ISMARA results: MBD2

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for MBD2

Z-value: 1.57

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Transcription factors associated with MBD2

Gene Symbol	Gene ID	Gene Info
MBD2 Ensembl NCBI GeneCards UniProt	ENSG00000134046.7	methyl-CpG binding domain protein 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
MBD2	hg19_v2_chr18_-_51750948_51751059	-0.60	4.7e-03	Click!

Activity profile of MBD2 motif

Sorted Z-values of MBD2 motif

No targets for MBD2

Network of associatons between targets according to the STRING database.

First level regulatory network of MBD2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.1	GO:0042035	regulation of cytokine biosynthetic process(GO:0042035)
0.6	1.9	GO:0021919	BMP signaling pathway involved in spinal cord dorsal/ventral patterning(GO:0021919)
0.6	1.8	GO:0060915	fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow(GO:0035602) fibroblast growth factor receptor signaling pathway involved in hemopoiesis(GO:0035603) fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow(GO:0035604) fibroblast growth factor receptor signaling pathway involved in mammary gland specification(GO:0060595) mammary gland bud formation(GO:0060615) branch elongation involved in salivary gland morphogenesis(GO:0060667) mesenchymal cell differentiation involved in lung development(GO:0060915)
0.0	1.8	GO:0050885	neuromuscular process controlling balance(GO:0050885)
0.1	1.5	GO:0070934	CRD-mediated mRNA stabilization(GO:0070934)
0.0	1.5	GO:0031643	positive regulation of myelination(GO:0031643)
0.2	1.4	GO:1900220	semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220)
0.1	1.4	GO:0070459	prolactin secretion(GO:0070459)
0.0	1.4	GO:0035767	endothelial cell chemotaxis(GO:0035767)
0.0	1.4	GO:0050766	positive regulation of phagocytosis(GO:0050766)

Showing 1 to 10 of 159 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.4	GO:0099501	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0	1.9	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.1	1.5	GO:0071204	histone pre-mRNA 3'end processing complex(GO:0071204)
0.0	1.5	GO:0016581	NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1	1.4	GO:0002116	semaphorin receptor complex(GO:0002116)
0.0	1.4	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.3	1.1	GO:0008043	intracellular ferritin complex(GO:0008043) ferritin complex(GO:0070288)
0.1	1.1	GO:0042612	MHC class I protein complex(GO:0042612)
0.3	1.0	GO:0072563	endothelial microparticle(GO:0072563)
0.1	1.0	GO:0043020	NADPH oxidase complex(GO:0043020)

Showing 1 to 10 of 56 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.6	GO:0004407	histone deacetylase activity(GO:0004407)
0.0	2.2	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	2.1	GO:0043425	bHLH transcription factor binding(GO:0043425)
0.2	1.9	GO:0045545	syndecan binding(GO:0045545)
0.0	1.9	GO:0004712	protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1	1.8	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.1	1.8	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	1.6	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1	1.3	GO:0005537	mannose binding(GO:0005537)
0.2	1.2	GO:0000179	rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)

Showing 1 to 10 of 94 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
2.3	PID FGF PATHWAY	FGF signaling pathway
1.8	PID PTP1B PATHWAY	Signaling events mediated by PTP1B
1.6	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.8	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.8	PID BMP PATHWAY	BMP receptor signaling
0.8	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.7	PID EPHB FWD PATHWAY	EPHB forward signaling
0.6	PID MYC PATHWAY	C-MYC pathway
0.5	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.5	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin

Showing 1 to 10 of 16 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.9	REACTOME FGFR2C LIGAND BINDING AND ACTIVATION	Genes involved in FGFR2c ligand binding and activation
0.1	1.2	REACTOME SEROTONIN RECEPTORS	Genes involved in Serotonin receptors
0.0	1.2	REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY	Genes involved in Adenylate cyclase inhibitory pathway
0.1	1.1	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.0	1.1	REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS	Genes involved in Golgi Associated Vesicle Biogenesis
0.0	0.8	REACTOME INITIAL TRIGGERING OF COMPLEMENT	Genes involved in Initial triggering of complement
0.0	0.8	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0	0.7	REACTOME CTNNB1 PHOSPHORYLATION CASCADE	Genes involved in Beta-catenin phosphorylation cascade
0.0	0.7	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.0	0.6	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse

Showing 1 to 10 of 24 entries

Results for MBD2

Z-value: 1.57

Motif logo

Transcription factors associated with MBD2

Activity-expression correlation:

Activity profile of MBD2 motif

Sorted Z-values of MBD2 motif

No targets for MBD2

Network of associatons between targets according to the STRING database.

First level regulatory network of MBD2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: