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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for LMX1B_MNX1_RAX2
Z-value: 1.88
Motif logo
Transcription factors associated with LMX1B_MNX1_RAX2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
LMX1B
|
ENSG00000136944.13 | LIM homeobox transcription factor 1 beta |
|
MNX1
|
ENSG00000130675.10 | motor neuron and pancreas homeobox 1 |
|
RAX2
|
ENSG00000173976.11 | retina and anterior neural fold homeobox 2 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MNX1 | hg19_v2_chr7_-_156803329_156803362 | -0.94 | 1.1e-09 | Click! |
| LMX1B | hg19_v2_chr9_+_129376722_129376748 | -0.94 | 1.4e-09 | Click! |
| RAX2 | hg19_v2_chr19_-_3772209_3772236 | 0.12 | 6.2e-01 | Click! |
Activity profile of LMX1B_MNX1_RAX2 motif
Sorted Z-values of LMX1B_MNX1_RAX2 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of LMX1B_MNX1_RAX2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 3.8 | GO:0060489 | orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490) |
| 1.0 | 8.9 | GO:1900623 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 0.7 | 2.0 | GO:0070175 | positive regulation of enamel mineralization(GO:0070175) |
| 0.6 | 22.2 | GO:0032331 | negative regulation of chondrocyte differentiation(GO:0032331) |
| 0.6 | 2.9 | GO:0060005 | vestibular reflex(GO:0060005) |
| 0.5 | 2.3 | GO:0042663 | regulation of endodermal cell fate specification(GO:0042663) |
| 0.4 | 1.7 | GO:0061357 | positive regulation of Wnt protein secretion(GO:0061357) |
| 0.3 | 1.4 | GO:1903045 | neural crest cell migration involved in sympathetic nervous system development(GO:1903045) |
| 0.3 | 8.0 | GO:0035589 | G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589) |
| 0.3 | 1.2 | GO:0002384 | hepatic immune response(GO:0002384) |
| 0.3 | 2.3 | GO:1905066 | positive regulation of ephrin receptor signaling pathway(GO:1901189) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068) |
| 0.3 | 0.8 | GO:0060738 | epithelial-mesenchymal signaling involved in prostate gland development(GO:0060738) |
| 0.3 | 4.3 | GO:0043249 | erythrocyte maturation(GO:0043249) |
| 0.3 | 3.3 | GO:0048706 | embryonic skeletal system development(GO:0048706) |
| 0.3 | 0.8 | GO:0002644 | negative regulation of tolerance induction(GO:0002644) positive regulation of interleukin-4 biosynthetic process(GO:0045404) |
| 0.2 | 0.7 | GO:1903774 | positive regulation of viral budding via host ESCRT complex(GO:1903774) |
| 0.2 | 1.1 | GO:0035513 | oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553) |
| 0.2 | 1.4 | GO:0061484 | hematopoietic stem cell homeostasis(GO:0061484) |
| 0.2 | 4.3 | GO:0097264 | self proteolysis(GO:0097264) |
| 0.2 | 0.9 | GO:0021827 | cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) |
| 0.2 | 2.5 | GO:1904352 | positive regulation of protein catabolic process in the vacuole(GO:1904352) |
| 0.2 | 2.7 | GO:0097475 | motor neuron migration(GO:0097475) |
| 0.2 | 12.0 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.1 | 2.0 | GO:0034058 | endosomal vesicle fusion(GO:0034058) |
| 0.1 | 3.3 | GO:1900745 | positive regulation of p38MAPK cascade(GO:1900745) |
| 0.1 | 0.7 | GO:0002501 | peptide antigen assembly with MHC protein complex(GO:0002501) |
| 0.1 | 0.4 | GO:0006429 | glutaminyl-tRNA aminoacylation(GO:0006425) leucyl-tRNA aminoacylation(GO:0006429) |
| 0.1 | 1.4 | GO:0021759 | globus pallidus development(GO:0021759) |
| 0.1 | 0.4 | GO:0046338 | phosphatidylethanolamine catabolic process(GO:0046338) |
| 0.1 | 0.3 | GO:0097187 | dentinogenesis(GO:0097187) regulation of sodium-dependent phosphate transport(GO:2000118) |
| 0.1 | 0.5 | GO:0048842 | positive regulation of axon extension involved in axon guidance(GO:0048842) |
| 0.1 | 0.7 | GO:0032468 | Golgi calcium ion homeostasis(GO:0032468) |
| 0.1 | 0.3 | GO:0072356 | chromosome passenger complex localization to kinetochore(GO:0072356) |
| 0.1 | 0.4 | GO:2001224 | positive regulation of neuron migration(GO:2001224) |
| 0.1 | 0.5 | GO:1904383 | response to sodium phosphate(GO:1904383) |
| 0.1 | 0.2 | GO:1904017 | cellular response to Thyroglobulin triiodothyronine(GO:1904017) |
| 0.1 | 0.2 | GO:0006667 | sphinganine metabolic process(GO:0006667) |
| 0.1 | 0.4 | GO:0035063 | nuclear speck organization(GO:0035063) |
| 0.1 | 1.9 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.1 | 3.8 | GO:0007274 | neuromuscular synaptic transmission(GO:0007274) |
| 0.1 | 0.9 | GO:0061734 | parkin-mediated mitophagy in response to mitochondrial depolarization(GO:0061734) |
| 0.1 | 1.3 | GO:0071578 | zinc II ion transmembrane import(GO:0071578) |
| 0.1 | 1.9 | GO:0071447 | cellular response to hydroperoxide(GO:0071447) |
| 0.1 | 0.8 | GO:0061669 | spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814) |
| 0.1 | 1.6 | GO:0071481 | cellular response to X-ray(GO:0071481) |
| 0.1 | 1.2 | GO:0072189 | ureter development(GO:0072189) |
| 0.1 | 2.0 | GO:0009954 | proximal/distal pattern formation(GO:0009954) |
| 0.1 | 1.3 | GO:0007379 | segment specification(GO:0007379) |
| 0.1 | 0.9 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
| 0.1 | 6.6 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.1 | 0.8 | GO:0007258 | JUN phosphorylation(GO:0007258) |
| 0.1 | 0.4 | GO:0060025 | primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185) regulation of synaptic activity(GO:0060025) |
| 0.1 | 12.5 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.1 | 1.4 | GO:0061049 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.1 | 1.3 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.1 | 0.2 | GO:0043438 | acetoacetic acid metabolic process(GO:0043438) |
| 0.1 | 0.4 | GO:1902261 | positive regulation of delayed rectifier potassium channel activity(GO:1902261) |
| 0.1 | 1.4 | GO:0003334 | keratinocyte development(GO:0003334) |
| 0.1 | 2.3 | GO:0031954 | positive regulation of protein autophosphorylation(GO:0031954) |
| 0.1 | 1.8 | GO:0045730 | respiratory burst(GO:0045730) |
| 0.0 | 0.7 | GO:0044341 | sodium-dependent phosphate transport(GO:0044341) |
| 0.0 | 1.1 | GO:0007064 | mitotic sister chromatid cohesion(GO:0007064) |
| 0.0 | 0.5 | GO:0043950 | positive regulation of cAMP-mediated signaling(GO:0043950) |
| 0.0 | 2.3 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 0.0 | 0.2 | GO:0072502 | cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502) |
| 0.0 | 0.9 | GO:0086016 | AV node cell action potential(GO:0086016) AV node cell to bundle of His cell signaling(GO:0086027) |
| 0.0 | 0.0 | GO:0021847 | ventricular zone neuroblast division(GO:0021847) |
| 0.0 | 0.2 | GO:0006540 | glutamate decarboxylation to succinate(GO:0006540) |
| 0.0 | 0.5 | GO:2000623 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623) |
| 0.0 | 0.1 | GO:0008616 | queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116) |
| 0.0 | 3.0 | GO:0061001 | regulation of dendritic spine morphogenesis(GO:0061001) |
| 0.0 | 0.2 | GO:0014722 | regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722) regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809) |
| 0.0 | 0.7 | GO:1900121 | negative regulation of receptor binding(GO:1900121) |
| 0.0 | 2.9 | GO:0036092 | phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092) |
| 0.0 | 1.7 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
| 0.0 | 0.3 | GO:1990253 | cellular response to leucine starvation(GO:1990253) |
| 0.0 | 3.1 | GO:0032508 | DNA duplex unwinding(GO:0032508) |
| 0.0 | 1.2 | GO:0051131 | chaperone-mediated protein complex assembly(GO:0051131) |
| 0.0 | 0.1 | GO:0051799 | negative regulation of hair follicle development(GO:0051799) |
| 0.0 | 0.1 | GO:1904899 | regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922) |
| 0.0 | 0.2 | GO:0021779 | oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780) |
| 0.0 | 0.2 | GO:0009449 | gamma-aminobutyric acid biosynthetic process(GO:0009449) |
| 0.0 | 0.2 | GO:0002933 | lipid hydroxylation(GO:0002933) |
| 0.0 | 0.5 | GO:0006183 | GTP biosynthetic process(GO:0006183) |
| 0.0 | 1.4 | GO:0006458 | 'de novo' protein folding(GO:0006458) |
| 0.0 | 0.2 | GO:0016078 | tRNA catabolic process(GO:0016078) |
| 0.0 | 0.4 | GO:0007084 | mitotic nuclear envelope reassembly(GO:0007084) |
| 0.0 | 0.4 | GO:0070072 | proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072) |
| 0.0 | 0.7 | GO:0001701 | in utero embryonic development(GO:0001701) |
| 0.0 | 0.7 | GO:0002230 | positive regulation of defense response to virus by host(GO:0002230) |
| 0.0 | 0.3 | GO:0030299 | intestinal cholesterol absorption(GO:0030299) intestinal lipid absorption(GO:0098856) |
| 0.0 | 0.3 | GO:0035873 | lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) |
| 0.0 | 10.4 | GO:0018105 | peptidyl-serine phosphorylation(GO:0018105) |
| 0.0 | 0.6 | GO:0050860 | negative regulation of T cell receptor signaling pathway(GO:0050860) |
| 0.0 | 0.1 | GO:0035726 | common myeloid progenitor cell proliferation(GO:0035726) |
| 0.0 | 0.1 | GO:0044026 | DNA hypermethylation(GO:0044026) |
| 0.0 | 0.2 | GO:0015889 | cobalamin transport(GO:0015889) |
| 0.0 | 0.2 | GO:0021615 | glossopharyngeal nerve morphogenesis(GO:0021615) |
| 0.0 | 2.0 | GO:0006501 | C-terminal protein lipidation(GO:0006501) |
| 0.0 | 0.3 | GO:0030277 | maintenance of gastrointestinal epithelium(GO:0030277) |
| 0.0 | 0.5 | GO:0045898 | regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898) |
| 0.0 | 0.8 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.0 | 0.1 | GO:0002018 | renin-angiotensin regulation of aldosterone production(GO:0002018) |
| 0.0 | 0.3 | GO:0015825 | L-serine transport(GO:0015825) |
| 0.0 | 0.3 | GO:0035563 | positive regulation of chromatin binding(GO:0035563) |
| 0.0 | 0.9 | GO:1904893 | negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893) |
| 0.0 | 0.4 | GO:0046039 | GTP metabolic process(GO:0046039) |
| 0.0 | 7.1 | GO:0051056 | regulation of small GTPase mediated signal transduction(GO:0051056) |
| 0.0 | 1.0 | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) |
| 0.0 | 2.4 | GO:0030308 | negative regulation of cell growth(GO:0030308) |
| 0.0 | 0.6 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 8.9 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 1.0 | 3.8 | GO:0060187 | cell pole(GO:0060187) |
| 0.6 | 3.4 | GO:0045272 | plasma membrane respiratory chain complex I(GO:0045272) |
| 0.2 | 1.2 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 0.2 | 2.2 | GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex(GO:0002193) |
| 0.2 | 3.2 | GO:0030478 | actin cap(GO:0030478) |
| 0.2 | 1.6 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.2 | 1.8 | GO:0032010 | phagolysosome(GO:0032010) |
| 0.1 | 6.7 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.1 | 0.9 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 0.1 | 2.7 | GO:0071565 | nBAF complex(GO:0071565) |
| 0.1 | 0.7 | GO:0042824 | MHC class I peptide loading complex(GO:0042824) |
| 0.1 | 1.3 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.1 | 0.2 | GO:0045095 | keratin filament(GO:0045095) |
| 0.1 | 1.9 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.1 | 1.4 | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671) |
| 0.1 | 0.5 | GO:1990578 | perinuclear endoplasmic reticulum membrane(GO:1990578) |
| 0.1 | 2.6 | GO:0030057 | desmosome(GO:0030057) |
| 0.1 | 0.4 | GO:0008282 | ATP-sensitive potassium channel complex(GO:0008282) |
| 0.1 | 0.3 | GO:1990131 | Gtr1-Gtr2 GTPase complex(GO:1990131) |
| 0.0 | 0.7 | GO:0001673 | male germ cell nucleus(GO:0001673) |
| 0.0 | 1.7 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.0 | 11.0 | GO:0043197 | dendritic spine(GO:0043197) |
| 0.0 | 1.3 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.0 | 0.7 | GO:0000815 | ESCRT III complex(GO:0000815) |
| 0.0 | 0.8 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.0 | 2.4 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 1.3 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 0.2 | GO:0031232 | extrinsic component of external side of plasma membrane(GO:0031232) |
| 0.0 | 0.2 | GO:0014802 | terminal cisterna(GO:0014802) |
| 0.0 | 0.2 | GO:0045009 | melanosome membrane(GO:0033162) chitosome(GO:0045009) |
| 0.0 | 8.2 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 0.4 | GO:0014701 | junctional sarcoplasmic reticulum membrane(GO:0014701) |
| 0.0 | 0.2 | GO:0000172 | ribonuclease MRP complex(GO:0000172) |
| 0.0 | 0.9 | GO:0031306 | intrinsic component of mitochondrial outer membrane(GO:0031306) |
| 0.0 | 0.5 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.0 | 2.8 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 1.0 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.0 | 0.5 | GO:0044232 | organelle membrane contact site(GO:0044232) |
| 0.0 | 0.7 | GO:0005605 | basal lamina(GO:0005605) |
| 0.0 | 0.3 | GO:0097427 | microtubule bundle(GO:0097427) |
| 0.0 | 1.0 | GO:0005865 | striated muscle thin filament(GO:0005865) |
| 0.0 | 0.4 | GO:0000177 | cytoplasmic exosome (RNase complex)(GO:0000177) |
| 0.0 | 0.2 | GO:0061202 | clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202) |
| 0.0 | 0.2 | GO:0017059 | serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211) |
| 0.0 | 0.4 | GO:0097381 | photoreceptor disc membrane(GO:0097381) |
| 0.0 | 0.2 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.0 | 3.4 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.0 | 0.3 | GO:1990023 | mitotic spindle midzone(GO:1990023) |
| 0.0 | 1.9 | GO:0000794 | condensed nuclear chromosome(GO:0000794) |
| 0.0 | 2.2 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.0 | 0.8 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.0 | 0.1 | GO:0035068 | micro-ribonucleoprotein complex(GO:0035068) |
| 0.0 | 31.9 | GO:0005794 | Golgi apparatus(GO:0005794) |
| 0.0 | 0.1 | GO:0097504 | Gemini of coiled bodies(GO:0097504) |
| 0.0 | 3.0 | GO:0005730 | nucleolus(GO:0005730) |
| 0.0 | 0.4 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 22.2 | GO:0051428 | peptide hormone receptor binding(GO:0051428) |
| 0.4 | 2.4 | GO:0052828 | phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828) |
| 0.4 | 1.2 | GO:0070119 | ciliary neurotrophic factor binding(GO:0070119) |
| 0.3 | 8.0 | GO:0001608 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.2 | 2.3 | GO:0045545 | syndecan binding(GO:0045545) |
| 0.2 | 1.6 | GO:0042030 | ATPase inhibitor activity(GO:0042030) |
| 0.2 | 1.1 | GO:0035515 | oxidative RNA demethylase activity(GO:0035515) |
| 0.2 | 4.0 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.2 | 1.0 | GO:0031852 | mu-type opioid receptor binding(GO:0031852) |
| 0.2 | 12.4 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.2 | 7.6 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.2 | 1.4 | GO:0000285 | 1-phosphatidylinositol-3-phosphate 5-kinase activity(GO:0000285) |
| 0.2 | 6.4 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.1 | 0.5 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 0.1 | 0.4 | GO:0004823 | glutamine-tRNA ligase activity(GO:0004819) leucine-tRNA ligase activity(GO:0004823) |
| 0.1 | 0.8 | GO:1990254 | keratin filament binding(GO:1990254) |
| 0.1 | 0.9 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 0.1 | 0.4 | GO:0008281 | sulfonylurea receptor activity(GO:0008281) |
| 0.1 | 0.9 | GO:0086006 | voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006) |
| 0.1 | 1.8 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 0.1 | 3.2 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.1 | 0.7 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.1 | 0.9 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
| 0.1 | 1.7 | GO:0000150 | recombinase activity(GO:0000150) |
| 0.1 | 0.7 | GO:0015319 | sodium:inorganic phosphate symporter activity(GO:0015319) |
| 0.1 | 4.6 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.1 | 1.6 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.1 | 1.6 | GO:0044213 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213) |
| 0.1 | 0.8 | GO:0016909 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
| 0.1 | 0.2 | GO:0000822 | inositol hexakisphosphate binding(GO:0000822) |
| 0.1 | 0.2 | GO:0016716 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716) |
| 0.1 | 3.1 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.0 | 0.5 | GO:0005168 | neurotrophin TRKA receptor binding(GO:0005168) |
| 0.0 | 0.4 | GO:0016812 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812) |
| 0.0 | 0.3 | GO:0015321 | sodium-dependent phosphate transmembrane transporter activity(GO:0015321) |
| 0.0 | 0.2 | GO:0008532 | N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532) |
| 0.0 | 5.0 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.0 | 1.4 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.0 | 2.4 | GO:0008094 | DNA-dependent ATPase activity(GO:0008094) |
| 0.0 | 0.6 | GO:0016018 | cyclosporin A binding(GO:0016018) |
| 0.0 | 1.1 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.0 | 0.2 | GO:0004351 | glutamate decarboxylase activity(GO:0004351) |
| 0.0 | 0.2 | GO:0033695 | oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875) |
| 0.0 | 1.5 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.0 | 1.0 | GO:0015002 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 0.1 | GO:0008479 | queuine tRNA-ribosyltransferase activity(GO:0008479) |
| 0.0 | 8.6 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 1.3 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 0.2 | GO:0004758 | serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454) |
| 0.0 | 0.4 | GO:0048156 | tau protein binding(GO:0048156) |
| 0.0 | 9.8 | GO:0000287 | magnesium ion binding(GO:0000287) |
| 0.0 | 0.4 | GO:0047499 | calcium-independent phospholipase A2 activity(GO:0047499) |
| 0.0 | 0.3 | GO:0003691 | double-stranded telomeric DNA binding(GO:0003691) |
| 0.0 | 8.3 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 1.5 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.0 | 0.2 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.0 | 0.3 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
| 0.0 | 0.7 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.0 | 0.5 | GO:0008494 | translation activator activity(GO:0008494) |
| 0.0 | 20.7 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.0 | 3.2 | GO:0047485 | protein N-terminus binding(GO:0047485) |
| 0.0 | 0.4 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.0 | 0.4 | GO:0043495 | protein anchor(GO:0043495) |
| 0.0 | 0.1 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.0 | 0.6 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
| 0.0 | 1.7 | GO:0016491 | oxidoreductase activity(GO:0016491) |
| 0.0 | 7.9 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 0.3 | GO:0015194 | L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889) |
| 0.0 | 0.8 | GO:0015026 | coreceptor activity(GO:0015026) |
| 0.0 | 0.1 | GO:0004591 | oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591) thiamine pyrophosphate binding(GO:0030976) |
| 0.0 | 0.3 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.0 | 0.1 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 22.8 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.3 | 10.1 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.1 | 4.6 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.0 | 3.1 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 2.2 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.0 | 2.3 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.0 | 4.0 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 2.3 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.0 | 4.0 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 2.2 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 1.9 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 6.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 1.7 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 1.8 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 0.7 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 1.8 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 0.8 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.0 | 0.4 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 0.8 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 0.9 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 0.2 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 0.5 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 8.9 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.2 | 4.0 | REACTOME ERKS ARE INACTIVATED | Genes involved in ERKs are inactivated |
| 0.2 | 9.8 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.1 | 19.4 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.1 | 2.6 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.1 | 2.4 | REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.1 | 2.2 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.1 | 6.6 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.1 | 1.2 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.1 | 1.4 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.0 | 0.7 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.0 | 0.5 | REACTOME DSCAM INTERACTIONS | Genes involved in DSCAM interactions |
| 0.0 | 0.9 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.0 | 0.8 | REACTOME CD28 DEPENDENT VAV1 PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
| 0.0 | 1.3 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 2.5 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 1.8 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.0 | 3.1 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 0.8 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.0 | 3.0 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 2.0 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.0 | 0.6 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.0 | 0.7 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.0 | 0.5 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.0 | 0.4 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.0 | 4.2 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 0.3 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.0 | 0.1 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.0 | 0.2 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.0 | 0.4 | REACTOME INWARDLY RECTIFYING K CHANNELS | Genes involved in Inwardly rectifying K+ channels |