ISMARA results: KLF12

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for KLF12

Z-value: 1.83

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Transcription factors associated with KLF12

Gene Symbol	Gene ID	Gene Info
KLF12 Ensembl NCBI GeneCards UniProt	ENSG00000118922.12	Kruppel like factor 12

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
KLF12	hg19_v2_chr13_-_74708372_74708409	-0.02	9.2e-01	Click!

Activity profile of KLF12 motif

Sorted Z-values of KLF12 motif

No targets for KLF12

Network of associatons between targets according to the STRING database.

First level regulatory network of KLF12

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	7.2	GO:1902164	mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
2.2	6.7	GO:0050720	regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) interleukin-1 beta biosynthetic process(GO:0050720)
0.2	5.0	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.6	4.5	GO:0071279	cellular response to cobalt ion(GO:0071279)
0.3	4.4	GO:0035826	rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680)
0.0	4.4	GO:0007173	epidermal growth factor receptor signaling pathway(GO:0007173)
0.3	3.8	GO:0002084	protein depalmitoylation(GO:0002084)
0.1	3.3	GO:0071577	zinc II ion transmembrane transport(GO:0071577)
0.1	2.4	GO:0015816	glycine transport(GO:0015816)
0.1	2.4	GO:0045717	negative regulation of fatty acid biosynthetic process(GO:0045717)

Showing 1 to 10 of 169 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	6.1	GO:0000790	nuclear chromatin(GO:0000790)
0.2	4.5	GO:0043203	axon hillock(GO:0043203)
0.3	4.4	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.0	4.2	GO:0072562	blood microparticle(GO:0072562)
0.0	3.0	GO:0016605	PML body(GO:0016605)
0.2	2.3	GO:0005642	annulate lamellae(GO:0005642)
0.1	2.3	GO:0031528	microvillus membrane(GO:0031528)
0.1	1.8	GO:0042788	polysomal ribosome(GO:0042788)
0.0	1.8	GO:0030670	phagocytic vesicle membrane(GO:0030670)
0.0	1.7	GO:0000792	heterochromatin(GO:0000792)

Showing 1 to 10 of 66 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	8.7	GO:0002039	p53 binding(GO:0002039)
0.2	5.9	GO:0001848	complement binding(GO:0001848)
1.0	5.2	GO:0044729	hemi-methylated DNA-binding(GO:0044729)
0.0	5.1	GO:0042826	histone deacetylase binding(GO:0042826)
0.0	4.6	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.3	3.8	GO:0008474	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.2	3.8	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.1	3.3	GO:0005385	zinc ion transmembrane transporter activity(GO:0005385)
0.0	3.1	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.1	2.8	GO:0030506	ankyrin binding(GO:0030506)

Showing 1 to 10 of 117 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	10.5	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.1	6.1	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.1	5.5	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.1	5.0	ST G ALPHA S PATHWAY	G alpha s Pathway
0.0	4.6	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.0	4.0	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	3.0	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.0	2.8	ST INTEGRIN SIGNALING PATHWAY	Integrin Signaling Pathway
0.0	2.3	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.0	1.8	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events

Showing 1 to 10 of 20 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	6.2	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.2	5.0	REACTOME INITIAL TRIGGERING OF COMPLEMENT	Genes involved in Initial triggering of complement
0.0	4.9	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.0	4.0	REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1	3.3	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.0	2.8	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.1	2.6	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport
0.1	2.3	REACTOME AMINE COMPOUND SLC TRANSPORTERS	Genes involved in Amine compound SLC transporters
0.1	2.2	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide
0.1	2.2	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling

Showing 1 to 10 of 35 entries

Results for KLF12

Z-value: 1.83

Motif logo

Transcription factors associated with KLF12

Activity-expression correlation:

Activity profile of KLF12 motif

Sorted Z-values of KLF12 motif

No targets for KLF12

Network of associatons between targets according to the STRING database.

First level regulatory network of KLF12

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: