ISMARA results: IRF6_IRF4

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for IRF6_IRF4_IRF5

Z-value: 2.51

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Transcription factors associated with IRF6_IRF4_IRF5

Gene Symbol	Gene ID	Gene Info
IRF6 Ensembl NCBI GeneCards UniProt	ENSG00000117595.6	interferon regulatory factor 6
IRF4 Ensembl NCBI GeneCards UniProt	ENSG00000137265.10	interferon regulatory factor 4
IRF5 Ensembl NCBI GeneCards UniProt	ENSG00000128604.14	interferon regulatory factor 5

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
IRF6	hg19_v2_chr1_-_209975494_209975511	0.38	1.0e-01	Click!
IRF4	hg19_v2_chr6_+_391739_391759	-0.30	2.0e-01	Click!
IRF5	hg19_v2_chr7_+_128577972_128578047	-0.27	2.5e-01	Click!

Activity profile of IRF6_IRF4_IRF5 motif

Sorted Z-values of IRF6_IRF4_IRF5 motif

No targets for IRF6_IRF4_IRF5

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF6_IRF4_IRF5

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	17.7	GO:0003373	dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.5	15.1	GO:0035455	response to interferon-alpha(GO:0035455)
0.1	11.8	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.8	7.1	GO:0034344	type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
0.5	6.3	GO:0070212	protein poly-ADP-ribosylation(GO:0070212)
0.1	5.3	GO:0070206	protein trimerization(GO:0070206)
1.0	5.1	GO:2000110	negative regulation of macrophage apoptotic process(GO:2000110)
0.5	5.0	GO:0090191	negative regulation of branching involved in ureteric bud morphogenesis(GO:0090191)
0.4	4.6	GO:0051902	negative regulation of mitochondrial depolarization(GO:0051902)
0.2	4.5	GO:0035456	response to interferon-beta(GO:0035456)

Showing 1 to 10 of 92 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	13.5	GO:0031965	nuclear membrane(GO:0031965)
0.0	7.4	GO:0031902	late endosome membrane(GO:0031902)
0.1	6.1	GO:0009925	basal plasma membrane(GO:0009925)
0.1	6.1	GO:0015030	Cajal body(GO:0015030)
0.0	5.7	GO:0032587	ruffle membrane(GO:0032587)
0.4	3.1	GO:0042406	extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0	2.5	GO:0005643	nuclear pore(GO:0005643)
0.1	2.0	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	1.9	GO:0035577	azurophil granule membrane(GO:0035577)
0.1	1.5	GO:0035985	senescence-associated heterochromatin focus(GO:0035985)

Showing 1 to 10 of 35 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	17.4	GO:0008017	microtubule binding(GO:0008017)
0.1	8.4	GO:0003727	single-stranded RNA binding(GO:0003727)
0.1	7.4	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.2	6.7	GO:0070403	NAD+ binding(GO:0070403)
0.0	6.0	GO:0030674	protein binding, bridging(GO:0030674)
0.0	5.4	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.3	3.0	GO:0042296	ISG15 transferase activity(GO:0042296)
0.1	2.7	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.1	2.7	GO:0032183	SUMO binding(GO:0032183)
0.0	2.6	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)

Showing 1 to 10 of 61 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.6	PID MYC PATHWAY	C-MYC pathway
0.0	4.1	PID TCPTP PATHWAY	Signaling events mediated by TCPTP
0.0	3.8	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.0	2.8	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	1.9	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.0	1.4	SIG PIP3 SIGNALING IN CARDIAC MYOCTES	Genes related to PIP3 signaling in cardiac myocytes
0.0	1.1	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.0	0.9	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.0	0.9	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.0	0.8	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions

Showing 1 to 10 of 11 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	38.9	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.6	12.6	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway
0.0	3.3	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.1	3.1	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1	2.9	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR
0.0	2.1	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.0	1.5	REACTOME G1 PHASE	Genes involved in G1 Phase
0.0	0.9	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
0.1	0.7	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0	0.7	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins

Showing 1 to 10 of 16 entries

Results for IRF6_IRF4_IRF5

Z-value: 2.51

Motif logo

Transcription factors associated with IRF6_IRF4_IRF5

Activity-expression correlation:

Activity profile of IRF6_IRF4_IRF5 motif

Sorted Z-values of IRF6_IRF4_IRF5 motif

No targets for IRF6_IRF4_IRF5

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF6_IRF4_IRF5

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: