ISMARA results: NFKB2

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NFKB2

Z-value: 1.73

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Transcription factors associated with NFKB2

Gene Symbol	Gene ID	Gene Info
NFKB2 Ensembl NCBI GeneCards UniProt	ENSG00000077150.13	nuclear factor kappa B subunit 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NFKB2	hg19_v2_chr10_+_104154229_104154354	0.64	2.3e-03	Click!

Activity profile of NFKB2 motif

Sorted Z-values of NFKB2 motif

No targets for NFKB2

Network of associatons between targets according to the STRING database.

First level regulatory network of NFKB2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	8.4	GO:0090023	positive regulation of neutrophil chemotaxis(GO:0090023)
1.0	5.1	GO:0015688	iron chelate transport(GO:0015688) siderophore transport(GO:0015891)
0.0	3.7	GO:0006521	regulation of cellular amino acid metabolic process(GO:0006521)
0.1	3.4	GO:0007620	copulation(GO:0007620)
0.1	2.7	GO:0090383	phagosome acidification(GO:0090383)
0.4	2.4	GO:0009181	purine nucleoside diphosphate catabolic process(GO:0009137) purine ribonucleoside diphosphate catabolic process(GO:0009181)
0.0	2.0	GO:0003197	endocardial cushion development(GO:0003197)
0.6	1.8	GO:0033634	positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.3	1.8	GO:0007089	traversing start control point of mitotic cell cycle(GO:0007089)
0.4	1.7	GO:0002268	follicular dendritic cell differentiation(GO:0002268)

Showing 1 to 10 of 161 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.9	GO:0035580	specific granule lumen(GO:0035580)
0.7	3.9	GO:0008537	proteasome activator complex(GO:0008537)
0.0	3.3	GO:0001533	cornified envelope(GO:0001533)
0.1	3.2	GO:0005605	basal lamina(GO:0005605)
0.0	2.8	GO:0005776	autophagosome(GO:0005776)
0.0	2.1	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.0	1.8	GO:0016592	mediator complex(GO:0016592)
0.4	1.7	GO:0033257	Bcl3/NF-kappaB2 complex(GO:0033257)
0.0	1.7	GO:0005758	mitochondrial intermembrane space(GO:0005758)
0.1	1.5	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)

Showing 1 to 10 of 56 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	8.4	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.4	3.9	GO:0061133	endopeptidase activator activity(GO:0061133)
0.0	3.8	GO:0005506	iron ion binding(GO:0005506)
0.3	3.4	GO:0030280	structural constituent of epidermis(GO:0030280)
0.1	2.4	GO:0017110	nucleoside-diphosphatase activity(GO:0017110)
0.0	2.1	GO:0004693	cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.1	2.0	GO:0038132	neuregulin binding(GO:0038132)
0.4	1.8	GO:0031726	CCR1 chemokine receptor binding(GO:0031726)
0.3	1.5	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.1	1.5	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)

Showing 1 to 10 of 114 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.6	ST INTERLEUKIN 4 PATHWAY	Interleukin 4 (IL-4) Pathway
0.0	2.8	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.0	2.3	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.0	1.6	PID IL23 PATHWAY	IL23-mediated signaling events
0.0	1.6	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0	1.6	PID IL12 2PATHWAY	IL12-mediated signaling events
0.0	1.4	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.0	1.4	PID HDAC CLASSI PATHWAY	Signaling events mediated by HDAC Class I
0.0	1.3	ST GAQ PATHWAY	G alpha q Pathway
0.0	1.2	PID S1P S1P1 PATHWAY	S1P1 pathway

Showing 1 to 10 of 25 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	10.4	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.1	3.9	REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0	1.6	REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI	Genes involved in RIP-mediated NFkB activation via DAI
0.1	1.5	REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	Genes involved in Formation of ATP by chemiosmotic coupling
0.1	1.4	REACTOME INITIAL TRIGGERING OF COMPLEMENT	Genes involved in Initial triggering of complement
0.0	1.4	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.0	1.4	REACTOME INSULIN RECEPTOR RECYCLING	Genes involved in Insulin receptor recycling
0.1	1.3	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.0	1.3	REACTOME HYALURONAN METABOLISM	Genes involved in Hyaluronan metabolism
0.1	1.0	REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS	Genes involved in Synthesis of substrates in N-glycan biosythesis

Showing 1 to 10 of 40 entries

Results for NFKB2

Z-value: 1.73

Motif logo

Transcription factors associated with NFKB2

Activity-expression correlation:

Activity profile of NFKB2 motif

Sorted Z-values of NFKB2 motif

No targets for NFKB2

Network of associatons between targets according to the STRING database.

First level regulatory network of NFKB2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: