ISMARA results: ISL2

Project

avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

Navigation

Downloads

Results for ISL2

Z-value: 1.14

Motif logo

Transcription factors associated with ISL2

Gene Symbol	Gene ID	Gene Info
ISL2 Ensembl NCBI GeneCards UniProt	ENSG00000159556.5	ISL LIM homeobox 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ISL2	hg19_v2_chr15_+_76629064_76629073	0.78	4.4e-05	Click!

Activity profile of ISL2 motif

Sorted Z-values of ISL2 motif

No targets for ISL2

Network of associatons between targets according to the STRING database.

First level regulatory network of ISL2

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	2.3	GO:0034392	negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.1	2.2	GO:0019227	neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1	2.0	GO:0051988	regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.1	1.8	GO:0072520	seminiferous tubule development(GO:0072520)
0.2	1.4	GO:0009753	response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.1	1.4	GO:1901078	negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0	1.4	GO:0045880	positive regulation of smoothened signaling pathway(GO:0045880)
0.0	1.4	GO:0003333	amino acid transmembrane transport(GO:0003333)
0.1	1.3	GO:0070933	histone H4 deacetylation(GO:0070933)
0.0	1.2	GO:0050919	negative chemotaxis(GO:0050919)

Showing 1 to 10 of 57 entries

Gene overrepresentation in cellular_component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	2.5	GO:0097149	centralspindlin complex(GO:0097149)
0.1	2.3	GO:0031089	platelet dense granule lumen(GO:0031089)
0.1	2.2	GO:0043194	axon initial segment(GO:0043194)
0.1	1.8	GO:0005828	kinetochore microtubule(GO:0005828)
0.1	1.4	GO:0060091	kinocilium(GO:0060091)
0.0	1.4	GO:0000930	gamma-tubulin complex(GO:0000930)
0.0	1.3	GO:0035861	site of double-strand break(GO:0035861)
0.0	1.0	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.1	0.9	GO:1990454	L-type voltage-gated calcium channel complex(GO:1990454)
0.0	0.9	GO:0030173	integral component of Golgi membrane(GO:0030173)

Showing 1 to 10 of 28 entries

Gene overrepresentation in molecular_function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	2.3	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
0.1	2.3	GO:0086080	protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0	2.0	GO:0017048	Rho GTPase binding(GO:0017048)
0.0	1.8	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.2	1.4	GO:0047086	phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086)
0.0	1.4	GO:0043015	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) gamma-tubulin binding(GO:0043015)
0.0	1.2	GO:0038191	neuropilin binding(GO:0038191)
0.1	1.1	GO:0008140	cAMP response element binding protein binding(GO:0008140)
0.1	1.1	GO:0008179	adenylate cyclase binding(GO:0008179)
0.0	1.1	GO:0008536	Ran GTPase binding(GO:0008536)

Showing 1 to 10 of 39 entries

Gene overrepresentation in C2:CP category:

Search:

Show entries

Total log-likelihood	Term	Description
3.7	PID PLK1 PATHWAY	PLK1 signaling events
1.3	PID TNF PATHWAY	TNF receptor signaling pathway
1.1	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway

Showing 1 to 3 of 3 entries

Gene overrepresentation in C2:CP:REACTOME category:

Search:

Show entries

Total log-likelihood	Term	Description
2.5	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
2.2	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
1.8	REACTOME KINESINS	Genes involved in Kinesins
1.4	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
1.0	REACTOME CTNNB1 PHOSPHORYLATION CASCADE	Genes involved in Beta-catenin phosphorylation cascade
0.9	REACTOME METAL ION SLC TRANSPORTERS	Genes involved in Metal ion SLC transporters
0.8	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.8	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.6	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.6	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis

Showing 1 to 10 of 16 entries

Results for ISL2

Z-value: 1.14

Motif logo

Transcription factors associated with ISL2

Activity-expression correlation:

Activity profile of ISL2 motif

Sorted Z-values of ISL2 motif

No targets for ISL2

Network of associatons between targets according to the STRING database.

First level regulatory network of ISL2

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: