ISMARA results: IRF9

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for IRF9

Z-value: 3.11

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Transcription factors associated with IRF9

Gene Symbol	Gene ID	Gene Info
IRF9 Ensembl NCBI GeneCards UniProt	ENSG00000213928.4	interferon regulatory factor 9

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
IRF9	hg19_v2_chr14_+_24630465_24630531	0.75	1.3e-04	Click!

Activity profile of IRF9 motif

Sorted Z-values of IRF9 motif

No targets for IRF9

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF9

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	62.1	GO:0060337	type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
1.5	31.5	GO:0003373	dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
1.3	15.4	GO:0032020	ISG15-protein conjugation(GO:0032020)
2.5	12.7	GO:2000110	negative regulation of macrophage apoptotic process(GO:2000110)
1.1	10.8	GO:0006659	phosphatidylserine biosynthetic process(GO:0006659) regulation of isomerase activity(GO:0010911) positive regulation of isomerase activity(GO:0010912) regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
2.3	9.0	GO:0034344	type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
0.7	8.0	GO:0070212	protein poly-ADP-ribosylation(GO:0070212)
0.0	7.0	GO:0009615	response to virus(GO:0009615)
1.2	4.7	GO:0009138	pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.1	3.9	GO:0045071	negative regulation of viral genome replication(GO:0045071)

Showing 1 to 10 of 44 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	32.0	GO:0005739	mitochondrion(GO:0005739)
0.0	28.0	GO:0031965	nuclear membrane(GO:0031965)
0.0	27.8	GO:0005730	nucleolus(GO:0005730)
0.0	8.6	GO:0010008	endosome membrane(GO:0010008)
0.0	6.8	GO:0032587	ruffle membrane(GO:0032587)
0.0	3.6	GO:0005771	multivesicular body(GO:0005771)
0.0	3.3	GO:0005643	nuclear pore(GO:0005643)
0.4	2.8	GO:0036021	endolysosome lumen(GO:0036021)
0.3	2.4	GO:0042406	extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0	2.4	GO:0005811	lipid particle(GO:0005811)

Showing 1 to 10 of 23 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.0	35.5	GO:0001730	2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.1	31.5	GO:0008017	microtubule binding(GO:0008017)
0.1	11.5	GO:0003727	single-stranded RNA binding(GO:0003727)
0.9	11.4	GO:0031386	protein tag(GO:0031386)
0.5	10.8	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.1	9.1	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.3	8.0	GO:0070403	NAD+ binding(GO:0070403)
1.2	4.7	GO:0009041	uridylate kinase activity(GO:0009041)
0.1	4.3	GO:0005521	lamin binding(GO:0005521)
0.4	4.1	GO:0042296	ISG15 transferase activity(GO:0042296)

Showing 1 to 10 of 44 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	9.4	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.3	4.0	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.0	2.4	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.0	1.6	SIG PIP3 SIGNALING IN CARDIAC MYOCTES	Genes related to PIP3 signaling in cardiac myocytes
0.0	1.4	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes

Showing 1 to 5 of 5 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	115.3	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.7	11.2	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway
0.1	4.1	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.7	2.9	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.0	2.4	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.0	1.3	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.0	1.0	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0	0.9	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.8	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.0	0.6	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism

Showing 1 to 10 of 13 entries

Results for IRF9

Z-value: 3.11

Motif logo

Transcription factors associated with IRF9

Activity-expression correlation:

Activity profile of IRF9 motif

Sorted Z-values of IRF9 motif

No targets for IRF9

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF9

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: