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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for NKX1-2_RAX
Z-value: 2.17
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Transcription factors associated with NKX1-2_RAX
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
NKX1-2
|
ENSG00000229544.6 | NK1 homeobox 2 |
|
RAX
|
ENSG00000134438.9 | retina and anterior neural fold homeobox |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NKX1-2 | hg19_v2_chr10_-_126138622_126138753 | 0.98 | 2.5e-13 | Click! |
| RAX | hg19_v2_chr18_-_56940611_56940660 | -0.44 | 5.0e-02 | Click! |
Activity profile of NKX1-2_RAX motif
Sorted Z-values of NKX1-2_RAX motif
Network of associatons between targets according to the STRING database.
First level regulatory network of NKX1-2_RAX
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 4.9 | GO:0061713 | neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713) |
| 0.8 | 2.5 | GO:0060488 | orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490) |
| 0.6 | 2.9 | GO:0043553 | vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324) negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) |
| 0.5 | 13.5 | GO:0035589 | G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589) |
| 0.5 | 2.6 | GO:0007070 | negative regulation of transcription during mitosis(GO:0007068) negative regulation of transcription from RNA polymerase II promoter during mitosis(GO:0007070) |
| 0.5 | 1.5 | GO:0006742 | NADP catabolic process(GO:0006742) pyridine nucleotide catabolic process(GO:0019364) |
| 0.4 | 4.0 | GO:0090063 | positive regulation of microtubule nucleation(GO:0090063) |
| 0.4 | 1.2 | GO:0001300 | chronological cell aging(GO:0001300) |
| 0.3 | 1.0 | GO:0072356 | chromosome passenger complex localization to kinetochore(GO:0072356) |
| 0.3 | 2.6 | GO:1901189 | positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068) |
| 0.3 | 7.4 | GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity(GO:0007175) |
| 0.3 | 11.4 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.3 | 1.5 | GO:0044240 | multicellular organism lipid catabolic process(GO:0044240) |
| 0.3 | 1.9 | GO:1903575 | cornified envelope assembly(GO:1903575) |
| 0.3 | 4.1 | GO:0043249 | erythrocyte maturation(GO:0043249) |
| 0.2 | 1.9 | GO:0006880 | intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577) |
| 0.2 | 3.3 | GO:0042420 | dopamine catabolic process(GO:0042420) |
| 0.2 | 1.6 | GO:1902261 | positive regulation of delayed rectifier potassium channel activity(GO:1902261) |
| 0.2 | 1.9 | GO:0060770 | negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770) |
| 0.2 | 0.7 | GO:0043456 | regulation of pentose-phosphate shunt(GO:0043456) |
| 0.1 | 1.2 | GO:0007256 | activation of JNKK activity(GO:0007256) |
| 0.1 | 0.4 | GO:0036466 | synaptic vesicle recycling via endosome(GO:0036466) |
| 0.1 | 3.0 | GO:0044126 | regulation of growth of symbiont in host(GO:0044126) |
| 0.1 | 0.6 | GO:0015722 | canalicular bile acid transport(GO:0015722) |
| 0.1 | 0.3 | GO:0018874 | benzoate metabolic process(GO:0018874) |
| 0.1 | 1.0 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 0.1 | 3.5 | GO:0048012 | hepatocyte growth factor receptor signaling pathway(GO:0048012) |
| 0.1 | 3.0 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.1 | 1.5 | GO:0006068 | ethanol catabolic process(GO:0006068) |
| 0.1 | 2.0 | GO:0002230 | positive regulation of defense response to virus by host(GO:0002230) |
| 0.1 | 3.4 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 0.0 | 6.1 | GO:0001578 | microtubule bundle formation(GO:0001578) |
| 0.0 | 0.8 | GO:0045176 | apical protein localization(GO:0045176) |
| 0.0 | 1.5 | GO:0010226 | response to lithium ion(GO:0010226) |
| 0.0 | 0.3 | GO:0003352 | regulation of cilium movement(GO:0003352) regulation of cilium beat frequency(GO:0003356) |
| 0.0 | 0.5 | GO:2000628 | regulation of miRNA metabolic process(GO:2000628) |
| 0.0 | 1.0 | GO:0006488 | dolichol-linked oligosaccharide biosynthetic process(GO:0006488) |
| 0.0 | 0.8 | GO:0006020 | inositol metabolic process(GO:0006020) |
| 0.0 | 0.2 | GO:0050882 | voluntary musculoskeletal movement(GO:0050882) |
| 0.0 | 0.3 | GO:2000767 | positive regulation of cytoplasmic translation(GO:2000767) |
| 0.0 | 0.4 | GO:0035331 | negative regulation of hippo signaling(GO:0035331) |
| 0.0 | 2.5 | GO:0070206 | protein trimerization(GO:0070206) |
| 0.0 | 0.6 | GO:0019371 | cyclooxygenase pathway(GO:0019371) |
| 0.0 | 3.3 | GO:0032508 | DNA duplex unwinding(GO:0032508) |
| 0.0 | 0.3 | GO:0098814 | spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814) |
| 0.0 | 0.2 | GO:2000782 | regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) positive regulation of barbed-end actin filament capping(GO:2000814) |
| 0.0 | 5.8 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.0 | 2.1 | GO:0031110 | regulation of microtubule polymerization or depolymerization(GO:0031110) |
| 0.0 | 0.2 | GO:0014717 | regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014717) satellite cell activation involved in skeletal muscle regeneration(GO:0014901) |
| 0.0 | 2.2 | GO:0043647 | inositol phosphate metabolic process(GO:0043647) |
| 0.0 | 1.3 | GO:0010107 | potassium ion import(GO:0010107) |
| 0.0 | 1.8 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 0.0 | 1.0 | GO:0006409 | tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431) |
| 0.0 | 2.2 | GO:0002456 | T cell mediated immunity(GO:0002456) |
| 0.0 | 7.0 | GO:0018105 | peptidyl-serine phosphorylation(GO:0018105) |
| 0.0 | 0.1 | GO:0031953 | negative regulation of protein autophosphorylation(GO:0031953) |
| 0.0 | 0.7 | GO:0051123 | RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123) |
| 0.0 | 2.2 | GO:0031424 | keratinization(GO:0031424) |
| 0.0 | 0.3 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.0 | 0.3 | GO:0030277 | maintenance of gastrointestinal epithelium(GO:0030277) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 2.9 | GO:1990032 | parallel fiber(GO:1990032) |
| 0.7 | 5.9 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.6 | 2.5 | GO:0060187 | cell pole(GO:0060187) |
| 0.4 | 11.4 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.4 | 7.3 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.3 | 2.6 | GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex(GO:0002193) |
| 0.2 | 1.0 | GO:0055087 | Ski complex(GO:0055087) |
| 0.2 | 4.0 | GO:0005869 | dynactin complex(GO:0005869) |
| 0.2 | 1.9 | GO:0044326 | dendritic spine neck(GO:0044326) |
| 0.2 | 4.9 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.2 | 1.3 | GO:0008282 | ATP-sensitive potassium channel complex(GO:0008282) |
| 0.1 | 2.1 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.1 | 1.0 | GO:0071204 | histone pre-mRNA 3'end processing complex(GO:0071204) |
| 0.1 | 1.6 | GO:0014701 | junctional sarcoplasmic reticulum membrane(GO:0014701) |
| 0.1 | 3.5 | GO:0031528 | microvillus membrane(GO:0031528) |
| 0.1 | 2.6 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.1 | 1.9 | GO:0043203 | axon hillock(GO:0043203) |
| 0.0 | 0.6 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.0 | 1.0 | GO:1990023 | mitotic spindle midzone(GO:1990023) |
| 0.0 | 0.7 | GO:0000124 | SAGA complex(GO:0000124) STAGA complex(GO:0030914) |
| 0.0 | 2.2 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 0.3 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 0.0 | 2.1 | GO:0015030 | Cajal body(GO:0015030) |
| 0.0 | 1.5 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.0 | 0.6 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.0 | 0.7 | GO:0097228 | sperm principal piece(GO:0097228) |
| 0.0 | 0.1 | GO:1990730 | VCP-NSFL1C complex(GO:1990730) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 4.9 | GO:0061714 | folic acid receptor activity(GO:0061714) |
| 0.5 | 13.5 | GO:0001608 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.4 | 2.2 | GO:0052829 | inositol-1,4-bisphosphate 1-phosphatase activity(GO:0004441) inositol-1,3,4-trisphosphate 1-phosphatase activity(GO:0052829) |
| 0.4 | 2.9 | GO:0035662 | Toll-like receptor 4 binding(GO:0035662) |
| 0.4 | 3.3 | GO:0008131 | primary amine oxidase activity(GO:0008131) |
| 0.3 | 1.3 | GO:0008281 | sulfonylurea receptor activity(GO:0008281) |
| 0.3 | 1.5 | GO:0035529 | NADH pyrophosphatase activity(GO:0035529) |
| 0.3 | 1.2 | GO:0004706 | JUN kinase kinase kinase activity(GO:0004706) |
| 0.3 | 2.9 | GO:0008142 | oxysterol binding(GO:0008142) |
| 0.3 | 1.0 | GO:0000026 | alpha-1,2-mannosyltransferase activity(GO:0000026) |
| 0.2 | 1.5 | GO:0047894 | flavonol 3-sulfotransferase activity(GO:0047894) |
| 0.2 | 0.6 | GO:0015432 | bile acid-exporting ATPase activity(GO:0015432) |
| 0.2 | 5.9 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.2 | 0.7 | GO:0046538 | bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538) |
| 0.1 | 2.6 | GO:0030957 | Tat protein binding(GO:0030957) |
| 0.1 | 2.6 | GO:0000150 | recombinase activity(GO:0000150) |
| 0.1 | 0.6 | GO:0004666 | prostaglandin-endoperoxide synthase activity(GO:0004666) |
| 0.1 | 0.8 | GO:0004771 | sterol esterase activity(GO:0004771) |
| 0.1 | 0.8 | GO:0033857 | diphosphoinositol-pentakisphosphate kinase activity(GO:0033857) |
| 0.1 | 7.2 | GO:0098632 | protein binding involved in cell-cell adhesion(GO:0098632) |
| 0.1 | 7.7 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.1 | 1.6 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.1 | 3.0 | GO:0019706 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.1 | 4.0 | GO:0070840 | dynein complex binding(GO:0070840) |
| 0.1 | 3.4 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.0 | 2.6 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.0 | 1.9 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.0 | 11.7 | GO:0000287 | magnesium ion binding(GO:0000287) |
| 0.0 | 0.4 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 0.0 | 0.3 | GO:0004321 | fatty-acyl-CoA synthase activity(GO:0004321) |
| 0.0 | 0.1 | GO:0030292 | protein tyrosine kinase inhibitor activity(GO:0030292) |
| 0.0 | 1.2 | GO:0031369 | translation initiation factor binding(GO:0031369) |
| 0.0 | 0.3 | GO:0008097 | 5S rRNA binding(GO:0008097) |
| 0.0 | 0.1 | GO:0047006 | 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006) |
| 0.0 | 2.8 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 0.5 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.0 | 1.0 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.0 | 0.7 | GO:0017025 | TBP-class protein binding(GO:0017025) |
| 0.0 | 0.4 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.0 | 1.3 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.0 | 1.8 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 2.3 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.0 | 0.3 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 11.1 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 7.3 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.1 | 2.3 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.1 | 2.8 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.1 | 4.0 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.1 | 5.9 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 2.9 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 2.2 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.0 | 2.6 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.0 | 3.5 | PID MET PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| 0.0 | 1.2 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.0 | 1.2 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 0.7 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 3.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 1.0 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.3 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.1 | 2.6 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.1 | 11.1 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 7.7 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.1 | 2.8 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.1 | 3.0 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.1 | 1.8 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.0 | 4.0 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 1.5 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.0 | 2.4 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.0 | 0.6 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.0 | 1.3 | REACTOME INWARDLY RECTIFYING K CHANNELS | Genes involved in Inwardly rectifying K+ channels |
| 0.0 | 1.2 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.0 | 0.4 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 0.5 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.0 | 0.4 | REACTOME PHOSPHORYLATION OF THE APC C | Genes involved in Phosphorylation of the APC/C |