ISMARA results: MESP1

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for MESP1

Z-value: 0.56

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Transcription factors associated with MESP1

Gene Symbol	Gene ID	Gene Info
MESP1 Ensembl NCBI GeneCards UniProt	ENSG00000166823.5	mesoderm posterior bHLH transcription factor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
MESP1	hg19_v2_chr15_-_90294523_90294541	0.80	2.8e-05	Click!

Activity profile of MESP1 motif

Sorted Z-values of MESP1 motif

No targets for MESP1

Network of associatons between targets according to the STRING database.

First level regulatory network of MESP1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	2.7	GO:2000189	positive regulation of cholesterol homeostasis(GO:2000189)
0.1	2.7	GO:1990573	potassium ion import across plasma membrane(GO:1990573)
0.1	2.2	GO:0051599	response to hydrostatic pressure(GO:0051599)
0.1	1.8	GO:0051014	actin filament severing(GO:0051014)
0.5	1.6	GO:0060927	Purkinje myocyte differentiation(GO:0003168) cardiac pacemaker cell fate commitment(GO:0060927) atrioventricular node cell fate commitment(GO:0060929)
0.2	1.6	GO:2000857	positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.2	1.6	GO:0043435	response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.0	1.6	GO:0090200	positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.0	1.6	GO:0097031	NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.4	1.5	GO:0060032	notochord regression(GO:0060032)

Showing 1 to 10 of 289 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.6	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0	2.5	GO:0090575	RNA polymerase II transcription factor complex(GO:0090575)
0.1	1.7	GO:0032059	bleb(GO:0032059)
0.0	1.7	GO:0090665	dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0	1.5	GO:0097546	ciliary base(GO:0097546)
0.0	1.3	GO:0005782	peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0	1.2	GO:0000145	exocyst(GO:0000145)
0.1	1.1	GO:0005587	collagen type IV trimer(GO:0005587)
0.0	1.1	GO:0031095	platelet dense tubular network membrane(GO:0031095)
0.0	1.1	GO:0035580	specific granule lumen(GO:0035580)

Showing 1 to 10 of 102 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.6	GO:0005391	sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0	2.0	GO:0005518	collagen binding(GO:0005518)
0.0	1.9	GO:0003707	steroid hormone receptor activity(GO:0003707)
0.1	1.8	GO:0005522	profilin binding(GO:0005522)
0.0	1.8	GO:0005504	fatty acid binding(GO:0005504)
0.0	1.8	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.3	1.6	GO:0010736	serum response element binding(GO:0010736)
0.2	1.5	GO:0015057	thrombin receptor activity(GO:0015057)
0.0	1.5	GO:0017022	myosin binding(GO:0017022)
0.1	1.3	GO:0015245	fatty acid transporter activity(GO:0015245)

Showing 1 to 10 of 199 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
2.5	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
2.1	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
1.6	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
1.5	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
1.3	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
1.2	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
1.2	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
1.2	NABA COLLAGENS	Genes encoding collagen proteins
1.2	PID PDGFRB PATHWAY	PDGFR-beta signaling pathway
1.1	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events

Showing 1 to 10 of 34 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.0	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.1	2.2	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.0	1.9	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.1	1.3	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0	1.3	REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0	1.3	REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0	1.2	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.0	1.2	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	1.1	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.1	0.9	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis

Showing 1 to 10 of 51 entries

Results for MESP1

Z-value: 0.56

Motif logo

Transcription factors associated with MESP1

Activity-expression correlation:

Activity profile of MESP1 motif

Sorted Z-values of MESP1 motif

No targets for MESP1

Network of associatons between targets according to the STRING database.

First level regulatory network of MESP1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: