ISMARA results: MEF2D

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for MEF2D_MEF2A

Z-value: 2.47

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Transcription factors associated with MEF2D_MEF2A

Gene Symbol	Gene ID	Gene Info
MEF2D Ensembl NCBI GeneCards UniProt	ENSG00000116604.13	myocyte enhancer factor 2D
MEF2A Ensembl NCBI GeneCards UniProt	ENSG00000068305.13	myocyte enhancer factor 2A

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
MEF2D	hg19_v2_chr1_-_156470515_156470542	-0.65	1.9e-03	Click!
MEF2A	hg19_v2_chr15_+_100106244_100106292	0.21	3.7e-01	Click!

Activity profile of MEF2D_MEF2A motif

Sorted Z-values of MEF2D_MEF2A motif

No targets for MEF2D_MEF2A

Network of associatons between targets according to the STRING database.

First level regulatory network of MEF2D_MEF2A

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.2	41.6	GO:0043435	response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
1.3	12.9	GO:1900019	regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.4	10.8	GO:0006853	carnitine shuttle(GO:0006853)
0.3	9.3	GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis(GO:0090051)
3.0	9.0	GO:0006059	hexitol metabolic process(GO:0006059)
0.0	7.8	GO:0098869	cellular oxidant detoxification(GO:0098869)
0.0	7.3	GO:0048706	embryonic skeletal system development(GO:0048706)
0.9	7.1	GO:0043353	enucleate erythrocyte differentiation(GO:0043353)
0.2	6.3	GO:0006825	copper ion transport(GO:0006825)
0.3	5.9	GO:0033327	Leydig cell differentiation(GO:0033327)

Showing 1 to 10 of 188 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	30.7	GO:0031965	nuclear membrane(GO:0031965)
0.0	10.4	GO:0016607	nuclear speck(GO:0016607)
0.0	10.2	GO:0005741	mitochondrial outer membrane(GO:0005741) organelle outer membrane(GO:0031968)
1.8	9.0	GO:0097454	Schwann cell microvillus(GO:0097454)
0.0	8.5	GO:0016323	basolateral plasma membrane(GO:0016323)
0.1	7.6	GO:0031430	M band(GO:0031430)
0.2	5.9	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.0	5.2	GO:0072562	blood microparticle(GO:0072562)
0.0	5.2	GO:0031225	anchored component of membrane(GO:0031225)
0.5	5.0	GO:0016012	sarcoglycan complex(GO:0016012)

Showing 1 to 10 of 84 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	49.8	GO:0004879	RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.4	12.9	GO:0005112	Notch binding(GO:0005112)
1.2	9.5	GO:0004095	carnitine O-palmitoyltransferase activity(GO:0004095)
1.0	9.1	GO:0001025	RNA polymerase III transcription factor binding(GO:0001025)
0.6	9.0	GO:0004032	alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.3	9.0	GO:0004602	glutathione peroxidase activity(GO:0004602)
0.4	7.0	GO:0005344	oxygen transporter activity(GO:0005344)
0.5	6.3	GO:0016724	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.6	5.8	GO:0018479	benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.2	5.6	GO:0015125	bile acid transmembrane transporter activity(GO:0015125)

Showing 1 to 10 of 134 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	39.8	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.1	12.6	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.1	7.2	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.1	6.4	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.0	5.7	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.0	5.1	PID INTEGRIN1 PATHWAY	Beta1 integrin cell surface interactions
0.0	5.0	PID IL12 2PATHWAY	IL12-mediated signaling events
0.0	4.3	PID ANGIOPOIETIN RECEPTOR PATHWAY	Angiopoietin receptor Tie2-mediated signaling
0.2	4.0	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.1	3.7	PID AP1 PATHWAY	AP-1 transcription factor network

Showing 1 to 10 of 34 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	37.2	REACTOME PIP3 ACTIVATES AKT SIGNALING	Genes involved in PIP3 activates AKT signaling
0.2	10.7	REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE	Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.1	9.5	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.5	9.1	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.1	7.8	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.0	6.6	REACTOME G ALPHA S SIGNALLING EVENTS	Genes involved in G alpha (s) signalling events
0.1	6.4	REACTOME METAL ION SLC TRANSPORTERS	Genes involved in Metal ion SLC transporters
0.1	6.1	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.3	5.8	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.1	5.5	REACTOME STEROID HORMONES	Genes involved in Steroid hormones

Showing 1 to 10 of 53 entries

Results for MEF2D_MEF2A

Z-value: 2.47

Motif logo

Transcription factors associated with MEF2D_MEF2A

Activity-expression correlation:

Activity profile of MEF2D_MEF2A motif

Sorted Z-values of MEF2D_MEF2A motif

No targets for MEF2D_MEF2A

Network of associatons between targets according to the STRING database.

First level regulatory network of MEF2D_MEF2A

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: