ISMARA results: IRX2

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for IRX2

Z-value: 0.47

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Transcription factors associated with IRX2

Gene Symbol	Gene ID	Gene Info
IRX2 Ensembl NCBI GeneCards UniProt	ENSG00000170561.8	iroquois homeobox 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
IRX2	hg19_v2_chr5_-_2751762_2751784	0.18	4.4e-01	Click!

Activity profile of IRX2 motif

Sorted Z-values of IRX2 motif

No targets for IRX2

Network of associatons between targets according to the STRING database.

First level regulatory network of IRX2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.6	GO:0018345	protein palmitoylation(GO:0018345)
0.0	0.4	GO:0031936	negative regulation of chromatin silencing(GO:0031936)
0.0	0.4	GO:0071578	zinc II ion transmembrane import(GO:0071578)
0.0	0.4	GO:0003334	keratinocyte development(GO:0003334)
0.1	0.3	GO:0044417	translocation of peptides or proteins into host(GO:0042000) translocation of peptides or proteins into host cell cytoplasm(GO:0044053) translocation of molecules into host(GO:0044417) translocation of peptides or proteins into other organism involved in symbiotic interaction(GO:0051808) translocation of molecules into other organism involved in symbiotic interaction(GO:0051836)
0.1	0.3	GO:0003131	mesodermal-endodermal cell signaling(GO:0003131) programmed DNA elimination(GO:0031049) chromosome breakage(GO:0031052) histone H2A-S139 phosphorylation(GO:0035978) positive regulation of cellular response to X-ray(GO:2000685)
0.1	0.3	GO:2001045	negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.1	0.3	GO:0031860	telomeric 3' overhang formation(GO:0031860)
0.0	0.3	GO:0060356	leucine import(GO:0060356)
0.0	0.3	GO:0043402	glucocorticoid mediated signaling pathway(GO:0043402)

Showing 1 to 10 of 37 entries

Gene overrepresentation in cellular_component category:

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Total log-likelihood	Term	Description
0.3	GO:0030870	Mre11 complex(GO:0030870)
0.3	GO:0035985	senescence-associated heterochromatin focus(GO:0035985)
0.3	GO:0016600	flotillin complex(GO:0016600)
0.3	GO:0002199	zona pellucida receptor complex(GO:0002199)
0.2	GO:0070852	cell body fiber(GO:0070852)
0.2	GO:0033263	CORVET complex(GO:0033263)
0.1	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.1	GO:0035354	Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354)
0.1	GO:0045293	MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.1	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)

Showing 1 to 10 of 10 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.6	GO:0019706	protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0	0.4	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.1	0.3	GO:0035501	MH1 domain binding(GO:0035501)
0.0	0.3	GO:0004883	glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.0	0.3	GO:0045295	gamma-catenin binding(GO:0045295)
0.0	0.3	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.1	0.2	GO:0010309	acireductone dioxygenase [iron(II)-requiring] activity(GO:0010309)
0.1	0.2	GO:0004483	mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483)
0.0	0.2	GO:0031681	G-protein beta-subunit binding(GO:0031681)
0.0	0.2	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)

Showing 1 to 10 of 16 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.4	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters

Showing 1 to 1 of 1 entries

Results for IRX2

Z-value: 0.47

Motif logo

Transcription factors associated with IRX2

Activity-expression correlation:

Activity profile of IRX2 motif

Sorted Z-values of IRX2 motif

No targets for IRX2

Network of associatons between targets according to the STRING database.

First level regulatory network of IRX2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP:REACTOME category: