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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for KLF13

Z-value: 1.41

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Transcription factors associated with KLF13

Gene Symbol Gene ID Gene Info
ENSG00000169926.5 Kruppel like factor 13

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
KLF13hg19_v2_chr15_+_31619013_31619095-0.483.2e-02Click!

Activity profile of KLF13 motif

Sorted Z-values of KLF13 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of KLF13

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.3 GO:1904784 NLRP1 inflammasome complex assembly(GO:1904784)
1.1 3.3 GO:0043449 cellular alkene metabolic process(GO:0043449)
0.8 2.3 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.4 1.5 GO:0006788 heme oxidation(GO:0006788)
0.4 1.4 GO:0006210 pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.3 1.6 GO:0006050 mannosamine metabolic process(GO:0006050) N-acetylmannosamine metabolic process(GO:0006051)
0.3 5.2 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.3 1.5 GO:0042360 vitamin E metabolic process(GO:0042360)
0.3 1.1 GO:1904199 positive regulation of regulation of vascular smooth muscle cell membrane depolarization(GO:1904199) regulation of vascular smooth muscle cell membrane depolarization(GO:1990736)
0.3 1.0 GO:1904978 regulation of endosome organization(GO:1904978)
0.2 0.7 GO:0043105 regulation of GTP cyclohydrolase I activity(GO:0043095) negative regulation of GTP cyclohydrolase I activity(GO:0043105)
0.2 1.1 GO:0030807 positive regulation of cyclic nucleotide catabolic process(GO:0030807) positive regulation of cAMP catabolic process(GO:0030822) positive regulation of purine nucleotide catabolic process(GO:0033123)
0.2 0.6 GO:0048003 synaptic vesicle recycling via endosome(GO:0036466) antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.2 1.3 GO:0033490 cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490)
0.2 1.6 GO:0090166 Golgi disassembly(GO:0090166)
0.2 0.8 GO:0001835 blastocyst hatching(GO:0001835) hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
0.2 2.7 GO:0010968 regulation of microtubule nucleation(GO:0010968)
0.2 2.7 GO:0015074 DNA integration(GO:0015074)
0.2 0.2 GO:0035494 SNARE complex disassembly(GO:0035494)
0.2 0.8 GO:0090285 negative regulation of protein glycosylation in Golgi(GO:0090285)
0.1 0.6 GO:0016333 morphogenesis of follicular epithelium(GO:0016333) establishment or maintenance of polarity of follicular epithelium(GO:0016334) establishment of planar polarity of follicular epithelium(GO:0042247)
0.1 1.1 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
0.1 0.4 GO:0070376 regulation of ERK5 cascade(GO:0070376) negative regulation of ERK5 cascade(GO:0070377)
0.1 4.4 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.1 0.7 GO:0034146 toll-like receptor 5 signaling pathway(GO:0034146)
0.1 0.8 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
0.1 0.3 GO:2000705 dense core granule biogenesis(GO:0061110) regulation of dense core granule biogenesis(GO:2000705)
0.1 0.3 GO:1990654 sebum secreting cell proliferation(GO:1990654)
0.1 1.2 GO:0006228 UTP biosynthetic process(GO:0006228)
0.1 0.5 GO:0019060 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.1 0.9 GO:0010820 positive regulation of T cell chemotaxis(GO:0010820)
0.1 2.3 GO:0035988 chondrocyte proliferation(GO:0035988)
0.1 1.0 GO:0010815 bradykinin catabolic process(GO:0010815)
0.1 0.3 GO:1902954 regulation of early endosome to recycling endosome transport(GO:1902954)
0.1 0.8 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.1 0.4 GO:0051697 protein delipidation(GO:0051697)
0.1 1.8 GO:0031643 positive regulation of myelination(GO:0031643)
0.1 0.9 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 1.2 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.5 GO:0097167 circadian regulation of translation(GO:0097167)
0.0 0.6 GO:0044126 regulation of growth of symbiont in host(GO:0044126)
0.0 1.1 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.0 0.6 GO:1900227 positive regulation of NLRP3 inflammasome complex assembly(GO:1900227)
0.0 0.6 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.0 1.2 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.0 0.0 GO:1904251 regulation of bile acid metabolic process(GO:1904251)
0.0 0.6 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.0 0.2 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.0 0.1 GO:0060406 positive regulation of penile erection(GO:0060406)
0.0 1.5 GO:0009303 rRNA transcription(GO:0009303)
0.0 0.4 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.0 0.3 GO:0043696 dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697)
0.0 2.4 GO:0008088 axo-dendritic transport(GO:0008088)
0.0 2.0 GO:0045824 negative regulation of innate immune response(GO:0045824)
0.0 0.4 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.0 2.8 GO:0006306 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.0 0.3 GO:0015860 purine nucleoside transmembrane transport(GO:0015860)
0.0 0.8 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0 0.1 GO:0098502 DNA dephosphorylation(GO:0098502)
0.0 1.4 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.4 GO:0051601 exocyst localization(GO:0051601)
0.0 0.9 GO:0045022 early endosome to late endosome transport(GO:0045022)
0.0 0.4 GO:0038180 nerve growth factor signaling pathway(GO:0038180)
0.0 0.4 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.1 GO:0046203 spermidine catabolic process(GO:0046203)
0.0 0.2 GO:0080182 histone H3-K4 trimethylation(GO:0080182)
0.0 0.3 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.0 0.4 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.8 GO:0034724 DNA replication-independent nucleosome assembly(GO:0006336) DNA replication-independent nucleosome organization(GO:0034724)
0.0 0.6 GO:0035428 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.0 0.1 GO:0002317 plasma cell differentiation(GO:0002317)
0.0 0.2 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 0.5 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 2.0 GO:0098869 cellular oxidant detoxification(GO:0098869)
0.0 0.4 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.0 0.8 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.0 0.3 GO:0070914 UV-damage excision repair(GO:0070914)
0.0 1.0 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 0.2 GO:0034599 cellular response to oxidative stress(GO:0034599)
0.0 0.2 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.0 0.1 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 6.3 GO:0072558 NLRP1 inflammasome complex(GO:0072558)
0.3 5.2 GO:0061700 GATOR2 complex(GO:0061700)
0.2 0.6 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.1 2.4 GO:0035253 ciliary rootlet(GO:0035253)
0.1 0.4 GO:0035189 Rb-E2F complex(GO:0035189)
0.1 1.2 GO:0030893 meiotic cohesin complex(GO:0030893)
0.1 0.6 GO:0042643 actomyosin, actin portion(GO:0042643)
0.1 0.9 GO:0070695 FHF complex(GO:0070695)
0.1 4.4 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 1.2 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.1 0.3 GO:0071203 WASH complex(GO:0071203)
0.1 0.4 GO:0098592 cytoplasmic side of apical plasma membrane(GO:0098592)
0.1 1.2 GO:0000137 Golgi cis cisterna(GO:0000137)
0.1 0.6 GO:0044194 cytolytic granule(GO:0044194)
0.1 2.6 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 0.6 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 1.0 GO:0008290 F-actin capping protein complex(GO:0008290)
0.1 0.8 GO:0030061 mitochondrial crista(GO:0030061)
0.1 0.6 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.1 0.3 GO:0071942 XPC complex(GO:0071942)
0.0 0.4 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 1.3 GO:0044232 organelle membrane contact site(GO:0044232)
0.0 0.4 GO:0033263 CORVET complex(GO:0033263)
0.0 0.6 GO:0097427 microtubule bundle(GO:0097427)
0.0 1.1 GO:0034706 sodium channel complex(GO:0034706)
0.0 1.0 GO:0030132 clathrin coat of coated pit(GO:0030132)
0.0 1.0 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.8 GO:0000145 exocyst(GO:0000145)
0.0 3.0 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.0 2.7 GO:0072686 mitotic spindle(GO:0072686)
0.0 0.6 GO:0005685 U1 snRNP(GO:0005685)
0.0 0.5 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 2.5 GO:0035579 specific granule membrane(GO:0035579)
0.0 0.7 GO:0031519 PcG protein complex(GO:0031519)
0.0 0.4 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.3 GO:0036038 MKS complex(GO:0036038)
0.0 1.1 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 0.8 GO:0005801 cis-Golgi network(GO:0005801)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.3 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
0.7 3.3 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)
0.4 1.6 GO:0045127 N-acetylglucosamine kinase activity(GO:0045127)
0.4 1.5 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.3 1.3 GO:0000248 C-5 sterol desaturase activity(GO:0000248) sterol desaturase activity(GO:0070704)
0.3 0.8 GO:0071633 dihydroceramidase activity(GO:0071633)
0.2 1.2 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.2 6.3 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.2 0.7 GO:0044549 GTP cyclohydrolase binding(GO:0044549)
0.2 2.3 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.2 0.5 GO:0097158 pre-mRNA intronic pyrimidine-rich binding(GO:0097158)
0.2 1.0 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.1 2.0 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.1 0.3 GO:0098770 FBXO family protein binding(GO:0098770)
0.1 0.6 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 0.6 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.1 1.2 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 0.3 GO:0000404 heteroduplex DNA loop binding(GO:0000404)
0.1 1.1 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1 0.6 GO:0008142 oxysterol binding(GO:0008142)
0.1 0.6 GO:0030348 syntaxin-3 binding(GO:0030348)
0.0 0.6 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.0 1.4 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.3 GO:0051185 coenzyme transporter activity(GO:0051185)
0.0 0.8 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.8 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 0.4 GO:0003696 satellite DNA binding(GO:0003696)
0.0 1.2 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 1.0 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.7 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.4 GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.0 2.4 GO:0019894 kinesin binding(GO:0019894)
0.0 0.3 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.1 GO:0034038 deoxyhypusine synthase activity(GO:0034038)
0.0 0.6 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.0 0.3 GO:0008158 hedgehog receptor activity(GO:0008158)
0.0 0.2 GO:0003945 N-acetyllactosamine synthase activity(GO:0003945)
0.0 0.1 GO:0051734 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0 0.1 GO:0031685 adenosine receptor binding(GO:0031685)
0.0 3.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.4 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.9 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.0 0.2 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.9 GO:0001671 ATPase activator activity(GO:0001671)
0.0 1.1 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.0 2.3 GO:0008276 protein methyltransferase activity(GO:0008276)
0.0 0.3 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.1 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
0.0 0.6 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.8 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.4 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.2 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.4 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.4 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.4 GO:0016881 acid-amino acid ligase activity(GO:0016881)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 6.3 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 4.0 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.0 5.0 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.1 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 1.0 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 1.0 PID NECTIN PATHWAY Nectin adhesion pathway
0.0 1.4 PID FGF PATHWAY FGF signaling pathway
0.0 0.4 ST GA12 PATHWAY G alpha 12 Pathway
0.0 0.4 PID ARF 3PATHWAY Arf1 pathway
0.0 0.8 PID HES HEY PATHWAY Notch-mediated HES/HEY network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.3 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.2 6.3 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.1 2.3 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.1 4.4 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 1.2 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 2.0 REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.1 2.3 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 1.5 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 0.4 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 2.4 REACTOME KINESINS Genes involved in Kinesins
0.0 0.6 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 1.4 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 1.4 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.4 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.7 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.4 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 1.4 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.8 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.6 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.4 REACTOME ARMS MEDIATED ACTIVATION Genes involved in ARMS-mediated activation
0.0 1.0 REACTOME CELL CELL JUNCTION ORGANIZATION Genes involved in Cell-cell junction organization
0.0 0.4 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 1.1 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.4 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 1.9 REACTOME MEIOSIS Genes involved in Meiosis