ISMARA results: MXI1_MYC

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for MXI1_MYC_MYCN

Z-value: 6.30

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Transcription factors associated with MXI1_MYC_MYCN

Gene Symbol	Gene ID	Gene Info
MXI1 Ensembl NCBI GeneCards UniProt	ENSG00000119950.16	MAX interactor 1, dimerization protein
MYC Ensembl NCBI GeneCards UniProt	ENSG00000136997.10	MYC proto-oncogene, bHLH transcription factor
MYCN Ensembl NCBI GeneCards UniProt	ENSG00000134323.10	MYCN proto-oncogene, bHLH transcription factor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
MXI1	hg19_v2_chr10_+_111967345_111967442	-0.97	4.7e-12	Click!
MYC	hg19_v2_chr8_+_128748466_128748487	-0.78	5.1e-05	Click!
MYCN	hg19_v2_chr2_+_16080659_16080686	0.34	1.4e-01	Click!

Activity profile of MXI1_MYC_MYCN motif

Sorted Z-values of MXI1_MYC_MYCN motif

No targets for MXI1_MYC_MYCN

Network of associatons between targets according to the STRING database.

First level regulatory network of MXI1_MYC_MYCN

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	33.6	GO:0006521	regulation of cellular amino acid metabolic process(GO:0006521)
1.5	27.6	GO:0030238	male sex determination(GO:0030238)
0.2	25.9	GO:0070125	mitochondrial translational elongation(GO:0070125)
5.0	24.8	GO:0071051	polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
1.2	24.2	GO:1990573	potassium ion import across plasma membrane(GO:1990573)
1.5	21.1	GO:0010739	positive regulation of protein kinase A signaling(GO:0010739)
0.5	20.5	GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
2.3	20.4	GO:1904636	response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637)
2.0	20.4	GO:0045039	protein import into mitochondrial inner membrane(GO:0045039)
2.8	19.4	GO:2000124	regulation of endocannabinoid signaling pathway(GO:2000124)

Showing 1 to 10 of 887 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	130.9	GO:0016021	integral component of membrane(GO:0016021)
0.1	107.0	GO:0005739	mitochondrion(GO:0005739)
0.1	42.1	GO:0005743	mitochondrial inner membrane(GO:0005743)
0.1	27.8	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
2.1	27.7	GO:0042788	polysomal ribosome(GO:0042788)
1.1	24.5	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)
1.5	23.3	GO:0000808	origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
1.5	22.8	GO:0000176	nuclear exosome (RNase complex)(GO:0000176)
0.1	22.4	GO:1904813	ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.2	21.6	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)

Showing 1 to 10 of 303 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	49.2	GO:0003735	structural constituent of ribosome(GO:0003735)
0.9	36.4	GO:0000217	DNA secondary structure binding(GO:0000217)
0.3	33.1	GO:0005507	copper ion binding(GO:0005507)
2.8	25.2	GO:0044020	histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.3	25.2	GO:0045182	translation regulator activity(GO:0045182)
1.1	23.9	GO:0005391	sodium:potassium-exchanging ATPase activity(GO:0005391)
0.3	22.7	GO:0019212	phosphatase inhibitor activity(GO:0019212)
0.7	20.9	GO:0070003	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.5	19.7	GO:0017134	fibroblast growth factor binding(GO:0017134)
0.1	19.5	GO:0051213	dioxygenase activity(GO:0051213)

Showing 1 to 10 of 599 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	24.3	PID AURORA A PATHWAY	Aurora A signaling
0.2	18.3	PID ENDOTHELIN PATHWAY	Endothelins
0.2	17.9	PID ILK PATHWAY	Integrin-linked kinase signaling
0.6	16.2	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.2	16.0	PID ATR PATHWAY	ATR signaling pathway
0.3	13.6	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.2	13.6	PID BMP PATHWAY	BMP receptor signaling
0.3	13.4	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.2	12.3	PID PLK1 PATHWAY	PLK1 signaling events
0.5	11.8	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.

Showing 1 to 10 of 93 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	47.7	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.4	36.1	REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1	Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.4	31.8	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.7	30.0	REACTOME EXTENSION OF TELOMERES	Genes involved in Extension of Telomeres
0.4	29.9	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.2	27.3	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.3	26.9	REACTOME MEIOTIC RECOMBINATION	Genes involved in Meiotic Recombination
0.4	24.5	REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT	Genes involved in ABC-family proteins mediated transport
0.5	23.8	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
1.8	22.8	REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	Genes involved in mRNA Decay by 3' to 5' Exoribonuclease

Showing 1 to 10 of 176 entries

Results for MXI1_MYC_MYCN

Z-value: 6.30

Motif logo

Transcription factors associated with MXI1_MYC_MYCN

Activity-expression correlation:

Activity profile of MXI1_MYC_MYCN motif

Sorted Z-values of MXI1_MYC_MYCN motif

No targets for MXI1_MYC_MYCN

Network of associatons between targets according to the STRING database.

First level regulatory network of MXI1_MYC_MYCN

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: