ISMARA results: KLF8

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for KLF8

Z-value: 3.75

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Transcription factors associated with KLF8

Gene Symbol	Gene ID	Gene Info
KLF8 Ensembl NCBI GeneCards UniProt	ENSG00000102349.10	Kruppel like factor 8

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
KLF8	hg19_v2_chrX_+_56259316_56259480	0.94	1.3e-09	Click!

Activity profile of KLF8 motif

Sorted Z-values of KLF8 motif

No targets for KLF8

Network of associatons between targets according to the STRING database.

First level regulatory network of KLF8

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	28.0	GO:0042744	hydrogen peroxide catabolic process(GO:0042744)
3.6	21.4	GO:0002760	positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
0.2	18.7	GO:2000649	regulation of sodium ion transmembrane transporter activity(GO:2000649)
1.1	18.0	GO:0048672	positive regulation of collateral sprouting(GO:0048672)
1.3	16.1	GO:0035986	senescence-associated heterochromatin focus assembly(GO:0035986)
1.1	14.9	GO:0036484	trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486) neural crest cell migration involved in autonomic nervous system development(GO:1901166)
0.4	13.1	GO:0031581	hemidesmosome assembly(GO:0031581)
0.5	12.3	GO:0060670	branching involved in labyrinthine layer morphogenesis(GO:0060670)
1.9	11.7	GO:0045110	intermediate filament bundle assembly(GO:0045110)
1.9	11.5	GO:1904274	tricellular tight junction assembly(GO:1904274)

Showing 1 to 10 of 999 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	28.1	GO:0030139	endocytic vesicle(GO:0030139)
3.1	21.4	GO:0097209	epidermal lamellar body(GO:0097209)
0.2	20.0	GO:0034707	chloride channel complex(GO:0034707)
0.1	18.8	GO:0019897	extrinsic component of plasma membrane(GO:0019897)
1.3	16.1	GO:0035985	senescence-associated heterochromatin focus(GO:0035985)
1.3	16.0	GO:0061689	tricellular tight junction(GO:0061689)
0.6	16.0	GO:0097386	glial cell projection(GO:0097386)
0.3	14.9	GO:0030057	desmosome(GO:0030057)
0.1	13.3	GO:0016605	PML body(GO:0016605)
0.1	12.2	GO:0005905	clathrin-coated pit(GO:0005905)

Showing 1 to 10 of 343 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	59.8	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.3	24.6	GO:0017080	sodium channel regulator activity(GO:0017080)
0.2	24.6	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.5	23.2	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	19.6	GO:0050839	cell adhesion molecule binding(GO:0050839)
0.8	17.9	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
1.8	17.8	GO:0008379	thioredoxin peroxidase activity(GO:0008379)
0.7	17.5	GO:0045499	chemorepellent activity(GO:0045499)
0.7	17.1	GO:0016918	retinal binding(GO:0016918)
0.4	16.2	GO:0051428	peptide hormone receptor binding(GO:0051428)

Showing 1 to 10 of 587 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	29.4	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2	18.6	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.1	18.0	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	16.8	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.1	16.0	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.5	14.4	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.5	13.2	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.2	12.6	ST P38 MAPK PATHWAY	p38 MAPK Pathway
0.1	11.9	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.3	9.3	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin

Showing 1 to 10 of 101 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	32.3	REACTOME GENERIC TRANSCRIPTION PATHWAY	Genes involved in Generic Transcription Pathway
0.2	21.9	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
0.2	20.4	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization
0.2	16.7	REACTOME G1 PHASE	Genes involved in G1 Phase
0.1	15.5	REACTOME DIABETES PATHWAYS	Genes involved in Diabetes pathways
0.5	11.9	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.5	11.7	REACTOME GAP JUNCTION ASSEMBLY	Genes involved in Gap junction assembly
0.2	11.4	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.2	10.0	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.3	9.1	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport

Showing 1 to 10 of 143 entries

Results for KLF8

Z-value: 3.75

Motif logo

Transcription factors associated with KLF8

Activity-expression correlation:

Activity profile of KLF8 motif

Sorted Z-values of KLF8 motif

No targets for KLF8

Network of associatons between targets according to the STRING database.

First level regulatory network of KLF8

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: