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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for ISL1
Z-value: 1.05
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Transcription factors associated with ISL1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
ISL1
|
ENSG00000016082.10 | ISL LIM homeobox 1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ISL1 | hg19_v2_chr5_+_50678921_50678921 | -0.27 | 2.5e-01 | Click! |
Activity profile of ISL1 motif
Sorted Z-values of ISL1 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of ISL1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 0.8 | GO:0031204 | posttranslational protein targeting to membrane, translocation(GO:0031204) |
| 0.1 | 0.8 | GO:0042271 | susceptibility to natural killer cell mediated cytotoxicity(GO:0042271) |
| 0.1 | 1.0 | GO:0086048 | membrane depolarization during bundle of His cell action potential(GO:0086048) |
| 0.1 | 0.7 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 0.1 | 0.5 | GO:0002426 | immunoglobulin production in mucosal tissue(GO:0002426) |
| 0.1 | 0.4 | GO:0001543 | ovarian follicle rupture(GO:0001543) |
| 0.1 | 0.4 | GO:0001544 | initiation of primordial ovarian follicle growth(GO:0001544) |
| 0.1 | 0.5 | GO:0046462 | monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651) |
| 0.1 | 0.3 | GO:0090427 | activation of meiosis(GO:0090427) |
| 0.1 | 0.3 | GO:1901340 | negative regulation of store-operated calcium channel activity(GO:1901340) |
| 0.1 | 0.7 | GO:1902896 | terminal web assembly(GO:1902896) |
| 0.1 | 0.7 | GO:0050653 | chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653) |
| 0.1 | 0.5 | GO:2001045 | negative regulation of integrin-mediated signaling pathway(GO:2001045) |
| 0.1 | 1.5 | GO:0002158 | osteoclast proliferation(GO:0002158) |
| 0.1 | 0.6 | GO:1904721 | negative regulation of mRNA cleavage(GO:0031438) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721) |
| 0.1 | 0.3 | GO:1902303 | regulation of heart rate by hormone(GO:0003064) negative regulation of potassium ion export(GO:1902303) |
| 0.1 | 0.5 | GO:0072425 | signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434) |
| 0.1 | 0.5 | GO:1903527 | positive regulation of membrane tubulation(GO:1903527) |
| 0.1 | 1.3 | GO:0098870 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 0.1 | 0.9 | GO:0001778 | plasma membrane repair(GO:0001778) |
| 0.1 | 0.2 | GO:0007387 | anterior compartment pattern formation(GO:0007387) posterior compartment specification(GO:0007388) |
| 0.1 | 0.5 | GO:0061113 | pancreas morphogenesis(GO:0061113) |
| 0.1 | 0.5 | GO:0070092 | regulation of glucagon secretion(GO:0070092) |
| 0.1 | 0.2 | GO:0046452 | dihydrofolate metabolic process(GO:0046452) |
| 0.1 | 0.4 | GO:0018032 | protein amidation(GO:0018032) |
| 0.1 | 0.3 | GO:0014835 | myoblast differentiation involved in skeletal muscle regeneration(GO:0014835) |
| 0.1 | 0.3 | GO:0010693 | negative regulation of alkaline phosphatase activity(GO:0010693) semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220) |
| 0.1 | 0.2 | GO:0001922 | B-1 B cell homeostasis(GO:0001922) |
| 0.1 | 0.7 | GO:0035331 | negative regulation of hippo signaling(GO:0035331) |
| 0.0 | 0.1 | GO:2000627 | rRNA import into mitochondrion(GO:0035928) regulation of miRNA catabolic process(GO:2000625) positive regulation of miRNA catabolic process(GO:2000627) |
| 0.0 | 0.2 | GO:2001180 | negative regulation of interleukin-10 secretion(GO:2001180) negative regulation of interleukin-12 secretion(GO:2001183) |
| 0.0 | 0.9 | GO:0033327 | Leydig cell differentiation(GO:0033327) |
| 0.0 | 0.7 | GO:0090091 | positive regulation of extracellular matrix disassembly(GO:0090091) |
| 0.0 | 0.5 | GO:0060020 | Bergmann glial cell differentiation(GO:0060020) |
| 0.0 | 1.2 | GO:0003334 | keratinocyte development(GO:0003334) |
| 0.0 | 0.2 | GO:1904565 | response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566) |
| 0.0 | 0.3 | GO:0022027 | interkinetic nuclear migration(GO:0022027) |
| 0.0 | 0.2 | GO:0036371 | protein localization to T-tubule(GO:0036371) |
| 0.0 | 0.4 | GO:0030242 | pexophagy(GO:0030242) |
| 0.0 | 0.5 | GO:0038003 | opioid receptor signaling pathway(GO:0038003) |
| 0.0 | 0.3 | GO:1901731 | positive regulation of platelet aggregation(GO:1901731) |
| 0.0 | 0.8 | GO:0006020 | inositol metabolic process(GO:0006020) |
| 0.0 | 0.2 | GO:0001880 | Mullerian duct regression(GO:0001880) |
| 0.0 | 0.7 | GO:0070914 | UV-damage excision repair(GO:0070914) |
| 0.0 | 0.5 | GO:0031848 | protection from non-homologous end joining at telomere(GO:0031848) |
| 0.0 | 0.2 | GO:0006436 | tryptophanyl-tRNA aminoacylation(GO:0006436) |
| 0.0 | 0.3 | GO:0030579 | ubiquitin-dependent SMAD protein catabolic process(GO:0030579) |
| 0.0 | 0.1 | GO:0018312 | peptidyl-serine ADP-ribosylation(GO:0018312) |
| 0.0 | 0.3 | GO:0070836 | caveola assembly(GO:0070836) |
| 0.0 | 0.2 | GO:1903435 | positive regulation of constitutive secretory pathway(GO:1903435) |
| 0.0 | 1.4 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 0.0 | 0.5 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 0.0 | 0.6 | GO:1904778 | regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778) |
| 0.0 | 0.1 | GO:0044793 | negative regulation by host of viral process(GO:0044793) negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199) |
| 0.0 | 0.3 | GO:0015074 | DNA integration(GO:0015074) |
| 0.0 | 0.3 | GO:0021859 | pyramidal neuron differentiation(GO:0021859) |
| 0.0 | 0.2 | GO:0034392 | negative regulation of smooth muscle cell apoptotic process(GO:0034392) |
| 0.0 | 1.2 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.0 | 0.1 | GO:0045629 | negative regulation of T-helper 2 cell differentiation(GO:0045629) |
| 0.0 | 0.2 | GO:0048245 | eosinophil chemotaxis(GO:0048245) |
| 0.0 | 0.0 | GO:1904204 | regulation of skeletal muscle hypertrophy(GO:1904204) |
| 0.0 | 1.1 | GO:0043268 | positive regulation of potassium ion transport(GO:0043268) |
| 0.0 | 0.3 | GO:0051967 | negative regulation of synaptic transmission, glutamatergic(GO:0051967) |
| 0.0 | 0.4 | GO:0006646 | phosphatidylethanolamine biosynthetic process(GO:0006646) |
| 0.0 | 0.1 | GO:0034128 | negative regulation of MyD88-independent toll-like receptor signaling pathway(GO:0034128) |
| 0.0 | 0.3 | GO:0046007 | negative regulation of activated T cell proliferation(GO:0046007) |
| 0.0 | 0.2 | GO:0014877 | response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) |
| 0.0 | 0.1 | GO:0032571 | response to vitamin K(GO:0032571) |
| 0.0 | 0.1 | GO:0006990 | positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990) |
| 0.0 | 0.1 | GO:0006177 | GMP biosynthetic process(GO:0006177) |
| 0.0 | 0.2 | GO:0031340 | positive regulation of vesicle fusion(GO:0031340) |
| 0.0 | 0.2 | GO:0048312 | intracellular distribution of mitochondria(GO:0048312) |
| 0.0 | 0.2 | GO:0038180 | nerve growth factor signaling pathway(GO:0038180) |
| 0.0 | 0.1 | GO:1902730 | regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) myoblast fate commitment(GO:0048625) positive regulation of proteoglycan biosynthetic process(GO:1902730) |
| 0.0 | 0.4 | GO:0060117 | auditory receptor cell development(GO:0060117) |
| 0.0 | 0.3 | GO:0007638 | mechanosensory behavior(GO:0007638) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.5 | GO:0070939 | Dsl1p complex(GO:0070939) |
| 0.1 | 0.7 | GO:1990357 | terminal web(GO:1990357) |
| 0.1 | 1.1 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 0.1 | 0.7 | GO:0060201 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.1 | 0.5 | GO:0098536 | deuterosome(GO:0098536) |
| 0.1 | 0.7 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
| 0.1 | 0.3 | GO:1902937 | inward rectifier potassium channel complex(GO:1902937) |
| 0.1 | 1.0 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.1 | 0.3 | GO:0016035 | zeta DNA polymerase complex(GO:0016035) |
| 0.0 | 0.7 | GO:0005828 | kinetochore microtubule(GO:0005828) |
| 0.0 | 0.8 | GO:0008091 | spectrin(GO:0008091) |
| 0.0 | 0.9 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.0 | 0.4 | GO:0072487 | MSL complex(GO:0072487) |
| 0.0 | 0.5 | GO:0016600 | flotillin complex(GO:0016600) |
| 0.0 | 0.4 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.0 | 0.1 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) |
| 0.0 | 0.5 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.0 | 0.1 | GO:0005902 | microvillus(GO:0005902) actin-based cell projection(GO:0098858) |
| 0.0 | 0.3 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
| 0.0 | 1.6 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 0.5 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.0 | 0.7 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 0.2 | GO:0031045 | dense core granule(GO:0031045) |
| 0.0 | 0.2 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.0 | 0.3 | GO:0000242 | pericentriolar material(GO:0000242) |
| 0.0 | 0.2 | GO:0070938 | contractile ring(GO:0070938) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.0 | GO:0086057 | voltage-gated calcium channel activity involved in bundle of His cell action potential(GO:0086057) |
| 0.2 | 1.5 | GO:0016941 | natriuretic peptide receptor activity(GO:0016941) |
| 0.2 | 0.5 | GO:0047225 | acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0047225) |
| 0.1 | 0.5 | GO:0004157 | dihydropyrimidinase activity(GO:0004157) |
| 0.1 | 0.7 | GO:0008955 | peptidoglycan glycosyltransferase activity(GO:0008955) |
| 0.1 | 0.8 | GO:0033857 | diphosphoinositol-pentakisphosphate kinase activity(GO:0033857) |
| 0.1 | 0.6 | GO:0060698 | endoribonuclease inhibitor activity(GO:0060698) |
| 0.1 | 0.5 | GO:1990254 | keratin filament binding(GO:1990254) |
| 0.1 | 0.4 | GO:0008195 | phosphatidate phosphatase activity(GO:0008195) |
| 0.1 | 0.3 | GO:0032184 | SUMO polymer binding(GO:0032184) |
| 0.1 | 0.6 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.1 | 0.7 | GO:0004321 | fatty-acyl-CoA synthase activity(GO:0004321) |
| 0.1 | 0.4 | GO:0004598 | peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598) |
| 0.1 | 0.3 | GO:0052740 | 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740) |
| 0.0 | 1.3 | GO:0086080 | protein binding involved in heterotypic cell-cell adhesion(GO:0086080) |
| 0.0 | 0.5 | GO:0004985 | opioid receptor activity(GO:0004985) |
| 0.0 | 0.3 | GO:0047179 | platelet-activating factor acetyltransferase activity(GO:0047179) |
| 0.0 | 0.2 | GO:0060230 | lipoprotein lipase activator activity(GO:0060230) |
| 0.0 | 0.6 | GO:0042731 | PH domain binding(GO:0042731) |
| 0.0 | 0.2 | GO:0051870 | methotrexate binding(GO:0051870) |
| 0.0 | 0.5 | GO:0035312 | 5'-3' exodeoxyribonuclease activity(GO:0035312) |
| 0.0 | 1.0 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.0 | 0.3 | GO:0000155 | phosphorelay sensor kinase activity(GO:0000155) |
| 0.0 | 0.2 | GO:0004830 | tryptophan-tRNA ligase activity(GO:0004830) |
| 0.0 | 0.1 | GO:1990404 | protein ADP-ribosylase activity(GO:1990404) |
| 0.0 | 0.5 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.0 | 0.7 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.0 | 0.7 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.0 | 0.9 | GO:0000217 | DNA secondary structure binding(GO:0000217) |
| 0.0 | 1.4 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.0 | 0.3 | GO:0051525 | NFAT protein binding(GO:0051525) |
| 0.0 | 0.1 | GO:0034046 | poly(G) binding(GO:0034046) |
| 0.0 | 0.5 | GO:0016671 | oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671) |
| 0.0 | 0.2 | GO:0070915 | lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915) |
| 0.0 | 0.3 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.0 | 1.8 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.0 | 0.1 | GO:0003938 | IMP dehydrogenase activity(GO:0003938) |
| 0.0 | 0.2 | GO:0030618 | transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618) |
| 0.0 | 0.3 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.0 | 0.1 | GO:0001849 | complement component C1q binding(GO:0001849) virion binding(GO:0046790) |
| 0.0 | 0.1 | GO:0016934 | extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934) |
| 0.0 | 0.4 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.0 | 0.3 | GO:0070300 | phosphatidic acid binding(GO:0070300) |
| 0.0 | 0.4 | GO:0000062 | fatty-acyl-CoA binding(GO:0000062) |
| 0.0 | 0.0 | GO:0008431 | vitamin E binding(GO:0008431) |
| 0.0 | 0.4 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.0 | 0.5 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.0 | 0.3 | GO:0008603 | cAMP-dependent protein kinase regulator activity(GO:0008603) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 2.0 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.0 | 0.5 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 0.2 | PID VEGFR1 PATHWAY | VEGFR1 specific signals |
| 0.0 | 0.6 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.0 | 0.7 | PID NECTIN PATHWAY | Nectin adhesion pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.5 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 0.7 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.0 | 1.0 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 0.5 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.0 | 0.7 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.0 | 0.4 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.0 | 0.5 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.0 | 1.4 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 0.3 | REACTOME ARMS MEDIATED ACTIVATION | Genes involved in ARMS-mediated activation |
| 0.0 | 3.0 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 0.3 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |