ISMARA results: NFATC2

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NFATC2_NFATC3

Z-value: 1.14

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Transcription factors associated with NFATC2_NFATC3

Gene Symbol	Gene ID	Gene Info
NFATC2 Ensembl NCBI GeneCards UniProt	ENSG00000101096.15	nuclear factor of activated T cells 2
NFATC3 Ensembl NCBI GeneCards UniProt	ENSG00000072736.14	nuclear factor of activated T cells 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NFATC2	hg19_v2_chr20_-_50159198_50159299	-0.42	6.6e-02	Click!
NFATC3	hg19_v2_chr16_+_68119764_68119868	0.38	9.8e-02	Click!

Activity profile of NFATC2_NFATC3 motif

Sorted Z-values of NFATC2_NFATC3 motif

No targets for NFATC2_NFATC3

Network of associatons between targets according to the STRING database.

First level regulatory network of NFATC2_NFATC3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.4	GO:0030835	negative regulation of actin filament depolymerization(GO:0030835)
0.0	4.3	GO:0070268	cornification(GO:0070268)
0.2	3.5	GO:0048672	positive regulation of collateral sprouting(GO:0048672)
0.2	2.9	GO:1903690	negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.9	2.6	GO:1902362	melanocyte apoptotic process(GO:1902362)
0.1	2.5	GO:0035855	megakaryocyte development(GO:0035855)
0.3	2.4	GO:1901297	positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.1	2.3	GO:0061029	eyelid development in camera-type eye(GO:0061029)
0.7	2.2	GO:0060279	regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
0.1	2.1	GO:0006600	creatine metabolic process(GO:0006600)

Showing 1 to 10 of 247 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	6.1	GO:0097610	cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1	3.3	GO:0005614	interstitial matrix(GO:0005614)
0.1	3.3	GO:0030057	desmosome(GO:0030057)
0.0	3.3	GO:0016363	nuclear matrix(GO:0016363)
0.1	2.6	GO:0071438	invadopodium membrane(GO:0071438)
0.2	2.4	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.7	2.2	GO:0043512	inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.1	2.2	GO:0045180	basal cortex(GO:0045180)
0.0	2.0	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	1.9	GO:0043034	costamere(GO:0043034)

Showing 1 to 10 of 94 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.3	GO:0003785	actin monomer binding(GO:0003785)
0.0	5.2	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2	3.9	GO:0019841	retinol binding(GO:0019841)
0.1	2.6	GO:0008239	dipeptidyl-peptidase activity(GO:0008239)
0.0	2.5	GO:0008536	Ran GTPase binding(GO:0008536)
0.1	2.4	GO:0000150	recombinase activity(GO:0000150)
0.1	2.4	GO:0035256	G-protein coupled glutamate receptor binding(GO:0035256)
0.4	2.2	GO:0070699	type II activin receptor binding(GO:0070699)
0.2	2.1	GO:0004111	creatine kinase activity(GO:0004111)
0.1	2.1	GO:0045504	dynein heavy chain binding(GO:0045504)

Showing 1 to 10 of 180 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	8.4	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.0	4.9	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.0	3.7	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.1	2.7	PID S1P S1P1 PATHWAY	S1P1 pathway
0.0	2.5	PID AVB3 INTEGRIN PATHWAY	Integrins in angiogenesis
0.0	2.3	PID ALK1 PATHWAY	ALK1 signaling events
0.0	2.3	PID AVB3 OPN PATHWAY	Osteopontin-mediated events
0.0	2.3	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.0	2.1	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.0	1.8	PID MYC PATHWAY	C-MYC pathway

Showing 1 to 10 of 30 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.9	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1	2.6	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.0	2.6	REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0	2.6	REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	Genes involved in Apoptotic cleavage of cellular proteins
0.0	2.5	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.2	2.2	REACTOME GLYCOPROTEIN HORMONES	Genes involved in Glycoprotein hormones
0.0	1.8	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
0.0	1.6	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.0	1.6	REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES	Genes involved in Loss of Nlp from mitotic centrosomes
0.0	1.3	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors

Showing 1 to 10 of 59 entries

Results for NFATC2_NFATC3

Z-value: 1.14

Motif logo

Transcription factors associated with NFATC2_NFATC3

Activity-expression correlation:

Activity profile of NFATC2_NFATC3 motif

Sorted Z-values of NFATC2_NFATC3 motif

No targets for NFATC2_NFATC3

Network of associatons between targets according to the STRING database.

First level regulatory network of NFATC2_NFATC3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: