ISMARA results: NKX2-5

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NKX2-5

Z-value: 0.50

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Transcription factors associated with NKX2-5

Gene Symbol	Gene ID	Gene Info
NKX2-5 Ensembl NCBI GeneCards UniProt	ENSG00000183072.9	NK2 homeobox 5

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NKX2-5	hg19_v2_chr5_-_172662230_172662267	-0.06	8.0e-01	Click!

Activity profile of NKX2-5 motif

Sorted Z-values of NKX2-5 motif

No targets for NKX2-5

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-5

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	GO:0090238	positive regulation of arachidonic acid secretion(GO:0090238)
0.0	0.4	GO:0070493	thrombin receptor signaling pathway(GO:0070493)
0.1	0.3	GO:0034444	regulation of plasma lipoprotein particle oxidation(GO:0034444) negative regulation of plasma lipoprotein particle oxidation(GO:0034445)
0.0	0.3	GO:0021546	rhombomere development(GO:0021546)
0.0	0.3	GO:0030238	male sex determination(GO:0030238)
0.0	0.3	GO:0090161	Golgi ribbon formation(GO:0090161)
0.0	0.3	GO:0006554	lysine catabolic process(GO:0006554)
0.1	0.2	GO:1903926	signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.1	0.2	GO:0030070	insulin processing(GO:0030070)
0.1	0.2	GO:1905229	cellular response to glycoprotein(GO:1904588) cellular response to thyrotropin-releasing hormone(GO:1905229)

Showing 1 to 10 of 36 entries

Gene overrepresentation in cellular_component category:

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Total log-likelihood	Term	Description
0.3	GO:0042788	polysomal ribosome(GO:0042788)
0.3	GO:0034366	spherical high-density lipoprotein particle(GO:0034366)
0.2	GO:0036038	MKS complex(GO:0036038)
0.1	GO:0097543	ciliary inversin compartment(GO:0097543)
0.0	GO:0005602	complement component C1 complex(GO:0005602)

Showing 1 to 5 of 5 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.5	GO:0047499	calcium-independent phospholipase A2 activity(GO:0047499)
0.1	0.3	GO:0102007	lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.0	0.3	GO:0071933	Arp2/3 complex binding(GO:0071933)
0.0	0.2	GO:0004045	aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0	0.2	GO:0004996	thyroid-stimulating hormone receptor activity(GO:0004996)
0.0	0.2	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.1	GO:0005427	proton-dependent oligopeptide secondary active transmembrane transporter activity(GO:0005427) secondary active oligopeptide transmembrane transporter activity(GO:0015322)
0.0	0.1	GO:0050613	delta14-sterol reductase activity(GO:0050613)
0.0	0.1	GO:0004766	spermidine synthase activity(GO:0004766)
0.0	0.1	GO:0010698	acetyltransferase activator activity(GO:0010698)

Showing 1 to 10 of 19 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.3	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network

Showing 1 to 1 of 1 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Total log-likelihood	Term	Description
0.6	REACTOME ACYL CHAIN REMODELLING OF PE	Genes involved in Acyl chain remodelling of PE
0.4	REACTOME G2 M DNA DAMAGE CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.4	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.3	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.2	REACTOME HORMONE LIGAND BINDING RECEPTORS	Genes involved in Hormone ligand-binding receptors
0.1	REACTOME OPSINS	Genes involved in Opsins

Showing 1 to 6 of 6 entries

Results for NKX2-5

Z-value: 0.50

Motif logo

Transcription factors associated with NKX2-5

Activity-expression correlation:

Activity profile of NKX2-5 motif

Sorted Z-values of NKX2-5 motif

No targets for NKX2-5

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-5

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: