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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for KLF15

Z-value: 1.11

Motif logo

Transcription factors associated with KLF15

Gene Symbol Gene ID Gene Info
ENSG00000163884.3 Kruppel like factor 15

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
KLF15hg19_v2_chr3_-_126076264_126076305-0.751.4e-04Click!

Activity profile of KLF15 motif

Sorted Z-values of KLF15 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of KLF15

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 5.9 GO:1904761 negative regulation of myofibroblast differentiation(GO:1904761)
0.8 4.5 GO:0002803 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
0.6 1.8 GO:2000297 negative regulation of synapse maturation(GO:2000297)
0.5 1.8 GO:0071894 histone H2B conserved C-terminal lysine ubiquitination(GO:0071894)
0.4 1.9 GO:0071477 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.4 1.1 GO:0051780 mevalonate transport(GO:0015728) behavioral response to nutrient(GO:0051780)
0.3 1.6 GO:1905071 occluding junction disassembly(GO:1905071) regulation of occluding junction disassembly(GO:1905073) positive regulation of occluding junction disassembly(GO:1905075)
0.3 0.9 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.3 1.5 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
0.3 2.3 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.3 0.9 GO:0048627 myoblast development(GO:0048627)
0.3 2.0 GO:0051684 maintenance of Golgi location(GO:0051684)
0.3 0.8 GO:0051102 DNA ligation involved in DNA recombination(GO:0051102)
0.3 2.3 GO:0071494 cellular response to UV-C(GO:0071494)
0.2 1.0 GO:0006597 spermine biosynthetic process(GO:0006597)
0.2 1.4 GO:0071422 tricarboxylic acid transport(GO:0006842) succinate transport(GO:0015744) citrate transport(GO:0015746) succinate transmembrane transport(GO:0071422)
0.2 0.9 GO:0007403 glial cell fate determination(GO:0007403) canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation(GO:0061324) regulation of chromatin-mediated maintenance of transcription(GO:1904499) positive regulation of chromatin-mediated maintenance of transcription(GO:1904501) regulation of euchromatin binding(GO:1904793)
0.2 2.3 GO:1901314 negative regulation of histone ubiquitination(GO:0033183) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315)
0.2 1.1 GO:0015688 iron chelate transport(GO:0015688) siderophore transport(GO:0015891)
0.2 0.6 GO:0061193 sensory organ boundary specification(GO:0008052) formation of organ boundary(GO:0010160) taste bud development(GO:0061193)
0.2 1.5 GO:0075509 receptor-mediated endocytosis of virus by host cell(GO:0019065) modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791) positive regulation of dopamine receptor signaling pathway(GO:0060161) endocytosis involved in viral entry into host cell(GO:0075509)
0.2 0.7 GO:0072086 specification of loop of Henle identity(GO:0072086) pattern specification involved in metanephros development(GO:0072268)
0.2 0.5 GO:0090222 centrosome-templated microtubule nucleation(GO:0090222)
0.2 0.7 GO:0035408 histone H3-T6 phosphorylation(GO:0035408)
0.2 0.7 GO:1903542 negative regulation of exosomal secretion(GO:1903542)
0.2 1.0 GO:1901490 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748) regulation of lymphangiogenesis(GO:1901490)
0.2 1.2 GO:1904381 Golgi apparatus mannose trimming(GO:1904381)
0.2 0.7 GO:0060151 peroxisome localization(GO:0060151) microtubule-based peroxisome localization(GO:0060152)
0.2 0.6 GO:0060448 dichotomous subdivision of terminal units involved in lung branching(GO:0060448)
0.2 1.6 GO:0016584 nucleosome positioning(GO:0016584)
0.2 1.1 GO:0072674 multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
0.1 0.4 GO:0035281 pre-miRNA export from nucleus(GO:0035281)
0.1 2.4 GO:0090361 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.1 1.3 GO:1902966 regulation of protein localization to early endosome(GO:1902965) positive regulation of protein localization to early endosome(GO:1902966)
0.1 0.8 GO:0035063 nuclear speck organization(GO:0035063)
0.1 1.1 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.1 0.3 GO:2001038 regulation of cellular response to drug(GO:2001038)
0.1 0.7 GO:2000973 regulation of pro-B cell differentiation(GO:2000973)
0.1 1.6 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.1 0.5 GO:0061582 intestinal epithelial cell migration(GO:0061582)
0.1 1.5 GO:0021759 globus pallidus development(GO:0021759)
0.1 0.6 GO:0021773 striatal medium spiny neuron differentiation(GO:0021773) NMDA glutamate receptor clustering(GO:0097114) positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000969)
0.1 0.3 GO:0060697 positive regulation of phospholipid catabolic process(GO:0060697)
0.1 0.3 GO:0018008 N-terminal peptidyl-glycine N-myristoylation(GO:0018008)
0.1 2.0 GO:0015816 glycine transport(GO:0015816)
0.1 0.6 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.1 0.7 GO:0045631 regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.1 0.7 GO:1902031 regulation of NADP metabolic process(GO:1902031)
0.1 1.3 GO:0043696 dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697)
0.1 0.3 GO:0032289 central nervous system myelin formation(GO:0032289)
0.1 0.2 GO:2000683 regulation of cellular response to X-ray(GO:2000683)
0.1 1.5 GO:0015074 DNA integration(GO:0015074)
0.1 0.3 GO:0061300 cerebellum vasculature development(GO:0061300)
0.1 2.1 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.1 0.5 GO:0097210 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.1 1.4 GO:2001032 regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.1 0.9 GO:1903715 regulation of aerobic respiration(GO:1903715)
0.1 1.7 GO:0034384 high-density lipoprotein particle clearance(GO:0034384)
0.1 0.5 GO:0021691 cerebellar Purkinje cell layer maturation(GO:0021691)
0.1 0.3 GO:2001302 response to interleukin-13(GO:0035962) cellular response to interleukin-13(GO:0035963) lipoxin biosynthetic process(GO:2001301) lipoxin A4 metabolic process(GO:2001302) lipoxin A4 biosynthetic process(GO:2001303)
0.1 0.3 GO:0036166 phenotypic switching(GO:0036166) regulation of phenotypic switching(GO:1900239)
0.1 0.2 GO:0006478 peptidyl-tyrosine sulfation(GO:0006478)
0.1 1.3 GO:1901748 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.1 0.4 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.1 1.4 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.1 1.0 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.1 1.2 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.1 0.2 GO:1903515 calcium ion transport from cytosol to endoplasmic reticulum(GO:1903515)
0.1 0.4 GO:0061084 regulation of protein refolding(GO:0061083) negative regulation of protein refolding(GO:0061084)
0.1 0.2 GO:1905053 regulation of base-excision repair(GO:1905051) positive regulation of base-excision repair(GO:1905053)
0.1 1.0 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.1 0.3 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.1 0.5 GO:0090649 response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650)
0.1 0.7 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.1 0.4 GO:0090283 regulation of protein glycosylation in Golgi(GO:0090283)
0.1 0.2 GO:0043634 polyadenylation-dependent ncRNA catabolic process(GO:0043634)
0.1 0.8 GO:0022417 protein maturation by protein folding(GO:0022417)
0.1 2.2 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.1 0.9 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966) negative regulation of dendritic spine maintenance(GO:1902951)
0.1 0.2 GO:0019085 early viral transcription(GO:0019085)
0.1 1.5 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
0.1 0.9 GO:0033227 dsRNA transport(GO:0033227)
0.1 0.2 GO:1904435 positive regulation of iron ion transport(GO:0034758) positive regulation of iron ion transmembrane transport(GO:0034761) regulation of iron ion import(GO:1900390) regulation of ferrous iron import into cell(GO:1903989) positive regulation of ferrous iron import into cell(GO:1903991) regulation of ferrous iron binding(GO:1904432) positive regulation of ferrous iron binding(GO:1904434) regulation of transferrin receptor binding(GO:1904435) positive regulation of transferrin receptor binding(GO:1904437) regulation of ferrous iron import across plasma membrane(GO:1904438) positive regulation of ferrous iron import across plasma membrane(GO:1904440)
0.1 0.7 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.1 1.3 GO:0051639 actin filament network formation(GO:0051639)
0.1 0.3 GO:0072619 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.1 0.3 GO:0019470 4-hydroxyproline catabolic process(GO:0019470)
0.0 2.3 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.6 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.0 0.5 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.0 1.0 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.0 0.7 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.0 0.2 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
0.0 0.3 GO:0072156 distal tubule morphogenesis(GO:0072156)
0.0 0.3 GO:0090625 mRNA cleavage involved in gene silencing by siRNA(GO:0090625)
0.0 0.2 GO:0044334 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.0 0.4 GO:0003415 chondrocyte hypertrophy(GO:0003415)
0.0 0.2 GO:0044210 'de novo' CTP biosynthetic process(GO:0044210)
0.0 0.3 GO:0098728 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.0 1.3 GO:0016180 snRNA processing(GO:0016180)
0.0 0.4 GO:0036089 cleavage furrow formation(GO:0036089)
0.0 0.3 GO:0046952 ketone body catabolic process(GO:0046952)
0.0 0.6 GO:2000291 regulation of myoblast proliferation(GO:2000291)
0.0 0.1 GO:0048250 mitochondrial iron ion transport(GO:0048250)
0.0 0.4 GO:0032776 DNA methylation on cytosine(GO:0032776)
0.0 0.7 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.0 0.2 GO:0033159 negative regulation of protein import into nucleus, translocation(GO:0033159)
0.0 0.6 GO:0033623 regulation of integrin activation(GO:0033623)
0.0 0.2 GO:0003095 pressure natriuresis(GO:0003095)
0.0 1.3 GO:0042921 glucocorticoid receptor signaling pathway(GO:0042921)
0.0 1.3 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.0 1.3 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.0 1.2 GO:0060074 synapse maturation(GO:0060074)
0.0 0.4 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.0 0.1 GO:0050976 detection of mechanical stimulus involved in sensory perception of touch(GO:0050976)
0.0 0.2 GO:0000255 allantoin metabolic process(GO:0000255)
0.0 0.6 GO:0051601 exocyst localization(GO:0051601)
0.0 1.1 GO:0036152 phosphatidylethanolamine acyl-chain remodeling(GO:0036152)
0.0 2.9 GO:0090307 mitotic spindle assembly(GO:0090307)
0.0 1.9 GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway(GO:0070423)
0.0 0.1 GO:0002372 myeloid dendritic cell cytokine production(GO:0002372)
0.0 0.1 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.0 0.3 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.0 0.6 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.0 0.6 GO:0002052 positive regulation of neuroblast proliferation(GO:0002052)
0.0 0.2 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.0 0.9 GO:0032786 positive regulation of DNA-templated transcription, elongation(GO:0032786)
0.0 0.3 GO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587)
0.0 0.8 GO:0002335 mature B cell differentiation(GO:0002335)
0.0 0.3 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383)
0.0 0.3 GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.0 0.6 GO:0098779 mitophagy in response to mitochondrial depolarization(GO:0098779)
0.0 0.1 GO:0090309 positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.0 0.5 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0 0.4 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 0.4 GO:0035372 protein localization to kinetochore(GO:0034501) protein localization to microtubule(GO:0035372)
0.0 0.3 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.0 0.1 GO:0045212 negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212)
0.0 2.8 GO:0042035 regulation of cytokine biosynthetic process(GO:0042035)
0.0 0.2 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.0 0.1 GO:0021553 olfactory nerve development(GO:0021553)
0.0 0.5 GO:0001502 cartilage condensation(GO:0001502)
0.0 0.3 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.0 0.8 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 0.3 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.0 0.5 GO:0031498 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498)
0.0 0.3 GO:2000507 positive regulation of energy homeostasis(GO:2000507)
0.0 0.2 GO:0006477 protein sulfation(GO:0006477)
0.0 0.0 GO:0038162 erythropoietin-mediated signaling pathway(GO:0038162)
0.0 0.7 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.8 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.0 0.0 GO:0003192 mitral valve formation(GO:0003192)
0.0 0.2 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.0 0.1 GO:0070213 protein auto-ADP-ribosylation(GO:0070213)
0.0 1.4 GO:0006378 mRNA polyadenylation(GO:0006378)
0.0 0.3 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.0 0.3 GO:0000733 DNA strand renaturation(GO:0000733)
0.0 0.2 GO:0034625 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.4 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 0.7 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 0.5 GO:0016578 histone deubiquitination(GO:0016578)
0.0 0.1 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.0 0.0 GO:0044727 DNA demethylation of male pronucleus(GO:0044727)
0.0 0.2 GO:0034243 regulation of transcription elongation from RNA polymerase II promoter(GO:0034243)
0.0 0.6 GO:0050873 brown fat cell differentiation(GO:0050873)
0.0 0.1 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.0 0.2 GO:0002440 production of molecular mediator of immune response(GO:0002440)
0.0 0.2 GO:1904714 regulation of chaperone-mediated autophagy(GO:1904714)
0.0 0.0 GO:0032228 regulation of synaptic transmission, GABAergic(GO:0032228)
0.0 0.5 GO:0031952 regulation of protein autophosphorylation(GO:0031952)
0.0 0.6 GO:1900739 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.0 0.2 GO:0098902 regulation of membrane depolarization during action potential(GO:0098902)
0.0 0.2 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.0 0.2 GO:0021511 spinal cord patterning(GO:0021511)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 4.5 GO:0097209 epidermal lamellar body(GO:0097209)
0.4 1.6 GO:0031213 RSF complex(GO:0031213)
0.2 3.4 GO:0097227 sperm annulus(GO:0097227)
0.1 1.9 GO:0001940 male pronucleus(GO:0001940)
0.1 0.6 GO:0098592 cytoplasmic side of apical plasma membrane(GO:0098592)
0.1 0.4 GO:0042565 RNA nuclear export complex(GO:0042565)
0.1 1.6 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1 1.3 GO:0051286 cell tip(GO:0051286)
0.1 1.1 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 0.8 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.1 1.4 GO:0042382 paraspeckles(GO:0042382)
0.1 1.4 GO:0097208 alveolar lamellar body(GO:0097208)
0.1 2.2 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 1.4 GO:0042587 glycogen granule(GO:0042587)
0.1 0.6 GO:0000799 nuclear condensin complex(GO:0000799)
0.1 1.5 GO:0032039 integrator complex(GO:0032039)
0.1 0.3 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.1 0.4 GO:0017102 methionyl glutamyl tRNA synthetase complex(GO:0017102)
0.1 0.7 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.1 2.9 GO:0097228 sperm principal piece(GO:0097228)
0.1 0.2 GO:0070195 growth hormone receptor complex(GO:0070195)
0.1 0.2 GO:0097629 extrinsic component of omegasome membrane(GO:0097629)
0.1 0.2 GO:0002945 cyclin K-CDK13 complex(GO:0002945)
0.0 0.3 GO:0071817 MMXD complex(GO:0071817)
0.0 0.5 GO:0042599 lamellar body(GO:0042599)
0.0 0.7 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.8 GO:0005916 fascia adherens(GO:0005916)
0.0 0.2 GO:0070931 Golgi-associated vesicle lumen(GO:0070931)
0.0 1.5 GO:0002080 acrosomal membrane(GO:0002080)
0.0 0.5 GO:0016600 flotillin complex(GO:0016600)
0.0 0.5 GO:0036449 microtubule minus-end(GO:0036449)
0.0 3.2 GO:0002102 podosome(GO:0002102)
0.0 0.4 GO:0016589 NURF complex(GO:0016589)
0.0 0.2 GO:0031905 early endosome lumen(GO:0031905)
0.0 0.5 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 1.7 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.9 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.2 GO:0097513 myosin II filament(GO:0097513)
0.0 0.7 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.3 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.3 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.1 GO:0030289 protein phosphatase 4 complex(GO:0030289)
0.0 0.4 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.3 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 0.3 GO:0060091 kinocilium(GO:0060091)
0.0 0.3 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.5 GO:0000124 SAGA complex(GO:0000124)
0.0 0.1 GO:0031417 NatC complex(GO:0031417)
0.0 0.2 GO:0072487 MSL complex(GO:0072487)
0.0 1.5 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.8 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.7 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.7 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 2.4 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.4 GO:0000346 transcription export complex(GO:0000346)
0.0 0.1 GO:1990246 uniplex complex(GO:1990246)
0.0 0.3 GO:0001741 XY body(GO:0001741)
0.0 1.9 GO:0035097 histone methyltransferase complex(GO:0035097)
0.0 0.1 GO:0098839 postsynaptic density membrane(GO:0098839)
0.0 0.3 GO:0033270 paranode region of axon(GO:0033270)
0.0 1.2 GO:0015030 Cajal body(GO:0015030)
0.0 0.2 GO:0097470 ribbon synapse(GO:0097470)
0.0 0.4 GO:0097440 apical dendrite(GO:0097440)
0.0 0.5 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.3 GO:0042641 actomyosin(GO:0042641)
0.0 1.5 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.8 GO:1990391 DNA repair complex(GO:1990391)
0.0 0.3 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.2 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 0.2 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 6.7 GO:0016607 nuclear speck(GO:0016607)
0.0 0.3 GO:0098576 lumenal side of membrane(GO:0098576)
0.0 0.0 GO:0048179 activin receptor complex(GO:0048179)
0.0 0.3 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 1.0 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.4 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.2 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 0.6 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0016964 alpha-2 macroglobulin receptor activity(GO:0016964)
0.4 1.3 GO:0098770 FBXO family protein binding(GO:0098770)
0.4 1.1 GO:0015130 mevalonate transmembrane transporter activity(GO:0015130)
0.3 1.0 GO:0016768 spermine synthase activity(GO:0016768)
0.3 1.4 GO:0050115 myosin-light-chain-phosphatase activity(GO:0050115)
0.2 1.4 GO:0017153 citrate transmembrane transporter activity(GO:0015137) succinate transmembrane transporter activity(GO:0015141) tricarboxylic acid transmembrane transporter activity(GO:0015142) sodium:dicarboxylate symporter activity(GO:0017153)
0.2 1.6 GO:0047493 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.2 0.7 GO:0035403 histone kinase activity (H3-T6 specific)(GO:0035403)
0.2 0.5 GO:0004968 gonadotropin-releasing hormone receptor activity(GO:0004968)
0.2 0.8 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.2 1.9 GO:1990226 histone methyltransferase binding(GO:1990226)
0.2 0.9 GO:0051033 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.1 0.4 GO:0090631 pre-miRNA transporter activity(GO:0090631)
0.1 2.0 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.1 1.7 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.1 1.6 GO:0005114 transforming growth factor beta receptor activity, type I(GO:0005025) type II transforming growth factor beta receptor binding(GO:0005114)
0.1 2.3 GO:0008199 ferric iron binding(GO:0008199)
0.1 0.3 GO:0019107 glycylpeptide N-tetradecanoyltransferase activity(GO:0004379) myristoyltransferase activity(GO:0019107)
0.1 0.3 GO:0003842 1-pyrroline-5-carboxylate dehydrogenase activity(GO:0003842)
0.1 1.0 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.1 0.7 GO:0004473 malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.1 1.8 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.1 0.6 GO:0047179 platelet-activating factor acetyltransferase activity(GO:0047179)
0.1 1.3 GO:0003996 acyl-CoA ligase activity(GO:0003996)
0.1 0.9 GO:0042610 CD8 receptor binding(GO:0042610)
0.1 0.6 GO:0032393 MHC class I receptor activity(GO:0032393)
0.1 0.5 GO:0008267 poly-glutamine tract binding(GO:0008267)
0.1 0.3 GO:0003858 3-hydroxybutyrate dehydrogenase activity(GO:0003858)
0.1 0.6 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.1 1.2 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.1 0.3 GO:0047977 hepoxilin-epoxide hydrolase activity(GO:0047977)
0.1 0.2 GO:0008476 protein-tyrosine sulfotransferase activity(GO:0008476)
0.1 1.1 GO:0047144 2-acylglycerol-3-phosphate O-acyltransferase activity(GO:0047144)
0.1 1.3 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.1 0.6 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.1 0.2 GO:0031775 lutropin-choriogonadotropic hormone receptor binding(GO:0031775) calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential(GO:0086039)
0.1 3.6 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.1 0.3 GO:0045322 unmethylated CpG binding(GO:0045322)
0.1 2.5 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 3.0 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.1 0.8 GO:0003910 DNA ligase (ATP) activity(GO:0003910)
0.1 1.1 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.1 0.8 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.1 2.1 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.1 1.9 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.1 0.8 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.1 0.3 GO:0050436 microfibril binding(GO:0050436)
0.0 0.3 GO:0039552 RIG-I binding(GO:0039552)
0.0 0.7 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.3 GO:0051021 GDP-dissociation inhibitor binding(GO:0051021) Rho GDP-dissociation inhibitor binding(GO:0051022)
0.0 0.2 GO:0003883 CTP synthase activity(GO:0003883)
0.0 1.4 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 0.3 GO:0035198 miRNA binding(GO:0035198)
0.0 0.6 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.4 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.0 GO:0005128 erythropoietin receptor binding(GO:0005128)
0.0 0.1 GO:0070984 SET domain binding(GO:0070984)
0.0 0.9 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.2 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.0 0.2 GO:0018685 alkane 1-monooxygenase activity(GO:0018685)
0.0 0.7 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.1 GO:0098782 mechanically-gated potassium channel activity(GO:0098782)
0.0 0.4 GO:0031386 protein tag(GO:0031386)
0.0 0.2 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 0.5 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.3 GO:0043139 5'-3' DNA helicase activity(GO:0043139)
0.0 0.4 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.2 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 0.4 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.0 2.3 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 1.1 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.6 GO:0000339 RNA cap binding(GO:0000339)
0.0 0.6 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 1.5 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 0.2 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.0 0.5 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.0 0.3 GO:0036310 annealing helicase activity(GO:0036310)
0.0 0.7 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.0 1.0 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.3 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 1.2 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.3 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.3 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.0 0.2 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.6 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.4 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.9 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 1.3 GO:0051018 protein kinase A binding(GO:0051018)
0.0 0.9 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.2 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 3.7 GO:0042393 histone binding(GO:0042393)
0.0 0.5 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.3 GO:0043560 insulin receptor substrate binding(GO:0043560)
0.0 0.0 GO:0016361 activin receptor activity, type I(GO:0016361)
0.0 0.4 GO:0031005 filamin binding(GO:0031005)
0.0 2.2 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 0.7 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 1.9 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 1.2 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 1.1 GO:0019003 GDP binding(GO:0019003)
0.0 0.2 GO:0044213 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.0 0.5 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.2 GO:0045295 gamma-catenin binding(GO:0045295)
0.0 0.0 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.0 0.1 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.1 GO:0097322 7SK snRNA binding(GO:0097322)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.4 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 4.6 PID PLK1 PATHWAY PLK1 signaling events
0.0 6.0 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 1.0 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.7 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 1.4 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 1.8 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 1.3 PID ERBB4 PATHWAY ErbB4 signaling events
0.0 2.5 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 1.8 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.0 1.8 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 0.8 PID CD40 PATHWAY CD40/CD40L signaling
0.0 2.5 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 0.2 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 2.5 PID CDC42 PATHWAY CDC42 signaling events
0.0 0.8 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 1.2 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.0 0.3 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 0.5 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.8 PID BCR 5PATHWAY BCR signaling pathway
0.0 1.0 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 0.9 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 1.5 PID P53 REGULATION PATHWAY p53 pathway
0.0 0.7 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.0 0.6 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 2.3 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.2 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 0.7 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.0 0.3 ST GA12 PATHWAY G alpha 12 Pathway
0.0 0.3 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 1.0 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 0.2 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.3 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.5 PID EPHB FWD PATHWAY EPHB forward signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.1 2.5 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 2.2 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 1.9 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 2.9 REACTOME KINESINS Genes involved in Kinesins
0.0 1.8 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.8 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.0 0.9 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 1.4 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 1.1 REACTOME ACYL CHAIN REMODELLING OF PE Genes involved in Acyl chain remodelling of PE
0.0 0.3 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 1.4 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 1.0 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 1.3 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.9 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 2.0 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.2 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.6 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.7 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 0.2 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.5 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 1.1 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 2.3 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 1.6 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 1.3 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.0 2.3 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 1.2 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 1.3 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.6 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.2 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.0 0.6 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.7 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.4 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 1.8 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.3 REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex
0.0 0.3 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 1.7 REACTOME DNA REPAIR Genes involved in DNA Repair
0.0 2.6 REACTOME DIABETES PATHWAYS Genes involved in Diabetes pathways
0.0 0.4 REACTOME MICRORNA MIRNA BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.0 0.2 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.2 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling