ISMARA results: NKX2-1

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NKX2-1

Z-value: 1.54

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Transcription factors associated with NKX2-1

Gene Symbol	Gene ID	Gene Info
NKX2-1 Ensembl NCBI GeneCards UniProt	ENSG00000136352.13	NK2 homeobox 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NKX2-1	hg19_v2_chr14_-_36990354_36990397	-0.90	7.3e-08	Click!

Activity profile of NKX2-1 motif

Sorted Z-values of NKX2-1 motif

No targets for NKX2-1

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.0	GO:0001837	epithelial to mesenchymal transition(GO:0001837)
1.5	4.5	GO:0060929	Purkinje myocyte differentiation(GO:0003168) cardiac pacemaker cell fate commitment(GO:0060927) atrioventricular node cell fate commitment(GO:0060929)
0.3	3.9	GO:0019375	galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.4	3.6	GO:0086024	adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.2	3.1	GO:0030238	male sex determination(GO:0030238)
0.0	3.1	GO:0055092	cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.1	2.9	GO:1990001	inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
0.1	2.8	GO:0050861	positive regulation of B cell receptor signaling pathway(GO:0050861)
0.2	2.3	GO:0019344	cysteine biosynthetic process(GO:0019344)
0.7	2.2	GO:2000830	vacuolar phosphate transport(GO:0007037) positive regulation of mitotic cell cycle DNA replication(GO:1903465) positive regulation of parathyroid hormone secretion(GO:2000830)

Showing 1 to 10 of 79 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.1	GO:0032993	protein-DNA complex(GO:0032993)
0.0	3.7	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.2	3.1	GO:0042788	polysomal ribosome(GO:0042788)
0.0	3.1	GO:0005791	rough endoplasmic reticulum(GO:0005791)
0.4	2.9	GO:0032133	chromosome passenger complex(GO:0032133)
0.0	1.5	GO:0005905	clathrin-coated pit(GO:0005905)
0.1	1.4	GO:0000778	condensed nuclear chromosome kinetochore(GO:0000778)
0.0	1.4	GO:0070821	tertiary granule membrane(GO:0070821)
0.3	1.3	GO:0042721	mitochondrial inner membrane protein insertion complex(GO:0042721)
0.0	1.3	GO:0030669	clathrin-coated endocytic vesicle membrane(GO:0030669)

Showing 1 to 10 of 31 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	6.7	GO:0050786	RAGE receptor binding(GO:0050786)
0.9	4.5	GO:0010736	serum response element binding(GO:0010736)
0.3	3.9	GO:0001733	galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.2	3.6	GO:0031698	beta-2 adrenergic receptor binding(GO:0031698)
0.1	3.1	GO:0000217	DNA secondary structure binding(GO:0000217)
0.0	3.0	GO:0008536	Ran GTPase binding(GO:0008536)
0.0	2.9	GO:0005125	cytokine activity(GO:0005125)
0.1	2.3	GO:0036374	glutathione hydrolase activity(GO:0036374)
0.2	2.2	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	1.6	GO:0051879	Hsp90 protein binding(GO:0051879)

Showing 1 to 10 of 57 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.3	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.0	3.3	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.1	3.1	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.0	2.9	PID AURORA A PATHWAY	Aurora A signaling
0.0	2.3	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.0	1.8	ST TUMOR NECROSIS FACTOR PATHWAY	Tumor Necrosis Factor Pathway.
0.1	1.6	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.0	1.5	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.0	1.4	PID PLK1 PATHWAY	PLK1 signaling events
0.0	1.4	PID RAC1 REG PATHWAY	Regulation of RAC1 activity

Showing 1 to 10 of 17 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.0	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.1	3.9	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
0.0	2.9	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	2.9	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.2	2.5	REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1	Genes involved in Signaling by activated point mutants of FGFR1
0.0	1.7	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.0	1.6	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	1.5	REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0	1.5	REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0	1.4	REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI	Genes involved in RIP-mediated NFkB activation via DAI

Showing 1 to 10 of 31 entries

Results for NKX2-1

Z-value: 1.54

Motif logo

Transcription factors associated with NKX2-1

Activity-expression correlation:

Activity profile of NKX2-1 motif

Sorted Z-values of NKX2-1 motif

No targets for NKX2-1

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: