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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for LEF1
Z-value: 1.65
Motif logo
Transcription factors associated with LEF1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
LEF1
|
ENSG00000138795.5 | lymphoid enhancer binding factor 1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| LEF1 | hg19_v2_chr4_-_109087906_109087953 | 0.74 | 1.7e-04 | Click! |
Activity profile of LEF1 motif
Sorted Z-values of LEF1 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of LEF1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 12.4 | GO:0060901 | regulation of monophenol monooxygenase activity(GO:0032771) positive regulation of monophenol monooxygenase activity(GO:0032773) negative regulation of catagen(GO:0051796) regulation of hair cycle by canonical Wnt signaling pathway(GO:0060901) positive regulation of melanosome transport(GO:1902910) |
| 1.0 | 4.2 | GO:0009956 | radial pattern formation(GO:0009956) |
| 0.7 | 2.8 | GO:0007499 | ectoderm and mesoderm interaction(GO:0007499) |
| 0.6 | 1.9 | GO:0060278 | regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279) |
| 0.6 | 3.7 | GO:0032625 | interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619) |
| 0.6 | 1.7 | GO:0048203 | vesicle targeting, trans-Golgi to endosome(GO:0048203) |
| 0.5 | 2.7 | GO:0007070 | negative regulation of transcription during mitosis(GO:0007068) negative regulation of transcription from RNA polymerase II promoter during mitosis(GO:0007070) |
| 0.5 | 2.6 | GO:0043553 | negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) |
| 0.5 | 5.7 | GO:0038044 | transforming growth factor-beta secretion(GO:0038044) |
| 0.5 | 1.8 | GO:0001835 | blastocyst hatching(GO:0001835) hatching(GO:0035188) organism emergence from protective structure(GO:0071684) |
| 0.5 | 1.8 | GO:1902544 | regulation of DNA N-glycosylase activity(GO:1902544) |
| 0.4 | 4.2 | GO:0071847 | TNFSF11-mediated signaling pathway(GO:0071847) |
| 0.4 | 2.5 | GO:0061343 | cell adhesion involved in heart morphogenesis(GO:0061343) |
| 0.4 | 1.2 | GO:2000297 | negative regulation of synapse maturation(GO:2000297) |
| 0.4 | 1.1 | GO:0070632 | spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790) |
| 0.3 | 1.0 | GO:2000393 | negative regulation of lamellipodium morphogenesis(GO:2000393) |
| 0.3 | 1.0 | GO:1903450 | regulation of G1 to G0 transition(GO:1903450) positive regulation of G1 to G0 transition(GO:1903452) |
| 0.3 | 8.1 | GO:0060670 | branching involved in labyrinthine layer morphogenesis(GO:0060670) |
| 0.3 | 2.4 | GO:0048625 | regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) myoblast fate commitment(GO:0048625) positive regulation of proteoglycan biosynthetic process(GO:1902730) |
| 0.3 | 0.6 | GO:2000729 | positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729) |
| 0.3 | 5.1 | GO:0015816 | glycine transport(GO:0015816) |
| 0.3 | 2.0 | GO:1903232 | melanosome assembly(GO:1903232) |
| 0.3 | 1.4 | GO:0032474 | otolith morphogenesis(GO:0032474) |
| 0.3 | 0.8 | GO:0060738 | epithelial-mesenchymal signaling involved in prostate gland development(GO:0060738) |
| 0.3 | 0.8 | GO:0007388 | anterior compartment pattern formation(GO:0007387) posterior compartment specification(GO:0007388) |
| 0.3 | 1.3 | GO:0003051 | angiotensin-mediated drinking behavior(GO:0003051) |
| 0.2 | 1.7 | GO:2001288 | positive regulation of caveolin-mediated endocytosis(GO:2001288) |
| 0.2 | 1.7 | GO:0070966 | nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966) |
| 0.2 | 2.0 | GO:1905150 | regulation of voltage-gated sodium channel activity(GO:1905150) |
| 0.2 | 0.7 | GO:0061110 | dense core granule biogenesis(GO:0061110) regulation of dense core granule biogenesis(GO:2000705) |
| 0.2 | 4.3 | GO:0014894 | response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) |
| 0.2 | 1.1 | GO:0021827 | cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) |
| 0.2 | 1.3 | GO:0002378 | immunoglobulin biosynthetic process(GO:0002378) |
| 0.2 | 0.9 | GO:0072086 | specification of loop of Henle identity(GO:0072086) pattern specification involved in metanephros development(GO:0072268) |
| 0.2 | 2.3 | GO:0003350 | pulmonary myocardium development(GO:0003350) |
| 0.2 | 1.9 | GO:0003383 | apical constriction(GO:0003383) |
| 0.2 | 3.4 | GO:0006600 | creatine metabolic process(GO:0006600) |
| 0.2 | 1.0 | GO:2001045 | negative regulation of integrin-mediated signaling pathway(GO:2001045) |
| 0.2 | 2.9 | GO:0018026 | peptidyl-lysine monomethylation(GO:0018026) |
| 0.2 | 1.7 | GO:1904885 | beta-catenin destruction complex assembly(GO:1904885) |
| 0.2 | 1.1 | GO:1900245 | positive regulation of MDA-5 signaling pathway(GO:1900245) |
| 0.2 | 0.6 | GO:1904247 | positive regulation of polynucleotide adenylyltransferase activity(GO:1904247) |
| 0.2 | 0.9 | GO:0002528 | regulation of vascular permeability involved in acute inflammatory response(GO:0002528) |
| 0.2 | 0.7 | GO:0050717 | positive regulation of interleukin-1 alpha secretion(GO:0050717) |
| 0.2 | 2.6 | GO:0001778 | plasma membrane repair(GO:0001778) |
| 0.2 | 2.0 | GO:0051694 | pointed-end actin filament capping(GO:0051694) |
| 0.2 | 1.1 | GO:0097368 | establishment of Sertoli cell barrier(GO:0097368) |
| 0.2 | 0.5 | GO:1990108 | protein linear deubiquitination(GO:1990108) |
| 0.2 | 1.7 | GO:0014809 | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809) |
| 0.2 | 2.9 | GO:1904262 | negative regulation of TORC1 signaling(GO:1904262) |
| 0.2 | 0.5 | GO:0002184 | cytoplasmic translational termination(GO:0002184) |
| 0.2 | 1.2 | GO:1990592 | protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592) |
| 0.2 | 0.5 | GO:0071879 | positive regulation of adrenergic receptor signaling pathway(GO:0071879) |
| 0.2 | 5.2 | GO:1902857 | positive regulation of nonmotile primary cilium assembly(GO:1902857) |
| 0.1 | 0.6 | GO:1903045 | neural crest cell migration involved in sympathetic nervous system development(GO:1903045) |
| 0.1 | 0.7 | GO:1900224 | positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224) |
| 0.1 | 0.4 | GO:0060931 | sinoatrial node cell development(GO:0060931) |
| 0.1 | 1.2 | GO:0019856 | 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856) |
| 0.1 | 0.8 | GO:1900147 | Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147) |
| 0.1 | 0.4 | GO:1902725 | negative regulation of satellite cell differentiation(GO:1902725) |
| 0.1 | 1.8 | GO:0048280 | vesicle fusion with Golgi apparatus(GO:0048280) |
| 0.1 | 0.4 | GO:1903625 | negative regulation of DNA catabolic process(GO:1903625) regulation of aminoacyl-tRNA ligase activity(GO:1903630) |
| 0.1 | 1.4 | GO:0046598 | positive regulation of viral entry into host cell(GO:0046598) |
| 0.1 | 1.5 | GO:0002051 | osteoblast fate commitment(GO:0002051) |
| 0.1 | 0.7 | GO:0070086 | ubiquitin-dependent endocytosis(GO:0070086) |
| 0.1 | 0.8 | GO:1903786 | mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound catabolic process(GO:1901377) regulation of glutathione biosynthetic process(GO:1903786) positive regulation of glutathione biosynthetic process(GO:1903788) |
| 0.1 | 0.8 | GO:2000670 | positive regulation of dendritic cell apoptotic process(GO:2000670) |
| 0.1 | 0.8 | GO:0051684 | maintenance of Golgi location(GO:0051684) |
| 0.1 | 0.4 | GO:0060166 | olfactory pit development(GO:0060166) |
| 0.1 | 0.7 | GO:0048388 | endosomal lumen acidification(GO:0048388) |
| 0.1 | 0.9 | GO:0022027 | interkinetic nuclear migration(GO:0022027) |
| 0.1 | 1.1 | GO:0060339 | negative regulation of type I interferon-mediated signaling pathway(GO:0060339) |
| 0.1 | 2.8 | GO:0007171 | activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171) |
| 0.1 | 0.3 | GO:0001544 | initiation of primordial ovarian follicle growth(GO:0001544) |
| 0.1 | 0.3 | GO:0051389 | inactivation of MAPKK activity(GO:0051389) |
| 0.1 | 0.6 | GO:1900042 | positive regulation of interleukin-2 secretion(GO:1900042) |
| 0.1 | 0.3 | GO:0002439 | chronic inflammatory response to antigenic stimulus(GO:0002439) |
| 0.1 | 1.2 | GO:0021759 | globus pallidus development(GO:0021759) |
| 0.1 | 0.6 | GO:0072660 | maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
| 0.1 | 0.4 | GO:0045763 | negative regulation of cellular amino acid metabolic process(GO:0045763) |
| 0.1 | 0.5 | GO:1990569 | UDP-N-acetylglucosamine transport(GO:0015788) UDP-N-acetylglucosamine transmembrane transport(GO:1990569) |
| 0.1 | 0.5 | GO:0008588 | release of cytoplasmic sequestered NF-kappaB(GO:0008588) |
| 0.1 | 0.5 | GO:0044855 | plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906) |
| 0.1 | 0.5 | GO:1904693 | midbrain morphogenesis(GO:1904693) |
| 0.1 | 0.3 | GO:0002894 | positive regulation of type IIa hypersensitivity(GO:0001798) positive regulation of type II hypersensitivity(GO:0002894) |
| 0.1 | 0.8 | GO:0032525 | somite rostral/caudal axis specification(GO:0032525) |
| 0.1 | 0.6 | GO:0034670 | chemotaxis to arachidonic acid(GO:0034670) response to arachidonic acid(GO:1904550) |
| 0.1 | 0.5 | GO:0014886 | transition between slow and fast fiber(GO:0014886) |
| 0.1 | 3.4 | GO:0042744 | hydrogen peroxide catabolic process(GO:0042744) |
| 0.1 | 1.5 | GO:0070050 | neuron cellular homeostasis(GO:0070050) |
| 0.1 | 0.4 | GO:2000312 | regulation of kainate selective glutamate receptor activity(GO:2000312) |
| 0.1 | 1.1 | GO:1903690 | negative regulation of wound healing, spreading of epidermal cells(GO:1903690) |
| 0.1 | 0.7 | GO:1905068 | positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068) |
| 0.1 | 0.3 | GO:1990637 | response to prolactin(GO:1990637) |
| 0.1 | 4.5 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 0.1 | 0.2 | GO:0089700 | protein kinase D signaling(GO:0089700) |
| 0.1 | 0.8 | GO:0051013 | microtubule severing(GO:0051013) |
| 0.1 | 1.1 | GO:2001224 | positive regulation of neuron migration(GO:2001224) |
| 0.1 | 0.3 | GO:0045875 | negative regulation of sister chromatid cohesion(GO:0045875) |
| 0.1 | 0.9 | GO:0019367 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
| 0.1 | 0.7 | GO:0010724 | regulation of definitive erythrocyte differentiation(GO:0010724) |
| 0.1 | 0.4 | GO:1901727 | positive regulation of histone deacetylase activity(GO:1901727) |
| 0.1 | 0.2 | GO:1900186 | negative regulation of clathrin-mediated endocytosis(GO:1900186) |
| 0.1 | 0.4 | GO:0046684 | response to pyrethroid(GO:0046684) |
| 0.1 | 1.0 | GO:0043985 | histone H4-R3 methylation(GO:0043985) |
| 0.1 | 3.5 | GO:0090162 | establishment of epithelial cell polarity(GO:0090162) |
| 0.1 | 1.7 | GO:0051531 | NFAT protein import into nucleus(GO:0051531) |
| 0.1 | 0.8 | GO:0090204 | protein localization to nuclear pore(GO:0090204) |
| 0.1 | 0.4 | GO:1903527 | positive regulation of membrane tubulation(GO:1903527) |
| 0.1 | 0.7 | GO:0018243 | protein O-linked glycosylation via threonine(GO:0018243) |
| 0.1 | 0.9 | GO:1902459 | positive regulation of stem cell population maintenance(GO:1902459) |
| 0.1 | 0.9 | GO:0090161 | Golgi ribbon formation(GO:0090161) |
| 0.1 | 1.8 | GO:0006054 | N-acetylneuraminate metabolic process(GO:0006054) |
| 0.1 | 0.4 | GO:0010643 | cell communication by chemical coupling(GO:0010643) |
| 0.1 | 2.1 | GO:0044705 | mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705) |
| 0.1 | 0.3 | GO:0061304 | retinal blood vessel morphogenesis(GO:0061304) |
| 0.1 | 0.3 | GO:0000415 | negative regulation of histone H3-K36 methylation(GO:0000415) |
| 0.1 | 0.4 | GO:0000436 | carbon catabolite regulation of transcription from RNA polymerase II promoter(GO:0000429) regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432) carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436) |
| 0.1 | 0.8 | GO:0070544 | histone H3-K36 demethylation(GO:0070544) |
| 0.1 | 1.3 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 0.1 | 0.3 | GO:0008204 | ergosterol biosynthetic process(GO:0006696) ergosterol metabolic process(GO:0008204) |
| 0.1 | 0.9 | GO:0070307 | lens fiber cell development(GO:0070307) |
| 0.1 | 3.8 | GO:0010107 | potassium ion import(GO:0010107) |
| 0.1 | 2.0 | GO:0015695 | organic cation transport(GO:0015695) |
| 0.1 | 0.9 | GO:0032467 | positive regulation of cytokinesis(GO:0032467) |
| 0.1 | 1.5 | GO:1900745 | positive regulation of p38MAPK cascade(GO:1900745) |
| 0.1 | 0.7 | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) |
| 0.1 | 1.2 | GO:0070935 | 3'-UTR-mediated mRNA stabilization(GO:0070935) |
| 0.1 | 0.3 | GO:0070495 | regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) |
| 0.1 | 1.8 | GO:0060674 | placenta blood vessel development(GO:0060674) |
| 0.1 | 2.1 | GO:0061157 | mRNA destabilization(GO:0061157) |
| 0.1 | 1.8 | GO:0060074 | synapse maturation(GO:0060074) |
| 0.1 | 0.3 | GO:0035026 | leading edge cell differentiation(GO:0035026) |
| 0.1 | 0.4 | GO:0045204 | MAPK export from nucleus(GO:0045204) |
| 0.1 | 0.8 | GO:0008090 | retrograde axonal transport(GO:0008090) |
| 0.1 | 0.8 | GO:0044341 | sodium-dependent phosphate transport(GO:0044341) |
| 0.1 | 0.8 | GO:0033327 | Leydig cell differentiation(GO:0033327) response to UV-A(GO:0070141) |
| 0.1 | 0.6 | GO:0006657 | CDP-choline pathway(GO:0006657) |
| 0.0 | 0.2 | GO:0090149 | mitochondrial membrane fission(GO:0090149) |
| 0.0 | 0.3 | GO:1903593 | regulation of histamine secretion by mast cell(GO:1903593) |
| 0.0 | 0.7 | GO:0006228 | UTP biosynthetic process(GO:0006228) |
| 0.0 | 0.1 | GO:0048368 | lateral mesoderm development(GO:0048368) |
| 0.0 | 1.9 | GO:0051654 | establishment of mitochondrion localization(GO:0051654) |
| 0.0 | 2.7 | GO:1900739 | regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740) |
| 0.0 | 1.9 | GO:0071425 | hematopoietic stem cell proliferation(GO:0071425) |
| 0.0 | 0.4 | GO:0071895 | odontoblast differentiation(GO:0071895) |
| 0.0 | 0.6 | GO:0006477 | protein sulfation(GO:0006477) |
| 0.0 | 0.2 | GO:0010157 | response to chlorate(GO:0010157) |
| 0.0 | 0.7 | GO:0030575 | nuclear body organization(GO:0030575) |
| 0.0 | 1.9 | GO:0048011 | neurotrophin TRK receptor signaling pathway(GO:0048011) |
| 0.0 | 0.5 | GO:0003264 | cardioblast proliferation(GO:0003263) regulation of cardioblast proliferation(GO:0003264) |
| 0.0 | 1.4 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 0.0 | 1.1 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.0 | 0.4 | GO:0097338 | response to clozapine(GO:0097338) |
| 0.0 | 0.5 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
| 0.0 | 0.2 | GO:0070980 | biphenyl catabolic process(GO:0070980) |
| 0.0 | 0.4 | GO:0070973 | protein localization to endoplasmic reticulum exit site(GO:0070973) |
| 0.0 | 0.9 | GO:0006020 | inositol metabolic process(GO:0006020) |
| 0.0 | 0.5 | GO:0009249 | protein lipoylation(GO:0009249) |
| 0.0 | 0.6 | GO:0000492 | box C/D snoRNP assembly(GO:0000492) |
| 0.0 | 1.0 | GO:0045662 | negative regulation of myoblast differentiation(GO:0045662) |
| 0.0 | 0.1 | GO:0003221 | right ventricular cardiac muscle tissue morphogenesis(GO:0003221) |
| 0.0 | 0.8 | GO:0097320 | membrane tubulation(GO:0097320) |
| 0.0 | 0.2 | GO:0003185 | primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185) |
| 0.0 | 0.5 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
| 0.0 | 0.2 | GO:2000288 | positive regulation of myoblast proliferation(GO:2000288) |
| 0.0 | 0.4 | GO:0090181 | regulation of cholesterol biosynthetic process(GO:0045540) regulation of cholesterol metabolic process(GO:0090181) |
| 0.0 | 0.3 | GO:0031022 | nuclear migration along microfilament(GO:0031022) |
| 0.0 | 0.8 | GO:0006895 | Golgi to endosome transport(GO:0006895) |
| 0.0 | 0.3 | GO:1902177 | positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902177) |
| 0.0 | 0.6 | GO:0007342 | fusion of sperm to egg plasma membrane(GO:0007342) |
| 0.0 | 0.5 | GO:0060044 | negative regulation of cardiac muscle cell proliferation(GO:0060044) |
| 0.0 | 0.2 | GO:0060023 | soft palate development(GO:0060023) |
| 0.0 | 0.1 | GO:2000843 | testosterone secretion(GO:0035936) regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922) regulation of testosterone secretion(GO:2000843) positive regulation of testosterone secretion(GO:2000845) |
| 0.0 | 0.5 | GO:0090557 | establishment of endothelial intestinal barrier(GO:0090557) |
| 0.0 | 5.2 | GO:0070268 | cornification(GO:0070268) |
| 0.0 | 0.6 | GO:0048739 | cardiac muscle fiber development(GO:0048739) |
| 0.0 | 1.6 | GO:0032757 | positive regulation of interleukin-8 production(GO:0032757) |
| 0.0 | 0.7 | GO:0007614 | short-term memory(GO:0007614) |
| 0.0 | 0.2 | GO:0061086 | negative regulation of histone H3-K27 methylation(GO:0061086) |
| 0.0 | 0.0 | GO:0021847 | ventricular zone neuroblast division(GO:0021847) |
| 0.0 | 0.3 | GO:0015889 | cobalamin transport(GO:0015889) |
| 0.0 | 1.1 | GO:0036152 | phosphatidylethanolamine acyl-chain remodeling(GO:0036152) |
| 0.0 | 0.2 | GO:2000158 | positive regulation of ubiquitin-specific protease activity(GO:2000158) |
| 0.0 | 0.1 | GO:1904814 | regulation of protein localization to chromosome, telomeric region(GO:1904814) positive regulation of protein localization to chromosome, telomeric region(GO:1904816) |
| 0.0 | 1.3 | GO:0043001 | Golgi to plasma membrane protein transport(GO:0043001) |
| 0.0 | 0.6 | GO:0006388 | tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388) |
| 0.0 | 2.3 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.0 | 0.7 | GO:0006337 | nucleosome disassembly(GO:0006337) |
| 0.0 | 0.3 | GO:0032287 | peripheral nervous system myelin maintenance(GO:0032287) |
| 0.0 | 0.3 | GO:0035246 | peptidyl-arginine N-methylation(GO:0035246) |
| 0.0 | 0.6 | GO:0034063 | stress granule assembly(GO:0034063) |
| 0.0 | 0.5 | GO:0060711 | labyrinthine layer development(GO:0060711) |
| 0.0 | 0.1 | GO:1990697 | protein depalmitoleylation(GO:1990697) |
| 0.0 | 0.1 | GO:0007512 | adult heart development(GO:0007512) |
| 0.0 | 0.3 | GO:0045329 | carnitine biosynthetic process(GO:0045329) |
| 0.0 | 0.7 | GO:0050860 | negative regulation of T cell receptor signaling pathway(GO:0050860) |
| 0.0 | 0.2 | GO:0033522 | histone H2A ubiquitination(GO:0033522) histone H2A monoubiquitination(GO:0035518) |
| 0.0 | 0.1 | GO:0050893 | sensory processing(GO:0050893) |
| 0.0 | 0.6 | GO:0051457 | maintenance of protein location in nucleus(GO:0051457) |
| 0.0 | 1.1 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.0 | 0.1 | GO:1903715 | regulation of aerobic respiration(GO:1903715) |
| 0.0 | 0.4 | GO:0002089 | lens morphogenesis in camera-type eye(GO:0002089) |
| 0.0 | 0.1 | GO:1902260 | negative regulation of delayed rectifier potassium channel activity(GO:1902260) |
| 0.0 | 0.1 | GO:0034476 | U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476) |
| 0.0 | 1.2 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 0.0 | 0.4 | GO:0016024 | CDP-diacylglycerol biosynthetic process(GO:0016024) |
| 0.0 | 0.1 | GO:0035426 | extracellular matrix-cell signaling(GO:0035426) |
| 0.0 | 1.3 | GO:0045445 | myoblast differentiation(GO:0045445) |
| 0.0 | 0.2 | GO:0035973 | aggrephagy(GO:0035973) |
| 0.0 | 2.7 | GO:0022617 | extracellular matrix disassembly(GO:0022617) |
| 0.0 | 2.2 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
| 0.0 | 1.3 | GO:0006968 | cellular defense response(GO:0006968) |
| 0.0 | 0.1 | GO:0043569 | negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569) |
| 0.0 | 0.5 | GO:0006509 | membrane protein ectodomain proteolysis(GO:0006509) |
| 0.0 | 0.3 | GO:0031507 | heterochromatin assembly(GO:0031507) |
| 0.0 | 0.8 | GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552) |
| 0.0 | 0.2 | GO:0070779 | gamma-aminobutyric acid biosynthetic process(GO:0009449) D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
| 0.0 | 0.3 | GO:0010592 | positive regulation of lamellipodium assembly(GO:0010592) |
| 0.0 | 0.2 | GO:0042475 | odontogenesis of dentin-containing tooth(GO:0042475) |
| 0.0 | 2.4 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.0 | 0.3 | GO:0032780 | negative regulation of ATPase activity(GO:0032780) |
| 0.0 | 1.6 | GO:0006749 | glutathione metabolic process(GO:0006749) |
| 0.0 | 0.2 | GO:0070571 | negative regulation of axon regeneration(GO:0048681) negative regulation of neuron projection regeneration(GO:0070571) |
| 0.0 | 0.1 | GO:0021831 | embryonic olfactory bulb interneuron precursor migration(GO:0021831) chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration(GO:0021834) |
| 0.0 | 0.4 | GO:0051016 | barbed-end actin filament capping(GO:0051016) |
| 0.0 | 0.2 | GO:0033623 | regulation of integrin activation(GO:0033623) |
| 0.0 | 1.5 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.0 | 0.7 | GO:0031648 | protein destabilization(GO:0031648) |
| 0.0 | 0.3 | GO:0051764 | actin crosslink formation(GO:0051764) |
| 0.0 | 0.0 | GO:0048250 | mitochondrial iron ion transport(GO:0048250) |
| 0.0 | 0.1 | GO:0030854 | positive regulation of granulocyte differentiation(GO:0030854) |
| 0.0 | 0.1 | GO:0098535 | de novo centriole assembly(GO:0098535) |
| 0.0 | 0.5 | GO:0043044 | ATP-dependent chromatin remodeling(GO:0043044) |
| 0.0 | 0.2 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
| 0.0 | 0.2 | GO:0046838 | phosphorylated carbohydrate dephosphorylation(GO:0046838) |
| 0.0 | 0.2 | GO:0060453 | regulation of gastric acid secretion(GO:0060453) |
| 0.0 | 0.6 | GO:0031952 | regulation of protein autophosphorylation(GO:0031952) |
| 0.0 | 0.2 | GO:0006995 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
| 0.0 | 0.8 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.0 | 0.2 | GO:0043031 | negative regulation of macrophage activation(GO:0043031) |
| 0.0 | 0.2 | GO:0030336 | negative regulation of cell migration(GO:0030336) |
| 0.0 | 0.2 | GO:2000810 | regulation of bicellular tight junction assembly(GO:2000810) |
| 0.0 | 0.1 | GO:0051138 | positive regulation of NK T cell differentiation(GO:0051138) |
| 0.0 | 0.9 | GO:0090502 | RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 3.8 | GO:0034686 | integrin alphav-beta8 complex(GO:0034686) |
| 1.6 | 4.7 | GO:0034685 | integrin alphav-beta6 complex(GO:0034685) |
| 0.6 | 1.9 | GO:0043511 | inhibin complex(GO:0043511) inhibin A complex(GO:0043512) |
| 0.4 | 2.0 | GO:0031905 | early endosome lumen(GO:0031905) |
| 0.4 | 1.1 | GO:0070762 | nuclear pore transmembrane ring(GO:0070762) |
| 0.4 | 1.1 | GO:0075341 | host cell PML body(GO:0075341) |
| 0.3 | 2.1 | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308) |
| 0.3 | 2.4 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) |
| 0.3 | 0.8 | GO:0008623 | CHRAC(GO:0008623) |
| 0.2 | 1.0 | GO:0071149 | TEAD-2-YAP complex(GO:0071149) |
| 0.2 | 1.7 | GO:1990578 | perinuclear endoplasmic reticulum membrane(GO:1990578) |
| 0.2 | 1.7 | GO:0016013 | syntrophin complex(GO:0016013) |
| 0.2 | 2.9 | GO:0061700 | GATOR2 complex(GO:0061700) |
| 0.2 | 0.5 | GO:0018444 | translation release factor complex(GO:0018444) |
| 0.2 | 6.0 | GO:0032156 | septin cytoskeleton(GO:0032156) |
| 0.1 | 6.5 | GO:0030057 | desmosome(GO:0030057) |
| 0.1 | 3.6 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.1 | 0.6 | GO:1903349 | omegasome membrane(GO:1903349) |
| 0.1 | 1.0 | GO:0032437 | cuticular plate(GO:0032437) |
| 0.1 | 0.3 | GO:0036194 | muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195) |
| 0.1 | 0.9 | GO:0070695 | FHF complex(GO:0070695) |
| 0.1 | 0.6 | GO:0031673 | H zone(GO:0031673) |
| 0.1 | 0.7 | GO:0032444 | activin responsive factor complex(GO:0032444) |
| 0.1 | 0.5 | GO:0071008 | U2-type post-mRNA release spliceosomal complex(GO:0071008) |
| 0.1 | 1.2 | GO:0070937 | CRD-mediated mRNA stability complex(GO:0070937) |
| 0.1 | 0.6 | GO:1990589 | ATF4-CREB1 transcription factor complex(GO:1990589) |
| 0.1 | 1.0 | GO:0016600 | flotillin complex(GO:0016600) |
| 0.1 | 0.3 | GO:0031933 | telomeric heterochromatin(GO:0031933) |
| 0.1 | 0.2 | GO:0097635 | extrinsic component of autophagosome membrane(GO:0097635) |
| 0.1 | 1.0 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.1 | 0.7 | GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex(GO:0002193) |
| 0.1 | 11.0 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.1 | 3.2 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.1 | 1.1 | GO:0045180 | basal cortex(GO:0045180) |
| 0.1 | 0.3 | GO:0031232 | extrinsic component of external side of plasma membrane(GO:0031232) |
| 0.1 | 1.1 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.1 | 0.7 | GO:0032059 | bleb(GO:0032059) |
| 0.1 | 1.7 | GO:0043197 | dendritic spine(GO:0043197) neuron spine(GO:0044309) |
| 0.1 | 0.9 | GO:0036449 | microtubule minus-end(GO:0036449) |
| 0.1 | 0.6 | GO:0072669 | tRNA-splicing ligase complex(GO:0072669) |
| 0.0 | 1.5 | GO:0031528 | microvillus membrane(GO:0031528) |
| 0.0 | 1.3 | GO:0031519 | PcG protein complex(GO:0031519) |
| 0.0 | 1.9 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.0 | 0.6 | GO:0070761 | pre-snoRNP complex(GO:0070761) |
| 0.0 | 1.2 | GO:0071141 | SMAD protein complex(GO:0071141) |
| 0.0 | 0.6 | GO:0044666 | MLL3/4 complex(GO:0044666) |
| 0.0 | 2.9 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.0 | 0.3 | GO:0097422 | tubular endosome(GO:0097422) |
| 0.0 | 9.2 | GO:0043296 | apical junction complex(GO:0043296) |
| 0.0 | 0.4 | GO:0016589 | NURF complex(GO:0016589) |
| 0.0 | 0.2 | GO:0042585 | germinal vesicle(GO:0042585) |
| 0.0 | 0.3 | GO:0008282 | ATP-sensitive potassium channel complex(GO:0008282) |
| 0.0 | 2.0 | GO:0005865 | striated muscle thin filament(GO:0005865) |
| 0.0 | 1.2 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.0 | 0.3 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 0.0 | 1.3 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 3.1 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 1.0 | GO:0031527 | filopodium membrane(GO:0031527) |
| 0.0 | 1.0 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.0 | 0.3 | GO:0005677 | chromatin silencing complex(GO:0005677) |
| 0.0 | 0.5 | GO:0030478 | actin cap(GO:0030478) |
| 0.0 | 0.6 | GO:0042405 | nuclear inclusion body(GO:0042405) |
| 0.0 | 0.3 | GO:0005587 | collagen type IV trimer(GO:0005587) |
| 0.0 | 1.1 | GO:0016235 | aggresome(GO:0016235) |
| 0.0 | 1.6 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.0 | 0.1 | GO:0035061 | interchromatin granule(GO:0035061) |
| 0.0 | 1.1 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.0 | 0.3 | GO:0042382 | paraspeckles(GO:0042382) |
| 0.0 | 0.6 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.0 | 0.4 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 0.0 | 0.5 | GO:0034709 | methylosome(GO:0034709) |
| 0.0 | 1.4 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
| 0.0 | 0.9 | GO:0043034 | costamere(GO:0043034) |
| 0.0 | 0.2 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.0 | 1.6 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 1.8 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
| 0.0 | 0.3 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.0 | 0.7 | GO:0035097 | histone methyltransferase complex(GO:0035097) |
| 0.0 | 0.7 | GO:0051233 | spindle midzone(GO:0051233) |
| 0.0 | 0.7 | GO:0015030 | Cajal body(GO:0015030) |
| 0.0 | 2.8 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 0.1 | GO:0098536 | deuterosome(GO:0098536) |
| 0.0 | 0.1 | GO:0016342 | catenin complex(GO:0016342) |
| 0.0 | 2.1 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.0 | 0.4 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.0 | 0.4 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
| 0.0 | 1.2 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 0.6 | GO:0071339 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.0 | 0.5 | GO:0000323 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 0.0 | 1.7 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 1.0 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.0 | 0.3 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
| 0.0 | 4.8 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.0 | 0.5 | GO:0032040 | small-subunit processome(GO:0032040) |
| 0.0 | 0.6 | GO:0030496 | midbody(GO:0030496) |
| 0.0 | 1.3 | GO:0043204 | perikaryon(GO:0043204) |
| 0.0 | 0.9 | GO:0097517 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 0.6 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.0 | 3.4 | GO:0001726 | ruffle(GO:0001726) |
| 0.0 | 0.4 | GO:0005921 | gap junction(GO:0005921) |
| 0.0 | 0.2 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.0 | 0.2 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 0.0 | 1.5 | GO:0000785 | chromatin(GO:0000785) |
| 0.0 | 3.8 | GO:0000151 | ubiquitin ligase complex(GO:0000151) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 3.8 | GO:1990430 | extracellular matrix protein binding(GO:1990430) |
| 0.9 | 3.7 | GO:0035650 | AP-1 adaptor complex binding(GO:0035650) |
| 0.9 | 2.6 | GO:0036313 | phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313) |
| 0.7 | 3.4 | GO:0005152 | interleukin-1 receptor antagonist activity(GO:0005152) |
| 0.6 | 1.8 | GO:0043739 | G/U mismatch-specific uracil-DNA glycosylase activity(GO:0043739) |
| 0.5 | 1.5 | GO:0019150 | D-ribulokinase activity(GO:0019150) |
| 0.5 | 0.5 | GO:0031690 | adrenergic receptor binding(GO:0031690) |
| 0.5 | 2.3 | GO:0047256 | beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256) |
| 0.4 | 1.8 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
| 0.4 | 1.2 | GO:1990698 | palmitoleoyltransferase activity(GO:1990698) |
| 0.3 | 5.1 | GO:0015187 | glycine transmembrane transporter activity(GO:0015187) |
| 0.3 | 3.4 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 0.3 | 1.2 | GO:0009041 | uridylate kinase activity(GO:0009041) |
| 0.2 | 1.5 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.2 | 1.6 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.2 | 0.8 | GO:1990175 | EH domain binding(GO:1990175) |
| 0.2 | 2.8 | GO:0097371 | MDM2/MDM4 family protein binding(GO:0097371) |
| 0.2 | 1.4 | GO:0045118 | azole transporter activity(GO:0045118) |
| 0.2 | 1.3 | GO:0008241 | peptidyl-dipeptidase activity(GO:0008241) |
| 0.2 | 3.5 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.1 | 2.7 | GO:0030957 | Tat protein binding(GO:0030957) |
| 0.1 | 0.9 | GO:0004522 | ribonuclease A activity(GO:0004522) |
| 0.1 | 2.9 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.1 | 3.4 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.1 | 0.5 | GO:0099609 | microtubule lateral binding(GO:0099609) |
| 0.1 | 2.8 | GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213) |
| 0.1 | 0.6 | GO:0004105 | choline-phosphate cytidylyltransferase activity(GO:0004105) |
| 0.1 | 1.7 | GO:0043125 | ErbB-3 class receptor binding(GO:0043125) |
| 0.1 | 0.7 | GO:0055077 | gap junction hemi-channel activity(GO:0055077) |
| 0.1 | 2.5 | GO:0045499 | chemorepellent activity(GO:0045499) |
| 0.1 | 0.4 | GO:0072591 | citrate-L-glutamate ligase activity(GO:0072591) |
| 0.1 | 0.7 | GO:0072320 | volume-sensitive chloride channel activity(GO:0072320) |
| 0.1 | 0.9 | GO:0033857 | diphosphoinositol-pentakisphosphate kinase activity(GO:0033857) |
| 0.1 | 1.7 | GO:0019870 | potassium channel inhibitor activity(GO:0019870) |
| 0.1 | 2.0 | GO:0030618 | transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618) |
| 0.1 | 0.8 | GO:0031697 | beta-1 adrenergic receptor binding(GO:0031697) |
| 0.1 | 0.9 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
| 0.1 | 1.5 | GO:0047144 | 2-acylglycerol-3-phosphate O-acyltransferase activity(GO:0047144) |
| 0.1 | 0.5 | GO:0005462 | UDP-N-acetylglucosamine transmembrane transporter activity(GO:0005462) |
| 0.1 | 1.9 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.1 | 0.8 | GO:0015319 | sodium:inorganic phosphate symporter activity(GO:0015319) |
| 0.1 | 1.8 | GO:0000014 | single-stranded DNA endodeoxyribonuclease activity(GO:0000014) |
| 0.1 | 0.7 | GO:0042835 | BRE binding(GO:0042835) |
| 0.1 | 1.7 | GO:0050998 | nitric-oxide synthase binding(GO:0050998) |
| 0.1 | 4.1 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 0.1 | 1.2 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |
| 0.1 | 1.2 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
| 0.1 | 0.6 | GO:0050119 | N-acetylglucosamine deacetylase activity(GO:0050119) |
| 0.1 | 0.3 | GO:0071987 | WD40-repeat domain binding(GO:0071987) |
| 0.1 | 2.0 | GO:0015101 | organic cation transmembrane transporter activity(GO:0015101) |
| 0.1 | 2.8 | GO:0005161 | platelet-derived growth factor receptor binding(GO:0005161) |
| 0.1 | 0.3 | GO:0008281 | sulfonylurea receptor activity(GO:0008281) |
| 0.1 | 0.3 | GO:0051996 | farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996) |
| 0.1 | 0.3 | GO:0015616 | DNA translocase activity(GO:0015616) |
| 0.1 | 0.9 | GO:0009922 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 0.1 | 0.3 | GO:0008336 | gamma-butyrobetaine dioxygenase activity(GO:0008336) |
| 0.1 | 0.8 | GO:0008568 | microtubule-severing ATPase activity(GO:0008568) |
| 0.1 | 0.6 | GO:1990763 | arrestin family protein binding(GO:1990763) |
| 0.1 | 0.3 | GO:0002046 | opsin binding(GO:0002046) |
| 0.1 | 0.5 | GO:0035243 | protein-arginine omega-N symmetric methyltransferase activity(GO:0035243) |
| 0.1 | 0.3 | GO:0010465 | nerve growth factor receptor activity(GO:0010465) |
| 0.1 | 0.5 | GO:0008079 | translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079) |
| 0.1 | 2.9 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.1 | 3.7 | GO:0036002 | pre-mRNA binding(GO:0036002) |
| 0.1 | 2.0 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.1 | 1.6 | GO:0030296 | protein tyrosine kinase activator activity(GO:0030296) |
| 0.1 | 0.2 | GO:1902271 | D3 vitamins binding(GO:1902271) |
| 0.1 | 1.4 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.1 | 2.0 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.1 | 0.4 | GO:0086006 | voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006) |
| 0.1 | 0.2 | GO:0004346 | glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309) |
| 0.1 | 3.9 | GO:0018024 | histone-lysine N-methyltransferase activity(GO:0018024) |
| 0.1 | 4.2 | GO:0031491 | nucleosome binding(GO:0031491) |
| 0.0 | 2.5 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.0 | 1.8 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.0 | 1.6 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.0 | 1.2 | GO:0031005 | filamin binding(GO:0031005) |
| 0.0 | 0.7 | GO:0051864 | histone demethylase activity (H3-K36 specific)(GO:0051864) |
| 0.0 | 0.5 | GO:1990226 | histone methyltransferase binding(GO:1990226) |
| 0.0 | 1.0 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
| 0.0 | 3.7 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 0.0 | 0.3 | GO:0016802 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.0 | 1.1 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.0 | 2.2 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.0 | 0.6 | GO:0046972 | histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972) |
| 0.0 | 0.3 | GO:0016273 | arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274) |
| 0.0 | 4.7 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.0 | 0.6 | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980) |
| 0.0 | 1.1 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.0 | 1.0 | GO:0005112 | Notch binding(GO:0005112) |
| 0.0 | 0.8 | GO:0004707 | MAP kinase activity(GO:0004707) |
| 0.0 | 5.4 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 1.6 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.0 | 0.6 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
| 0.0 | 0.3 | GO:0048495 | Roundabout binding(GO:0048495) |
| 0.0 | 0.4 | GO:0060002 | plus-end directed microfilament motor activity(GO:0060002) |
| 0.0 | 1.6 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.0 | 0.3 | GO:0003835 | beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835) |
| 0.0 | 0.7 | GO:0000150 | recombinase activity(GO:0000150) |
| 0.0 | 1.0 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.0 | 1.9 | GO:0001221 | transcription cofactor binding(GO:0001221) |
| 0.0 | 0.2 | GO:0016316 | phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828) |
| 0.0 | 0.6 | GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206) |
| 0.0 | 1.1 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.0 | 0.5 | GO:0045159 | myosin II binding(GO:0045159) |
| 0.0 | 0.3 | GO:0034452 | dynactin binding(GO:0034452) |
| 0.0 | 1.6 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.0 | 0.3 | GO:0030023 | extracellular matrix constituent conferring elasticity(GO:0030023) |
| 0.0 | 0.5 | GO:0043024 | ribosomal small subunit binding(GO:0043024) |
| 0.0 | 0.2 | GO:0035800 | deubiquitinase activator activity(GO:0035800) |
| 0.0 | 0.2 | GO:0097027 | ubiquitin-protein transferase activator activity(GO:0097027) |
| 0.0 | 0.2 | GO:1990459 | transferrin receptor binding(GO:1990459) |
| 0.0 | 0.2 | GO:0001517 | N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) |
| 0.0 | 3.9 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.0 | 0.6 | GO:0008266 | poly-pyrimidine tract binding(GO:0008187) poly(U) RNA binding(GO:0008266) |
| 0.0 | 5.7 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.0 | 1.8 | GO:0005080 | protein kinase C binding(GO:0005080) |
| 0.0 | 1.5 | GO:0004407 | histone deacetylase activity(GO:0004407) |
| 0.0 | 0.3 | GO:0031419 | cobalamin binding(GO:0031419) |
| 0.0 | 0.5 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.0 | 0.4 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
| 0.0 | 0.1 | GO:1990699 | palmitoleyl hydrolase activity(GO:1990699) |
| 0.0 | 1.2 | GO:0051393 | alpha-actinin binding(GO:0051393) |
| 0.0 | 1.6 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.0 | 0.2 | GO:0004594 | pantothenate kinase activity(GO:0004594) |
| 0.0 | 2.2 | GO:0033613 | activating transcription factor binding(GO:0033613) |
| 0.0 | 0.7 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
| 0.0 | 0.9 | GO:0051959 | dynein light intermediate chain binding(GO:0051959) |
| 0.0 | 1.0 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.0 | 0.8 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.0 | 0.2 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) |
| 0.0 | 0.1 | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575) |
| 0.0 | 0.6 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.0 | 0.7 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.0 | 11.3 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.0 | 0.6 | GO:0070063 | RNA polymerase binding(GO:0070063) |
| 0.0 | 0.5 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.0 | 1.0 | GO:0016504 | peptidase activator activity(GO:0016504) |
| 0.0 | 0.4 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.0 | 0.7 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.0 | 0.2 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.0 | 0.1 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.0 | 0.6 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.0 | 0.2 | GO:0003831 | beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831) |
| 0.0 | 0.6 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
| 0.0 | 0.3 | GO:0098748 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.0 | 0.3 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
| 0.0 | 10.3 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.0 | 0.4 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.0 | 0.4 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.0 | 0.0 | GO:0005119 | smoothened binding(GO:0005119) |
| 0.0 | 1.3 | GO:0019003 | GDP binding(GO:0019003) |
| 0.0 | 3.2 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 0.6 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 0.0 | 0.7 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
| 0.0 | 0.1 | GO:0050510 | N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510) |
| 0.0 | 0.9 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
| 0.0 | 0.9 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 0.2 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
| 0.0 | 1.3 | GO:0047485 | protein N-terminus binding(GO:0047485) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.2 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 3.0 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.1 | 2.3 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.1 | 1.3 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.1 | 1.5 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.1 | 3.5 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.1 | 5.9 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 6.5 | PID FOXO PATHWAY | FoxO family signaling |
| 0.1 | 1.8 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.1 | 1.5 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
| 0.0 | 5.0 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.0 | 1.3 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.0 | 4.7 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.0 | 3.3 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.0 | 2.5 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 2.9 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 3.5 | PID P73PATHWAY | p73 transcription factor network |
| 0.0 | 3.0 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.0 | 0.8 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 2.3 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 0.5 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.0 | 1.2 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 1.1 | PID ERBB2 ERBB3 PATHWAY | ErbB2/ErbB3 signaling events |
| 0.0 | 1.2 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.0 | 0.5 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 0.5 | PID ERBB1 RECEPTOR PROXIMAL PATHWAY | EGF receptor (ErbB1) signaling pathway |
| 0.0 | 1.2 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 2.1 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.0 | 0.9 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.0 | 1.1 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.0 | 0.1 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
| 0.0 | 0.5 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.0 | 0.9 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 0.3 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.0 | 0.2 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.0 | 0.3 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.0 | 1.3 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 0.5 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 0.8 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 8.5 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.2 | 12.3 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.2 | 1.9 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |
| 0.1 | 2.8 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.1 | 1.8 | REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 0.1 | 4.8 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.1 | 3.5 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.1 | 1.7 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.1 | 6.1 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.1 | 1.6 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.1 | 1.6 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.0 | 1.5 | REACTOME ACYL CHAIN REMODELLING OF PE | Genes involved in Acyl chain remodelling of PE |
| 0.0 | 1.4 | REACTOME AMINE COMPOUND SLC TRANSPORTERS | Genes involved in Amine compound SLC transporters |
| 0.0 | 7.3 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.0 | 2.0 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 2.0 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 0.7 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.0 | 1.3 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.0 | 1.1 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.0 | 1.4 | REACTOME CELL CELL JUNCTION ORGANIZATION | Genes involved in Cell-cell junction organization |
| 0.0 | 2.9 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 0.6 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.0 | 1.2 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.0 | 0.4 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.0 | 0.3 | REACTOME INWARDLY RECTIFYING K CHANNELS | Genes involved in Inwardly rectifying K+ channels |
| 0.0 | 3.5 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 0.9 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.0 | 1.1 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.0 | 0.6 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.0 | 0.5 | REACTOME METABOLISM OF NON CODING RNA | Genes involved in Metabolism of non-coding RNA |
| 0.0 | 0.6 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.0 | 0.6 | REACTOME PROCESSING OF INTRONLESS PRE MRNAS | Genes involved in Processing of Intronless Pre-mRNAs |
| 0.0 | 1.3 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 1.8 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.0 | 1.1 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.0 | 5.0 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.0 | 0.4 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.0 | 0.3 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.0 | 0.3 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.0 | 0.2 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.0 | 0.6 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.0 | 0.2 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.0 | 0.4 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |
| 0.0 | 0.2 | REACTOME VITAMIN B5 PANTOTHENATE METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |