ISMARA results: NFAT5

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NFAT5

Z-value: 1.07

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Transcription factors associated with NFAT5

Gene Symbol	Gene ID	Gene Info
NFAT5 Ensembl NCBI GeneCards UniProt	ENSG00000102908.16	nuclear factor of activated T cells 5

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NFAT5	hg19_v2_chr16_+_69600209_69600254	-0.80	2.2e-05	Click!

Activity profile of NFAT5 motif

Sorted Z-values of NFAT5 motif

No targets for NFAT5

Network of associatons between targets according to the STRING database.

First level regulatory network of NFAT5

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.5	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1	2.5	GO:0032060	bleb assembly(GO:0032060)
0.1	2.0	GO:0051601	exocyst localization(GO:0051601)
0.1	1.9	GO:0043152	induction of bacterial agglutination(GO:0043152)
0.1	1.6	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.1	1.2	GO:0031087	deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0	1.2	GO:0006536	glutamate metabolic process(GO:0006536)
0.3	1.0	GO:0045082	positive regulation of interleukin-10 biosynthetic process(GO:0045082)
0.0	1.0	GO:0032201	telomere maintenance via semi-conservative replication(GO:0032201)
0.0	1.0	GO:0007271	synaptic transmission, cholinergic(GO:0007271)

Showing 1 to 10 of 66 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.8	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.0	2.0	GO:0000145	exocyst(GO:0000145)
0.1	1.9	GO:0005577	fibrinogen complex(GO:0005577)
0.3	1.0	GO:0033257	Bcl3/NF-kappaB2 complex(GO:0033257)
0.2	1.0	GO:0043625	delta DNA polymerase complex(GO:0043625)
0.0	0.8	GO:0034366	spherical high-density lipoprotein particle(GO:0034366)
0.2	0.7	GO:0009330	DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)
0.0	0.7	GO:0030914	SAGA complex(GO:0000124) STAGA complex(GO:0030914)
0.0	0.7	GO:0010369	chromocenter(GO:0010369)
0.1	0.6	GO:0000015	phosphopyruvate hydratase complex(GO:0000015)

Showing 1 to 10 of 34 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.1	GO:0004869	cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0	2.9	GO:0008013	beta-catenin binding(GO:0008013)
0.2	1.2	GO:0047820	D-glutamate cyclase activity(GO:0047820)
0.0	1.0	GO:0033130	acetylcholine receptor binding(GO:0033130)
0.0	1.0	GO:0003887	DNA-directed DNA polymerase activity(GO:0003887)
0.0	0.9	GO:0061578	Lys63-specific deubiquitinase activity(GO:0061578)
0.0	0.9	GO:0015467	G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0	0.9	GO:0031418	L-ascorbic acid binding(GO:0031418)
0.1	0.8	GO:0003796	lysozyme activity(GO:0003796)
0.0	0.8	GO:0050786	RAGE receptor binding(GO:0050786)

Showing 1 to 10 of 51 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
5.6	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
1.9	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
1.9	PID LYSOPHOSPHOLIPID PATHWAY	LPA receptor mediated events
1.1	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
1.0	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.9	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.9	PID CXCR3 PATHWAY	CXCR3-mediated signaling events
0.7	PID S1P META PATHWAY	Sphingosine 1-phosphate (S1P) pathway

Showing 1 to 8 of 8 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.2	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.1	1.6	REACTOME INITIAL TRIGGERING OF COMPLEMENT	Genes involved in Initial triggering of complement
0.0	1.6	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0	1.1	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.1	1.0	REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND	Genes involved in Removal of the Flap Intermediate from the C-strand
0.0	1.0	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0	0.8	REACTOME MICRORNA MIRNA BIOGENESIS	Genes involved in MicroRNA (miRNA) Biogenesis
0.0	0.7	REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0	0.5	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.0	0.5	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE

Showing 1 to 10 of 11 entries

Results for NFAT5

Z-value: 1.07

Motif logo

Transcription factors associated with NFAT5

Activity-expression correlation:

Activity profile of NFAT5 motif

Sorted Z-values of NFAT5 motif

No targets for NFAT5

Network of associatons between targets according to the STRING database.

First level regulatory network of NFAT5

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: