ISMARA results: MEIS3

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for MEIS3_TGIF2LX

Z-value: 0.62

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Transcription factors associated with MEIS3_TGIF2LX

Gene Symbol	Gene ID	Gene Info
MEIS3 Ensembl NCBI GeneCards UniProt	ENSG00000105419.13	Meis homeobox 3
TGIF2LX Ensembl NCBI GeneCards UniProt	ENSG00000153779.8	TGFB induced factor homeobox 2 like X-linked

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
MEIS3	hg19_v2_chr19_-_47922373_47922572	0.74	1.7e-04	Click!

Activity profile of MEIS3_TGIF2LX motif

Sorted Z-values of MEIS3_TGIF2LX motif

No targets for MEIS3_TGIF2LX

Network of associatons between targets according to the STRING database.

First level regulatory network of MEIS3_TGIF2LX

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	2.5	GO:0009051	pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0	2.1	GO:0006805	xenobiotic metabolic process(GO:0006805)
0.2	1.4	GO:0071395	response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.0	1.4	GO:0071391	cellular response to estrogen stimulus(GO:0071391)
0.1	1.2	GO:0060050	positive regulation of protein glycosylation(GO:0060050)
0.1	1.0	GO:0032308	regulation of prostaglandin secretion(GO:0032306) positive regulation of prostaglandin secretion(GO:0032308)
0.0	0.9	GO:0051608	histamine transport(GO:0051608)
0.1	0.7	GO:2000110	negative regulation of macrophage apoptotic process(GO:2000110)
0.1	0.7	GO:0098989	NMDA selective glutamate receptor signaling pathway(GO:0098989)
0.1	0.7	GO:0086024	adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)

Showing 1 to 10 of 62 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.0	GO:0031229	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0	0.7	GO:0090665	dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1	0.6	GO:0033063	Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0	0.6	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.0	0.6	GO:0008385	IkappaB kinase complex(GO:0008385)
0.0	0.5	GO:0016012	sarcoglycan complex(GO:0016012)
0.0	0.4	GO:0005736	DNA-directed RNA polymerase I complex(GO:0005736)
0.0	0.4	GO:0097381	photoreceptor disc membrane(GO:0097381)
0.1	0.3	GO:0055087	Ski complex(GO:0055087)
0.1	0.3	GO:0009368	endopeptidase Clp complex(GO:0009368)

Showing 1 to 10 of 22 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	2.5	GO:0004345	glucose-6-phosphate dehydrogenase activity(GO:0004345)
0.2	1.4	GO:0047086	phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086)
0.0	1.1	GO:0046965	retinoid X receptor binding(GO:0046965)
0.1	1.0	GO:0004931	extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1	0.9	GO:0005329	dopamine transmembrane transporter activity(GO:0005329)
0.1	0.9	GO:0004028	3-chloroallyl aldehyde dehydrogenase activity(GO:0004028) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0	0.9	GO:0070410	co-SMAD binding(GO:0070410)
0.0	0.8	GO:0050786	RAGE receptor binding(GO:0050786)
0.0	0.8	GO:0001105	RNA polymerase II transcription coactivator activity(GO:0001105)
0.1	0.7	GO:0047685	amine sulfotransferase activity(GO:0047685)

Showing 1 to 10 of 48 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.9	ST TUMOR NECROSIS FACTOR PATHWAY	Tumor Necrosis Factor Pathway.

Showing 1 to 1 of 1 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Total log-likelihood	Term	Description
0.9	REACTOME ABACAVIR TRANSPORT AND METABOLISM	Genes involved in Abacavir transport and metabolism
0.9	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.8	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.7	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.7	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
0.6	REACTOME IRAK1 RECRUITS IKK COMPLEX	Genes involved in IRAK1 recruits IKK complex
0.5	REACTOME AMINE DERIVED HORMONES	Genes involved in Amine-derived hormones
0.4	REACTOME OPSINS	Genes involved in Opsins
0.4	REACTOME RNA POL III CHAIN ELONGATION	Genes involved in RNA Polymerase III Chain Elongation
0.4	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins

Showing 1 to 10 of 12 entries

Results for MEIS3_TGIF2LX

Z-value: 0.62

Motif logo

Transcription factors associated with MEIS3_TGIF2LX

Activity-expression correlation:

Activity profile of MEIS3_TGIF2LX motif

Sorted Z-values of MEIS3_TGIF2LX motif

No targets for MEIS3_TGIF2LX

Network of associatons between targets according to the STRING database.

First level regulatory network of MEIS3_TGIF2LX

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: