ISMARA results: LEF1

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for LEF1

Z-value: 1.65

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Transcription factors associated with LEF1

Gene Symbol	Gene ID	Gene Info
LEF1 Ensembl NCBI GeneCards UniProt	ENSG00000138795.5	lymphoid enhancer binding factor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
LEF1	hg19_v2_chr4_-_109087906_109087953	0.74	1.7e-04	Click!

Activity profile of LEF1 motif

Sorted Z-values of LEF1 motif

No targets for LEF1

Network of associatons between targets according to the STRING database.

First level regulatory network of LEF1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.1	12.4	GO:0060901	regulation of monophenol monooxygenase activity(GO:0032771) positive regulation of monophenol monooxygenase activity(GO:0032773) negative regulation of catagen(GO:0051796) regulation of hair cycle by canonical Wnt signaling pathway(GO:0060901) positive regulation of melanosome transport(GO:1902910)
0.3	8.1	GO:0060670	branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.5	5.7	GO:0038044	transforming growth factor-beta secretion(GO:0038044)
0.2	5.2	GO:1902857	positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0	5.2	GO:0070268	cornification(GO:0070268)
0.3	5.1	GO:0015816	glycine transport(GO:0015816)
0.1	4.5	GO:0006376	mRNA splice site selection(GO:0006376)
0.2	4.3	GO:0014894	response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
1.0	4.2	GO:0009956	radial pattern formation(GO:0009956)
0.4	4.2	GO:0071847	TNFSF11-mediated signaling pathway(GO:0071847)

Showing 1 to 10 of 245 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	11.0	GO:0005913	cell-cell adherens junction(GO:0005913)
0.0	9.2	GO:0043296	apical junction complex(GO:0043296)
0.1	6.5	GO:0030057	desmosome(GO:0030057)
0.2	6.0	GO:0032156	septin cytoskeleton(GO:0032156)
0.0	4.8	GO:0000790	nuclear chromatin(GO:0000790)
1.6	4.7	GO:0034685	integrin alphav-beta6 complex(GO:0034685)
1.9	3.8	GO:0034686	integrin alphav-beta8 complex(GO:0034686)
0.0	3.8	GO:0000151	ubiquitin ligase complex(GO:0000151)
0.1	3.6	GO:0071564	npBAF complex(GO:0071564)
0.0	3.4	GO:0001726	ruffle(GO:0001726)

Showing 1 to 10 of 104 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	11.3	GO:0045296	cadherin binding(GO:0045296)
0.0	10.3	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)
0.0	5.7	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.0	5.4	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.3	5.1	GO:0015187	glycine transmembrane transporter activity(GO:0015187)
0.0	4.7	GO:0001618	virus receptor activity(GO:0001618)
0.1	4.2	GO:0031491	nucleosome binding(GO:0031491)
0.1	4.1	GO:0004385	guanylate kinase activity(GO:0004385)
0.1	3.9	GO:0018024	histone-lysine N-methyltransferase activity(GO:0018024)
0.0	3.9	GO:0003730	mRNA 3'-UTR binding(GO:0003730)

Showing 1 to 10 of 160 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	7.2	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1	6.5	PID FOXO PATHWAY	FoxO family signaling
0.1	5.9	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.0	5.0	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.0	4.7	PID AP1 PATHWAY	AP-1 transcription factor network
0.1	3.5	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.0	3.5	PID P73PATHWAY	p73 transcription factor network
0.0	3.3	PID P53 REGULATION PATHWAY	p53 pathway
0.1	3.0	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.0	3.0	PID VEGFR1 2 PATHWAY	Signaling events mediated by VEGFR1 and VEGFR2

Showing 1 to 10 of 39 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	12.3	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.4	8.5	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0	7.3	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.1	6.1	REACTOME O LINKED GLYCOSYLATION OF MUCINS	Genes involved in O-linked glycosylation of mucins
0.0	5.0	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
0.1	4.8	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.1	3.5	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0	3.5	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0	2.9	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.1	2.8	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions

Showing 1 to 10 of 44 entries

Results for LEF1

Z-value: 1.65

Motif logo

Transcription factors associated with LEF1

Activity-expression correlation:

Activity profile of LEF1 motif

Sorted Z-values of LEF1 motif

No targets for LEF1

Network of associatons between targets according to the STRING database.

First level regulatory network of LEF1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: