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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NFKB2

Z-value: 1.73

Motif logo

Transcription factors associated with NFKB2

Gene Symbol Gene ID Gene Info
ENSG00000077150.13 nuclear factor kappa B subunit 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NFKB2hg19_v2_chr10_+_104154229_1041543540.642.3e-03Click!

Activity profile of NFKB2 motif

Sorted Z-values of NFKB2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NFKB2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 5.1 GO:0015688 iron chelate transport(GO:0015688) siderophore transport(GO:0015891)
0.6 1.8 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.5 1.4 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.4 1.7 GO:0002268 follicular dendritic cell differentiation(GO:0002268)
0.4 1.2 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.4 2.4 GO:0009181 purine nucleoside diphosphate catabolic process(GO:0009137) purine ribonucleoside diphosphate catabolic process(GO:0009181)
0.3 0.9 GO:1903217 regulation of protein processing involved in protein targeting to mitochondrion(GO:1903216) negative regulation of protein processing involved in protein targeting to mitochondrion(GO:1903217)
0.3 8.4 GO:0090023 positive regulation of neutrophil chemotaxis(GO:0090023)
0.3 1.8 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.3 0.8 GO:1900106 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.2 0.7 GO:0034553 respiratory chain complex II assembly(GO:0034552) mitochondrial respiratory chain complex II assembly(GO:0034553) mitochondrial respiratory chain complex II biogenesis(GO:0097032)
0.2 0.5 GO:0002232 leukocyte chemotaxis involved in inflammatory response(GO:0002232)
0.2 1.2 GO:0034224 cellular response to zinc ion starvation(GO:0034224)
0.2 0.7 GO:0044209 AMP salvage(GO:0044209)
0.2 1.0 GO:0060364 frontal suture morphogenesis(GO:0060364)
0.2 0.7 GO:0045226 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.2 0.5 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.2 0.5 GO:2000588 positive regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000588)
0.2 0.7 GO:0046122 purine deoxyribonucleoside metabolic process(GO:0046122)
0.2 0.8 GO:0032218 riboflavin transport(GO:0032218)
0.2 0.8 GO:0033091 positive regulation of immature T cell proliferation(GO:0033091)
0.1 3.4 GO:0007620 copulation(GO:0007620)
0.1 1.3 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.1 0.4 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.1 0.7 GO:0039689 negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
0.1 0.4 GO:2000395 regulation of ubiquitin-dependent endocytosis(GO:2000395) positive regulation of ubiquitin-dependent endocytosis(GO:2000397)
0.1 0.7 GO:0000720 pyrimidine dimer repair by nucleotide-excision repair(GO:0000720)
0.1 0.4 GO:2000563 positive regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000563)
0.1 0.4 GO:1905224 clathrin-coated pit assembly(GO:1905224)
0.1 1.5 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.1 0.6 GO:0035063 nuclear speck organization(GO:0035063)
0.1 0.3 GO:1904897 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.1 1.5 GO:0060155 platelet dense granule organization(GO:0060155)
0.1 0.8 GO:0010898 positive regulation of triglyceride catabolic process(GO:0010898)
0.1 0.6 GO:1901857 positive regulation of cellular respiration(GO:1901857)
0.1 0.6 GO:1903659 regulation of complement-dependent cytotoxicity(GO:1903659)
0.1 0.5 GO:0033132 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.1 0.7 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
0.1 0.2 GO:0060697 positive regulation of phospholipid catabolic process(GO:0060697)
0.1 0.2 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.1 0.4 GO:0090156 cellular sphingolipid homeostasis(GO:0090156)
0.1 0.3 GO:0042631 cellular response to water deprivation(GO:0042631)
0.1 2.7 GO:0090383 phagosome acidification(GO:0090383)
0.1 0.8 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1 0.3 GO:0031508 pericentric heterochromatin assembly(GO:0031508) regulation of chromosome condensation(GO:0060623)
0.1 0.5 GO:1904381 Golgi apparatus mannose trimming(GO:1904381)
0.1 0.3 GO:0035690 cellular response to drug(GO:0035690)
0.1 0.2 GO:0060455 negative regulation of gastric acid secretion(GO:0060455)
0.1 0.2 GO:0048294 negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.1 1.4 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 0.4 GO:1904849 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.1 0.2 GO:0009386 translational attenuation(GO:0009386)
0.1 0.5 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.1 0.6 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.1 0.4 GO:0019348 dolichol metabolic process(GO:0019348)
0.1 0.4 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.1 0.5 GO:0000821 regulation of arginine metabolic process(GO:0000821)
0.1 0.2 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.0 1.5 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.0 0.4 GO:0006701 progesterone biosynthetic process(GO:0006701)
0.0 0.3 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.0 0.2 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.0 0.5 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
0.0 0.3 GO:0033277 abortive mitotic cell cycle(GO:0033277)
0.0 0.8 GO:0043313 regulation of neutrophil degranulation(GO:0043313)
0.0 0.2 GO:0034499 late endosome to Golgi transport(GO:0034499)
0.0 0.6 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.0 0.1 GO:0031548 regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031548)
0.0 0.2 GO:0098582 innate vocalization behavior(GO:0098582)
0.0 0.3 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.0 0.3 GO:0040038 polar body extrusion after meiotic divisions(GO:0040038) formin-nucleated actin cable assembly(GO:0070649)
0.0 0.6 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0 0.5 GO:0048102 autophagic cell death(GO:0048102)
0.0 0.1 GO:0003220 left ventricular cardiac muscle tissue morphogenesis(GO:0003220)
0.0 0.3 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
0.0 0.5 GO:0032328 alanine transport(GO:0032328) D-amino acid transport(GO:0042940)
0.0 0.7 GO:0031507 heterochromatin assembly(GO:0031507)
0.0 0.3 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.0 0.3 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.0 0.4 GO:0046322 negative regulation of fatty acid oxidation(GO:0046322)
0.0 3.7 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.0 1.3 GO:0044458 motile cilium assembly(GO:0044458)
0.0 0.4 GO:0060174 limb bud formation(GO:0060174)
0.0 0.2 GO:0030382 sperm mitochondrion organization(GO:0030382)
0.0 0.1 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
0.0 0.2 GO:0007386 compartment pattern specification(GO:0007386)
0.0 0.7 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.4 GO:0010225 response to UV-C(GO:0010225)
0.0 0.6 GO:1902222 L-phenylalanine metabolic process(GO:0006558) L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
0.0 2.0 GO:0003197 endocardial cushion development(GO:0003197)
0.0 0.6 GO:0015732 prostaglandin transport(GO:0015732)
0.0 0.6 GO:0006032 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0 0.7 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.0 0.7 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0 0.1 GO:0007538 primary sex determination(GO:0007538)
0.0 0.8 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.0 0.6 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.0 0.3 GO:0097113 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.0 0.1 GO:0042441 eye pigment biosynthetic process(GO:0006726) eye pigment metabolic process(GO:0042441) pigment metabolic process involved in developmental pigmentation(GO:0043324) pigment metabolic process involved in pigmentation(GO:0043474)
0.0 0.3 GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway(GO:0034128)
0.0 0.2 GO:1901341 activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0 0.2 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.0 0.6 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.3 GO:2000628 regulation of miRNA metabolic process(GO:2000628)
0.0 0.2 GO:0006438 valyl-tRNA aminoacylation(GO:0006438)
0.0 0.2 GO:1902856 negative regulation of nonmotile primary cilium assembly(GO:1902856)
0.0 0.5 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.3 GO:0098903 regulation of membrane repolarization during action potential(GO:0098903)
0.0 0.2 GO:0046940 nucleoside monophosphate phosphorylation(GO:0046940)
0.0 1.3 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.0 0.2 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0 0.2 GO:0046826 negative regulation of protein export from nucleus(GO:0046826)
0.0 0.3 GO:0051660 establishment of centrosome localization(GO:0051660)
0.0 0.8 GO:0016242 negative regulation of macroautophagy(GO:0016242)
0.0 0.4 GO:0001675 acrosome assembly(GO:0001675)
0.0 1.1 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.2 GO:0097398 response to interleukin-17(GO:0097396) cellular response to interleukin-17(GO:0097398)
0.0 0.5 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.0 0.2 GO:0023035 CD40 signaling pathway(GO:0023035) protein linear polyubiquitination(GO:0097039)
0.0 0.4 GO:0003373 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.0 0.3 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 0.1 GO:0061300 cerebellum vasculature development(GO:0061300)
0.0 0.2 GO:0032494 response to peptidoglycan(GO:0032494)
0.0 0.2 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.2 GO:0010968 regulation of microtubule nucleation(GO:0010968)
0.0 1.0 GO:0007257 activation of JUN kinase activity(GO:0007257)
0.0 0.5 GO:0032060 bleb assembly(GO:0032060)
0.0 0.3 GO:0040016 embryonic cleavage(GO:0040016)
0.0 0.2 GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447)
0.0 1.5 GO:0006734 NADH metabolic process(GO:0006734)
0.0 0.3 GO:0023041 neuronal signal transduction(GO:0023041)
0.0 0.2 GO:0097167 circadian regulation of translation(GO:0097167)
0.0 1.1 GO:0006953 acute-phase response(GO:0006953)
0.0 0.1 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 0.9 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.3 GO:0007351 blastoderm segmentation(GO:0007350) tripartite regional subdivision(GO:0007351) anterior/posterior axis specification, embryo(GO:0008595)
0.0 0.2 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 1.0 GO:0019985 translesion synthesis(GO:0019985)
0.0 0.2 GO:0034201 response to oleic acid(GO:0034201)
0.0 0.1 GO:0060005 vestibular reflex(GO:0060005)
0.0 0.3 GO:0060081 membrane hyperpolarization(GO:0060081)
0.0 0.5 GO:0090140 regulation of mitochondrial fission(GO:0090140)
0.0 0.0 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.0 0.3 GO:0019372 lipoxygenase pathway(GO:0019372)
0.0 0.5 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.2 GO:0048664 neuron fate determination(GO:0048664)
0.0 0.4 GO:0030207 chondroitin sulfate catabolic process(GO:0030207)
0.0 0.2 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.0 0.7 GO:0006363 transcription elongation from RNA polymerase I promoter(GO:0006362) termination of RNA polymerase I transcription(GO:0006363)
0.0 0.1 GO:1904141 mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141)
0.0 0.2 GO:0007162 negative regulation of cell adhesion(GO:0007162)
0.0 0.0 GO:0061433 cellular response to caloric restriction(GO:0061433) negative regulation of oligodendrocyte progenitor proliferation(GO:0070446)
0.0 0.5 GO:0035767 endothelial cell chemotaxis(GO:0035767)
0.0 0.1 GO:0042420 dopamine catabolic process(GO:0042420)
0.0 0.2 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.0 0.2 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.0 0.2 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.0 0.1 GO:0097084 vascular smooth muscle cell development(GO:0097084)
0.0 0.7 GO:0050710 negative regulation of cytokine secretion(GO:0050710)
0.0 0.5 GO:0030199 collagen fibril organization(GO:0030199)
0.0 0.1 GO:0030205 dermatan sulfate metabolic process(GO:0030205) dermatan sulfate biosynthetic process(GO:0030208)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 3.9 GO:0008537 proteasome activator complex(GO:0008537)
0.4 1.7 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
0.3 0.8 GO:0036117 hyaluranon cable(GO:0036117)
0.2 0.5 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.1 1.3 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 0.3 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 0.4 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.1 0.7 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.1 1.4 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 0.4 GO:1990876 cytoplasmic side of nuclear pore(GO:1990876)
0.1 1.5 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 1.5 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 0.6 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.1 0.2 GO:0031501 mannosyltransferase complex(GO:0031501)
0.1 0.4 GO:0035339 SPOTS complex(GO:0035339)
0.1 3.2 GO:0005605 basal lamina(GO:0005605)
0.1 0.7 GO:0001739 sex chromatin(GO:0001739)
0.1 0.4 GO:0070435 Shc-EGFR complex(GO:0070435)
0.1 0.5 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 5.9 GO:0035580 specific granule lumen(GO:0035580)
0.0 0.3 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.0 0.7 GO:0005677 chromatin silencing complex(GO:0005677)
0.0 3.3 GO:0001533 cornified envelope(GO:0001533)
0.0 0.3 GO:0001740 Barr body(GO:0001740)
0.0 1.1 GO:0010369 chromocenter(GO:0010369)
0.0 0.2 GO:0071797 LUBAC complex(GO:0071797)
0.0 1.8 GO:0016592 mediator complex(GO:0016592)
0.0 0.7 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.4 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 0.2 GO:0032044 DSIF complex(GO:0032044)
0.0 0.4 GO:0098839 postsynaptic density membrane(GO:0098839)
0.0 0.4 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.0 0.2 GO:0005833 hemoglobin complex(GO:0005833)
0.0 0.3 GO:0016461 unconventional myosin complex(GO:0016461)
0.0 1.1 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.4 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.5 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.3 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.1 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 0.4 GO:0044232 organelle membrane contact site(GO:0044232)
0.0 0.7 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.0 2.8 GO:0005776 autophagosome(GO:0005776)
0.0 0.1 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.0 2.1 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 0.7 GO:0008021 synaptic vesicle(GO:0008021)
0.0 0.1 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.0 0.4 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 1.1 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 1.7 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.3 GO:0042555 MCM complex(GO:0042555)
0.0 0.3 GO:0032059 bleb(GO:0032059)
0.0 0.1 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 0.1 GO:0016342 catenin complex(GO:0016342)
0.0 0.2 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.3 GO:0043194 node of Ranvier(GO:0033268) axon initial segment(GO:0043194)
0.0 0.1 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 8.4 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.4 3.9 GO:0061133 endopeptidase activator activity(GO:0061133)
0.4 1.8 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.3 1.0 GO:0052856 NADHX epimerase activity(GO:0052856) NADPHX epimerase activity(GO:0052857)
0.3 1.5 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.3 3.4 GO:0030280 structural constituent of epidermis(GO:0030280)
0.2 1.2 GO:0050473 prostaglandin-endoperoxide synthase activity(GO:0004666) arachidonate 15-lipoxygenase activity(GO:0050473)
0.2 0.9 GO:0047708 biotinidase activity(GO:0047708)
0.2 0.9 GO:0003943 N-acetylgalactosamine-4-sulfatase activity(GO:0003943)
0.2 1.2 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.2 0.7 GO:0002060 purine nucleobase binding(GO:0002060)
0.2 1.3 GO:0071535 RING-like zinc finger domain binding(GO:0071535)
0.2 0.8 GO:0032217 riboflavin transporter activity(GO:0032217)
0.1 0.6 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.1 2.0 GO:0038132 neuregulin binding(GO:0038132)
0.1 0.5 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 0.3 GO:0060001 minus-end directed microfilament motor activity(GO:0060001)
0.1 2.4 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)
0.1 0.3 GO:0038131 neuregulin receptor activity(GO:0038131)
0.1 0.6 GO:0045569 TRAIL binding(GO:0045569)
0.1 0.4 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.1 0.5 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.1 0.5 GO:0070026 nitric oxide binding(GO:0070026)
0.1 0.9 GO:0030249 cyclase regulator activity(GO:0010851) guanylate cyclase regulator activity(GO:0030249)
0.1 0.7 GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599)
0.1 0.3 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.1 0.3 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.1 0.7 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.1 0.7 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1 0.2 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
0.1 0.3 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.1 0.8 GO:0030274 LIM domain binding(GO:0030274)
0.1 0.3 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.1 0.2 GO:0097158 pre-mRNA intronic pyrimidine-rich binding(GO:0097158)
0.1 0.5 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 0.4 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.1 0.2 GO:0019976 interleukin-2 receptor activity(GO:0004911) interleukin-2 binding(GO:0019976)
0.1 1.5 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 1.4 GO:0035198 miRNA binding(GO:0035198)
0.1 0.2 GO:0005046 KDEL sequence binding(GO:0005046)
0.0 0.4 GO:0048408 epidermal growth factor binding(GO:0048408)
0.0 0.1 GO:0072544 L-DOPA receptor activity(GO:0035643) L-DOPA binding(GO:0072544)
0.0 0.2 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 0.2 GO:0004917 interleukin-7 receptor activity(GO:0004917)
0.0 0.6 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.0 0.1 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.0 0.6 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.0 0.1 GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.0 0.2 GO:0016532 superoxide dismutase copper chaperone activity(GO:0016532)
0.0 0.2 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
0.0 0.3 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.5 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.0 0.4 GO:0032051 clathrin light chain binding(GO:0032051)
0.0 0.8 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.6 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.4 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.0 0.6 GO:0004568 chitinase activity(GO:0004568)
0.0 0.2 GO:0030492 hemoglobin binding(GO:0030492)
0.0 0.7 GO:0001054 RNA polymerase I activity(GO:0001054)
0.0 0.2 GO:0070736 protein-glycine ligase activity, initiating(GO:0070736)
0.0 0.5 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.1 GO:0048763 calcium-induced calcium release activity(GO:0048763)
0.0 2.1 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 0.2 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.0 0.5 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 0.5 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.0 0.7 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.2 GO:0004832 valine-tRNA ligase activity(GO:0004832)
0.0 0.6 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.8 GO:0005003 ephrin receptor activity(GO:0005003)
0.0 0.2 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.2 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.0 0.1 GO:0016499 orexin receptor activity(GO:0016499)
0.0 1.3 GO:0042056 chemoattractant activity(GO:0042056)
0.0 1.0 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.4 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.9 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.2 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
0.0 0.5 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.3 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.0 0.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.1 GO:0005330 dopamine:sodium symporter activity(GO:0005330)
0.0 0.1 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.0 0.6 GO:0008483 transaminase activity(GO:0008483)
0.0 0.6 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.1 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.0 0.3 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 0.9 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.2 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 0.2 GO:0070087 chromo shadow domain binding(GO:0070087)
0.0 0.5 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.0 0.2 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 3.8 GO:0005506 iron ion binding(GO:0005506)
0.0 0.4 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.2 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 0.3 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.3 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.3 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.1 GO:0022865 transmembrane electron transfer carrier(GO:0022865)
0.0 0.0 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
0.0 0.4 GO:0030332 cyclin binding(GO:0030332)
0.0 0.3 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.2 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.3 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 0.2 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.2 GO:0031996 thioesterase binding(GO:0031996)
0.0 0.3 GO:0000400 four-way junction DNA binding(GO:0000400)
0.0 0.2 GO:0047760 butyrate-CoA ligase activity(GO:0047760)
0.0 0.6 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.4 GO:0017127 cholesterol transporter activity(GO:0017127)
0.0 0.0 GO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.0 0.3 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 1.4 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 0.6 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.5 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.1 3.6 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.0 0.5 PID IL27 PATHWAY IL27-mediated signaling events
0.0 0.5 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 2.8 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 1.2 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 1.6 PID IL23 PATHWAY IL23-mediated signaling events
0.0 1.3 ST GAQ PATHWAY G alpha q Pathway
0.0 1.6 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 2.3 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.0 1.6 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 1.4 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.8 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.5 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.8 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 0.8 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 0.3 ST GA12 PATHWAY G alpha 12 Pathway
0.0 0.6 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 0.5 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 1.0 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.7 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.3 PID ERBB1 RECEPTOR PROXIMAL PATHWAY EGF receptor (ErbB1) signaling pathway
0.0 0.3 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 0.3 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 1.4 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 10.4 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 1.3 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 1.5 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 1.4 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.1 1.0 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1 3.9 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 1.3 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 1.4 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 1.6 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.8 REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES Genes involved in p75NTR recruits signalling complexes
0.0 1.4 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 0.4 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.5 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.1 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.0 0.6 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.7 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.7 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.0 0.7 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.7 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 0.5 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 0.6 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.3 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.4 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.4 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 0.4 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.5 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.6 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.6 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.6 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.0 0.2 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.6 REACTOME ORC1 REMOVAL FROM CHROMATIN Genes involved in Orc1 removal from chromatin
0.0 1.0 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 0.3 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.8 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 1.0 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.5 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.3 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.6 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.5 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.2 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi