ISMARA results: NKX6-2

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NKX6-2

Z-value: 1.22

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Transcription factors associated with NKX6-2

Gene Symbol	Gene ID	Gene Info
NKX6-2 Ensembl NCBI GeneCards UniProt	ENSG00000148826.6	NK6 homeobox 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NKX6-2	hg19_v2_chr10_-_134599556_134599653	-0.17	4.8e-01	Click!

Activity profile of NKX6-2 motif

Sorted Z-values of NKX6-2 motif

No targets for NKX6-2

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX6-2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	6.4	GO:0001578	microtubule bundle formation(GO:0001578)
0.2	3.7	GO:0097264	self proteolysis(GO:0097264)
1.2	3.6	GO:0070175	positive regulation of enamel mineralization(GO:0070175)
0.1	3.5	GO:0032331	negative regulation of chondrocyte differentiation(GO:0032331)
0.1	3.0	GO:0006704	glucocorticoid biosynthetic process(GO:0006704)
0.1	2.9	GO:0071481	cellular response to X-ray(GO:0071481)
0.4	2.0	GO:0060266	negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.2	1.9	GO:0003383	apical constriction(GO:0003383)
0.1	1.8	GO:1904352	positive regulation of protein catabolic process in the vacuole(GO:1904352)
0.0	1.8	GO:0006614	SRP-dependent cotranslational protein targeting to membrane(GO:0006614)

Showing 1 to 10 of 73 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.2	GO:0030175	filopodium(GO:0030175)
0.6	4.8	GO:0097442	CA3 pyramidal cell dendrite(GO:0097442)
0.1	3.6	GO:0005605	basal lamina(GO:0005605)
0.4	2.9	GO:0097129	cyclin D2-CDK4 complex(GO:0097129)
0.0	1.8	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.0	1.1	GO:0030286	dynein complex(GO:0030286)
0.2	1.0	GO:1990131	Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0	1.0	GO:0048786	presynaptic active zone(GO:0048786)
0.2	0.9	GO:0031673	H zone(GO:0031673)
0.0	0.8	GO:0042629	mast cell granule(GO:0042629)

Showing 1 to 10 of 30 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.8	GO:0002162	dystroglycan binding(GO:0002162)
0.1	4.0	GO:0051428	peptide hormone receptor binding(GO:0051428)
1.0	3.0	GO:0003845	11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.0	2.5	GO:0008083	growth factor activity(GO:0008083)
0.1	2.0	GO:0048273	mitogen-activated protein kinase p38 binding(GO:0048273)
0.0	1.4	GO:0005109	frizzled binding(GO:0005109)
0.0	1.3	GO:0005544	calcium-dependent phospholipid binding(GO:0005544)
0.0	1.2	GO:0031492	nucleosomal DNA binding(GO:0031492)
0.0	1.2	GO:0050699	WW domain binding(GO:0050699)
0.0	1.1	GO:0045504	dynein heavy chain binding(GO:0045504)

Showing 1 to 10 of 53 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.8	PID LKB1 PATHWAY	LKB1 signaling events
0.1	4.0	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.0	2.9	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.0	2.6	ST JNK MAPK PATHWAY	JNK MAPK Pathway
0.0	1.4	PID P73PATHWAY	p73 transcription factor network
0.0	1.2	PID MTOR 4PATHWAY	mTOR signaling pathway
0.0	1.2	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.0	1.1	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0	0.9	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.0	0.8	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.

Showing 1 to 10 of 14 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.0	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
0.1	3.0	REACTOME STEROID HORMONES	Genes involved in Steroid hormones
0.0	2.5	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	2.5	REACTOME G1 PHASE	Genes involved in G1 Phase
0.0	1.8	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.0	1.4	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.0	1.3	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.0	1.0	REACTOME ACTIVATED POINT MUTANTS OF FGFR2	Genes involved in Activated point mutants of FGFR2
0.0	1.0	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	0.9	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac

Showing 1 to 10 of 20 entries

Results for NKX6-2

Z-value: 1.22

Motif logo

Transcription factors associated with NKX6-2

Activity-expression correlation:

Activity profile of NKX6-2 motif

Sorted Z-values of NKX6-2 motif

No targets for NKX6-2

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX6-2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: