ISMARA results: MAF

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for MAF_NRL

Z-value: 0.54

Motif logo

Transcription factors associated with MAF_NRL

Gene Symbol	Gene ID	Gene Info
MAF Ensembl NCBI GeneCards UniProt	ENSG00000178573.6	MAF bZIP transcription factor
NRL Ensembl NCBI GeneCards UniProt	ENSG00000129535.8	neural retina leucine zipper

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NRL	hg19_v2_chr14_-_24584138_24584223	0.45	4.6e-02	Click!
MAF	hg19_v2_chr16_-_79634595_79634620	-0.26	2.7e-01	Click!

Activity profile of MAF_NRL motif

Sorted Z-values of MAF_NRL motif

No targets for MAF_NRL

Network of associatons between targets according to the STRING database.

First level regulatory network of MAF_NRL

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.3	GO:0031915	positive regulation of synaptic plasticity(GO:0031915)
0.1	0.7	GO:0021842	directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.1	0.6	GO:2000809	positive regulation of synaptic vesicle clustering(GO:2000809)
0.1	0.5	GO:0010900	negative regulation of phosphatidylcholine catabolic process(GO:0010900)
0.1	0.5	GO:0050653	chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
0.0	0.5	GO:0043402	glucocorticoid mediated signaling pathway(GO:0043402)
0.1	0.4	GO:0046725	negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308)
0.1	0.4	GO:0048691	modulation by virus of host transcription(GO:0019056) positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026)
0.1	0.4	GO:0006001	fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.1	0.4	GO:1903615	regulation of protein tyrosine phosphatase activity(GO:1903613) positive regulation of protein tyrosine phosphatase activity(GO:1903615)

Showing 1 to 10 of 100 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.3	GO:0070033	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.1	1.0	GO:0016012	sarcoglycan complex(GO:0016012)
0.0	0.8	GO:0005916	fascia adherens(GO:0005916)
0.0	0.7	GO:0030673	axolemma(GO:0030673)
0.0	0.5	GO:0042627	chylomicron(GO:0042627)
0.1	0.4	GO:1902912	pyruvate kinase complex(GO:1902912)
0.1	0.4	GO:0031262	Ndc80 complex(GO:0031262)
0.0	0.4	GO:0005922	connexon complex(GO:0005922)
0.0	0.3	GO:0000172	ribonuclease MRP complex(GO:0000172)
0.0	0.3	GO:0070436	Grb2-EGFR complex(GO:0070436)

Showing 1 to 10 of 40 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.3	GO:0017075	syntaxin-1 binding(GO:0017075)
0.0	1.0	GO:0001786	phosphatidylserine binding(GO:0001786)
0.0	0.8	GO:0045294	alpha-catenin binding(GO:0045294)
0.1	0.7	GO:0005176	ErbB-2 class receptor binding(GO:0005176)
0.1	0.5	GO:0008955	peptidoglycan glycosyltransferase activity(GO:0008955)
0.1	0.5	GO:0038051	glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.1	0.5	GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.1	0.4	GO:0004743	pyruvate kinase activity(GO:0004743)
0.1	0.4	GO:0031752	D5 dopamine receptor binding(GO:0031752)
0.0	0.4	GO:0018479	benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)

Showing 1 to 10 of 68 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
0.7	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.6	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.4	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.4	PID S1P S1P4 PATHWAY	S1P4 pathway

Showing 1 to 4 of 4 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Total log-likelihood	Term	Description
0.8	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.5	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.4	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.4	REACTOME REGULATION OF IFNA SIGNALING	Genes involved in Regulation of IFNA signaling
0.3	REACTOME SOS MEDIATED SIGNALLING	Genes involved in SOS-mediated signalling
0.2	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.1	REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR	Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor

Showing 1 to 7 of 7 entries

Results for MAF_NRL

Z-value: 0.54

Motif logo

Transcription factors associated with MAF_NRL

Activity-expression correlation:

Activity profile of MAF_NRL motif

Sorted Z-values of MAF_NRL motif

No targets for MAF_NRL

Network of associatons between targets according to the STRING database.

First level regulatory network of MAF_NRL

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: