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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for IRF3
Z-value: 2.41
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Transcription factors associated with IRF3
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
IRF3
|
ENSG00000126456.11 | interferon regulatory factor 3 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRF3 | hg19_v2_chr19_-_50169064_50169132 | 0.57 | 9.1e-03 | Click! |
Activity profile of IRF3 motif
Sorted Z-values of IRF3 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of IRF3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 6.3 | GO:0034344 | type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) |
| 1.4 | 6.9 | GO:2000110 | negative regulation of macrophage apoptotic process(GO:2000110) |
| 1.1 | 3.3 | GO:1901253 | negative regulation of dendritic cell cytokine production(GO:0002731) negative regulation of intracellular transport of viral material(GO:1901253) |
| 0.9 | 11.1 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 0.9 | 13.3 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) |
| 0.8 | 8.8 | GO:0018377 | protein myristoylation(GO:0018377) |
| 0.6 | 2.3 | GO:0046967 | cytosol to ER transport(GO:0046967) |
| 0.4 | 0.4 | GO:0002590 | regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590) |
| 0.4 | 1.3 | GO:0002519 | natural killer cell tolerance induction(GO:0002519) positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190) |
| 0.4 | 5.1 | GO:0070212 | protein poly-ADP-ribosylation(GO:0070212) |
| 0.3 | 2.4 | GO:0000432 | regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432) |
| 0.3 | 4.7 | GO:0034058 | endosomal vesicle fusion(GO:0034058) |
| 0.3 | 2.5 | GO:0045591 | positive regulation of regulatory T cell differentiation(GO:0045591) |
| 0.2 | 0.7 | GO:0044830 | modulation by host of viral RNA genome replication(GO:0044830) positive regulation of intracellular transport of viral material(GO:1901254) |
| 0.2 | 0.5 | GO:0002428 | antigen processing and presentation of peptide antigen via MHC class Ib(GO:0002428) |
| 0.2 | 0.9 | GO:0090086 | negative regulation of protein deubiquitination(GO:0090086) |
| 0.2 | 0.9 | GO:0036269 | swimming behavior(GO:0036269) |
| 0.2 | 0.6 | GO:0051866 | general adaptation syndrome(GO:0051866) |
| 0.2 | 4.1 | GO:0003374 | dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374) |
| 0.2 | 1.5 | GO:0018242 | protein O-linked glycosylation via serine(GO:0018242) |
| 0.2 | 1.7 | GO:0032696 | negative regulation of interleukin-13 production(GO:0032696) |
| 0.2 | 1.6 | GO:0097039 | protein linear polyubiquitination(GO:0097039) |
| 0.1 | 1.6 | GO:2001181 | positive regulation of interleukin-10 secretion(GO:2001181) |
| 0.1 | 1.0 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
| 0.1 | 0.8 | GO:1900245 | positive regulation of MDA-5 signaling pathway(GO:1900245) |
| 0.1 | 0.7 | GO:0030885 | regulation of myeloid dendritic cell activation(GO:0030885) |
| 0.1 | 0.5 | GO:0002501 | peptide antigen assembly with MHC protein complex(GO:0002501) |
| 0.1 | 3.4 | GO:0097296 | activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296) |
| 0.1 | 6.0 | GO:0044364 | killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364) |
| 0.1 | 0.1 | GO:0038183 | bile acid signaling pathway(GO:0038183) |
| 0.1 | 1.2 | GO:0016199 | axon midline choice point recognition(GO:0016199) |
| 0.1 | 0.8 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.1 | 3.8 | GO:0035456 | response to interferon-beta(GO:0035456) |
| 0.1 | 2.7 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.1 | 0.6 | GO:1903435 | positive regulation of constitutive secretory pathway(GO:1903435) |
| 0.1 | 2.4 | GO:2000404 | regulation of T cell migration(GO:2000404) |
| 0.1 | 0.4 | GO:0052551 | response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565) |
| 0.1 | 0.6 | GO:0035881 | amacrine cell differentiation(GO:0035881) |
| 0.1 | 2.1 | GO:0045838 | positive regulation of membrane potential(GO:0045838) |
| 0.1 | 1.4 | GO:0016559 | peroxisome fission(GO:0016559) |
| 0.1 | 1.1 | GO:0030202 | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014) heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210) |
| 0.1 | 0.4 | GO:0070383 | DNA cytosine deamination(GO:0070383) |
| 0.1 | 0.9 | GO:0060338 | regulation of type I interferon-mediated signaling pathway(GO:0060338) |
| 0.1 | 5.8 | GO:0060135 | maternal process involved in female pregnancy(GO:0060135) |
| 0.1 | 0.6 | GO:1990504 | dense core granule exocytosis(GO:1990504) |
| 0.0 | 0.6 | GO:0038003 | opioid receptor signaling pathway(GO:0038003) |
| 0.0 | 0.5 | GO:0060700 | regulation of ribonuclease activity(GO:0060700) |
| 0.0 | 0.2 | GO:0060940 | epithelial to mesenchymal transition involved in cardiac fibroblast development(GO:0060940) |
| 0.0 | 1.2 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 0.0 | 0.3 | GO:0021891 | olfactory bulb interneuron development(GO:0021891) |
| 0.0 | 0.5 | GO:0034498 | early endosome to Golgi transport(GO:0034498) |
| 0.0 | 2.8 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 0.0 | 0.4 | GO:0045008 | depyrimidination(GO:0045008) |
| 0.0 | 0.1 | GO:0061743 | motor learning(GO:0061743) |
| 0.0 | 1.6 | GO:0019369 | arachidonic acid metabolic process(GO:0019369) |
| 0.0 | 0.3 | GO:0002430 | complement receptor mediated signaling pathway(GO:0002430) |
| 0.0 | 0.4 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.0 | 0.9 | GO:0050435 | beta-amyloid metabolic process(GO:0050435) |
| 0.0 | 0.4 | GO:0015695 | organic cation transport(GO:0015695) |
| 0.0 | 0.2 | GO:0034378 | chylomicron assembly(GO:0034378) |
| 0.0 | 0.1 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) |
| 0.0 | 0.8 | GO:0070206 | protein trimerization(GO:0070206) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 1.7 | GO:0032002 | interleukin-28 receptor complex(GO:0032002) |
| 0.3 | 2.3 | GO:0042825 | TAP complex(GO:0042825) |
| 0.3 | 0.5 | GO:0042824 | MHC class I peptide loading complex(GO:0042824) |
| 0.3 | 1.6 | GO:0071797 | LUBAC complex(GO:0071797) |
| 0.2 | 0.7 | GO:1902737 | dendritic filopodium(GO:1902737) |
| 0.2 | 1.5 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 0.2 | 2.3 | GO:0016589 | NURF complex(GO:0016589) |
| 0.2 | 6.0 | GO:0034385 | very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385) |
| 0.2 | 1.3 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.1 | 2.4 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.1 | 0.9 | GO:0030485 | smooth muscle contractile fiber(GO:0030485) |
| 0.1 | 0.4 | GO:0030895 | apolipoprotein B mRNA editing enzyme complex(GO:0030895) |
| 0.1 | 0.5 | GO:0031905 | early endosome lumen(GO:0031905) |
| 0.1 | 0.5 | GO:0030905 | retromer, tubulation complex(GO:0030905) |
| 0.0 | 3.8 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.0 | 0.8 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.0 | 0.3 | GO:0097169 | AIM2 inflammasome complex(GO:0097169) |
| 0.0 | 1.2 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 0.3 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.0 | 0.7 | GO:0031233 | intrinsic component of external side of plasma membrane(GO:0031233) |
| 0.0 | 0.4 | GO:0045277 | respiratory chain complex IV(GO:0045277) |
| 0.0 | 0.1 | GO:0020003 | symbiont-containing vacuole(GO:0020003) symbiont-containing vacuole membrane(GO:0020005) |
| 0.0 | 3.4 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.0 | 1.6 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 0.4 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.0 | 1.4 | GO:0009986 | cell surface(GO:0009986) |
| 0.0 | 1.6 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 1.0 | GO:0015030 | Cajal body(GO:0015030) |
| 0.0 | 0.9 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.0 | 2.3 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 12.0 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 9.3 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.6 | 7.8 | GO:0031386 | protein tag(GO:0031386) |
| 0.3 | 2.4 | GO:0005134 | interleukin-2 receptor binding(GO:0005134) |
| 0.3 | 3.2 | GO:0042296 | ISG15 transferase activity(GO:0042296) |
| 0.3 | 1.3 | GO:0048030 | disaccharide binding(GO:0048030) |
| 0.3 | 1.4 | GO:0031849 | olfactory receptor binding(GO:0031849) |
| 0.3 | 1.4 | GO:0015433 | peptide antigen-transporting ATPase activity(GO:0015433) |
| 0.2 | 1.0 | GO:0015440 | peptide-transporting ATPase activity(GO:0015440) TAP binding(GO:0046977) TAP1 binding(GO:0046978) TAP2 binding(GO:0046979) |
| 0.2 | 5.8 | GO:0008035 | high-density lipoprotein particle binding(GO:0008035) |
| 0.2 | 0.9 | GO:0033754 | indoleamine 2,3-dioxygenase activity(GO:0033754) |
| 0.2 | 1.5 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 0.2 | 5.1 | GO:0070403 | NAD+ binding(GO:0070403) |
| 0.1 | 2.1 | GO:0015038 | glutathione disulfide oxidoreductase activity(GO:0015038) |
| 0.1 | 1.1 | GO:0015016 | [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016) |
| 0.1 | 1.1 | GO:0019864 | IgG binding(GO:0019864) |
| 0.1 | 0.9 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
| 0.1 | 0.7 | GO:0034046 | poly(G) binding(GO:0034046) |
| 0.1 | 3.3 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.1 | 0.5 | GO:1990460 | leptin receptor binding(GO:1990460) |
| 0.1 | 0.4 | GO:0000702 | oxidized base lesion DNA N-glycosylase activity(GO:0000702) |
| 0.1 | 0.4 | GO:0047844 | deoxycytidine deaminase activity(GO:0047844) |
| 0.1 | 3.3 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.1 | 0.5 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.1 | 0.6 | GO:0004985 | opioid receptor activity(GO:0004985) |
| 0.1 | 6.9 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 0.1 | 7.5 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.0 | 2.5 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
| 0.0 | 1.3 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.0 | 0.2 | GO:0047374 | methylumbelliferyl-acetate deacetylase activity(GO:0047374) |
| 0.0 | 0.4 | GO:0004046 | aminoacylase activity(GO:0004046) |
| 0.0 | 1.4 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.0 | 6.0 | GO:0005254 | chloride channel activity(GO:0005254) |
| 0.0 | 1.5 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.0 | 2.4 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
| 0.0 | 0.3 | GO:0004983 | neuropeptide Y receptor activity(GO:0004983) |
| 0.0 | 0.6 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.0 | 0.3 | GO:0004875 | complement receptor activity(GO:0004875) |
| 0.0 | 1.0 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.0 | 0.1 | GO:0038181 | bile acid receptor activity(GO:0038181) |
| 0.0 | 0.1 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 0.0 | 0.4 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.0 | 0.4 | GO:0015002 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 0.4 | GO:0008519 | ammonium transmembrane transporter activity(GO:0008519) |
| 0.0 | 1.6 | GO:0016811 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.5 | SIG IL4RECEPTOR IN B LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
| 0.0 | 6.9 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 2.4 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 1.4 | PID TRAIL PATHWAY | TRAIL signaling pathway |
| 0.0 | 0.5 | PID THROMBIN PAR1 PATHWAY | PAR1-mediated thrombin signaling events |
| 0.0 | 3.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 0.9 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 0.8 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 13.2 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.4 | 40.1 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 0.5 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.1 | 3.2 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.1 | 5.7 | REACTOME ER PHAGOSOME PATHWAY | Genes involved in ER-Phagosome pathway |
| 0.1 | 1.6 | REACTOME PD1 SIGNALING | Genes involved in PD-1 signaling |
| 0.0 | 2.1 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.0 | 0.4 | REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G | Genes involved in Vif-mediated degradation of APOBEC3G |
| 0.0 | 1.4 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.0 | 0.9 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.0 | 1.2 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 0.8 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.0 | 0.4 | REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 0.0 | 1.1 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.0 | 1.2 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.0 | 0.6 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.0 | 0.7 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.0 | 1.1 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 0.3 | REACTOME INFLAMMASOMES | Genes involved in Inflammasomes |