ISMARA results: NFIA

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NFIA

Z-value: 3.40

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Transcription factors associated with NFIA

Gene Symbol	Gene ID	Gene Info
NFIA Ensembl NCBI GeneCards UniProt	ENSG00000162599.11	nuclear factor I A

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NFIA	hg19_v2_chr1_+_61330931_61331017	0.92	1.4e-08	Click!

Activity profile of NFIA motif

Sorted Z-values of NFIA motif

No targets for NFIA

Network of associatons between targets according to the STRING database.

First level regulatory network of NFIA

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	28.2	GO:0031581	hemidesmosome assembly(GO:0031581)
0.1	22.9	GO:0030216	keratinocyte differentiation(GO:0030216)
0.4	21.7	GO:0060512	prostate gland morphogenesis(GO:0060512)
1.1	20.0	GO:0043587	tongue morphogenesis(GO:0043587)
0.1	19.2	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
6.1	18.3	GO:1902173	negative regulation of keratinocyte apoptotic process(GO:1902173)
0.7	15.4	GO:0010759	positive regulation of macrophage chemotaxis(GO:0010759)
0.4	14.0	GO:0061436	establishment of skin barrier(GO:0061436)
0.1	12.5	GO:0007173	epidermal growth factor receptor signaling pathway(GO:0007173)
4.0	12.0	GO:0060278	regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)

Showing 1 to 10 of 222 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	46.7	GO:0045095	keratin filament(GO:0045095)
0.3	24.8	GO:0001533	cornified envelope(GO:0001533)
0.1	19.3	GO:0043202	lysosomal lumen(GO:0043202)
0.1	16.0	GO:0017053	transcriptional repressor complex(GO:0017053)
0.1	13.3	GO:0005882	intermediate filament(GO:0005882)
4.0	12.0	GO:0043512	inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.1	10.4	GO:0043198	dendritic shaft(GO:0043198)
0.1	9.9	GO:0035577	azurophil granule membrane(GO:0035577)
0.1	9.4	GO:0002102	podosome(GO:0002102)
1.4	8.1	GO:0031673	H zone(GO:0031673)

Showing 1 to 10 of 101 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	47.9	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.0	31.8	GO:0005198	structural molecule activity(GO:0005198)
0.2	24.9	GO:0097110	scaffold protein binding(GO:0097110)
0.8	18.5	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.3	14.7	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	14.0	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1	12.1	GO:0047485	protein N-terminus binding(GO:0047485)
2.0	12.0	GO:0070699	type II activin receptor binding(GO:0070699)
0.0	11.3	GO:0005509	calcium ion binding(GO:0005509)
0.3	11.1	GO:0004181	metallocarboxypeptidase activity(GO:0004181)

Showing 1 to 10 of 165 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	39.0	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.1	35.3	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3	16.7	PID ALK1 PATHWAY	ALK1 signaling events
0.2	16.5	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.2	15.7	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.0	14.9	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.1	10.3	PID FOXO PATHWAY	FoxO family signaling
0.2	10.0	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.1	9.1	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.1	8.0	PID TGFBR PATHWAY	TGF-beta receptor signaling

Showing 1 to 10 of 42 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	13.4	REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS	Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.2	10.8	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
0.1	10.3	REACTOME MHC CLASS II ANTIGEN PRESENTATION	Genes involved in MHC class II antigen presentation
1.0	10.1	REACTOME GLYCOPROTEIN HORMONES	Genes involved in Glycoprotein hormones
0.1	8.9	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization
0.4	8.0	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.1	7.9	REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS	Genes involved in Amino acid and oligopeptide SLC transporters
0.2	6.9	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.3	6.6	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling
0.1	6.0	REACTOME MEIOTIC RECOMBINATION	Genes involved in Meiotic Recombination

Showing 1 to 10 of 58 entries

Results for NFIA

Z-value: 3.40

Motif logo

Transcription factors associated with NFIA

Activity-expression correlation:

Activity profile of NFIA motif

Sorted Z-values of NFIA motif

No targets for NFIA

Network of associatons between targets according to the STRING database.

First level regulatory network of NFIA

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: