ISMARA results: MEIS2

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for MEIS2

Z-value: 3.75

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Transcription factors associated with MEIS2

Gene Symbol	Gene ID	Gene Info
MEIS2 Ensembl NCBI GeneCards UniProt	ENSG00000134138.15	Meis homeobox 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
MEIS2	hg19_v2_chr15_-_37391507_37391604	0.39	9.3e-02	Click!

Activity profile of MEIS2 motif

Sorted Z-values of MEIS2 motif

No targets for MEIS2

Network of associatons between targets according to the STRING database.

First level regulatory network of MEIS2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	33.1	GO:0018149	peptide cross-linking(GO:0018149)
2.0	23.8	GO:0070487	monocyte aggregation(GO:0070487)
0.2	20.5	GO:0070268	cornification(GO:0070268)
0.7	19.3	GO:0051798	positive regulation of hair follicle development(GO:0051798)
0.5	17.8	GO:0031581	hemidesmosome assembly(GO:0031581)
0.2	17.8	GO:0042795	snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.4	16.7	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
2.3	16.3	GO:0002786	regulation of antimicrobial peptide production(GO:0002784) regulation of antibacterial peptide production(GO:0002786)
0.2	14.3	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.8	13.0	GO:0008090	retrograde axonal transport(GO:0008090)

Showing 1 to 10 of 1,017 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	50.8	GO:0001533	cornified envelope(GO:0001533)
0.2	29.6	GO:0016605	PML body(GO:0016605)
0.1	28.7	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.2	28.1	GO:0005882	intermediate filament(GO:0005882)
0.1	27.9	GO:0016607	nuclear speck(GO:0016607)
0.1	20.4	GO:0005913	cell-cell adherens junction(GO:0005913)
2.3	18.7	GO:0035692	macrophage migration inhibitory factor receptor complex(GO:0035692)
0.2	17.7	GO:0035577	azurophil granule membrane(GO:0035577)
1.6	17.4	GO:0005610	laminin-5 complex(GO:0005610)
2.5	17.3	GO:0097209	epidermal lamellar body(GO:0097209)

Showing 1 to 10 of 366 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	59.5	GO:0003700	transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.2	58.0	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.1	28.3	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.6	27.0	GO:0098641	cadherin binding involved in cell-cell adhesion(GO:0098641)
1.0	22.9	GO:0005149	interleukin-1 receptor binding(GO:0005149)
2.8	22.0	GO:0042289	MHC class II protein binding(GO:0042289)
0.0	17.6	GO:0005525	GTP binding(GO:0005525)
0.7	15.3	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.3	14.2	GO:0051010	microtubule plus-end binding(GO:0051010)
0.7	14.1	GO:0050700	CARD domain binding(GO:0050700)

Showing 1 to 10 of 633 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	25.8	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.7	24.7	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.2	20.1	PID CDC42 PATHWAY	CDC42 signaling events
0.2	18.2	PID NOTCH PATHWAY	Notch signaling pathway
0.3	17.7	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.6	17.5	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.2	17.0	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.3	16.4	PID IL1 PATHWAY	IL1-mediated signaling events
0.1	16.4	PID REG GR PATHWAY	Glucocorticoid receptor regulatory network
0.1	14.0	PID CASPASE PATHWAY	Caspase cascade in apoptosis

Showing 1 to 10 of 99 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	45.7	REACTOME GENERIC TRANSCRIPTION PATHWAY	Genes involved in Generic Transcription Pathway
0.1	17.1	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization
0.8	16.1	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.1	14.9	REACTOME MHC CLASS II ANTIGEN PRESENTATION	Genes involved in MHC class II antigen presentation
0.3	14.0	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.4	13.1	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.5	12.7	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.3	12.2	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.1	12.0	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.4	11.8	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions

Showing 1 to 10 of 163 entries

Results for MEIS2

Z-value: 3.75

Motif logo

Transcription factors associated with MEIS2

Activity-expression correlation:

Activity profile of MEIS2 motif

Sorted Z-values of MEIS2 motif

No targets for MEIS2

Network of associatons between targets according to the STRING database.

First level regulatory network of MEIS2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: