulation of regulatory T cell differentiation(GO:0045591)
1.1 4.3 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
1.0 12.3 GO:0015760 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
1.0 3.0 GO:0021776 smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
1.0 4.0 GO:0046725 negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308)
0.9 10.4 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
0.9 4.7 GO:0021557 optic cup structural organization(GO:0003409) oculomotor nerve development(GO:0021557) oculomotor nerve morphogenesis(GO:0021622) oculomotor nerve formation(GO:0021623)
0.9 10.3 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902)
0.9 28.5 GO:0035456 response to interferon-beta(GO:0035456)
0.9 13.4 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.8 2.5 GO:1990108 protein linear deubiquitination(GO:1990108)
0.8 55.7 GO:0045824 negative regulation of innate immune response(GO:0045824)
0.8 4.0 GO:2000638 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.7 18.2 GO:0051798 positive regulation of hair follicle development(GO:0051798)
0.7 16.4 GO:0010818 T cell chemotaxis(GO:0010818)
0.7 4.9 GO:0070383 DNA cytosine deamination(GO:0070383)
0.6 1.9 GO:0060129 regulation of calcium-independent cell-cell adhesion(GO:0051040) thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.6 1.9 GO:0036451 cap mRNA methylation(GO:0036451)
0.6 2.6 GO:0070895 transposon integration(GO:0070893) regulation of transposon integration(GO:0070894) negative regulation of transposon integration(GO:0070895)
0.6 30.0 GO:0046825 regulation of protein export from nucleus(GO:0046825)
0.6 1.9 GO:0048627 myoblast development(GO:0048627)
0.6 7.5 GO:0035986 senescence-associated heterochromatin focus assembly(GO:0035986)
0.6 1.8 GO:1904596 regulation of connective tissue replacement involved in inflammatory response wound healing(GO:1904596) negative regulation of connective tissue replacement involved in inflammatory response wound healing(GO:1904597) regulation of advanced glycation end-product receptor activity(GO:1904603) negative regulation of advanced glycation end-product receptor activity(GO:1904604) negative regulation of connective tissue replacement(GO:1905204)
0.6 2.8 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.5 11.5 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.5 5.9 GO:0098795 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.5 10.4 GO:0090179 planar cell polarity pathway involved in neural tube closure(GO:0090179)
0.5 5.2 GO:1990504 dense core granule exocytosis(GO:1990504)
0.5 5.5 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
0.5 1.0 GO:0055099 response to high density lipoprotein particle(GO:0055099)
0.5 1.9 GO:1990535 neuron projection maintenance(GO:1990535)
0.5 2.8 GO:0010793 regulation of mRNA export from nucleus(GO:0010793)
0.5 1.4 GO:0048007 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.5 2.3 GO:1902724 mineralocorticoid receptor signaling pathway(GO:0031959) positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728)
0.4 1.7 GO:0010481 ectoderm and mesoderm interaction(GO:0007499) epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482)
0.4 1.3 GO:0032289 central nervous system myelin formation(GO:0032289)
0.4 8.6 GO:2000404 regulation of T cell migration(GO:2000404)
0.4 15.7 GO:0036152 phosphatidylethanolamine acyl-chain remodeling(GO:0036152)
0.4 7.8 GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.4 0.8 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.4 2.3 GO:1904925 positive regulation of macromitophagy(GO:1901526) positive regulation of mitophagy in response to mitochondrial depolarization(GO:1904925)
0.4 11.8 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.4 30.3 GO:0070206 protein trimerization(GO:0070206)
0.4 17.4 GO:0031640 killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364)
0.3 3.0 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.3 6.1 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.3 1.0 GO:0006624 vacuolar protein processing(GO:0006624)
0.3 1.6 GO:0097403 cellular response to raffinose(GO:0097403) response to raffinose(GO:1901545)
0.3 1.9 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.3 1.8 GO:0070777 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.3 3.0 GO:0009134 nucleoside diphosphate catabolic process(GO:0009134)
0.3 1.4 GO:1990418 response to insulin-like growth factor stimulus(GO:1990418)
0.3 9.9 GO:0002076 osteoblast development(GO:0002076)
0.3 1.7 GO:0006953 acute-phase response(GO:0006953)
0.3 10.3 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.3 0.8 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.3 0.3 GO:1902958 neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:0036482) positive regulation of mitochondrial electron transport, NADH to ubiquinone(GO:1902958) regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903383) negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903384)
0.3 3.8 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.3 0.8 GO:0010160 sensory organ boundary specification(GO:0008052) formation of organ boundary(GO:0010160) taste bud development(GO:0061193)
0.3 1.5 GO:1904222 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.3 2.0 GO:0048014 Tie signaling pathway(GO:0048014)
0.2 3.8 GO:0070141 response to UV-A(GO:0070141)
0.2 6.6 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.2 0.5 GO:2000729 positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.2 0.9 GO:0002501 peptide antigen assembly with MHC protein complex(GO:0002501)
0.2 4.6 GO:0048706 embryonic skeletal system development(GO:0048706)
0.2 3.2 GO:0002456 T cell mediated immunity(GO:0002456)
0.2 10.7 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.2 0.9 GO:0046909 intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445)
0.2 0.2 GO:1904933 regulation of cell proliferation in midbrain(GO:1904933)
0.2 2.2 GO:0016584 nucleosome positioning(GO:0016584)
0.2 0.7 GO:0048852 diencephalon morphogenesis(GO:0048852)
0.2 2.4 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.2 19.1 GO:0060135 maternal process involved in female pregnancy(GO:0060135)
0.2 1.6 GO:0019086 late viral transcription(GO:0019086)
0.2 2.4 GO:0035095 behavioral response to nicotine(GO:0035095)
0.2 2.4 GO:0021759 globus pallidus development(GO:0021759)
0.2 1.0 GO:0007525 somatic muscle development(GO:0007525)
0.2 0.6 GO:0090114 COPII-coated vesicle budding(GO:0090114)
0.2 0.8 GO:0005986 sucrose biosynthetic process(GO:0005986)
0.2 1.4 GO:0045345 positive regulation of MHC class I biosynthetic process(GO:0045345)
0.2 3.3 GO:0002385 mucosal immune response(GO:0002385)
0.2 0.7 GO:0009972 cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087)
0.2 1.4 GO:0007296 vitellogenesis(GO:0007296)
0.2 0.7 GO:1903045 neural crest cell migration involved in sympathetic nervous system development(GO:1903045)
0.2 1.0 GO:0002035 brain renin-angiotensin system(GO:0002035)
0.2 0.8 GO:0036343 negative regulation of extracellular matrix disassembly(GO:0010716) psychomotor behavior(GO:0036343)
0.2 2.5 GO:0035634 response to stilbenoid(GO:0035634)
0.2 1.0 GO:0072695 negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695)
0.2 2.9 GO:0038092 nodal signaling pathway(GO:0038092)
0.2 0.8 GO:0038155 interleukin-23-mediated signaling pathway(GO:0038155)
0.2 2.3 GO:0007258 JUN phosphorylation(GO:0007258)
0.2 0.6 GO:0042335 cuticle development(GO:0042335)
0.2 1.3 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.2 4.1 GO:0001649 osteoblast differentiation(GO:0001649)
0.2 1.1 GO:0008218 bioluminescence(GO:0008218)
0.2 0.6 GO:0036017 response to erythropoietin(GO:0036017) cellular response to erythropoietin(GO:0036018)
0.2 1.2 GO:1902952 positive regulation of dendritic spine maintenance(GO:1902952)
0.1 0.7 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.1 3.9 GO:1900116 extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1 0.3 GO:0031017 exocrine pancreas development(GO:0031017)
0.1 0.6 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.1 3.6 GO:0050995 negative regulation of lipid catabolic process(GO:0050995)
0.1 0.9 GO:0071351 interleukin-18-mediated signaling pathway(GO:0035655) cellular response to interleukin-18(GO:0071351)
0.1 0.4 GO:0033037 polysaccharide localization(GO:0033037)
0.1 3.0 GO:0003417 growth plate cartilage development(GO:0003417)
0.1 2.3 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.1 0.9 GO:2000402 negative regulation of lymphocyte migration(GO:2000402)
0.1 4.1 GO:0071294 cellular response to zinc ion(GO:0071294)
0.1 1.2 GO:0090385 phagosome-lysosome fusion(GO:0090385)
0.1 10.2 GO:0030835 negative regulation of actin filament depolymerization(GO:0030835)
0.1 0.8 GO:0052551 response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565)
0.1 1.8 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.1 3.2 GO:0006853 carnitine shuttle(GO:0006853)
0.1 0.4 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
0.1 0.8 GO:0007060 male meiosis chromosome segregation(GO:0007060)
0.1 1.1 GO:1902035 positive regulation of hematopoietic stem cell proliferation(GO:1902035)
0.1 1.0 GO:0006741 NADP biosynthetic process(GO:0006741)
0.1 0.6 GO:1904977 lymphatic endothelial cell migration(GO:1904977)
0.1 0.8 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.1 0.9 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.1 2.8 GO:0007021 tubulin complex assembly(GO:0007021)
0.1 0.3 GO:1904017 cellular response to Thyroglobulin triiodothyronine(GO:1904017)
0.1 2.4 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.1 1.6 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.1 0.3 GO:0048200 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.1 0.8 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.1 0.3 GO:0051138 positive regulation of NK T cell differentiation(GO:0051138)
0.1 3.3 GO:0048305 immunoglobulin secretion(GO:0048305)
0.1 2.7 GO:0032897 negative regulation of viral transcription(GO:0032897)
0.1 0.6 GO:0033490 cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490)
0.1 4.9 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 1.8 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.1 0.3 GO:0034130 toll-like receptor 1 signaling pathway(GO:0034130)
0.1 0.7 GO:0010025 wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.1 6.0 GO:0043171 peptide catabolic process(GO:0043171)
0.1 38.9 GO:0009615 response to virus(GO:0009615)
0.1 0.9 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.1 1.5 GO:0035855 megakaryocyte development(GO:0035855)
0.1 2.2 GO:0060065 uterus development(GO:0060065)
0.1 2.7 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.1 6.5 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.1 0.6 GO:1900227 positive regulation of NLRP3 inflammasome complex assembly(GO:1900227)
0.1 0.6 GO:0070163 adiponectin secretion(GO:0070162) regulation of adiponectin secretion(GO:0070163) negative regulation of adiponectin secretion(GO:0070164)
0.1 0.3 GO:0002439 chronic inflammatory response to antigenic stimulus(GO:0002439)
0.1 0.2 GO:0021569 rhombomere 3 development(GO:0021569)
0.1 1.5 GO:0006600 creatine metabolic process(GO:0006600)
0.1 0.4 GO:0048630 skeletal muscle tissue growth(GO:0048630)
0.1 0.3 GO:0006429 leucyl-tRNA aminoacylation(GO:0006429)
0.1 0.1 GO:0046666 retinal cell programmed cell death(GO:0046666) regulation of retinal cell programmed cell death(GO:0046668)
0.1 0.3 GO:0003366 cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
0.1 0.2 GO:0006533 aspartate catabolic process(GO:0006533)
0.1 1.1 GO:0070535 histone H2A K63-linked ubiquitination(GO:0070535)
0.1 11.1 GO:0006903 vesicle targeting(GO:0006903)
0.1 1.6 GO:0045838 positive regulation of membrane potential(GO:0045838)
0.1 1.5 GO:0046415 urate metabolic process(GO:0046415)
0.1 0.2 GO:0033685 negative regulation of luteinizing hormone secretion(GO:0033685) operant conditioning(GO:0035106)
0.1 1.2 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.1 0.3 GO:0018197 peptidyl-aspartic acid modification(GO:0018197) peptidyl-aspartic acid hydroxylation(GO:0042264)
0.1 0.5 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.1 0.5 GO:0021778 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.1 0.6 GO:1902416 positive regulation of mRNA binding(GO:1902416)
0.1 0.6 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.1 4.5 GO:0006968 cellular defense response(GO:0006968)
0.1 2.9 GO:0042994 cytoplasmic sequestering of transcription factor(GO:0042994)
0.1 0.5 GO:0032445 fructose import(GO:0032445) carbohydrate import into cell(GO:0097319) carbohydrate import across plasma membrane(GO:0098704) fructose import across plasma membrane(GO:1990539)
0.1 0.3 GO:0051971 positive regulation of transmission of nerve impulse(GO:0051971)
0.1 0.6 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.1 1.0 GO:0043249 erythrocyte maturation(GO:0043249)
0.1 0.5 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469) determination of liver left/right asymmetry(GO:0071910)
0.1 1.8 GO:0030220 platelet formation(GO:0030220)
0.1 0.4 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.1 0.1 GO:0070560 protein secretion by platelet(GO:0070560)
0.1 0.6 GO:0060174 limb bud formation(GO:0060174)
0.1 0.8 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.1 0.7 GO:0060022 hard palate development(GO:0060022)
0.1 1.7 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.1 0.1 GO:0042222 interleukin-1 biosynthetic process(GO:0042222) interleukin-1 beta biosynthetic process(GO:0050720)
0.1 0.1 GO:0006581 acetylcholine catabolic process in synaptic cleft(GO:0001507) acetylcholine catabolic process(GO:0006581)
0.1 1.0 GO:0007351 tripartite regional subdivision(GO:0007351) anterior/posterior axis specification, embryo(GO:0008595)
0.1 0.3 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.1 3.6 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
0.1 0.1 GO:0035566 regulation of metanephros size(GO:0035566) negative regulation of cytolysis(GO:0045918)
0.1 2.3 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 0.5 GO:0010225 response to UV-C(GO:0010225)
0.1 1.2 GO:0031953 negative regulation of protein autophosphorylation(GO:0031953)
0.1 0.2 GO:0072223 cell migration involved in coronary angiogenesis(GO:0060981) metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.1 0.9 GO:1904896 ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903)
0.1 1.2 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.1 1.2 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.1 0.3 GO:0098743 cell aggregation(GO:0098743)
0.1 0.2 GO:0051563 smooth endoplasmic reticulum calcium ion homeostasis(GO:0051563)
0.1 1.0 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.1 1.0 GO:0043536 positive regulation of blood vessel endothelial cell migration(GO:0043536)
0.1 0.2 GO:0048539 bone marrow development(GO:0048539)
0.1 0.4 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.1 0.4 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.1 0.6 GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.1 1.9 GO:0045124 regulation of bone resorption(GO:0045124)
0.1 0.2 GO:0048698 negative regulation of collateral sprouting in absence of injury(GO:0048698)
0.1 0.5 GO:0023041 neuronal signal transduction(GO:0023041)
0.1 1.9 GO:0046627 negative regulation of insulin receptor signaling pathway(GO:0046627)
0.0 1.6 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.0 0.2 GO:0009253 peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)
0.0 2.1 GO:1900739 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.0 0.7 GO:0033227 dsRNA transport(GO:0033227)
0.0 0.7 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.2 GO:1900110 negative regulation of histone H3-K9 dimethylation(GO:1900110)
0.0 2.1 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.0 0.2 GO:0008343 adult feeding behavior(GO:0008343)
0.0 0.7 GO:0072189 ureter development(GO:0072189)
0.0 0.3 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.0 0.4 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.0 0.1 GO:0050822 peptide stabilization(GO:0050822) peptide antigen stabilization(GO:0050823)
0.0 0.3 GO:0002370 natural killer cell cytokine production(GO:0002370) regulation of natural killer cell cytokine production(GO:0002727) positive regulation of natural killer cell cytokine production(GO:0002729) positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
0.0 1.2 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.7 GO:0046520 sphingoid biosynthetic process(GO:0046520)
0.0 0.3 GO:0032488 Cdc42 protein signal transduction(GO:0032488) anterior/posterior axon guidance(GO:0033564)
0.0 0.5 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 0.9 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.0 0.7 GO:0006032 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0 0.5 GO:0042953 lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872)
0.0 0.2 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.0 0.2 GO:0042670 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0 0.3 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.0 0.4 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 0.3 GO:0048839 inner ear development(GO:0048839)
0.0 10.1 GO:0042157 lipoprotein metabolic process(GO:0042157)
0.0 0.2 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.0 1.4 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.0 0.2 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.0 4.5 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 5.7 GO:0070268 cornification(GO:0070268)
0.0 0.3 GO:0010529 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)
0.0 0.2 GO:0032960 regulation of inositol trisphosphate biosynthetic process(GO:0032960)
0.0 0.6 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
0.0 0.2 GO:0032439 endosome localization(GO:0032439)
0.0 3.8 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 0.2 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.0 0.5 GO:0014877 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.0 0.2 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.0 1.8 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.4 GO:0045725 positive regulation of glycogen biosynthetic process(GO:0045725)
0.0 0.6 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.1 GO:0097156 fasciculation of motor neuron axon(GO:0097156)
0.0 0.7 GO:0042359 vitamin D metabolic process(GO:0042359)
0.0 0.4 GO:0014029 neural crest formation(GO:0014029)
0.0 0.3 GO:0090160 Golgi to lysosome transport(GO:0090160)
0.0 0.5 GO:0016578 histone deubiquitination(GO:0016578)
0.0 0.2 GO:0043654 recognition of apoptotic cell(GO:0043654)
0.0 0.1 GO:0048840 otolith morphogenesis(GO:0032474) otolith development(GO:0048840)
0.0 0.6 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0 0.1 GO:0007162 negative regulation of cell adhesion(GO:0007162)
0.0 0.1 GO:0032736 positive regulation of interleukin-13 production(GO:0032736)
0.0 0.4 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.0 1.1 GO:0007340 acrosome reaction(GO:0007340)
0.0 1.2 GO:0009247 glycolipid biosynthetic process(GO:0009247)
0.0 0.2 GO:0090266 regulation of spindle checkpoint(GO:0090231) regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.7 GO:0045907 positive regulation of vasoconstriction(GO:0045907)
0.0 0.3 GO:0060044 negative regulation of cardiac muscle cell proliferation(GO:0060044)
0.0 2.9 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.0 0.3 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 1.8 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.1 GO:1900019 regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.0 0.2 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.0 0.5 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.2 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.0 0.2 GO:0003360 brainstem development(GO:0003360)
0.0 0.2 GO:0090259 regulation of retinal ganglion cell axon guidance(GO:0090259) dorsal root ganglion development(GO:1990791)
0.0 0.8 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.0 0.2 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.0 0.4 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.3 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.0 GO:1905123 regulation of glucosylceramidase activity(GO:1905123)
0.0 0.2 GO:0009409 response to cold(GO:0009409)
0.0 3.1 GO:0006661 phosphatidylinositol biosynthetic process(GO:0006661)
0.0 0.2 GO:1990034 calcium ion export from cell(GO:1990034)
0.0 0.7 GO:0008209 androgen metabolic process(GO:0008209)
0.0 0.1 GO:0019236 response to pheromone(GO:0019236)
0.0 0.9 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.0 GO:0036369 transcription factor catabolic process(GO:0036369)
0.0 0.5 GO:0035666 TRIF-dependent toll-like receptor signaling pathway(GO:0035666)
0.0 0.6 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.3 GO:0015671 oxygen transport(GO:0015671)
0.0 0.2 GO:0071474 cellular hyperosmotic response(GO:0071474)
0.0 0.3 GO:0016180 snRNA processing(GO:0016180)
0.0 0.1 GO:0042357 thiamine diphosphate metabolic process(GO:0042357)
0.0 0.3 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.7 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 0.3 GO:0030336 negative regulation of cell migration(GO:0030336)
0.0 0.4 GO:0003341 cilium movement(GO:0003341)
0.0 0.5 GO:0001958 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0 0.3 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 0.1 GO:0030091 protein repair(GO:0030091)
0.0 0.5 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.2 GO:0002087 regulation of respiratory gaseous exchange by neurological system process(GO:0002087)
0.0 0.3 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.0 0.1 GO:0090154 positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.0 0.1 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.0 0.1 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.0 0.1 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.0 0.2 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process(GO:0070525)
0.0 0.5 GO:0010390 histone monoubiquitination(GO:0010390)
0.0 0.3 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.2 GO:0060315 negative regulation of release of sequestered calcium ion into cytosol(GO:0051280) negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315)
0.0 0.6 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.0 0.2 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0 0.1 GO:1901341 activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0 0.2 GO:0006458 'de novo' protein folding(GO:0006458)
0.0 1.4 GO:0007286 spermatid development(GO:0007286)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
4.4 30.5 GO:0097179 protease inhibitor complex(GO:0097179)
2.2 15.5 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
1.7 5.1 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
1.3 3.8 GO:1902737 dendritic filopodium(GO:1902737)
1.2 8.2 GO:0042825 TAP complex(GO:0042825)
1.0 6.1 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.9 4.7 GO:0031905 early endosome lumen(GO:0031905)
0.8 26.3 GO:0034385 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.7 10.0 GO:0031089 platelet dense granule lumen(GO:0031089)
0.6 7.5 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.6 2.3 GO:0031213 RSF complex(GO:0031213)
0.6 4.0 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.6 1.7 GO:0032002 interleukin-28 receptor complex(GO:0032002)
0.5 4.0 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.4 38.3 GO:0015030 Cajal body(GO:0015030)
0.4 3.4 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.4 1.6 GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354)
0.4 0.8 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.3 4.1 GO:0030870 Mre11 complex(GO:0030870)
0.3 7.3 GO:0008385 IkappaB kinase complex(GO:0008385)
0.3 0.8 GO:0042022 interleukin-12 receptor complex(GO:0042022)
0.3 9.3 GO:0098553 integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.3 29.0 GO:0035577 azurophil granule membrane(GO:0035577)
0.2 0.7 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.2 0.5 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.2 1.8 GO:0032010 phagolysosome(GO:0032010)
0.2 9.3 GO:0071437 invadopodium(GO:0071437)
0.2 2.3 GO:0005610 laminin-5 complex(GO:0005610)
0.2 9.6 GO:0018995 host(GO:0018995) host cell(GO:0043657)
0.2 0.8 GO:0030936 collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936)
0.2 2.6 GO:0030478 actin cap(GO:0030478)
0.2 1.5 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.2 8.4 GO:0030057 desmosome(GO:0030057)
0.2 0.7 GO:0071020 post-spliceosomal complex(GO:0071020)
0.2 2.2 GO:0005688 U6 snRNP(GO:0005688)
0.2 5.0 GO:0036020 endolysosome membrane(GO:0036020)
0.2 0.9 GO:0005879 axonemal microtubule(GO:0005879)
0.2 1.4 GO:1990111 spermatoproteasome complex(GO:1990111)
0.2 19.7 GO:0005811 lipid particle(GO:0005811)
0.2 19.2 GO:0005637 nuclear inner membrane(GO:0005637)
0.2 1.7 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.2 11.7 GO:0005643 nuclear pore(GO:0005643)
0.1 2.5 GO:0097512 cardiac myofibril(GO:0097512)
0.1 4.1 GO:0031528 microvillus membrane(GO:0031528)
0.1 1.3 GO:0016589 NURF complex(GO:0016589)
0.1 0.4 GO:0001534 radial spoke(GO:0001534)
0.1 1.3 GO:0070552 BRISC complex(GO:0070552)
0.1 0.4 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.1 1.0 GO:0043196 varicosity(GO:0043196)
0.1 2.9 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 0.3 GO:0070765 gamma-secretase complex(GO:0070765)
0.1 3.0 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.1 13.7 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 0.7 GO:1902560 GMP reductase complex(GO:1902560)
0.1 1.1 GO:0032059 bleb(GO:0032059)
0.1 0.7 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 16.8 GO:0031902 late endosome membrane(GO:0031902)
0.1 15.4 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 2.1 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 0.6 GO:0036021 endolysosome lumen(GO:0036021)
0.1 5.2 GO:0009925 basal plasma membrane(GO:0009925)
0.1 22.6 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.1 53.3 GO:0016607 nuclear speck(GO:0016607)
0.1 11.3 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 8.2 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 1.2 GO:0072546 ER membrane protein complex(GO:0072546)
0.1 1.9 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.1 11.0 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 0.5 GO:0061617 MICOS complex(GO:0061617)
0.1 0.3 GO:0072534 perineuronal net(GO:0072534)
0.1 0.8 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 14.5 GO:0005769 early endosome(GO:0005769)
0.1 0.7 GO:0042788 polysomal ribosome(GO:0042788)
0.1 1.3 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 1.0 GO:0001673 male germ cell nucleus(GO:0001673)
0.1 1.2 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 1.0 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 11.6 GO:0032587 ruffle membrane(GO:0032587)
0.1 0.6 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.1 25.5 GO:0031965 nuclear membrane(GO:0031965)
0.1 0.5 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.1 0.4 GO:0005899 insulin receptor complex(GO:0005899)
0.1 0.2 GO:1990812 growth cone filopodium(GO:1990812)
0.1 0.7 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 0.2 GO:0097443 sorting endosome(GO:0097443)
0.1 0.7 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.1 0.3 GO:0034669 integrin alpha4-beta7 complex(GO:0034669)
0.1 1.2 GO:0031143 pseudopodium(GO:0031143)
0.1 0.3 GO:0071547 piP-body(GO:0071547)
0.1 0.2 GO:0070985 TFIIK complex(GO:0070985)
0.0 1.0 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 20.4 GO:0010008 endosome membrane(GO:0010008)
0.0 0.3 GO:0005833 hemoglobin complex(GO:0005833)
0.0 0.5 GO:0036157 outer dynein arm(GO:0036157)
0.0 0.2 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.0 0.6 GO:0097427 microtubule bundle(GO:0097427)
0.0 3.7 GO:0031201 SNARE complex(GO:0031201)
0.0 0.6 GO:0033391 chromatoid body(GO:0033391)
0.0 4.9 GO:0016363 nuclear matrix(GO:0016363)
0.0 0.2 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.0 13.7 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 1.6 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.0 3.7 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.8 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 3.3 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.5 GO:0070938 contractile ring(GO:0070938)
0.0 2.5 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 95.1 GO:0005739 mitochondrion(GO:0005739)
0.0 2.0 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 2.2 GO:0055037 recycling endosome(GO:0055037)
0.0 12.6 GO:0000790 nuclear chromatin(GO:0000790)
0.0 0.4 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.4 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.5 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.9 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.3 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 3.4 GO:0071944 cell periphery(GO:0071944)
0.0 5.4 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.3 GO:0032039 integrator complex(GO:0032039)
0.0 0.7 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 0.8 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.5 GO:0000124 SAGA complex(GO:0000124)
0.0 0.7 GO:0005581 collagen trimer(GO:0005581)
0.0 8.1 GO:0070062 extracellular exosome(GO:0070062)
0.0 0.6 GO:0031301 integral component of organelle membrane(GO:0031301)
0.0 1.2 GO:0016235 aggresome(GO:0016235)
0.0 1.0 GO:0008180 COP9 signalosome(GO:0008180)
0.0 2.1 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 1.2 GO:0043198 dendritic shaft(GO:0043198)
0.0 1.8 GO:0035579 specific granule membrane(GO:0035579)
0.0 0.6 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 15.7 GO:0000139 Golgi membrane(GO:0000139)
0.0 0.1 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.2 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.5 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 1.9 GO:0030018 Z disc(GO:0030018)
0.0 0.3 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 1.7 GO:0030175 filopodium(GO:0030175)
0.0 0.8 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 0.5 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.2 GO:0001520 outer dense fiber(GO:0001520)
0.0 0.4 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.0 GO:0097444 spine apparatus(GO:0097444)
0.0 2.2 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 0.2 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.3 GO:1990752 microtubule end(GO:1990752)
0.0 1.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.1 GO:0044306 neuron projection terminus(GO:0044306)
0.0 0.1 GO:0097165 nuclear stress granule(GO:0097165)
0.0 9.8 GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network(GO:0042175)
0.0 0.3 GO:0099738 cell cortex region(GO:0099738)
0.0 0.1 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.4 GO:0031430 M band(GO:0031430)
0.0 0.0 GO:0070703 inner mucus layer(GO:0070702) outer mucus layer(GO:0070703)
0.0 8.0 GO:0005794 Golgi apparatus(GO:0005794)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.4 52.5 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
3.3 9.9 GO:0008859 exoribonuclease II activity(GO:0008859)
2.8 22.2 GO:0042289 MHC class II protein binding(GO:0042289)
2.7 10.8 GO:0009041 uridylate kinase activity(GO:0009041)
2.5 12.6 GO:0031849 olfactory receptor binding(GO:0031849)
1.7 7.0 GO:0033754 indoleamine 2,3-dioxygenase activity(GO:0033754)
1.6 12.9 GO:0015526 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
1.4 5.8 GO:0048030 disaccharide binding(GO:0048030)
1.4 19.3 GO:0089720 caspase binding(GO:0089720)
1.3 11.8 GO:0046977 TAP binding(GO:0046977) TAP1 binding(GO:0046978)
1.3 12.9 GO:0042296 ISG15 transferase activity(GO:0042296)
1.2 15.4 GO:0031386 protein tag(GO:0031386)
1.1 3.3 GO:0042007 interleukin-18 binding(GO:0042007)
1.1 10.6 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.9 3.7 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.9 21.4 GO:0008035 high-density lipoprotein particle binding(GO:0008035)
0.9 6.1 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.8 31.0 GO:0005521 lamin binding(GO:0005521)
0.7 4.5 GO:0015333 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.7 38.4 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.7 5.5 GO:0004126 cytidine deaminase activity(GO:0004126)
0.6 1.9 GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483)
0.6 4.5 GO:0034046 poly(G) binding(GO:0034046)
0.6 1.8 GO:1904599 advanced glycation end-product binding(GO:1904599)
0.6 11.8 GO:0050700 CARD domain binding(GO:0050700)
0.5 15.2 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.5 1.0 GO:0034437 glycoprotein transporter activity(GO:0034437)
0.4 3.1 GO:0070087 chromo shadow domain binding(GO:0070087)
0.4 12.4 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.4 9.7 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.4 53.0 GO:0003725 double-stranded RNA binding(GO:0003725)
0.4 1.5 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.4 1.5 GO:0005115 receptor tyrosine kinase-like orphan receptor binding(GO:0005115) chemoattractant activity involved in axon guidance(GO:1902379)
0.4 1.4 GO:0047273 galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity(GO:0047273)
0.4 0.7 GO:0051033 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.3 1.4 GO:0050698 proteoglycan sulfotransferase activity(GO:0050698)
0.3 3.1 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.3 11.5 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.3 3.0 GO:0071723 lipopeptide binding(GO:0071723)
0.3 20.1 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.3 13.1 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.3 2.8 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.3 0.9 GO:0060001 minus-end directed microfilament motor activity(GO:0060001)
0.3 4.0 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.3 6.6 GO:0008391 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.3 10.7 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.3 1.7 GO:0042015 interleukin-20 binding(GO:0042015)
0.3 1.4 GO:0004556 alpha-amylase activity(GO:0004556)
0.3 0.8 GO:0016517 interleukin-12 receptor activity(GO:0016517)
0.3 2.3 GO:0004340 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.2 0.7 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.2 9.2 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.2 7.7 GO:0008266 poly(U) RNA binding(GO:0008266)
0.2 0.7 GO:0008386 cholesterol monooxygenase (side-chain-cleaving) activity(GO:0008386)
0.2 54.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 1.5 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.2 9.2 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.2 0.6 GO:0032090 Pyrin domain binding(GO:0032090)
0.2 11.2 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.2 1.2 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.2 0.6 GO:0033149 FFAT motif binding(GO:0033149)
0.2 0.8 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
0.2 3.7 GO:0030957 Tat protein binding(GO:0030957)
0.2 2.5 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.2 2.7 GO:0019211 phosphatase activator activity(GO:0019211)
0.2 2.3 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.2 11.4 GO:0003785 actin monomer binding(GO:0003785)
0.2 1.1 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.2 1.8 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.2 0.9 GO:0102008 cytosolic dipeptidase activity(GO:0102008)
0.2 1.0 GO:0005168 neurotrophin TRKA receptor binding(GO:0005168)
0.2 2.8 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.2 1.0 GO:0070573 metallodipeptidase activity(GO:0070573)
0.2 20.4 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.2 0.8 GO:0047374 methylumbelliferyl-acetate deacetylase activity(GO:0047374)
0.2 1.5 GO:0004111 creatine kinase activity(GO:0004111)
0.1 0.7 GO:0036435 K48-linked polyubiquitin binding(GO:0036435)
0.1 0.4 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.1 0.7 GO:1990460 leptin receptor binding(GO:1990460)
0.1 2.9 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 19.6 GO:0005254 chloride channel activity(GO:0005254)
0.1 1.0 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.1 1.7 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.1 2.7 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)
0.1 2.6 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 6.0 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 0.7 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.1 0.7 GO:0047179 platelet-activating factor acetyltransferase activity(GO:0047179)
0.1 2.1 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.1 1.6 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.1 0.8 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.1 6.7 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 7.6 GO:0030507 spectrin binding(GO:0030507)
0.1 3.0 GO:0032183 SUMO binding(GO:0032183)
0.1 0.2 GO:0098770 FBXO family protein binding(GO:0098770)
0.1 3.9 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.1 0.8 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.1 0.7 GO:0003920 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.1 13.8 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.1 3.2 GO:0002162 dystroglycan binding(GO:0002162)
0.1 2.0 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 1.5 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.1 59.4 GO:0005525 GTP binding(GO:0005525)
0.1 4.4 GO:0004623 phospholipase A2 activity(GO:0004623)
0.1 0.4 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.1 0.3 GO:0004823 leucine-tRNA ligase activity(GO:0004823)
0.1 0.9 GO:0045159 myosin II binding(GO:0045159)
0.1 0.7 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.1 1.5 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.1 27.9 GO:0030674 protein binding, bridging(GO:0030674)
0.1 0.3 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.1 2.2 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 0.4 GO:0050659 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659)
0.1 1.2 GO:0070513 death domain binding(GO:0070513)
0.1 0.5 GO:0004977 melanocortin receptor activity(GO:0004977)
0.1 1.0 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 0.9 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.1 7.0 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 0.5 GO:0005499 vitamin D binding(GO:0005499)
0.1 2.1 GO:0005523 tropomyosin binding(GO:0005523)
0.1 0.5 GO:0005353 fructose transmembrane transporter activity(GO:0005353)
0.1 1.8 GO:0031005 filamin binding(GO:0031005)
0.1 0.6 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.1 0.6 GO:0004985 opioid receptor activity(GO:0004985)
0.1 0.5 GO:0000405 bubble DNA binding(GO:0000405)
0.1 0.4 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.1 0.3 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.1 4.9 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 8.1 GO:0031490 chromatin DNA binding(GO:0031490)
0.1 3.0 GO:0042056 chemoattractant activity(GO:0042056)
0.1 0.3 GO:0030492 hemoglobin binding(GO:0030492)
0.1 2.9 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.1 0.2 GO:0008441 3'(2'),5'-bisphosphate nucleotidase activity(GO:0008441)
0.1 0.5 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.1 1.0 GO:0098505 single-stranded telomeric DNA binding(GO:0043047) G-rich strand telomeric DNA binding(GO:0098505)
0.1 1.4 GO:0003993 acid phosphatase activity(GO:0003993)
0.1 0.2 GO:0004995 tachykinin receptor activity(GO:0004995)
0.1 0.8 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.1 0.2 GO:0019864 IgG binding(GO:0019864)
0.1 0.7 GO:0042826 histone deacetylase binding(GO:0042826)
0.1 1.8 GO:0031491 nucleosome binding(GO:0031491)
0.1 0.5 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.1 0.4 GO:0047820 D-glutamate cyclase activity(GO:0047820)
0.1 0.6 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.1 1.2 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.1 0.7 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.1 0.5 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.1 0.3 GO:0034584 piRNA binding(GO:0034584)
0.0 0.6 GO:0036122 BMP binding(GO:0036122)
0.0 7.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 2.0 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 0.1 GO:0016503 pheromone receptor activity(GO:0016503)
0.0 0.7 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.0 0.2 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 0.3 GO:0071532 ankyrin repeat binding(GO:0071532)
0.0 6.8 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.1 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.0 0.4 GO:0071837 HMG box domain binding(GO:0071837)
0.0 1.0 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 0.5 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 18.3 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 1.8 GO:0050699 WW domain binding(GO:0050699)
0.0 0.7 GO:0004568 chitinase activity(GO:0004568)
0.0 1.3 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 0.3 GO:0051400 BH domain binding(GO:0051400)
0.0 1.1 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.5 GO:0015288 protein channel activity(GO:0015266) porin activity(GO:0015288)
0.0 0.3 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 1.2 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 1.3 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.7 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.2 GO:0016402 pristanoyl-CoA oxidase activity(GO:0016402)
0.0 0.3 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.0 1.8 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 2.2 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.3 GO:0042301 phosphate ion binding(GO:0042301)
0.0 0.9 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.2 GO:0001595 angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.0 0.1 GO:0001515 opioid peptide activity(GO:0001515)
0.0 5.2 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459)
0.0 0.2 GO:0004782 sulfinoalanine decarboxylase activity(GO:0004782)
0.0 0.2 GO:0008267 poly-glutamine tract binding(GO:0008267)
0.0 30.6 GO:0008270 zinc ion binding(GO:0008270)
0.0 0.8 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.3 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 1.5 GO:0019903 protein phosphatase binding(GO:0019903)
0.0 0.2 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.2 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.1 GO:0008320 protein transmembrane transporter activity(GO:0008320) macromolecule transmembrane transporter activity(GO:0022884)
0.0 0.2 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.0 0.4 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 8.0 GO:0016746 transferase activity, transferring acyl groups(GO:0016746)
0.0 0.4 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 0.2 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.0 0.6 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.2 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.0 1.6 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.6 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 0.3 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.5 GO:0000339 RNA cap binding(GO:0000339)
0.0 0.2 GO:0070628 proteasome binding(GO:0070628)
0.0 0.4 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.3 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.0 0.1 GO:0002114 interleukin-33 receptor activity(GO:0002114)
0.0 0.6 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.5 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 0.2 GO:0003796 lysozyme activity(GO:0003796)
0.0 2.2 GO:0042393 histone binding(GO:0042393)
0.0 1.3 GO:0001047 core promoter binding(GO:0001047)
0.0 0.2 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.0 0.5 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.3 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.8 GO:0043621 protein self-association(GO:0043621)
0.0 0.2 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 0.1 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 0.3 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 4.0 GO:0030246 carbohydrate binding(GO:0030246)
0.0 1.2 GO:0051213 dioxygenase activity(GO:0051213)
0.0 0.0 GO:0038187 lipopolysaccharide receptor activity(GO:0001875) signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 0.4 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.0 0.2 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 0.2 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.6 GO:0019213 deacetylase activity(GO:0019213)
0.0 0.8 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 0.1 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987)
0.0 12.1 GO:0003700 transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 0.2 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.2 GO:0005158 insulin receptor binding(GO:0005158)
0.0 0.2 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.0 0.1 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 12.6 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.5 19.6 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.5 7.3 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.5 27.0 PID MYC PATHWAY C-MYC pathway
0.4 7.3 SIG IL4RECEPTOR IN B LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.3 2.3 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.3 7.8 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.2 7.7 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.2 8.1 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.2 4.2 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.2 17.3 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.1 7.4 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.1 2.5 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 12.5 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 16.0 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.1 2.3 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 5.6 PID IL4 2PATHWAY IL4-mediated signaling events
0.1 3.7 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.1 7.6 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 11.4 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.1 1.0 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.1 5.9 PID TELOMERASE PATHWAY Regulation of Telomerase
0.1 2.9 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.1 2.7 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 1.7 PID ERBB1 RECEPTOR PROXIMAL PATHWAY EGF receptor (ErbB1) signaling pathway
0.1 10.1 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 2.9 PID TRAIL PATHWAY TRAIL signaling pathway
0.1 3.2 PID GLYPICAN 1PATHWAY Glypican 1 network
0.1 3.6 PID LKB1 PATHWAY LKB1 signaling events
0.1 5.3 PID NOTCH PATHWAY Notch signaling pathway
0.1 17.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 0.6 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.1 0.2 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 1.1 PID IL2 1PATHWAY IL2-mediated signaling events
0.0 1.2 PID IL23 PATHWAY IL23-mediated signaling events
0.0 11.9 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.8 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.0 1.9 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.0 2.9 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.6 PID CD40 PATHWAY CD40/CD40L signaling
0.0 1.6 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 1.1 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 0.9 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 6.5 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 1.9 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.4 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 1.2 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.9 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.2 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.3 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.4 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 0.4 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.0 0.7 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.3 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.7 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.4 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 0.2 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.5 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.2 PID S1P S1P1 PATHWAY S1P1 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 322.8 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
1.3 21.5 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
1.1 4.4 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
1.0 21.1 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.7 13.6 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.6 5.1 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.6 28.9 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.5 5.4 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.5 34.5 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.4 8.9 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.4 17.0 REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.4 3.5 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.3 11.9 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.2 5.9 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.2 6.8 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.2 15.0 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.2 14.8 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 12.8 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.1 4.3 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 1.6 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.1 2.1 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.1 7.3 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 1.4 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 3.5 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 1.0 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.1 2.1 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1 2.2 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.1 0.8 REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES Genes involved in p75NTR recruits signalling complexes
0.1 2.6 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 2.0 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.1 1.6 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.1 3.9 REACTOME G1 PHASE Genes involved in G1 Phase
0.1 2.0 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 1.5 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.1 1.0 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.1 1.0 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.1 1.2 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.1 0.7 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 2.2 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 1.1 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 1.2 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.4 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 1.6 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 2.0 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.9 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.8 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.0 0.6 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.0 0.9 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.7 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 1.1 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 1.1 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 0.4 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 3.2 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.1 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.3 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 1.1 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.7 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.9 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 1.3 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.0 0.3 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 1.4 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 0.4 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 1.4 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.0 0.6 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.2 REACTOME TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER Genes involved in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
0.0 0.4 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.2 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.6 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.4 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 0.2 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 1.0 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 1.2 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.2 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.0 0.4 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.8 REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.0 0.3 REACTOME INTERFERON SIGNALING Genes involved in Interferon Signaling