ISMARA results: KLF3

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for KLF3

Z-value: 1.04

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Transcription factors associated with KLF3

Gene Symbol	Gene ID	Gene Info
KLF3 Ensembl NCBI GeneCards UniProt	ENSG00000109787.8	Kruppel like factor 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
KLF3	hg19_v2_chr4_+_38665810_38665827	-0.33	1.5e-01	Click!

Activity profile of KLF3 motif

Sorted Z-values of KLF3 motif

No targets for KLF3

Network of associatons between targets according to the STRING database.

First level regulatory network of KLF3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.8	GO:0030223	neutrophil differentiation(GO:0030223)
0.3	1.4	GO:1904245	regulation of polynucleotide adenylyltransferase activity(GO:1904245)
0.2	1.1	GO:0006051	mannosamine metabolic process(GO:0006050) N-acetylmannosamine metabolic process(GO:0006051)
0.0	1.1	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	1.0	GO:0006853	carnitine shuttle(GO:0006853)
0.0	1.0	GO:0060338	regulation of type I interferon-mediated signaling pathway(GO:0060338)
0.0	1.0	GO:0006953	acute-phase response(GO:0006953)
0.1	0.9	GO:0043152	induction of bacterial agglutination(GO:0043152)
0.1	0.9	GO:0030388	fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0	0.9	GO:0006636	unsaturated fatty acid biosynthetic process(GO:0006636)

Showing 1 to 10 of 150 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.6	GO:0030173	integral component of Golgi membrane(GO:0030173)
0.1	1.2	GO:0070578	RISC-loading complex(GO:0070578)
0.0	1.1	GO:0031430	M band(GO:0031430)
0.1	0.8	GO:0034750	Scrib-APC-beta-catenin complex(GO:0034750)
0.1	0.8	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.8	GO:0071438	invadopodium membrane(GO:0071438)
0.0	0.8	GO:0000307	cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0	0.7	GO:0035748	myelin sheath abaxonal region(GO:0035748)
0.0	0.7	GO:0005852	eukaryotic translation initiation factor 3 complex(GO:0005852)
0.1	0.5	GO:0033185	dolichol-phosphate-mannose synthase complex(GO:0033185)

Showing 1 to 10 of 42 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.6	GO:0031702	type 1 angiotensin receptor binding(GO:0031702)
0.1	1.4	GO:0019957	C-C chemokine binding(GO:0019957)
0.0	1.1	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.3	1.0	GO:0045127	N-acetylglucosamine kinase activity(GO:0045127)
0.1	1.0	GO:0004095	carnitine O-palmitoyltransferase activity(GO:0004095)
0.0	1.0	GO:0031994	insulin-like growth factor I binding(GO:0031994)
0.0	1.0	GO:0008035	high-density lipoprotein particle binding(GO:0008035)
0.0	1.0	GO:0030332	cyclin binding(GO:0030332)
0.1	0.9	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.0	0.9	GO:0005385	zinc ion transmembrane transporter activity(GO:0005385)

Showing 1 to 10 of 90 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.0	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0	1.4	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.1	1.0	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.0	1.0	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.0	0.7	ST INTERLEUKIN 4 PATHWAY	Interleukin 4 (IL-4) Pathway
0.0	0.3	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network

Showing 1 to 6 of 6 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Total log-likelihood	Term	Description
1.2	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
1.1	REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE	Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
1.0	REACTOME REGULATION OF IFNA SIGNALING	Genes involved in Regulation of IFNA signaling
0.9	REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP	Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.9	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.9	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.8	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.7	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.7	REACTOME PACKAGING OF TELOMERE ENDS	Genes involved in Packaging Of Telomere Ends
0.6	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis

Showing 1 to 10 of 24 entries

Results for KLF3

Z-value: 1.04

Motif logo

Transcription factors associated with KLF3

Activity-expression correlation:

Activity profile of KLF3 motif

Sorted Z-values of KLF3 motif

No targets for KLF3

Network of associatons between targets according to the STRING database.

First level regulatory network of KLF3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: