ISMARA results: NKX2-6

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NKX2-6

Z-value: 1.01

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Transcription factors associated with NKX2-6

Gene Symbol	Gene ID	Gene Info
NKX2-6 Ensembl NCBI GeneCards UniProt	ENSG00000180053.6	NK2 homeobox 6

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NKX2-6	hg19_v2_chr8_-_23563922_23564111	0.04	8.6e-01	Click!

Activity profile of NKX2-6 motif

Sorted Z-values of NKX2-6 motif

No targets for NKX2-6

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-6

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.3	GO:0090140	regulation of mitochondrial fission(GO:0090140)
0.2	2.2	GO:0006572	tyrosine catabolic process(GO:0006572)
0.2	2.1	GO:0000727	double-strand break repair via break-induced replication(GO:0000727)
0.4	1.8	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.3	1.6	GO:0034421	post-translational protein acetylation(GO:0034421)
0.2	1.6	GO:0060414	aorta smooth muscle tissue morphogenesis(GO:0060414)
0.2	1.6	GO:0086024	adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.2	1.5	GO:0099590	neurotransmitter receptor internalization(GO:0099590)
0.1	1.3	GO:0070986	left/right axis specification(GO:0070986)
0.1	1.2	GO:0098870	neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)

Showing 1 to 10 of 80 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.2	GO:0016459	myosin complex(GO:0016459)
0.0	2.1	GO:0101003	ficolin-1-rich granule membrane(GO:0101003)
0.0	1.7	GO:0032154	cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1	1.6	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.1	1.5	GO:0036020	endolysosome membrane(GO:0036020)
0.1	1.3	GO:0070652	HAUS complex(GO:0070652)
0.0	1.3	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.0	1.3	GO:0036126	sperm flagellum(GO:0036126)
0.0	1.2	GO:0043194	axon initial segment(GO:0043194)
0.2	1.1	GO:0048476	Holliday junction resolvase complex(GO:0048476)

Showing 1 to 10 of 43 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	3.3	GO:0060002	plus-end directed microfilament motor activity(GO:0060002)
0.1	2.2	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.4	1.8	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)
0.2	1.6	GO:0004468	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.2	1.6	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.1	1.6	GO:0031698	beta-2 adrenergic receptor binding(GO:0031698)
0.0	1.5	GO:0098748	clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.4	1.3	GO:0033867	Fas-activated serine/threonine kinase activity(GO:0033867)
0.0	1.2	GO:0086080	protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.4	1.1	GO:0048257	3'-flap endonuclease activity(GO:0048257)

Showing 1 to 10 of 70 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
1.6	PID AURORA B PATHWAY	Aurora B signaling
1.1	PID BARD1 PATHWAY	BARD1 signaling events
0.6	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.5	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.5	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.3	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.3	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events

Showing 1 to 7 of 7 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.5	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.1	1.8	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.1	1.5	REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	Genes involved in Retrograde neurotrophin signalling
0.1	1.3	REACTOME POL SWITCHING	Genes involved in Polymerase switching
0.0	1.2	REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS	Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.0	1.2	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.1	1.1	REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0	1.1	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.1	1.0	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.0	1.0	REACTOME MITOCHONDRIAL TRNA AMINOACYLATION	Genes involved in Mitochondrial tRNA aminoacylation

Showing 1 to 10 of 31 entries

Results for NKX2-6

Z-value: 1.01

Motif logo

Transcription factors associated with NKX2-6

Activity-expression correlation:

Activity profile of NKX2-6 motif

Sorted Z-values of NKX2-6 motif

No targets for NKX2-6

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-6

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: