ISMARA results: NOTO_VSX2_DLX2_DLX6

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NOTO_VSX2_DLX2_DLX6_NKX6-1

Z-value: 1.78

Motif logo

Transcription factors associated with NOTO_VSX2_DLX2_DLX6_NKX6-1

Gene Symbol	Gene ID	Gene Info
NOTO Ensembl NCBI GeneCards UniProt	ENSG00000214513.3	notochord homeobox
VSX2 Ensembl NCBI GeneCards UniProt	ENSG00000119614.2	visual system homeobox 2
DLX2 Ensembl NCBI GeneCards UniProt	ENSG00000115844.6	distal-less homeobox 2
DLX6 Ensembl NCBI GeneCards UniProt	ENSG00000006377.9	distal-less homeobox 6
NKX6-1 Ensembl NCBI GeneCards UniProt	ENSG00000163623.5	NK6 homeobox 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NKX6-1	hg19_v2_chr4_-_85419603_85419603	-0.54	1.5e-02	Click!
DLX6	hg19_v2_chr7_+_96634850_96634874	0.45	4.7e-02	Click!
NOTO	hg19_v2_chr2_+_73429386_73429386	0.23	3.2e-01	Click!
DLX2	hg19_v2_chr2_-_172967621_172967637	-0.23	3.3e-01	Click!

Activity profile of NOTO_VSX2_DLX2_DLX6_NKX6-1 motif

Sorted Z-values of NOTO_VSX2_DLX2_DLX6_NKX6-1 motif

No targets for NOTO_VSX2_DLX2_DLX6_NKX6-1

Network of associatons between targets according to the STRING database.

First level regulatory network of NOTO_VSX2_DLX2_DLX6_NKX6-1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	14.3	GO:0032331	negative regulation of chondrocyte differentiation(GO:0032331)
0.1	5.0	GO:0006120	mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.5	4.6	GO:1900623	regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.0	3.7	GO:0007219	Notch signaling pathway(GO:0007219)
0.0	3.6	GO:0001578	microtubule bundle formation(GO:0001578)
0.1	3.4	GO:0007274	neuromuscular synaptic transmission(GO:0007274)
1.1	3.3	GO:0070563	negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.3	3.3	GO:0021759	globus pallidus development(GO:0021759)
0.1	2.9	GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0	2.9	GO:0061001	regulation of dendritic spine morphogenesis(GO:0061001)

Showing 1 to 10 of 180 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	8.4	GO:0043209	myelin sheath(GO:0043209)
0.0	7.1	GO:0043197	dendritic spine(GO:0043197)
0.6	4.6	GO:0035692	macrophage migration inhibitory factor receptor complex(GO:0035692)
0.1	4.1	GO:0030964	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.4	3.2	GO:0097442	CA3 pyramidal cell dendrite(GO:0097442)
0.0	2.7	GO:0031594	neuromuscular junction(GO:0031594)
0.1	2.4	GO:0032839	dendrite cytoplasm(GO:0032839)
0.0	2.1	GO:0042383	sarcolemma(GO:0042383)
0.0	1.8	GO:0008023	transcription elongation factor complex(GO:0008023)
0.1	1.6	GO:0071953	elastic fiber(GO:0071953)

Showing 1 to 10 of 63 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	14.5	GO:0051428	peptide hormone receptor binding(GO:0051428)
0.0	11.1	GO:0051015	actin filament binding(GO:0051015)
0.0	6.4	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1	5.0	GO:0008137	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1	4.4	GO:0005540	hyaluronic acid binding(GO:0005540)
0.0	4.4	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.1	3.3	GO:0001161	intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.1	2.9	GO:0045028	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1	2.2	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0	2.1	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)

Showing 1 to 10 of 99 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	14.4	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.0	5.0	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.0	4.7	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.1	4.6	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1	4.5	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.0	3.3	PID LKB1 PATHWAY	LKB1 signaling events
0.0	2.5	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.0	1.9	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.0	1.8	PID ARF6 PATHWAY	Arf6 signaling events
0.0	1.6	PID RHOA REG PATHWAY	Regulation of RhoA activity

Showing 1 to 10 of 18 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	13.8	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
0.2	4.6	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.0	2.8	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.1	2.4	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.0	2.2	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	1.5	REACTOME INTEGRATION OF ENERGY METABOLISM	Genes involved in Integration of energy metabolism
0.1	1.3	REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA	Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0	1.0	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	0.9	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.0	0.9	REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT	Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)

Showing 1 to 10 of 40 entries

Results for NOTO_VSX2_DLX2_DLX6_NKX6-1

Z-value: 1.78

Motif logo

Transcription factors associated with NOTO_VSX2_DLX2_DLX6_NKX6-1

Activity-expression correlation:

Activity profile of NOTO_VSX2_DLX2_DLX6_NKX6-1 motif

Sorted Z-values of NOTO_VSX2_DLX2_DLX6_NKX6-1 motif

No targets for NOTO_VSX2_DLX2_DLX6_NKX6-1

Network of associatons between targets according to the STRING database.

First level regulatory network of NOTO_VSX2_DLX2_DLX6_NKX6-1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: