ISMARA results: MLX_USF2_USF1

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for MLX_USF2_USF1_PAX2

Z-value: 2.17

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Transcription factors associated with MLX_USF2_USF1_PAX2

Gene Symbol	Gene ID	Gene Info
MLX Ensembl NCBI GeneCards UniProt	ENSG00000108788.7	MAX dimerization protein MLX
USF2 Ensembl NCBI GeneCards UniProt	ENSG00000105698.11	upstream transcription factor 2, c-fos interacting
USF1 Ensembl NCBI GeneCards UniProt	ENSG00000158773.10	upstream transcription factor 1
PAX2 Ensembl NCBI GeneCards UniProt	ENSG00000075891.17	paired box 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
PAX2	hg19_v2_chr10_+_102505468_102505546	-0.82	1.0e-05	Click!
USF2	hg19_v2_chr19_+_35759824_35759891	-0.60	5.1e-03	Click!
USF1	hg19_v2_chr1_-_161015663_161015694	0.55	1.3e-02	Click!
MLX	hg19_v2_chr17_+_40719073_40719092	0.24	3.0e-01	Click!

Activity profile of MLX_USF2_USF1_PAX2 motif

Sorted Z-values of MLX_USF2_USF1_PAX2 motif

No targets for MLX_USF2_USF1_PAX2

Network of associatons between targets according to the STRING database.

First level regulatory network of MLX_USF2_USF1_PAX2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.3	29.8	GO:0061484	hematopoietic stem cell homeostasis(GO:0061484)
0.1	20.3	GO:0006368	transcription elongation from RNA polymerase II promoter(GO:0006368)
2.8	19.5	GO:1902963	regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
3.0	18.1	GO:0008626	granzyme-mediated apoptotic signaling pathway(GO:0008626)
1.2	13.8	GO:0090204	protein localization to nuclear pore(GO:0090204)
4.1	12.4	GO:0015728	mevalonate transport(GO:0015728) behavioral response to nutrient(GO:0051780)
0.6	11.9	GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.5	11.8	GO:0070816	phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
1.1	11.0	GO:1903764	regulation of potassium ion export across plasma membrane(GO:1903764)
0.7	10.8	GO:0002191	cap-dependent translational initiation(GO:0002191)

Showing 1 to 10 of 500 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.5	34.9	GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
3.1	18.8	GO:0070381	endosome to plasma membrane transport vesicle(GO:0070381)
0.7	18.5	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.4	17.3	GO:0044665	MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
1.6	14.1	GO:0044194	cytolytic granule(GO:0044194)
0.5	13.4	GO:0035327	transcriptionally active chromatin(GO:0035327)
1.0	11.4	GO:0000439	core TFIIH complex(GO:0000439)
0.7	11.0	GO:0097025	MPP7-DLG1-LIN7 complex(GO:0097025)
0.0	10.3	GO:0001650	fibrillar center(GO:0001650)
0.1	9.8	GO:0016605	PML body(GO:0016605)

Showing 1 to 10 of 217 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	28.5	GO:0045296	cadherin binding(GO:0045296)
0.0	27.8	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)
1.3	18.8	GO:0032050	clathrin heavy chain binding(GO:0032050)
0.1	18.0	GO:0001618	virus receptor activity(GO:0001618)
0.6	15.0	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0	14.6	GO:0015631	tubulin binding(GO:0015631)
0.3	14.4	GO:0070273	phosphatidylinositol-4-phosphate binding(GO:0070273)
4.1	12.4	GO:0015130	mevalonate transmembrane transporter activity(GO:0015130)
1.7	11.8	GO:0004741	[pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.1	11.4	GO:0047485	protein N-terminus binding(GO:0047485)

Showing 1 to 10 of 297 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	14.8	PID LKB1 PATHWAY	LKB1 signaling events
0.2	12.7	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway
0.1	12.0	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.1	9.8	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.1	8.2	PID MYC PATHWAY	C-MYC pathway
0.1	6.4	PID MTOR 4PATHWAY	mTOR signaling pathway
0.1	6.1	PID CDC42 PATHWAY	CDC42 signaling events
0.1	5.9	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
0.1	5.6	PID ERBB4 PATHWAY	ErbB4 signaling events
0.1	5.5	PID AURORA B PATHWAY	Aurora B signaling

Showing 1 to 10 of 66 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	24.2	REACTOME PYRUVATE METABOLISM	Genes involved in Pyruvate metabolism
0.7	17.5	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling
0.1	15.7	REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	Genes involved in Apoptotic cleavage of cellular proteins
0.4	12.3	REACTOME FORMATION OF INCISION COMPLEX IN GG NER	Genes involved in Formation of incision complex in GG-NER
0.4	10.6	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.1	10.3	REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS	Genes involved in Golgi Associated Vesicle Biogenesis
0.2	7.1	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.3	6.8	REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	Genes involved in Vitamin B5 (pantothenate) metabolism
0.2	6.7	REACTOME INSULIN RECEPTOR RECYCLING	Genes involved in Insulin receptor recycling
0.2	6.3	REACTOME G0 AND EARLY G1	Genes involved in G0 and Early G1

Showing 1 to 10 of 100 entries

Results for MLX_USF2_USF1_PAX2

Z-value: 2.17

Motif logo

Transcription factors associated with MLX_USF2_USF1_PAX2

Activity-expression correlation:

Activity profile of MLX_USF2_USF1_PAX2 motif

Sorted Z-values of MLX_USF2_USF1_PAX2 motif

No targets for MLX_USF2_USF1_PAX2

Network of associatons between targets according to the STRING database.

First level regulatory network of MLX_USF2_USF1_PAX2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: