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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NKX1-2_RAX

Z-value: 2.17

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Transcription factors associated with NKX1-2_RAX

Gene Symbol Gene ID Gene Info
ENSG00000229544.6 NK1 homeobox 2
ENSG00000134438.9 retina and anterior neural fold homeobox

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX1-2hg19_v2_chr10_-_126138622_1261387530.982.5e-13Click!
RAXhg19_v2_chr18_-_56940611_56940660-0.445.0e-02Click!

Activity profile of NKX1-2_RAX motif

Sorted Z-values of NKX1-2_RAX motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX1-2_RAX

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.9 GO:0061713 neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713)
0.8 2.5 GO:0060488 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.6 2.9 GO:0043553 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324) negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.5 13.5 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.5 2.6 GO:0007070 negative regulation of transcription during mitosis(GO:0007068) negative regulation of transcription from RNA polymerase II promoter during mitosis(GO:0007070)
0.5 1.5 GO:0006742 NADP catabolic process(GO:0006742) pyridine nucleotide catabolic process(GO:0019364)
0.4 4.0 GO:0090063 positive regulation of microtubule nucleation(GO:0090063)
0.4 1.2 GO:0001300 chronological cell aging(GO:0001300)
0.3 1.0 GO:0072356 chromosome passenger complex localization to kinetochore(GO:0072356)
0.3 2.6 GO:1901189 positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.3 7.4 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.3 11.4 GO:0031581 hemidesmosome assembly(GO:0031581)
0.3 1.5 GO:0044240 multicellular organism lipid catabolic process(GO:0044240)
0.3 1.9 GO:1903575 cornified envelope assembly(GO:1903575)
0.3 4.1 GO:0043249 erythrocyte maturation(GO:0043249)
0.2 1.9 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.2 3.3 GO:0042420 dopamine catabolic process(GO:0042420)
0.2 1.6 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.2 1.9 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.2 0.7 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.1 1.2 GO:0007256 activation of JNKK activity(GO:0007256)
0.1 0.4 GO:0036466 synaptic vesicle recycling via endosome(GO:0036466)
0.1 3.0 GO:0044126 regulation of growth of symbiont in host(GO:0044126)
0.1 0.6 GO:0015722 canalicular bile acid transport(GO:0015722)
0.1 0.3 GO:0018874 benzoate metabolic process(GO:0018874)
0.1 1.0 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.1 3.5 GO:0048012 hepatocyte growth factor receptor signaling pathway(GO:0048012)
0.1 3.0 GO:0018345 protein palmitoylation(GO:0018345)
0.1 1.5 GO:0006068 ethanol catabolic process(GO:0006068)
0.1 2.0 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.1 3.4 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 6.1 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 0.8 GO:0045176 apical protein localization(GO:0045176)
0.0 1.5 GO:0010226 response to lithium ion(GO:0010226)
0.0 0.3 GO:0003352 regulation of cilium movement(GO:0003352) regulation of cilium beat frequency(GO:0003356)
0.0 0.5 GO:2000628 regulation of miRNA metabolic process(GO:2000628)
0.0 1.0 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 0.8 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.2 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.0 0.3 GO:2000767 positive regulation of cytoplasmic translation(GO:2000767)
0.0 0.4 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 2.5 GO:0070206 protein trimerization(GO:0070206)
0.0 0.6 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 3.3 GO:0032508 DNA duplex unwinding(GO:0032508)
0.0 0.3 GO:0098814 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.0 0.2 GO:2000782 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) positive regulation of barbed-end actin filament capping(GO:2000814)
0.0 5.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 2.1 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.0 0.2 GO:0014717 regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014717) satellite cell activation involved in skeletal muscle regeneration(GO:0014901)
0.0 2.2 GO:0043647 inositol phosphate metabolic process(GO:0043647)
0.0 1.3 GO:0010107 potassium ion import(GO:0010107)
0.0 1.8 GO:0030574 collagen catabolic process(GO:0030574)
0.0 1.0 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.0 2.2 GO:0002456 T cell mediated immunity(GO:0002456)
0.0 7.0 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 0.1 GO:0031953 negative regulation of protein autophosphorylation(GO:0031953)
0.0 0.7 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 2.2 GO:0031424 keratinization(GO:0031424)
0.0 0.3 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.3 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 2.9 GO:1990032 parallel fiber(GO:1990032)
0.7 5.9 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.6 2.5 GO:0060187 cell pole(GO:0060187)
0.4 11.4 GO:0030056 hemidesmosome(GO:0030056)
0.4 7.3 GO:0060077 inhibitory synapse(GO:0060077)
0.3 2.6 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.2 1.0 GO:0055087 Ski complex(GO:0055087)
0.2 4.0 GO:0005869 dynactin complex(GO:0005869)
0.2 1.9 GO:0044326 dendritic spine neck(GO:0044326)
0.2 4.9 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.2 1.3 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.1 2.1 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 1.0 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.1 1.6 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.1 3.5 GO:0031528 microvillus membrane(GO:0031528)
0.1 2.6 GO:0071564 npBAF complex(GO:0071564)
0.1 1.9 GO:0043203 axon hillock(GO:0043203)
0.0 0.6 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 1.0 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 0.7 GO:0000124 SAGA complex(GO:0000124) STAGA complex(GO:0030914)
0.0 2.2 GO:0045095 keratin filament(GO:0045095)
0.0 0.3 GO:0042788 polysomal ribosome(GO:0042788)
0.0 2.1 GO:0015030 Cajal body(GO:0015030)
0.0 1.5 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.6 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.7 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.1 GO:1990730 VCP-NSFL1C complex(GO:1990730)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.9 GO:0061714 folic acid receptor activity(GO:0061714)
0.5 13.5 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.4 2.2 GO:0052829 inositol-1,4-bisphosphate 1-phosphatase activity(GO:0004441) inositol-1,3,4-trisphosphate 1-phosphatase activity(GO:0052829)
0.4 2.9 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.4 3.3 GO:0008131 primary amine oxidase activity(GO:0008131)
0.3 1.3 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.3 1.5 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.3 1.2 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.3 2.9 GO:0008142 oxysterol binding(GO:0008142)
0.3 1.0 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.2 1.5 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894)
0.2 0.6 GO:0015432 bile acid-exporting ATPase activity(GO:0015432)
0.2 5.9 GO:0002162 dystroglycan binding(GO:0002162)
0.2 0.7 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.1 2.6 GO:0030957 Tat protein binding(GO:0030957)
0.1 2.6 GO:0000150 recombinase activity(GO:0000150)
0.1 0.6 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.1 0.8 GO:0004771 sterol esterase activity(GO:0004771)
0.1 0.8 GO:0033857 diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.1 7.2 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.1 7.7 GO:0001784 phosphotyrosine binding(GO:0001784)
0.1 1.6 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 3.0 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 4.0 GO:0070840 dynein complex binding(GO:0070840)
0.1 3.4 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 2.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 1.9 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 11.7 GO:0000287 magnesium ion binding(GO:0000287)
0.0 0.4 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.3 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.0 0.1 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 1.2 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 0.3 GO:0008097 5S rRNA binding(GO:0008097)
0.0 0.1 GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006)
0.0 2.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.5 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 1.0 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.7 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 0.4 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 1.3 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 1.8 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 2.3 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.3 GO:0045505 dynein intermediate chain binding(GO:0045505)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 11.1 NABA COLLAGENS Genes encoding collagen proteins
0.1 7.3 PID CD40 PATHWAY CD40/CD40L signaling
0.1 2.3 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 2.8 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.1 4.0 PID NCADHERIN PATHWAY N-cadherin signaling events
0.1 5.9 PID LKB1 PATHWAY LKB1 signaling events
0.0 2.9 PID RAS PATHWAY Regulation of Ras family activation
0.0 2.2 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 2.6 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.0 3.5 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 1.2 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.0 1.2 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.7 PID MYC PATHWAY C-MYC pathway
0.0 3.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.0 PID PTP1B PATHWAY Signaling events mediated by PTP1B

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.3 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.1 2.6 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 11.1 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 7.7 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 2.8 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1 3.0 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 1.8 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 4.0 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 1.5 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 2.4 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 0.6 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 1.3 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.0 1.2 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.4 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.5 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.4 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C