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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for JUN

Z-value: 1.28

Motif logo

Transcription factors associated with JUN

Gene Symbol Gene ID Gene Info
ENSG00000177606.5 Jun proto-oncogene, AP-1 transcription factor subunit

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
JUNhg19_v2_chr1_-_59249732_592497850.714.4e-04Click!

Activity profile of JUN motif

Sorted Z-values of JUN motif

Network of associatons between targets according to the STRING database.

First level regulatory network of JUN

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:1904235 regulation of substrate-dependent cell migration, cell attachment to substrate(GO:1904235) positive regulation of substrate-dependent cell migration, cell attachment to substrate(GO:1904237)
0.3 1.2 GO:0051710 cytolysis by symbiont of host cells(GO:0001897) regulation of cytolysis in other organism(GO:0051710)
0.3 0.3 GO:0046543 development of secondary sexual characteristics(GO:0045136) development of secondary female sexual characteristics(GO:0046543)
0.3 0.8 GO:1902598 creatine transport(GO:0015881) creatine transmembrane transport(GO:1902598)
0.3 1.0 GO:1990637 response to prolactin(GO:1990637)
0.2 2.8 GO:0007042 lysosomal lumen acidification(GO:0007042)
0.2 0.7 GO:1901069 guanosine-containing compound catabolic process(GO:1901069)
0.2 0.6 GO:0060279 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
0.2 1.1 GO:0045903 positive regulation of translational fidelity(GO:0045903)
0.2 1.6 GO:0010040 response to iron(II) ion(GO:0010040)
0.2 0.5 GO:0046041 ITP metabolic process(GO:0046041)
0.2 0.5 GO:0045994 positive regulation of translational initiation by iron(GO:0045994)
0.2 1.1 GO:0030035 microspike assembly(GO:0030035)
0.1 0.4 GO:1903410 lysine import(GO:0034226) L-lysine import(GO:0061461) L-lysine import into cell(GO:1903410)
0.1 0.4 GO:0071586 CAAX-box protein processing(GO:0071586) CAAX-box protein maturation(GO:0080120)
0.1 1.0 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.1 1.1 GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.1 0.4 GO:0061386 closure of optic fissure(GO:0061386)
0.1 0.7 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.1 0.8 GO:0035026 leading edge cell differentiation(GO:0035026)
0.1 0.4 GO:0072616 interleukin-18 secretion(GO:0072616)
0.1 0.4 GO:0006117 acetaldehyde metabolic process(GO:0006117)
0.1 0.9 GO:0043163 cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.1 0.4 GO:1990108 protein linear deubiquitination(GO:1990108)
0.1 0.5 GO:1903722 regulation of centriole elongation(GO:1903722)
0.1 1.2 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.1 0.3 GO:1903774 positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.1 0.3 GO:0043309 regulation of eosinophil degranulation(GO:0043309) positive regulation of eosinophil degranulation(GO:0043311) positive regulation of eosinophil activation(GO:1902568)
0.1 0.3 GO:1990709 maintenance of synapse structure(GO:0099558) presynaptic active zone organization(GO:1990709)
0.1 0.5 GO:0009183 purine deoxyribonucleoside diphosphate biosynthetic process(GO:0009183)
0.1 0.4 GO:0032773 regulation of monophenol monooxygenase activity(GO:0032771) positive regulation of monophenol monooxygenase activity(GO:0032773) negative regulation of catagen(GO:0051796) regulation of hair cycle by canonical Wnt signaling pathway(GO:0060901) positive regulation of melanosome transport(GO:1902910)
0.1 0.4 GO:0032792 negative regulation of CREB transcription factor activity(GO:0032792)
0.1 0.4 GO:0009236 cobalamin biosynthetic process(GO:0009236)
0.1 0.4 GO:1900535 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
0.1 0.4 GO:0045226 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.1 0.4 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.1 0.3 GO:0022007 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.1 0.3 GO:0006286 base-excision repair, base-free sugar-phosphate removal(GO:0006286)
0.1 0.2 GO:0048320 axial mesoderm morphogenesis(GO:0048319) axial mesoderm formation(GO:0048320)
0.1 0.6 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.1 0.2 GO:0006581 acetylcholine catabolic process in synaptic cleft(GO:0001507) acetylcholine catabolic process(GO:0006581)
0.1 0.9 GO:1902474 positive regulation of protein localization to synapse(GO:1902474)
0.1 0.7 GO:0045054 constitutive secretory pathway(GO:0045054)
0.1 0.3 GO:0001560 regulation of cell growth by extracellular stimulus(GO:0001560)
0.1 0.1 GO:1902080 regulation of calcium ion import into sarcoplasmic reticulum(GO:1902080) negative regulation of calcium ion import into sarcoplasmic reticulum(GO:1902081)
0.1 2.0 GO:0007567 parturition(GO:0007567)
0.1 0.3 GO:0033591 response to L-ascorbic acid(GO:0033591)
0.1 0.2 GO:0090258 negative regulation of mitochondrial fission(GO:0090258) positive regulation of mitochondrial DNA metabolic process(GO:1901860) response to methionine(GO:1904640)
0.1 0.2 GO:1904073 trophectodermal cell proliferation(GO:0001834) regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
0.1 0.2 GO:1904924 negative regulation of mitophagy in response to mitochondrial depolarization(GO:1904924)
0.1 0.3 GO:1901545 cellular response to raffinose(GO:0097403) response to raffinose(GO:1901545)
0.1 0.3 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.1 0.6 GO:0070777 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.1 0.3 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.1 0.2 GO:0034164 negative regulation of toll-like receptor 9 signaling pathway(GO:0034164)
0.1 0.3 GO:0033132 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.1 0.8 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.1 0.2 GO:1902525 regulation of protein monoubiquitination(GO:1902525) positive regulation of protein monoubiquitination(GO:1902527)
0.1 2.6 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.1 0.2 GO:0035284 rhombomere 5 development(GO:0021571) central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.1 0.5 GO:0010898 positive regulation of triglyceride catabolic process(GO:0010898)
0.1 1.2 GO:2000052 positive regulation of non-canonical Wnt signaling pathway(GO:2000052)
0.1 1.0 GO:0071027 nuclear RNA surveillance(GO:0071027) nuclear mRNA surveillance(GO:0071028)
0.1 0.2 GO:0007343 egg activation(GO:0007343)
0.1 0.6 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 1.3 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0 0.2 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.0 0.5 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.0 0.3 GO:0072675 multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
0.0 2.5 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.0 0.3 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.0 0.2 GO:0003335 corneocyte development(GO:0003335)
0.0 0.2 GO:0018057 peptidyl-lysine oxidation(GO:0018057)
0.0 0.6 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.0 0.3 GO:0097278 complement-dependent cytotoxicity(GO:0097278) regulation of complement-dependent cytotoxicity(GO:1903659)
0.0 0.2 GO:0070173 regulation of enamel mineralization(GO:0070173)
0.0 0.3 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.0 0.2 GO:0060459 subthalamic nucleus development(GO:0021763) prolactin secreting cell differentiation(GO:0060127) left lung development(GO:0060459) left lung morphogenesis(GO:0060460) superior vena cava morphogenesis(GO:0060578)
0.0 0.1 GO:0036451 cap mRNA methylation(GO:0036451)
0.0 0.6 GO:1901096 regulation of autophagosome maturation(GO:1901096)
0.0 0.2 GO:1903347 negative regulation of bicellular tight junction assembly(GO:1903347)
0.0 0.2 GO:0097091 synaptic vesicle clustering(GO:0097091)
0.0 0.5 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 0.2 GO:1990502 dense core granule maturation(GO:1990502)
0.0 0.1 GO:0035698 CD8-positive, alpha-beta T cell extravasation(GO:0035697) CD8-positive, alpha-beta cytotoxic T cell extravasation(GO:0035698) positive regulation of necroptotic process(GO:0060545) regulation of T cell extravasation(GO:2000407) regulation of CD8-positive, alpha-beta T cell extravasation(GO:2000449) regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation(GO:2000452)
0.0 0.2 GO:0030807 positive regulation of cyclic nucleotide catabolic process(GO:0030807) positive regulation of cAMP catabolic process(GO:0030822) positive regulation of purine nucleotide catabolic process(GO:0033123)
0.0 0.1 GO:1900738 dense core granule biogenesis(GO:0061110) positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738) positive regulation of relaxation of cardiac muscle(GO:1901899) regulation of dense core granule biogenesis(GO:2000705)
0.0 0.3 GO:0048539 bone marrow development(GO:0048539)
0.0 0.3 GO:0003322 pancreatic A cell development(GO:0003322)
0.0 0.4 GO:1902902 negative regulation of autophagosome assembly(GO:1902902)
0.0 0.2 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025) negative regulation of mRNA processing(GO:0050686)
0.0 0.4 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.0 1.0 GO:0042730 fibrinolysis(GO:0042730)
0.0 0.2 GO:0072658 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.4 GO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.0 0.1 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
0.0 0.1 GO:0032479 regulation of type I interferon production(GO:0032479) type I interferon production(GO:0032606)
0.0 0.6 GO:0015939 pantothenate metabolic process(GO:0015939)
0.0 0.3 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.0 0.2 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 0.3 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.0 0.2 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0 0.3 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
0.0 1.0 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.0 0.9 GO:0031639 plasminogen activation(GO:0031639)
0.0 0.2 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 1.4 GO:0051281 positive regulation of release of sequestered calcium ion into cytosol(GO:0051281)
0.0 0.1 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.0 0.5 GO:0000050 urea cycle(GO:0000050)
0.0 0.4 GO:0070072 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.1 GO:0050848 regulation of calcium-mediated signaling(GO:0050848)
0.0 0.5 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.0 0.3 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.0 0.2 GO:0007341 penetration of zona pellucida(GO:0007341)
0.0 1.1 GO:0002076 osteoblast development(GO:0002076)
0.0 0.4 GO:0032782 bile acid secretion(GO:0032782)
0.0 0.1 GO:0033489 cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490)
0.0 0.2 GO:2000323 negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
0.0 0.5 GO:0051775 response to redox state(GO:0051775)
0.0 0.1 GO:0045065 cytotoxic T cell differentiation(GO:0045065)
0.0 1.1 GO:0019433 triglyceride catabolic process(GO:0019433)
0.0 0.4 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.0 0.1 GO:0015783 GDP-fucose transport(GO:0015783) purine nucleotide-sugar transport(GO:0036079)
0.0 1.6 GO:0010107 potassium ion import(GO:0010107)
0.0 0.2 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.0 0.3 GO:0006657 CDP-choline pathway(GO:0006657)
0.0 0.4 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.0 0.4 GO:1901748 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.0 0.4 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.0 0.1 GO:0006669 sphinganine-1-phosphate biosynthetic process(GO:0006669)
0.0 0.3 GO:0031086 nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086)
0.0 0.1 GO:1902396 protein localization to bicellular tight junction(GO:1902396)
0.0 1.2 GO:0050427 purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.0 0.1 GO:0051708 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0 0.1 GO:1902941 regulation of cyclic nucleotide-gated ion channel activity(GO:1902159) positive regulation of cyclic nucleotide-gated ion channel activity(GO:1902161) regulation of voltage-gated chloride channel activity(GO:1902941) positive regulation of voltage-gated chloride channel activity(GO:1902943)
0.0 0.3 GO:0070365 hepatocyte differentiation(GO:0070365)
0.0 0.2 GO:0031438 negative regulation of mRNA cleavage(GO:0031438) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.0 0.8 GO:0060644 mammary gland epithelial cell differentiation(GO:0060644)
0.0 0.8 GO:0045907 positive regulation of vasoconstriction(GO:0045907)
0.0 1.2 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.1 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387) epithelial to mesenchymal transition involved in cardiac fibroblast development(GO:0060940)
0.0 0.1 GO:2001016 positive regulation of skeletal muscle cell differentiation(GO:2001016)
0.0 0.1 GO:0060332 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.0 0.1 GO:0021530 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.0 0.4 GO:0031268 pseudopodium organization(GO:0031268)
0.0 0.7 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.1 GO:0003419 growth plate cartilage chondrocyte proliferation(GO:0003419)
0.0 0.3 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.0 1.1 GO:0031648 protein destabilization(GO:0031648)
0.0 0.4 GO:0010761 fibroblast migration(GO:0010761)
0.0 0.3 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.0 0.4 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.2 GO:0035904 aorta development(GO:0035904)
0.0 0.4 GO:0006089 lactate metabolic process(GO:0006089)
0.0 0.3 GO:0060856 establishment of blood-brain barrier(GO:0060856)
0.0 0.5 GO:0002052 positive regulation of neuroblast proliferation(GO:0002052)
0.0 0.2 GO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.0 0.1 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.2 GO:0051552 flavone metabolic process(GO:0051552)
0.0 0.4 GO:0007507 heart development(GO:0007507)
0.0 0.3 GO:0019532 oxalate transport(GO:0019532)
0.0 0.1 GO:0003025 regulation of systemic arterial blood pressure by baroreceptor feedback(GO:0003025)
0.0 0.2 GO:0033299 secretion of lysosomal enzymes(GO:0033299)
0.0 0.1 GO:2000825 positive regulation of androgen receptor activity(GO:2000825)
0.0 0.3 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.5 GO:0006825 copper ion transport(GO:0006825)
0.0 0.0 GO:0008628 hormone-mediated apoptotic signaling pathway(GO:0008628)
0.0 0.2 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.0 0.2 GO:0015866 ADP transport(GO:0015866)
0.0 0.2 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.0 0.2 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 0.2 GO:0015871 choline transport(GO:0015871)
0.0 0.2 GO:0033227 dsRNA transport(GO:0033227)
0.0 0.1 GO:0016584 nucleosome positioning(GO:0016584)
0.0 0.3 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.4 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0 0.2 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 0.3 GO:0034587 piRNA metabolic process(GO:0034587)
0.0 0.1 GO:0090238 positive regulation of arachidonic acid secretion(GO:0090238)
0.0 0.1 GO:0000066 mitochondrial ornithine transport(GO:0000066) ornithine transport(GO:0015822)
0.0 0.2 GO:0010867 positive regulation of triglyceride biosynthetic process(GO:0010867)
0.0 0.2 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 0.3 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.9 GO:0032330 regulation of chondrocyte differentiation(GO:0032330)
0.0 0.1 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.0 0.1 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.0 1.2 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0 0.0 GO:0046833 snRNA export from nucleus(GO:0006408) positive regulation of RNA export from nucleus(GO:0046833)
0.0 0.0 GO:0038034 signal transduction in absence of ligand(GO:0038034) extrinsic apoptotic signaling pathway in absence of ligand(GO:0097192)
0.0 0.1 GO:0051665 membrane raft localization(GO:0051665)
0.0 0.1 GO:0051418 interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)
0.0 0.1 GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
0.0 0.4 GO:0050667 homocysteine metabolic process(GO:0050667)
0.0 0.0 GO:0045917 positive regulation of activation of membrane attack complex(GO:0001970) positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259)
0.0 0.7 GO:0050434 positive regulation of viral transcription(GO:0050434)
0.0 0.1 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 1.3 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 0.2 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.1 GO:0090625 mRNA cleavage involved in gene silencing by siRNA(GO:0090625)
0.0 0.1 GO:2000507 positive regulation of energy homeostasis(GO:2000507)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.0 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.2 0.6 GO:0043511 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.2 2.1 GO:0098560 cytoplasmic side of late endosome membrane(GO:0098560)
0.2 0.9 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.2 0.5 GO:0043224 nuclear SCF ubiquitin ligase complex(GO:0043224)
0.2 1.4 GO:0035976 AP1 complex(GO:0035976)
0.1 0.4 GO:0035525 NF-kappaB p50/p65 complex(GO:0035525)
0.1 0.3 GO:0005595 collagen type XII trimer(GO:0005595)
0.1 0.5 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.1 0.3 GO:0033011 perinuclear theca(GO:0033011)
0.1 1.2 GO:0005577 fibrinogen complex(GO:0005577)
0.1 0.3 GO:1990742 microvesicle(GO:1990742)
0.1 1.6 GO:0044754 autolysosome(GO:0044754)
0.1 0.3 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 0.5 GO:0016013 syntrophin complex(GO:0016013)
0.0 0.1 GO:0030689 Noc complex(GO:0030689)
0.0 0.5 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.3 GO:0032021 NELF complex(GO:0032021)
0.0 0.2 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 1.9 GO:0032590 dendrite membrane(GO:0032590)
0.0 0.5 GO:0030673 axolemma(GO:0030673)
0.0 0.2 GO:0044393 microspike(GO:0044393)
0.0 0.2 GO:0002081 outer acrosomal membrane(GO:0002081)
0.0 0.2 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.0 0.3 GO:0060200 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.0 0.8 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.3 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 0.2 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0 0.2 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.0 0.4 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 0.3 GO:0071546 pi-body(GO:0071546)
0.0 0.3 GO:0000125 PCAF complex(GO:0000125)
0.0 0.4 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.4 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.0 0.2 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.0 0.1 GO:0036156 inner dynein arm(GO:0036156)
0.0 0.3 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.5 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.2 GO:0045323 interleukin-1 receptor complex(GO:0045323)
0.0 0.3 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 2.0 GO:0001533 cornified envelope(GO:0001533)
0.0 0.2 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.0 0.4 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.8 GO:0005859 muscle myosin complex(GO:0005859)
0.0 0.3 GO:1990909 Wnt signalosome(GO:1990909)
0.0 0.3 GO:0043219 lateral loop(GO:0043219)
0.0 0.4 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.6 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.7 GO:0031143 pseudopodium(GO:0031143)
0.0 0.4 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.2 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.0 0.7 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.6 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.3 GO:0000813 ESCRT I complex(GO:0000813)
0.0 1.3 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.2 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.1 GO:0008275 gamma-tubulin small complex(GO:0008275)
0.0 0.2 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.1 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.0 1.2 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.8 GO:0005776 autophagosome(GO:0005776)
0.0 0.2 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 0.1 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.0 0.2 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 1.6 GO:0022626 cytosolic ribosome(GO:0022626)
0.0 1.6 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.2 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.4 GO:0002080 acrosomal membrane(GO:0002080)
0.0 1.2 GO:0005811 lipid particle(GO:0005811)
0.0 0.0 GO:0005846 nuclear cap binding complex(GO:0005846)
0.0 1.2 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 0.3 GO:0033270 paranode region of axon(GO:0033270)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0004947 bradykinin receptor activity(GO:0004947)
0.3 1.0 GO:0034353 RNA pyrophosphohydrolase activity(GO:0034353)
0.3 0.9 GO:0004618 phosphoglycerate kinase activity(GO:0004618)
0.3 0.8 GO:0005308 creatine transmembrane transporter activity(GO:0005308)
0.3 0.8 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.3 1.3 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.3 1.3 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.2 0.6 GO:0031177 phosphopantetheine binding(GO:0031177)
0.2 1.1 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.2 1.0 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.2 0.7 GO:0044715 8-oxo-dGDP phosphatase activity(GO:0044715)
0.2 0.5 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427)
0.2 2.5 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 1.1 GO:1990932 5.8S rRNA binding(GO:1990932)
0.1 0.6 GO:0050509 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity(GO:0050509)
0.1 1.2 GO:0003796 lysozyme activity(GO:0003796)
0.1 0.6 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.1 0.6 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 0.5 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.1 2.8 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 0.9 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.1 0.3 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.1 0.3 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142) phosphatidate cytidylyltransferase activity(GO:0004605)
0.1 0.4 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 0.8 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.1 1.5 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 0.9 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 0.6 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 0.4 GO:0004609 phosphatidylserine decarboxylase activity(GO:0004609)
0.1 1.1 GO:0030957 Tat protein binding(GO:0030957)
0.1 0.2 GO:0004040 amidase activity(GO:0004040)
0.1 0.6 GO:0004305 ethanolamine kinase activity(GO:0004305)
0.0 0.5 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.0 1.6 GO:0031489 myosin V binding(GO:0031489)
0.0 0.7 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 0.4 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.3 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.0 0.5 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 1.3 GO:0043495 protein anchor(GO:0043495)
0.0 0.4 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 0.2 GO:0030197 extracellular matrix constituent, lubricant activity(GO:0030197)
0.0 1.2 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.0 0.1 GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483)
0.0 0.4 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.4 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0 0.4 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 0.3 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 0.1 GO:0031716 calcitonin receptor binding(GO:0031716)
0.0 0.2 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0 0.8 GO:0001054 RNA polymerase I activity(GO:0001054)
0.0 0.4 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.2 GO:0051033 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.0 0.4 GO:0071532 ankyrin repeat binding(GO:0071532)
0.0 0.5 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.0 0.6 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.5 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 0.2 GO:0008384 IkappaB kinase activity(GO:0008384)
0.0 0.3 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 0.1 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.0 0.5 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.0 0.4 GO:0019826 oxygen sensor activity(GO:0019826)
0.0 0.3 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.2 GO:0034046 poly(G) binding(GO:0034046)
0.0 1.0 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.1 GO:0050211 procollagen galactosyltransferase activity(GO:0050211)
0.0 0.2 GO:0035473 lipase binding(GO:0035473)
0.0 0.5 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.4 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.0 2.8 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.4 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 0.1 GO:0036080 GDP-fucose transmembrane transporter activity(GO:0005457) purine nucleotide-sugar transmembrane transporter activity(GO:0036080)
0.0 0.2 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.1 GO:0052839 inositol 5-diphosphate pentakisphosphate 5-kinase activity(GO:0052836) inositol diphosphate tetrakisphosphate kinase activity(GO:0052839)
0.0 0.2 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.4 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.0 0.2 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.1 GO:0005260 channel-conductance-controlling ATPase activity(GO:0005260)
0.0 0.6 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.4 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.0 1.4 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.2 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.0 0.6 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.7 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.0 0.1 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.5 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.2 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.2 GO:1903136 cuprous ion binding(GO:1903136)
0.0 0.1 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)
0.0 1.7 GO:0005179 hormone activity(GO:0005179)
0.0 1.2 GO:0016504 peptidase activator activity(GO:0016504)
0.0 0.3 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.2 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.3 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.0 0.2 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 0.2 GO:0038132 neuregulin binding(GO:0038132)
0.0 0.2 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.0 0.4 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.0 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.0 0.4 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.0 0.3 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 0.3 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.2 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.2 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.0 0.1 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.0 0.1 GO:0008481 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.0 0.3 GO:0042923 neuropeptide binding(GO:0042923)
0.0 0.7 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 0.3 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.1 GO:0004660 protein farnesyltransferase activity(GO:0004660)
0.0 1.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.6 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.0 0.1 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.0 0.3 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.1 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.4 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 1.4 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 0.2 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.5 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.6 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.2 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.0 0.3 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.0 0.1 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.0 0.5 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 2.8 GO:0005125 cytokine activity(GO:0005125)
0.0 0.2 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.2 GO:0005522 profilin binding(GO:0005522)
0.0 1.5 GO:0051213 dioxygenase activity(GO:0051213)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 ST STAT3 PATHWAY STAT3 Pathway
0.0 3.2 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 2.2 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.0 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.3 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 0.8 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.2 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 1.1 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 0.9 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 2.0 PID AP1 PATHWAY AP-1 transcription factor network
0.0 0.4 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 1.1 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 0.6 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.6 PID ALK1 PATHWAY ALK1 signaling events
0.0 0.2 PID S1P S1P4 PATHWAY S1P4 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.8 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.1 0.6 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.1 1.3 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 1.4 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0 0.9 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 1.2 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 1.8 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.3 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 1.3 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.8 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.5 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.5 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 2.5 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.4 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.7 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.4 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.4 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.4 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 3.7 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.5 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 2.5 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.7 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 1.0 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.8 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 0.5 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.4 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.3 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 1.3 REACTOME CIRCADIAN CLOCK Genes involved in Circadian Clock
0.0 0.3 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.4 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.3 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.4 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
0.0 0.3 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.2 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.0 0.3 REACTOME ACYL CHAIN REMODELLING OF PE Genes involved in Acyl chain remodelling of PE
0.0 0.8 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis