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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for NFKB2
Z-value: 1.73
Motif logo
Transcription factors associated with NFKB2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
NFKB2
|
ENSG00000077150.13 | nuclear factor kappa B subunit 2 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFKB2 | hg19_v2_chr10_+_104154229_104154354 | 0.64 | 2.3e-03 | Click! |
Activity profile of NFKB2 motif
Sorted Z-values of NFKB2 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of NFKB2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 5.1 | GO:0015688 | iron chelate transport(GO:0015688) siderophore transport(GO:0015891) |
| 0.6 | 1.8 | GO:0033634 | positive regulation of cell-cell adhesion mediated by integrin(GO:0033634) |
| 0.5 | 1.4 | GO:0009786 | regulation of asymmetric cell division(GO:0009786) |
| 0.4 | 1.7 | GO:0002268 | follicular dendritic cell differentiation(GO:0002268) |
| 0.4 | 1.2 | GO:0090271 | positive regulation of fibroblast growth factor production(GO:0090271) |
| 0.4 | 2.4 | GO:0009181 | purine nucleoside diphosphate catabolic process(GO:0009137) purine ribonucleoside diphosphate catabolic process(GO:0009181) |
| 0.3 | 0.9 | GO:1903217 | regulation of protein processing involved in protein targeting to mitochondrion(GO:1903216) negative regulation of protein processing involved in protein targeting to mitochondrion(GO:1903217) |
| 0.3 | 8.4 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 0.3 | 1.8 | GO:0007089 | traversing start control point of mitotic cell cycle(GO:0007089) |
| 0.3 | 0.8 | GO:1900106 | hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106) |
| 0.2 | 0.7 | GO:0034553 | respiratory chain complex II assembly(GO:0034552) mitochondrial respiratory chain complex II assembly(GO:0034553) mitochondrial respiratory chain complex II biogenesis(GO:0097032) |
| 0.2 | 0.5 | GO:0002232 | leukocyte chemotaxis involved in inflammatory response(GO:0002232) |
| 0.2 | 1.2 | GO:0034224 | cellular response to zinc ion starvation(GO:0034224) |
| 0.2 | 0.7 | GO:0044209 | AMP salvage(GO:0044209) |
| 0.2 | 1.0 | GO:0060364 | frontal suture morphogenesis(GO:0060364) |
| 0.2 | 0.7 | GO:0045226 | extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379) |
| 0.2 | 0.5 | GO:0051771 | negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771) |
| 0.2 | 0.5 | GO:2000588 | positive regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000588) |
| 0.2 | 0.7 | GO:0046122 | purine deoxyribonucleoside metabolic process(GO:0046122) |
| 0.2 | 0.8 | GO:0032218 | riboflavin transport(GO:0032218) |
| 0.2 | 0.8 | GO:0033091 | positive regulation of immature T cell proliferation(GO:0033091) |
| 0.1 | 3.4 | GO:0007620 | copulation(GO:0007620) |
| 0.1 | 1.3 | GO:0002480 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480) |
| 0.1 | 0.4 | GO:1901842 | negative regulation of high voltage-gated calcium channel activity(GO:1901842) |
| 0.1 | 0.7 | GO:0039689 | negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034) |
| 0.1 | 0.4 | GO:2000395 | regulation of ubiquitin-dependent endocytosis(GO:2000395) positive regulation of ubiquitin-dependent endocytosis(GO:2000397) |
| 0.1 | 0.7 | GO:0000720 | pyrimidine dimer repair by nucleotide-excision repair(GO:0000720) |
| 0.1 | 0.4 | GO:2000563 | positive regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000563) |
| 0.1 | 0.4 | GO:1905224 | clathrin-coated pit assembly(GO:1905224) |
| 0.1 | 1.5 | GO:0015991 | ATP hydrolysis coupled proton transport(GO:0015991) |
| 0.1 | 0.6 | GO:0035063 | nuclear speck organization(GO:0035063) |
| 0.1 | 0.3 | GO:1904897 | regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922) |
| 0.1 | 1.5 | GO:0060155 | platelet dense granule organization(GO:0060155) |
| 0.1 | 0.8 | GO:0010898 | positive regulation of triglyceride catabolic process(GO:0010898) |
| 0.1 | 0.6 | GO:1901857 | positive regulation of cellular respiration(GO:1901857) |
| 0.1 | 0.6 | GO:1903659 | regulation of complement-dependent cytotoxicity(GO:1903659) |
| 0.1 | 0.5 | GO:0033132 | negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300) |
| 0.1 | 0.7 | GO:0046604 | positive regulation of mitotic centrosome separation(GO:0046604) |
| 0.1 | 0.2 | GO:0060697 | positive regulation of phospholipid catabolic process(GO:0060697) |
| 0.1 | 0.2 | GO:0019287 | isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287) |
| 0.1 | 0.4 | GO:0090156 | cellular sphingolipid homeostasis(GO:0090156) |
| 0.1 | 0.3 | GO:0042631 | cellular response to water deprivation(GO:0042631) |
| 0.1 | 2.7 | GO:0090383 | phagosome acidification(GO:0090383) |
| 0.1 | 0.8 | GO:0007168 | receptor guanylyl cyclase signaling pathway(GO:0007168) |
| 0.1 | 0.3 | GO:0031508 | pericentric heterochromatin assembly(GO:0031508) regulation of chromosome condensation(GO:0060623) |
| 0.1 | 0.5 | GO:1904381 | Golgi apparatus mannose trimming(GO:1904381) |
| 0.1 | 0.3 | GO:0035690 | cellular response to drug(GO:0035690) |
| 0.1 | 0.2 | GO:0060455 | negative regulation of gastric acid secretion(GO:0060455) |
| 0.1 | 0.2 | GO:0048294 | negative regulation of isotype switching to IgE isotypes(GO:0048294) |
| 0.1 | 1.4 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.1 | 0.4 | GO:1904849 | positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546) |
| 0.1 | 0.2 | GO:0009386 | translational attenuation(GO:0009386) |
| 0.1 | 0.5 | GO:0070936 | protein K48-linked ubiquitination(GO:0070936) |
| 0.1 | 0.6 | GO:1903265 | positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265) |
| 0.1 | 0.4 | GO:0019348 | dolichol metabolic process(GO:0019348) |
| 0.1 | 0.4 | GO:0031580 | membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580) |
| 0.1 | 0.5 | GO:0000821 | regulation of arginine metabolic process(GO:0000821) |
| 0.1 | 0.2 | GO:0046013 | regulation of T cell homeostatic proliferation(GO:0046013) |
| 0.0 | 1.5 | GO:0046597 | negative regulation of viral entry into host cell(GO:0046597) |
| 0.0 | 0.4 | GO:0006701 | progesterone biosynthetic process(GO:0006701) |
| 0.0 | 0.3 | GO:0007598 | blood coagulation, extrinsic pathway(GO:0007598) |
| 0.0 | 0.2 | GO:0060010 | Sertoli cell fate commitment(GO:0060010) |
| 0.0 | 0.5 | GO:2001199 | negative regulation of dendritic cell differentiation(GO:2001199) |
| 0.0 | 0.3 | GO:0033277 | abortive mitotic cell cycle(GO:0033277) |
| 0.0 | 0.8 | GO:0043313 | regulation of neutrophil degranulation(GO:0043313) |
| 0.0 | 0.2 | GO:0034499 | late endosome to Golgi transport(GO:0034499) |
| 0.0 | 0.6 | GO:0061179 | negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179) |
| 0.0 | 0.1 | GO:0031548 | regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031548) |
| 0.0 | 0.2 | GO:0098582 | innate vocalization behavior(GO:0098582) |
| 0.0 | 0.3 | GO:0006072 | glycerol-3-phosphate metabolic process(GO:0006072) |
| 0.0 | 0.3 | GO:0040038 | polar body extrusion after meiotic divisions(GO:0040038) formin-nucleated actin cable assembly(GO:0070649) |
| 0.0 | 0.6 | GO:0006048 | UDP-N-acetylglucosamine biosynthetic process(GO:0006048) |
| 0.0 | 0.5 | GO:0048102 | autophagic cell death(GO:0048102) |
| 0.0 | 0.1 | GO:0003220 | left ventricular cardiac muscle tissue morphogenesis(GO:0003220) |
| 0.0 | 0.3 | GO:0070164 | negative regulation of adiponectin secretion(GO:0070164) |
| 0.0 | 0.5 | GO:0032328 | alanine transport(GO:0032328) D-amino acid transport(GO:0042940) |
| 0.0 | 0.7 | GO:0031507 | heterochromatin assembly(GO:0031507) |
| 0.0 | 0.3 | GO:0016191 | synaptic vesicle uncoating(GO:0016191) |
| 0.0 | 0.3 | GO:1902261 | positive regulation of delayed rectifier potassium channel activity(GO:1902261) |
| 0.0 | 0.4 | GO:0046322 | negative regulation of fatty acid oxidation(GO:0046322) |
| 0.0 | 3.7 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 0.0 | 1.3 | GO:0044458 | motile cilium assembly(GO:0044458) |
| 0.0 | 0.4 | GO:0060174 | limb bud formation(GO:0060174) |
| 0.0 | 0.2 | GO:0030382 | sperm mitochondrion organization(GO:0030382) |
| 0.0 | 0.1 | GO:1904204 | regulation of skeletal muscle hypertrophy(GO:1904204) |
| 0.0 | 0.2 | GO:0007386 | compartment pattern specification(GO:0007386) |
| 0.0 | 0.7 | GO:0001574 | ganglioside biosynthetic process(GO:0001574) |
| 0.0 | 0.4 | GO:0010225 | response to UV-C(GO:0010225) |
| 0.0 | 0.6 | GO:1902222 | L-phenylalanine metabolic process(GO:0006558) L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222) |
| 0.0 | 2.0 | GO:0003197 | endocardial cushion development(GO:0003197) |
| 0.0 | 0.6 | GO:0015732 | prostaglandin transport(GO:0015732) |
| 0.0 | 0.6 | GO:0006032 | chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032) |
| 0.0 | 0.7 | GO:0042340 | keratan sulfate catabolic process(GO:0042340) |
| 0.0 | 0.7 | GO:0070935 | 3'-UTR-mediated mRNA stabilization(GO:0070935) |
| 0.0 | 0.1 | GO:0007538 | primary sex determination(GO:0007538) |
| 0.0 | 0.8 | GO:0043011 | myeloid dendritic cell differentiation(GO:0043011) |
| 0.0 | 0.6 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.0 | 0.3 | GO:0097113 | AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688) |
| 0.0 | 0.1 | GO:0042441 | eye pigment biosynthetic process(GO:0006726) eye pigment metabolic process(GO:0042441) pigment metabolic process involved in developmental pigmentation(GO:0043324) pigment metabolic process involved in pigmentation(GO:0043474) |
| 0.0 | 0.3 | GO:0034128 | negative regulation of MyD88-independent toll-like receptor signaling pathway(GO:0034128) |
| 0.0 | 0.2 | GO:1901341 | activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341) |
| 0.0 | 0.2 | GO:0001915 | negative regulation of T cell mediated cytotoxicity(GO:0001915) |
| 0.0 | 0.6 | GO:0005513 | detection of calcium ion(GO:0005513) |
| 0.0 | 0.3 | GO:2000628 | regulation of miRNA metabolic process(GO:2000628) |
| 0.0 | 0.2 | GO:0006438 | valyl-tRNA aminoacylation(GO:0006438) |
| 0.0 | 0.2 | GO:1902856 | negative regulation of nonmotile primary cilium assembly(GO:1902856) |
| 0.0 | 0.5 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
| 0.0 | 0.3 | GO:0098903 | regulation of membrane repolarization during action potential(GO:0098903) |
| 0.0 | 0.2 | GO:0046940 | nucleoside monophosphate phosphorylation(GO:0046940) |
| 0.0 | 1.3 | GO:0030212 | hyaluronan metabolic process(GO:0030212) |
| 0.0 | 0.2 | GO:0046642 | negative regulation of alpha-beta T cell proliferation(GO:0046642) |
| 0.0 | 0.2 | GO:0046826 | negative regulation of protein export from nucleus(GO:0046826) |
| 0.0 | 0.3 | GO:0051660 | establishment of centrosome localization(GO:0051660) |
| 0.0 | 0.8 | GO:0016242 | negative regulation of macroautophagy(GO:0016242) |
| 0.0 | 0.4 | GO:0001675 | acrosome assembly(GO:0001675) |
| 0.0 | 1.1 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 0.0 | 0.2 | GO:0097398 | response to interleukin-17(GO:0097396) cellular response to interleukin-17(GO:0097398) |
| 0.0 | 0.5 | GO:0097067 | cellular response to thyroid hormone stimulus(GO:0097067) |
| 0.0 | 0.2 | GO:0023035 | CD40 signaling pathway(GO:0023035) protein linear polyubiquitination(GO:0097039) |
| 0.0 | 0.4 | GO:0003373 | dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374) |
| 0.0 | 0.3 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 0.0 | 0.1 | GO:0061300 | cerebellum vasculature development(GO:0061300) |
| 0.0 | 0.2 | GO:0032494 | response to peptidoglycan(GO:0032494) |
| 0.0 | 0.2 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
| 0.0 | 0.2 | GO:0010968 | regulation of microtubule nucleation(GO:0010968) |
| 0.0 | 1.0 | GO:0007257 | activation of JUN kinase activity(GO:0007257) |
| 0.0 | 0.5 | GO:0032060 | bleb assembly(GO:0032060) |
| 0.0 | 0.3 | GO:0040016 | embryonic cleavage(GO:0040016) |
| 0.0 | 0.2 | GO:0000447 | endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447) |
| 0.0 | 1.5 | GO:0006734 | NADH metabolic process(GO:0006734) |
| 0.0 | 0.3 | GO:0023041 | neuronal signal transduction(GO:0023041) |
| 0.0 | 0.2 | GO:0097167 | circadian regulation of translation(GO:0097167) |
| 0.0 | 1.1 | GO:0006953 | acute-phase response(GO:0006953) |
| 0.0 | 0.1 | GO:0016973 | poly(A)+ mRNA export from nucleus(GO:0016973) |
| 0.0 | 0.9 | GO:0006198 | cAMP catabolic process(GO:0006198) |
| 0.0 | 0.3 | GO:0007351 | blastoderm segmentation(GO:0007350) tripartite regional subdivision(GO:0007351) anterior/posterior axis specification, embryo(GO:0008595) |
| 0.0 | 0.2 | GO:0006621 | protein retention in ER lumen(GO:0006621) |
| 0.0 | 1.0 | GO:0019985 | translesion synthesis(GO:0019985) |
| 0.0 | 0.2 | GO:0034201 | response to oleic acid(GO:0034201) |
| 0.0 | 0.1 | GO:0060005 | vestibular reflex(GO:0060005) |
| 0.0 | 0.3 | GO:0060081 | membrane hyperpolarization(GO:0060081) |
| 0.0 | 0.5 | GO:0090140 | regulation of mitochondrial fission(GO:0090140) |
| 0.0 | 0.0 | GO:0002025 | vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025) |
| 0.0 | 0.3 | GO:0019372 | lipoxygenase pathway(GO:0019372) |
| 0.0 | 0.5 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.0 | 0.2 | GO:0048664 | neuron fate determination(GO:0048664) |
| 0.0 | 0.4 | GO:0030207 | chondroitin sulfate catabolic process(GO:0030207) |
| 0.0 | 0.2 | GO:0030050 | vesicle transport along actin filament(GO:0030050) |
| 0.0 | 0.7 | GO:0006363 | transcription elongation from RNA polymerase I promoter(GO:0006362) termination of RNA polymerase I transcription(GO:0006363) |
| 0.0 | 0.1 | GO:1904141 | mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141) |
| 0.0 | 0.2 | GO:0007162 | negative regulation of cell adhesion(GO:0007162) |
| 0.0 | 0.0 | GO:0061433 | cellular response to caloric restriction(GO:0061433) negative regulation of oligodendrocyte progenitor proliferation(GO:0070446) |
| 0.0 | 0.5 | GO:0035767 | endothelial cell chemotaxis(GO:0035767) |
| 0.0 | 0.1 | GO:0042420 | dopamine catabolic process(GO:0042420) |
| 0.0 | 0.2 | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) |
| 0.0 | 0.2 | GO:0034244 | negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244) |
| 0.0 | 0.2 | GO:0090360 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 0.0 | 0.1 | GO:0097084 | vascular smooth muscle cell development(GO:0097084) |
| 0.0 | 0.7 | GO:0050710 | negative regulation of cytokine secretion(GO:0050710) |
| 0.0 | 0.5 | GO:0030199 | collagen fibril organization(GO:0030199) |
| 0.0 | 0.1 | GO:0030205 | dermatan sulfate metabolic process(GO:0030205) dermatan sulfate biosynthetic process(GO:0030208) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 3.9 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 0.4 | 1.7 | GO:0033257 | Bcl3/NF-kappaB2 complex(GO:0033257) |
| 0.3 | 0.8 | GO:0036117 | hyaluranon cable(GO:0036117) |
| 0.2 | 0.5 | GO:0097057 | TRAF2-GSTP1 complex(GO:0097057) |
| 0.1 | 1.3 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.1 | 0.3 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.1 | 0.4 | GO:0033185 | dolichol-phosphate-mannose synthase complex(GO:0033185) |
| 0.1 | 0.7 | GO:0000110 | nucleotide-excision repair factor 1 complex(GO:0000110) |
| 0.1 | 1.4 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
| 0.1 | 0.4 | GO:1990876 | cytoplasmic side of nuclear pore(GO:1990876) |
| 0.1 | 1.5 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.1 | 1.5 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.1 | 0.6 | GO:0097169 | AIM2 inflammasome complex(GO:0097169) |
| 0.1 | 0.2 | GO:0031501 | mannosyltransferase complex(GO:0031501) |
| 0.1 | 0.4 | GO:0035339 | SPOTS complex(GO:0035339) |
| 0.1 | 3.2 | GO:0005605 | basal lamina(GO:0005605) |
| 0.1 | 0.7 | GO:0001739 | sex chromatin(GO:0001739) |
| 0.1 | 0.4 | GO:0070435 | Shc-EGFR complex(GO:0070435) |
| 0.1 | 0.5 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.1 | 5.9 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.0 | 0.3 | GO:0071598 | neuronal ribonucleoprotein granule(GO:0071598) |
| 0.0 | 0.7 | GO:0005677 | chromatin silencing complex(GO:0005677) |
| 0.0 | 3.3 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 0.3 | GO:0001740 | Barr body(GO:0001740) |
| 0.0 | 1.1 | GO:0010369 | chromocenter(GO:0010369) |
| 0.0 | 0.2 | GO:0071797 | LUBAC complex(GO:0071797) |
| 0.0 | 1.8 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 0.7 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 0.0 | 0.4 | GO:0002116 | semaphorin receptor complex(GO:0002116) |
| 0.0 | 0.2 | GO:0032044 | DSIF complex(GO:0032044) |
| 0.0 | 0.4 | GO:0098839 | postsynaptic density membrane(GO:0098839) |
| 0.0 | 0.4 | GO:0002199 | zona pellucida receptor complex(GO:0002199) |
| 0.0 | 0.2 | GO:0005833 | hemoglobin complex(GO:0005833) |
| 0.0 | 0.3 | GO:0016461 | unconventional myosin complex(GO:0016461) |
| 0.0 | 1.1 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.0 | 0.4 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.0 | 0.5 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.0 | 0.3 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.0 | 0.1 | GO:0042720 | mitochondrial inner membrane peptidase complex(GO:0042720) |
| 0.0 | 0.4 | GO:0044232 | organelle membrane contact site(GO:0044232) |
| 0.0 | 0.7 | GO:0005849 | mRNA cleavage factor complex(GO:0005849) |
| 0.0 | 2.8 | GO:0005776 | autophagosome(GO:0005776) |
| 0.0 | 0.1 | GO:0042567 | insulin-like growth factor ternary complex(GO:0042567) |
| 0.0 | 2.1 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 0.7 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.0 | 0.1 | GO:0042272 | nuclear RNA export factor complex(GO:0042272) |
| 0.0 | 0.4 | GO:0031011 | Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202) |
| 0.0 | 1.1 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.0 | 1.7 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.0 | 0.3 | GO:0042555 | MCM complex(GO:0042555) |
| 0.0 | 0.3 | GO:0032059 | bleb(GO:0032059) |
| 0.0 | 0.1 | GO:0030915 | Smc5-Smc6 complex(GO:0030915) |
| 0.0 | 0.1 | GO:0016342 | catenin complex(GO:0016342) |
| 0.0 | 0.2 | GO:0030870 | Mre11 complex(GO:0030870) |
| 0.0 | 0.3 | GO:0043194 | node of Ranvier(GO:0033268) axon initial segment(GO:0043194) |
| 0.0 | 0.1 | GO:0045009 | melanosome membrane(GO:0033162) chitosome(GO:0045009) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 8.4 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.4 | 3.9 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 0.4 | 1.8 | GO:0031726 | CCR1 chemokine receptor binding(GO:0031726) |
| 0.3 | 1.0 | GO:0052856 | NADHX epimerase activity(GO:0052856) NADPHX epimerase activity(GO:0052857) |
| 0.3 | 1.5 | GO:0050501 | hyaluronan synthase activity(GO:0050501) |
| 0.3 | 3.4 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
| 0.2 | 1.2 | GO:0050473 | prostaglandin-endoperoxide synthase activity(GO:0004666) arachidonate 15-lipoxygenase activity(GO:0050473) |
| 0.2 | 0.9 | GO:0047708 | biotinidase activity(GO:0047708) |
| 0.2 | 0.9 | GO:0003943 | N-acetylgalactosamine-4-sulfatase activity(GO:0003943) |
| 0.2 | 1.2 | GO:0047756 | chondroitin 4-sulfotransferase activity(GO:0047756) |
| 0.2 | 0.7 | GO:0002060 | purine nucleobase binding(GO:0002060) |
| 0.2 | 1.3 | GO:0071535 | RING-like zinc finger domain binding(GO:0071535) |
| 0.2 | 0.8 | GO:0032217 | riboflavin transporter activity(GO:0032217) |
| 0.1 | 0.6 | GO:0001716 | L-amino-acid oxidase activity(GO:0001716) |
| 0.1 | 2.0 | GO:0038132 | neuregulin binding(GO:0038132) |
| 0.1 | 0.5 | GO:0034714 | type III transforming growth factor beta receptor binding(GO:0034714) |
| 0.1 | 0.3 | GO:0060001 | minus-end directed microfilament motor activity(GO:0060001) |
| 0.1 | 2.4 | GO:0017110 | nucleoside-diphosphatase activity(GO:0017110) |
| 0.1 | 0.3 | GO:0038131 | neuregulin receptor activity(GO:0038131) |
| 0.1 | 0.6 | GO:0045569 | TRAIL binding(GO:0045569) |
| 0.1 | 0.4 | GO:0004582 | dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582) |
| 0.1 | 0.5 | GO:1990050 | phosphatidic acid transporter activity(GO:1990050) |
| 0.1 | 0.5 | GO:0070026 | nitric oxide binding(GO:0070026) |
| 0.1 | 0.9 | GO:0030249 | cyclase regulator activity(GO:0010851) guanylate cyclase regulator activity(GO:0030249) |
| 0.1 | 0.7 | GO:1990599 | 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599) |
| 0.1 | 0.3 | GO:0047066 | phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066) |
| 0.1 | 0.3 | GO:0031811 | G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812) |
| 0.1 | 0.7 | GO:0019136 | deoxynucleoside kinase activity(GO:0019136) |
| 0.1 | 0.7 | GO:0003828 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828) |
| 0.1 | 0.2 | GO:0004584 | dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584) |
| 0.1 | 0.3 | GO:0005105 | type 1 fibroblast growth factor receptor binding(GO:0005105) |
| 0.1 | 0.8 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.1 | 0.3 | GO:0008532 | N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532) |
| 0.1 | 0.2 | GO:0097158 | pre-mRNA intronic pyrimidine-rich binding(GO:0097158) |
| 0.1 | 0.5 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 0.1 | 0.4 | GO:0004466 | long-chain-acyl-CoA dehydrogenase activity(GO:0004466) |
| 0.1 | 0.2 | GO:0019976 | interleukin-2 receptor activity(GO:0004911) interleukin-2 binding(GO:0019976) |
| 0.1 | 1.5 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.1 | 1.4 | GO:0035198 | miRNA binding(GO:0035198) |
| 0.1 | 0.2 | GO:0005046 | KDEL sequence binding(GO:0005046) |
| 0.0 | 0.4 | GO:0048408 | epidermal growth factor binding(GO:0048408) |
| 0.0 | 0.1 | GO:0072544 | L-DOPA receptor activity(GO:0035643) L-DOPA binding(GO:0072544) |
| 0.0 | 0.2 | GO:0033829 | O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829) |
| 0.0 | 0.2 | GO:0004917 | interleukin-7 receptor activity(GO:0004917) |
| 0.0 | 0.6 | GO:0002151 | G-quadruplex RNA binding(GO:0002151) |
| 0.0 | 0.1 | GO:0005169 | neurotrophin TRKB receptor binding(GO:0005169) |
| 0.0 | 0.6 | GO:0004465 | lipoprotein lipase activity(GO:0004465) |
| 0.0 | 0.1 | GO:0001537 | N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537) |
| 0.0 | 0.2 | GO:0016532 | superoxide dismutase copper chaperone activity(GO:0016532) |
| 0.0 | 0.2 | GO:0046899 | nucleoside triphosphate adenylate kinase activity(GO:0046899) |
| 0.0 | 0.3 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
| 0.0 | 0.5 | GO:0097027 | ubiquitin-protein transferase activator activity(GO:0097027) |
| 0.0 | 0.4 | GO:0032051 | clathrin light chain binding(GO:0032051) |
| 0.0 | 0.8 | GO:0050700 | CARD domain binding(GO:0050700) |
| 0.0 | 0.6 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.0 | 0.4 | GO:0004415 | hyalurononglucosaminidase activity(GO:0004415) |
| 0.0 | 0.6 | GO:0004568 | chitinase activity(GO:0004568) |
| 0.0 | 0.2 | GO:0030492 | hemoglobin binding(GO:0030492) |
| 0.0 | 0.7 | GO:0001054 | RNA polymerase I activity(GO:0001054) |
| 0.0 | 0.2 | GO:0070736 | protein-glycine ligase activity, initiating(GO:0070736) |
| 0.0 | 0.5 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
| 0.0 | 0.1 | GO:0048763 | calcium-induced calcium release activity(GO:0048763) |
| 0.0 | 2.1 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.0 | 0.2 | GO:0008273 | calcium, potassium:sodium antiporter activity(GO:0008273) |
| 0.0 | 0.5 | GO:0022889 | L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889) |
| 0.0 | 0.5 | GO:0015174 | basic amino acid transmembrane transporter activity(GO:0015174) |
| 0.0 | 0.7 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
| 0.0 | 0.2 | GO:0004832 | valine-tRNA ligase activity(GO:0004832) |
| 0.0 | 0.6 | GO:0004065 | arylsulfatase activity(GO:0004065) |
| 0.0 | 0.8 | GO:0005003 | ephrin receptor activity(GO:0005003) |
| 0.0 | 0.2 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
| 0.0 | 0.2 | GO:0004957 | prostaglandin E receptor activity(GO:0004957) |
| 0.0 | 0.1 | GO:0016499 | orexin receptor activity(GO:0016499) |
| 0.0 | 1.3 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.0 | 1.0 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.0 | 0.4 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.0 | 0.9 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 0.2 | GO:0004699 | calcium-independent protein kinase C activity(GO:0004699) |
| 0.0 | 0.5 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
| 0.0 | 0.3 | GO:0047429 | nucleoside-triphosphate diphosphatase activity(GO:0047429) |
| 0.0 | 0.2 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
| 0.0 | 0.1 | GO:0005330 | dopamine:sodium symporter activity(GO:0005330) |
| 0.0 | 0.1 | GO:0004105 | choline-phosphate cytidylyltransferase activity(GO:0004105) |
| 0.0 | 0.6 | GO:0008483 | transaminase activity(GO:0008483) |
| 0.0 | 0.6 | GO:0015269 | calcium-activated potassium channel activity(GO:0015269) |
| 0.0 | 0.1 | GO:0004517 | nitric-oxide synthase activity(GO:0004517) |
| 0.0 | 0.3 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.0 | 0.9 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.0 | 0.2 | GO:0019869 | chloride channel inhibitor activity(GO:0019869) |
| 0.0 | 0.2 | GO:0070087 | chromo shadow domain binding(GO:0070087) |
| 0.0 | 0.5 | GO:0004745 | retinol dehydrogenase activity(GO:0004745) |
| 0.0 | 0.2 | GO:0008526 | phosphatidylinositol transporter activity(GO:0008526) |
| 0.0 | 3.8 | GO:0005506 | iron ion binding(GO:0005506) |
| 0.0 | 0.4 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.0 | 0.2 | GO:0000268 | peroxisome targeting sequence binding(GO:0000268) |
| 0.0 | 0.3 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.0 | 0.3 | GO:0004579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 0.0 | 0.3 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.0 | 0.1 | GO:0022865 | transmembrane electron transfer carrier(GO:0022865) |
| 0.0 | 0.0 | GO:0004939 | beta-adrenergic receptor activity(GO:0004939) |
| 0.0 | 0.4 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.0 | 0.3 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 0.0 | 0.2 | GO:0004972 | NMDA glutamate receptor activity(GO:0004972) |
| 0.0 | 0.3 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
| 0.0 | 0.2 | GO:0008420 | CTD phosphatase activity(GO:0008420) |
| 0.0 | 0.2 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.0 | 0.3 | GO:0000400 | four-way junction DNA binding(GO:0000400) |
| 0.0 | 0.2 | GO:0047760 | butyrate-CoA ligase activity(GO:0047760) |
| 0.0 | 0.6 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.0 | 0.4 | GO:0017127 | cholesterol transporter activity(GO:0017127) |
| 0.0 | 0.0 | GO:0046970 | NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970) |
| 0.0 | 0.3 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.0 | 1.4 | GO:0015078 | hydrogen ion transmembrane transporter activity(GO:0015078) |
| 0.0 | 0.6 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 0.5 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
| 0.1 | 3.6 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.0 | 0.5 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.0 | 0.5 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.0 | 2.8 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 1.2 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.0 | 1.6 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.0 | 1.3 | ST GAQ PATHWAY | G alpha q Pathway |
| 0.0 | 1.6 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.0 | 2.3 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.0 | 1.6 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.0 | 1.4 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 0.8 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 0.5 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.0 | 0.8 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.0 | 0.8 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.0 | 0.3 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.0 | 0.6 | PID TRAIL PATHWAY | TRAIL signaling pathway |
| 0.0 | 0.5 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 1.0 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 0.7 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 0.3 | PID ERBB1 RECEPTOR PROXIMAL PATHWAY | EGF receptor (ErbB1) signaling pathway |
| 0.0 | 0.3 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.0 | 0.3 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 1.4 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 10.4 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 1.3 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.1 | 1.5 | REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.1 | 1.4 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.1 | 1.0 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.1 | 3.9 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.0 | 1.3 | REACTOME HYALURONAN METABOLISM | Genes involved in Hyaluronan metabolism |
| 0.0 | 1.4 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.0 | 1.6 | REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI | Genes involved in RIP-mediated NFkB activation via DAI |
| 0.0 | 0.8 | REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES | Genes involved in p75NTR recruits signalling complexes |
| 0.0 | 1.4 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.0 | 0.4 | REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS | Genes involved in Membrane binding and targetting of GAG proteins |
| 0.0 | 0.5 | REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS | Genes involved in Tandem pore domain potassium channels |
| 0.0 | 0.1 | REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 | Genes involved in Signaling by activated point mutants of FGFR1 |
| 0.0 | 0.6 | REACTOME THE ACTIVATION OF ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
| 0.0 | 0.7 | REACTOME RNA POL III CHAIN ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |
| 0.0 | 0.7 | REACTOME REGULATION OF IFNA SIGNALING | Genes involved in Regulation of IFNA signaling |
| 0.0 | 0.7 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.0 | 0.7 | REACTOME PROCESSING OF INTRONLESS PRE MRNAS | Genes involved in Processing of Intronless Pre-mRNAs |
| 0.0 | 0.5 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |
| 0.0 | 0.6 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.0 | 0.3 | REACTOME SIGNALING BY FGFR3 MUTANTS | Genes involved in Signaling by FGFR3 mutants |
| 0.0 | 0.4 | REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.0 | 0.4 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |
| 0.0 | 0.4 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.0 | 0.5 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.0 | 0.6 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.0 | 0.6 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.0 | 0.6 | REACTOME MRNA 3 END PROCESSING | Genes involved in mRNA 3'-end processing |
| 0.0 | 0.2 | REACTOME PROSTANOID LIGAND RECEPTORS | Genes involved in Prostanoid ligand receptors |
| 0.0 | 0.6 | REACTOME ORC1 REMOVAL FROM CHROMATIN | Genes involved in Orc1 removal from chromatin |
| 0.0 | 1.0 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.0 | 0.3 | REACTOME RETROGRADE NEUROTROPHIN SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
| 0.0 | 0.8 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.0 | 1.0 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.0 | 0.5 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.0 | 0.3 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.0 | 0.6 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.0 | 0.5 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.0 | 0.2 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |