ISMARA results: IRX3

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for IRX3

Z-value: 1.84

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Transcription factors associated with IRX3

Gene Symbol	Gene ID	Gene Info
IRX3 Ensembl NCBI GeneCards UniProt	ENSG00000177508.11	iroquois homeobox 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
IRX3	hg19_v2_chr16_-_54320675_54320715	-0.83	6.2e-06	Click!

Activity profile of IRX3 motif

Sorted Z-values of IRX3 motif

No targets for IRX3

Network of associatons between targets according to the STRING database.

First level regulatory network of IRX3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	8.0	GO:0018149	peptide cross-linking(GO:0018149)
0.5	6.5	GO:0070487	monocyte aggregation(GO:0070487)
0.0	5.4	GO:1902476	chloride transmembrane transport(GO:1902476)
0.7	4.7	GO:0002786	regulation of antimicrobial peptide production(GO:0002784) regulation of antibacterial peptide production(GO:0002786)
0.0	4.1	GO:0042267	natural killer cell mediated cytotoxicity(GO:0042267)
0.1	3.8	GO:0045104	intermediate filament cytoskeleton organization(GO:0045104)
0.2	3.7	GO:0071803	positive regulation of podosome assembly(GO:0071803)
0.1	3.7	GO:0009312	oligosaccharide biosynthetic process(GO:0009312)
0.1	3.6	GO:0042149	cellular response to glucose starvation(GO:0042149)
0.8	3.3	GO:0050717	positive regulation of interleukin-1 alpha secretion(GO:0050717)

Showing 1 to 10 of 220 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	11.0	GO:0001533	cornified envelope(GO:0001533)
0.7	4.7	GO:0097209	epidermal lamellar body(GO:0097209)
0.0	4.0	GO:0045095	keratin filament(GO:0045095)
0.5	3.4	GO:0097179	protease inhibitor complex(GO:0097179)
0.2	3.2	GO:0042613	MHC class II protein complex(GO:0042613)
0.1	2.8	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	2.7	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.3	2.6	GO:0035692	macrophage migration inhibitory factor receptor complex(GO:0035692)
0.1	2.5	GO:0030127	COPII vesicle coat(GO:0030127)
0.0	2.4	GO:0031594	neuromuscular junction(GO:0031594)

Showing 1 to 10 of 91 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	10.4	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.2	5.3	GO:0005229	intracellular calcium activated chloride channel activity(GO:0005229)
0.2	4.1	GO:0005149	interleukin-1 receptor binding(GO:0005149)
0.0	3.7	GO:0004869	cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.2	3.3	GO:0032395	MHC class II receptor activity(GO:0032395)
0.1	3.3	GO:0050700	CARD domain binding(GO:0050700)
0.0	3.3	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0	3.1	GO:0033558	histone deacetylase activity(GO:0004407) protein deacetylase activity(GO:0033558)
0.9	2.7	GO:0005150	interleukin-1, Type I receptor binding(GO:0005150)
0.2	2.7	GO:0019534	toxin transporter activity(GO:0019534)

Showing 1 to 10 of 146 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	10.6	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2	7.2	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.1	6.1	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.0	5.6	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0	4.9	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.0	3.0	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.0	2.9	PID IL1 PATHWAY	IL1-mediated signaling events
0.1	2.5	PID ALK1 PATHWAY	ALK1 signaling events
0.1	2.4	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.1	2.2	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Showing 1 to 10 of 26 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	7.4	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling
0.2	3.8	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.1	3.6	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.1	3.3	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.1	3.0	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.1	2.7	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
0.0	2.7	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.1	2.5	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0	2.5	REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0	2.4	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)

Showing 1 to 10 of 48 entries

Results for IRX3

Z-value: 1.84

Motif logo

Transcription factors associated with IRX3

Activity-expression correlation:

Activity profile of IRX3 motif

Sorted Z-values of IRX3 motif

No targets for IRX3

Network of associatons between targets according to the STRING database.

First level regulatory network of IRX3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: