avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

• Motif significance table
• Sample table
• Mean activities
• All promoters sorted by FOV

• Activity table
• Activity delta table
• Regulatory interactions
• Motifs sorted by significance
• Expression table
• Download the whole report

Gene Symbol	Gene ID	Gene Info
LHX8 Links Ensembl NCBI GeneCards UniProt	ENSG00000162624.10	LIM homeobox 8

Gene	Promoter	Pearson corr. coef.	P-value	Plot
LHX8	hg19_v2_chr1_+_75594119_75594119	-0.67	1.3e-03	Click!

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Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.2	GO:0018242	protein O-linked glycosylation via serine(GO:0018242)
0.2	1.2	GO:1903786	mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound catabolic process(GO:1901377) regulation of glutathione biosynthetic process(GO:1903786) positive regulation of glutathione biosynthetic process(GO:1903788)
0.2	0.5	GO:0033024	mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025) regulation of mast cell proliferation(GO:0070666) positive regulation of mast cell proliferation(GO:0070668)
0.1	0.6	GO:1904793	glial cell fate determination(GO:0007403) canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation(GO:0061324) regulation of chromatin-mediated maintenance of transcription(GO:1904499) positive regulation of chromatin-mediated maintenance of transcription(GO:1904501) regulation of euchromatin binding(GO:1904793)
0.1	0.4	GO:2000097	regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.1	0.5	GO:0021502	neural fold elevation formation(GO:0021502) elastin metabolic process(GO:0051541) epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030) positive regulation of chemokine-mediated signaling pathway(GO:0070101)
0.1	0.5	GO:0031291	Ran protein signal transduction(GO:0031291)
0.1	0.2	GO:0060489	orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.1	0.4	GO:2000638	regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.1	0.2	GO:0033693	neurofilament bundle assembly(GO:0033693)
0.1	1.0	GO:0008090	retrograde axonal transport(GO:0008090)
0.1	0.3	GO:0034334	adherens junction maintenance(GO:0034334)
0.1	0.5	GO:0071494	cellular response to UV-C(GO:0071494)
0.1	0.4	GO:1990564	protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.0	0.6	GO:0035986	senescence-associated heterochromatin focus assembly(GO:0035986)
0.0	0.1	GO:0035359	negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
0.0	0.6	GO:0018243	protein O-linked glycosylation via threonine(GO:0018243)
0.0	0.1	GO:0061386	closure of optic fissure(GO:0061386)
0.0	0.1	GO:0002589	regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590) positive regulation of iron ion transport(GO:0034758) positive regulation of iron ion transmembrane transport(GO:0034761) regulation of iron ion import(GO:1900390) regulation of ferrous iron import into cell(GO:1903989) positive regulation of ferrous iron import into cell(GO:1903991) regulation of ferrous iron binding(GO:1904432) positive regulation of ferrous iron binding(GO:1904434) regulation of transferrin receptor binding(GO:1904435) positive regulation of transferrin receptor binding(GO:1904437) regulation of ferrous iron import across plasma membrane(GO:1904438) positive regulation of ferrous iron import across plasma membrane(GO:1904440) response to iron ion starvation(GO:1990641)
0.0	0.3	GO:1904207	regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.0	1.2	GO:0030208	dermatan sulfate biosynthetic process(GO:0030208)
0.0	0.2	GO:0044501	modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
0.0	0.2	GO:0032764	negative regulation of mast cell cytokine production(GO:0032764) negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.0	0.1	GO:0034059	response to anoxia(GO:0034059)
0.0	0.2	GO:2000661	positive regulation of interleukin-1-mediated signaling pathway(GO:2000661)
0.0	0.1	GO:0051037	regulation of transcription involved in meiotic cell cycle(GO:0051037)
0.0	0.8	GO:0090110	cargo loading into COPII-coated vesicle(GO:0090110)
0.0	0.3	GO:0071896	protein localization to adherens junction(GO:0071896)
0.0	0.2	GO:0042539	hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.0	0.1	GO:0002316	follicular B cell differentiation(GO:0002316)
0.0	0.4	GO:2000042	negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0	0.4	GO:0021759	globus pallidus development(GO:0021759)
0.0	0.1	GO:0097045	phosphatidylserine exposure on blood platelet(GO:0097045)
0.0	0.1	GO:0060424	foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492)
0.0	0.2	GO:2000538	regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.0	0.2	GO:0098881	exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967)
0.0	0.1	GO:0061015	snRNA import into nucleus(GO:0061015)
0.0	0.2	GO:1901297	positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.0	0.1	GO:2000301	negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0	0.2	GO:0090063	positive regulation of microtubule nucleation(GO:0090063)
0.0	2.1	GO:0016266	O-glycan processing(GO:0016266)
0.0	0.6	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.0	0.3	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0	0.4	GO:0021670	lateral ventricle development(GO:0021670)
0.0	0.1	GO:0006172	ADP biosynthetic process(GO:0006172)
0.0	0.1	GO:0018352	protein-pyridoxal-5-phosphate linkage(GO:0018352)
0.0	0.0	GO:0048213	Golgi vesicle prefusion complex stabilization(GO:0048213)
0.0	0.1	GO:0070980	biphenyl catabolic process(GO:0070980)
0.0	0.1	GO:1902990	DNA replication, removal of RNA primer(GO:0043137) mitotic telomere maintenance via semi-conservative replication(GO:1902990)
0.0	0.1	GO:0006422	aspartyl-tRNA aminoacylation(GO:0006422)
0.0	0.2	GO:0038007	netrin-activated signaling pathway(GO:0038007)
0.0	0.1	GO:0071492	cellular response to UV-A(GO:0071492)
0.0	0.3	GO:0097034	mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0	0.2	GO:0051028	mRNA transport(GO:0051028)
0.0	0.0	GO:0032097	positive regulation of response to food(GO:0032097) positive regulation of appetite(GO:0032100)
0.0	0.1	GO:0006189	'de novo' IMP biosynthetic process(GO:0006189)
0.0	0.1	GO:0002933	lipid hydroxylation(GO:0002933)

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	1.0	GO:0031673	H zone(GO:0031673)
0.1	0.4	GO:0005595	collagen type XII trimer(GO:0005595)
0.1	0.4	GO:0005879	axonemal microtubule(GO:0005879)
0.1	0.6	GO:0070369	Scrib-APC-beta-catenin complex(GO:0034750) beta-catenin-TCF7L2 complex(GO:0070369)
0.1	0.2	GO:0060187	cell pole(GO:0060187)
0.1	0.2	GO:1990796	photoreceptor cell terminal bouton(GO:1990796)
0.1	0.4	GO:1990452	Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0	0.6	GO:0035985	senescence-associated heterochromatin focus(GO:0035985)
0.0	0.3	GO:0043541	UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.0	0.8	GO:0030127	COPII vesicle coat(GO:0030127)
0.0	0.4	GO:0036449	microtubule minus-end(GO:0036449)
0.0	0.0	GO:0017119	Golgi transport complex(GO:0017119)
0.0	0.3	GO:0097025	MPP7-DLG1-LIN7 complex(GO:0097025)
0.0	0.2	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0	0.5	GO:0097431	mitotic spindle pole(GO:0097431)
0.0	0.3	GO:0033269	internode region of axon(GO:0033269)
0.0	0.3	GO:0005744	mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.0	0.1	GO:1990357	terminal web(GO:1990357)
0.0	0.5	GO:0031528	microvillus membrane(GO:0031528)
0.0	0.2	GO:0005883	neurofilament(GO:0005883)
0.0	0.2	GO:0005869	dynactin complex(GO:0005869)
0.0	0.2	GO:0000940	condensed chromosome outer kinetochore(GO:0000940)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	1.2	GO:0047757	chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.1	0.4	GO:0031862	prostanoid receptor binding(GO:0031862)
0.1	0.5	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.1	0.2	GO:0060001	minus-end directed microfilament motor activity(GO:0060001)
0.1	0.4	GO:0061649	ubiquitinated histone binding(GO:0061649)
0.1	0.3	GO:0050509	N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity(GO:0050509)
0.1	0.2	GO:0030158	protein xylosyltransferase activity(GO:0030158)
0.1	2.3	GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0	0.4	GO:0050816	phosphothreonine binding(GO:0050816)
0.0	0.2	GO:0004909	interleukin-1, Type I, activating receptor activity(GO:0004909)
0.0	0.4	GO:0030020	extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0	0.2	GO:0043423	3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0	0.1	GO:0033149	FFAT motif binding(GO:0033149)
0.0	0.6	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0	0.5	GO:0001161	intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.0	0.2	GO:0050544	arachidonic acid binding(GO:0050544)
0.0	0.6	GO:0045294	alpha-catenin binding(GO:0045294)
0.0	1.0	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.5	GO:0015467	G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0	0.9	GO:0070840	dynein complex binding(GO:0070840)
0.0	0.2	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.0	0.1	GO:0035473	lipase binding(GO:0035473)
0.0	0.6	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	1.2	GO:0001221	transcription cofactor binding(GO:0001221)
0.0	0.1	GO:0004095	carnitine O-palmitoyltransferase activity(GO:0004095)
0.0	0.1	GO:0030881	beta-2-microglobulin binding(GO:0030881)
0.0	0.1	GO:0072542	protein phosphatase activator activity(GO:0072542)
0.0	0.5	GO:0003887	DNA-directed DNA polymerase activity(GO:0003887)
0.0	0.2	GO:0022820	potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0	0.0	GO:0016838	carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.0	0.5	GO:0035035	histone acetyltransferase binding(GO:0035035)
0.0	0.1	GO:0047006	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006)

Gene overrepresentation in C2:CP category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.1	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0	0.6	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.0	0.4	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.6	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0	0.8	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0	2.2	REACTOME O LINKED GLYCOSYLATION OF MUCINS	Genes involved in O-linked glycosylation of mucins
0.0	0.5	REACTOME REGULATION OF KIT SIGNALING	Genes involved in Regulation of KIT signaling
0.0	0.1	REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION	Genes involved in Influenza Viral RNA Transcription and Replication
0.0	0.7	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	1.2	REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM	Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.0	0.5	REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0	0.3	REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0	0.3	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis