ISMARA results: NKX1-2

Project

avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

Navigation

Downloads

Results for NKX1-2_RAX

Z-value: 2.17

Motif logo

Transcription factors associated with NKX1-2_RAX

Gene Symbol	Gene ID	Gene Info
NKX1-2 Ensembl NCBI GeneCards UniProt	ENSG00000229544.6	NK1 homeobox 2
RAX Ensembl NCBI GeneCards UniProt	ENSG00000134438.9	retina and anterior neural fold homeobox

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NKX1-2	hg19_v2_chr10_-_126138622_126138753	0.98	2.5e-13	Click!
RAX	hg19_v2_chr18_-_56940611_56940660	-0.44	5.0e-02	Click!

Activity profile of NKX1-2_RAX motif

Sorted Z-values of NKX1-2_RAX motif

No targets for NKX1-2_RAX

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX1-2_RAX

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	13.5	GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.3	11.4	GO:0031581	hemidesmosome assembly(GO:0031581)
0.3	7.4	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0	7.0	GO:0018105	peptidyl-serine phosphorylation(GO:0018105)
0.0	6.1	GO:0001578	microtubule bundle formation(GO:0001578)
0.0	5.8	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.6	4.9	GO:0061713	neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713)
0.3	4.1	GO:0043249	erythrocyte maturation(GO:0043249)
0.4	4.0	GO:0090063	positive regulation of microtubule nucleation(GO:0090063)
0.1	3.5	GO:0048012	hepatocyte growth factor receptor signaling pathway(GO:0048012)

Showing 1 to 10 of 60 entries

Gene overrepresentation in cellular_component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	11.4	GO:0030056	hemidesmosome(GO:0030056)
0.4	7.3	GO:0060077	inhibitory synapse(GO:0060077)
0.7	5.9	GO:0097442	CA3 pyramidal cell dendrite(GO:0097442)
0.2	4.9	GO:0031362	anchored component of external side of plasma membrane(GO:0031362)
0.2	4.0	GO:0005869	dynactin complex(GO:0005869)
0.1	3.5	GO:0031528	microvillus membrane(GO:0031528)
1.0	2.9	GO:1990032	parallel fiber(GO:1990032)
0.3	2.6	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.1	2.6	GO:0071564	npBAF complex(GO:0071564)
0.6	2.5	GO:0060187	cell pole(GO:0060187)

Showing 1 to 10 of 27 entries

Gene overrepresentation in molecular_function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	13.5	GO:0001608	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	11.7	GO:0000287	magnesium ion binding(GO:0000287)
0.1	7.7	GO:0001784	phosphotyrosine binding(GO:0001784)
0.1	7.2	GO:0098632	protein binding involved in cell-cell adhesion(GO:0098632)
0.2	5.9	GO:0002162	dystroglycan binding(GO:0002162)
1.2	4.9	GO:0061714	folic acid receptor activity(GO:0061714)
0.1	4.0	GO:0070840	dynein complex binding(GO:0070840)
0.1	3.4	GO:0004003	ATP-dependent DNA helicase activity(GO:0004003)
0.4	3.3	GO:0008131	primary amine oxidase activity(GO:0008131)
0.1	3.0	GO:0019706	protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)

Showing 1 to 10 of 43 entries

Gene overrepresentation in C2:CP category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	11.1	NABA COLLAGENS	Genes encoding collagen proteins
0.1	7.3	PID CD40 PATHWAY	CD40/CD40L signaling
0.1	5.9	PID LKB1 PATHWAY	LKB1 signaling events
0.1	4.0	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.0	3.6	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	3.5	PID MET PATHWAY	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0	2.9	PID RAS PATHWAY	Regulation of Ras family activation
0.1	2.8	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.0	2.6	PID PS1 PATHWAY	Presenilin action in Notch and Wnt signaling
0.1	2.3	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network

Showing 1 to 10 of 15 entries

Gene overrepresentation in C2:CP:REACTOME category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	11.1	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.1	7.7	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0	4.0	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1	3.3	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.1	3.0	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.1	2.8	REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1	2.6	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.0	2.4	REACTOME ERK MAPK TARGETS	Genes involved in ERK/MAPK targets
0.1	1.8	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.0	1.5	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules

Showing 1 to 10 of 16 entries

Results for NKX1-2_RAX

Z-value: 2.17

Motif logo

Transcription factors associated with NKX1-2_RAX

Activity-expression correlation:

Activity profile of NKX1-2_RAX motif

Sorted Z-values of NKX1-2_RAX motif

No targets for NKX1-2_RAX

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX1-2_RAX

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: