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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for NR1H2
Z-value: 2.16
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Transcription factors associated with NR1H2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
NR1H2
|
ENSG00000131408.9 | nuclear receptor subfamily 1 group H member 2 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NR1H2 | hg19_v2_chr19_+_50879705_50879775 | 0.96 | 2.2e-11 | Click! |
Activity profile of NR1H2 motif
Sorted Z-values of NR1H2 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of NR1H2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 5.6 | GO:0036100 | leukotriene catabolic process(GO:0036100) leukotriene B4 catabolic process(GO:0036101) leukotriene B4 metabolic process(GO:0036102) icosanoid catabolic process(GO:1901523) fatty acid derivative catabolic process(GO:1901569) |
| 0.8 | 6.1 | GO:2000860 | positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860) |
| 0.5 | 1.4 | GO:2001247 | positive regulation of phosphatidylcholine biosynthetic process(GO:2001247) |
| 0.4 | 3.1 | GO:0046125 | thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125) |
| 0.4 | 2.5 | GO:0009051 | pentose-phosphate shunt, oxidative branch(GO:0009051) |
| 0.4 | 1.9 | GO:0070682 | proteasome regulatory particle assembly(GO:0070682) |
| 0.3 | 1.9 | GO:0036015 | response to interleukin-3(GO:0036015) cellular response to interleukin-3(GO:0036016) |
| 0.3 | 2.8 | GO:0050747 | positive regulation of lipoprotein metabolic process(GO:0050747) |
| 0.3 | 0.8 | GO:2000397 | regulation of ubiquitin-dependent endocytosis(GO:2000395) positive regulation of ubiquitin-dependent endocytosis(GO:2000397) |
| 0.3 | 1.3 | GO:1903644 | regulation of chaperone-mediated protein folding(GO:1903644) |
| 0.3 | 2.4 | GO:0060136 | embryonic process involved in female pregnancy(GO:0060136) |
| 0.3 | 1.8 | GO:1903281 | protein transport into plasma membrane raft(GO:0044861) positive regulation of calcium:sodium antiporter activity(GO:1903281) positive regulation of potassium ion import(GO:1903288) |
| 0.3 | 2.4 | GO:0055064 | chloride ion homeostasis(GO:0055064) |
| 0.3 | 2.3 | GO:0097068 | response to thyroxine(GO:0097068) response to L-phenylalanine derivative(GO:1904386) |
| 0.3 | 3.4 | GO:0001561 | fatty acid alpha-oxidation(GO:0001561) |
| 0.3 | 0.8 | GO:0044205 | 'de novo' UMP biosynthetic process(GO:0044205) |
| 0.3 | 1.8 | GO:0060356 | leucine import(GO:0060356) |
| 0.2 | 0.7 | GO:2000824 | negative regulation of androgen receptor activity(GO:2000824) |
| 0.2 | 1.9 | GO:0086024 | adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024) |
| 0.2 | 1.5 | GO:0090238 | positive regulation of arachidonic acid secretion(GO:0090238) |
| 0.2 | 2.2 | GO:0014722 | regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722) |
| 0.2 | 1.1 | GO:0048539 | bone marrow development(GO:0048539) |
| 0.1 | 1.7 | GO:0071907 | determination of digestive tract left/right asymmetry(GO:0071907) |
| 0.1 | 2.8 | GO:0032688 | negative regulation of interferon-beta production(GO:0032688) |
| 0.1 | 3.8 | GO:0006646 | phosphatidylethanolamine biosynthetic process(GO:0006646) |
| 0.1 | 1.0 | GO:0032483 | regulation of Rab protein signal transduction(GO:0032483) |
| 0.1 | 0.9 | GO:0015811 | L-cystine transport(GO:0015811) |
| 0.1 | 1.6 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.1 | 1.9 | GO:1900746 | regulation of vascular endothelial growth factor signaling pathway(GO:1900746) |
| 0.1 | 1.2 | GO:0046146 | tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146) |
| 0.1 | 2.4 | GO:0030949 | positive regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030949) |
| 0.1 | 6.6 | GO:0030866 | cortical actin cytoskeleton organization(GO:0030866) |
| 0.1 | 0.3 | GO:0070460 | thyroid-stimulating hormone secretion(GO:0070460) regulation of thyroid-stimulating hormone secretion(GO:2000612) |
| 0.1 | 0.6 | GO:0050917 | sensory perception of umami taste(GO:0050917) |
| 0.1 | 2.0 | GO:0032836 | glomerular basement membrane development(GO:0032836) |
| 0.1 | 0.9 | GO:0070245 | positive regulation of thymocyte apoptotic process(GO:0070245) |
| 0.1 | 0.3 | GO:2000342 | negative regulation of chemokine (C-X-C motif) ligand 2 production(GO:2000342) |
| 0.1 | 0.6 | GO:0002155 | regulation of thyroid hormone mediated signaling pathway(GO:0002155) kinin cascade(GO:0002254) plasma kallikrein-kinin cascade(GO:0002353) |
| 0.1 | 0.2 | GO:0048075 | positive regulation of eye pigmentation(GO:0048075) |
| 0.1 | 1.2 | GO:0042984 | amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984) |
| 0.1 | 1.1 | GO:0040016 | embryonic cleavage(GO:0040016) |
| 0.1 | 0.6 | GO:0006572 | tyrosine catabolic process(GO:0006572) |
| 0.1 | 0.3 | GO:1902775 | mitochondrial large ribosomal subunit assembly(GO:1902775) |
| 0.1 | 1.6 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.1 | 0.4 | GO:1903436 | regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490) |
| 0.1 | 0.5 | GO:0097647 | calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647) |
| 0.1 | 0.3 | GO:1904100 | regulation of protein O-linked glycosylation(GO:1904098) positive regulation of protein O-linked glycosylation(GO:1904100) |
| 0.1 | 0.8 | GO:0043951 | negative regulation of cAMP-mediated signaling(GO:0043951) |
| 0.1 | 0.4 | GO:0070475 | rRNA base methylation(GO:0070475) |
| 0.1 | 1.2 | GO:0002115 | store-operated calcium entry(GO:0002115) |
| 0.1 | 0.8 | GO:0035845 | photoreceptor cell outer segment organization(GO:0035845) |
| 0.0 | 2.8 | GO:0006730 | one-carbon metabolic process(GO:0006730) |
| 0.0 | 0.2 | GO:0017198 | N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920) |
| 0.0 | 0.7 | GO:0051256 | mitotic spindle midzone assembly(GO:0051256) |
| 0.0 | 0.9 | GO:0006071 | glycerol metabolic process(GO:0006071) |
| 0.0 | 4.5 | GO:0006081 | cellular aldehyde metabolic process(GO:0006081) |
| 0.0 | 0.1 | GO:1904247 | positive regulation of polynucleotide adenylyltransferase activity(GO:1904247) |
| 0.0 | 1.1 | GO:0006895 | Golgi to endosome transport(GO:0006895) |
| 0.0 | 2.7 | GO:0045742 | positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742) |
| 0.0 | 0.2 | GO:0070901 | mitochondrial tRNA methylation(GO:0070901) |
| 0.0 | 4.2 | GO:0035690 | cellular response to drug(GO:0035690) |
| 0.0 | 0.8 | GO:0097264 | self proteolysis(GO:0097264) |
| 0.0 | 0.3 | GO:0051013 | microtubule severing(GO:0051013) |
| 0.0 | 1.1 | GO:0043651 | linoleic acid metabolic process(GO:0043651) |
| 0.0 | 0.5 | GO:0061088 | regulation of sequestering of zinc ion(GO:0061088) |
| 0.0 | 0.3 | GO:0051534 | negative regulation of NFAT protein import into nucleus(GO:0051534) |
| 0.0 | 1.0 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.0 | 0.1 | GO:0042796 | snRNA transcription from RNA polymerase III promoter(GO:0042796) |
| 0.0 | 3.2 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.0 | 0.1 | GO:0002625 | regulation of T cell antigen processing and presentation(GO:0002625) |
| 0.0 | 8.6 | GO:0006888 | ER to Golgi vesicle-mediated transport(GO:0006888) |
| 0.0 | 0.2 | GO:0035803 | egg coat formation(GO:0035803) |
| 0.0 | 0.3 | GO:0002291 | T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291) |
| 0.0 | 0.4 | GO:0001514 | selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451) |
| 0.0 | 0.8 | GO:0090140 | regulation of mitochondrial fission(GO:0090140) |
| 0.0 | 1.8 | GO:0042267 | natural killer cell mediated cytotoxicity(GO:0042267) |
| 0.0 | 0.4 | GO:0051601 | exocyst localization(GO:0051601) |
| 0.0 | 0.4 | GO:0055070 | copper ion homeostasis(GO:0055070) |
| 0.0 | 0.0 | GO:0045925 | positive regulation of female receptivity(GO:0045925) |
| 0.0 | 0.8 | GO:0046710 | GDP metabolic process(GO:0046710) |
| 0.0 | 1.7 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.0 | 0.1 | GO:0071418 | cellular response to amine stimulus(GO:0071418) |
| 0.0 | 1.3 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.0 | 0.3 | GO:0080182 | histone H3-K4 trimethylation(GO:0080182) |
| 0.0 | 0.6 | GO:0035590 | purinergic nucleotide receptor signaling pathway(GO:0035590) |
| 0.0 | 0.3 | GO:0060009 | Sertoli cell development(GO:0060009) |
| 0.0 | 0.3 | GO:0050930 | induction of positive chemotaxis(GO:0050930) |
| 0.0 | 0.3 | GO:0002523 | leukocyte migration involved in inflammatory response(GO:0002523) |
| 0.0 | 0.1 | GO:0032431 | activation of phospholipase A2 activity(GO:0032431) |
| 0.0 | 2.3 | GO:0008637 | apoptotic mitochondrial changes(GO:0008637) |
| 0.0 | 0.4 | GO:0016180 | snRNA processing(GO:0016180) |
| 0.0 | 0.3 | GO:0007250 | activation of NF-kappaB-inducing kinase activity(GO:0007250) |
| 0.0 | 0.2 | GO:0006995 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
| 0.0 | 0.7 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.0 | 0.1 | GO:0061086 | negative regulation of histone H3-K27 methylation(GO:0061086) |
| 0.0 | 0.1 | GO:0006228 | UTP biosynthetic process(GO:0006228) |
| 0.0 | 0.1 | GO:0048845 | venous blood vessel morphogenesis(GO:0048845) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 2.4 | GO:0071062 | rough endoplasmic reticulum lumen(GO:0048237) alphav-beta3 integrin-vitronectin complex(GO:0071062) |
| 0.2 | 2.0 | GO:0005587 | collagen type IV trimer(GO:0005587) |
| 0.2 | 2.1 | GO:0000137 | Golgi cis cisterna(GO:0000137) |
| 0.1 | 2.4 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.1 | 1.6 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.1 | 7.6 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.1 | 1.9 | GO:0008540 | proteasome regulatory particle, base subcomplex(GO:0008540) |
| 0.1 | 0.2 | GO:0005602 | complement component C1 complex(GO:0005602) |
| 0.1 | 1.8 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.1 | 2.2 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
| 0.1 | 0.6 | GO:0034687 | integrin alphaL-beta2 complex(GO:0034687) |
| 0.1 | 0.8 | GO:0030991 | intraciliary transport particle A(GO:0030991) |
| 0.1 | 0.2 | GO:0031085 | BLOC-3 complex(GO:0031085) |
| 0.1 | 0.4 | GO:0005874 | microtubule(GO:0005874) |
| 0.1 | 0.7 | GO:0060091 | kinocilium(GO:0060091) |
| 0.1 | 6.1 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.1 | 3.9 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 1.1 | GO:0000783 | telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783) |
| 0.0 | 5.5 | GO:0031903 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.0 | 0.1 | GO:0070939 | Dsl1p complex(GO:0070939) |
| 0.0 | 0.3 | GO:0005964 | phosphorylase kinase complex(GO:0005964) |
| 0.0 | 3.3 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.0 | 0.8 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 0.0 | 1.0 | GO:0005763 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.0 | 0.1 | GO:0070702 | inner mucus layer(GO:0070702) outer mucus layer(GO:0070703) |
| 0.0 | 0.4 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.0 | 0.4 | GO:0097487 | multivesicular body, internal vesicle(GO:0097487) |
| 0.0 | 0.9 | GO:0031305 | intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305) |
| 0.0 | 1.9 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.0 | 0.2 | GO:0030678 | mitochondrial ribonuclease P complex(GO:0030678) |
| 0.0 | 0.4 | GO:0032039 | integrator complex(GO:0032039) |
| 0.0 | 0.4 | GO:0036038 | MKS complex(GO:0036038) |
| 0.0 | 0.2 | GO:0031415 | NatA complex(GO:0031415) |
| 0.0 | 0.6 | GO:0031229 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) |
| 0.0 | 0.8 | GO:0090545 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.0 | 0.9 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 1.3 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 4.1 | GO:0030496 | midbody(GO:0030496) |
| 0.0 | 7.2 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 0.2 | GO:0044232 | organelle membrane contact site(GO:0044232) |
| 0.0 | 1.7 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.0 | 1.7 | GO:0005930 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
| 0.0 | 1.7 | GO:0031966 | mitochondrial membrane(GO:0031966) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 4.3 | GO:0097259 | tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871) 20-hydroxy-leukotriene B4 omega oxidase activity(GO:0097258) 20-aldehyde-leukotriene B4 20-monooxygenase activity(GO:0097259) |
| 1.1 | 3.4 | GO:0019166 | trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166) |
| 0.9 | 2.8 | GO:0080101 | phosphatidyl-N-methylethanolamine N-methyltransferase activity(GO:0000773) phosphatidylethanolamine N-methyltransferase activity(GO:0004608) phosphatidyl-N-dimethylethanolamine N-methyltransferase activity(GO:0080101) |
| 0.8 | 2.3 | GO:0030572 | cardiolipin synthase activity(GO:0008808) phosphatidyltransferase activity(GO:0030572) CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity(GO:0043337) |
| 0.5 | 3.1 | GO:0004797 | thymidine kinase activity(GO:0004797) |
| 0.5 | 4.5 | GO:0018479 | benzaldehyde dehydrogenase (NAD+) activity(GO:0018479) |
| 0.4 | 1.3 | GO:0010698 | acetyltransferase activator activity(GO:0010698) |
| 0.4 | 1.2 | GO:0008124 | phenylalanine 4-monooxygenase activity(GO:0004505) 4-alpha-hydroxytetrahydrobiopterin dehydratase activity(GO:0008124) |
| 0.4 | 1.5 | GO:0004727 | prenylated protein tyrosine phosphatase activity(GO:0004727) |
| 0.4 | 1.1 | GO:0045485 | omega-6 fatty acid desaturase activity(GO:0045485) |
| 0.3 | 3.8 | GO:0004305 | ethanolamine kinase activity(GO:0004305) |
| 0.3 | 1.0 | GO:0047661 | racemase and epimerase activity, acting on amino acids and derivatives(GO:0016855) racemase activity, acting on amino acids and derivatives(GO:0036361) amino-acid racemase activity(GO:0047661) |
| 0.3 | 1.3 | GO:0050051 | leukotriene-B4 20-monooxygenase activity(GO:0050051) |
| 0.3 | 1.6 | GO:0004616 | phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616) |
| 0.3 | 0.9 | GO:0017057 | 6-phosphogluconolactonase activity(GO:0017057) |
| 0.3 | 5.1 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.2 | 0.9 | GO:0002094 | polyprenyltransferase activity(GO:0002094) |
| 0.2 | 0.8 | GO:0016635 | oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635) |
| 0.2 | 0.7 | GO:0035939 | microsatellite binding(GO:0035939) |
| 0.2 | 7.5 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 0.1 | 1.4 | GO:0070181 | small ribosomal subunit rRNA binding(GO:0070181) |
| 0.1 | 0.9 | GO:0015184 | L-cystine transmembrane transporter activity(GO:0015184) |
| 0.1 | 0.4 | GO:0009383 | rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383) |
| 0.1 | 2.4 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
| 0.1 | 1.9 | GO:0031698 | beta-2 adrenergic receptor binding(GO:0031698) |
| 0.1 | 1.8 | GO:0005432 | calcium:sodium antiporter activity(GO:0005432) |
| 0.1 | 1.8 | GO:0005391 | sodium:potassium-exchanging ATPase activity(GO:0005391) |
| 0.1 | 2.4 | GO:0001871 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
| 0.1 | 0.6 | GO:0004800 | thyroxine 5'-deiodinase activity(GO:0004800) |
| 0.1 | 1.2 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.1 | 1.1 | GO:0047499 | calcium-independent phospholipase A2 activity(GO:0047499) |
| 0.1 | 2.0 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.1 | 1.0 | GO:0035612 | AP-2 adaptor complex binding(GO:0035612) |
| 0.1 | 7.4 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.1 | 0.6 | GO:0030369 | ICAM-3 receptor activity(GO:0030369) |
| 0.1 | 1.1 | GO:0098505 | G-rich strand telomeric DNA binding(GO:0098505) |
| 0.1 | 7.7 | GO:0005518 | collagen binding(GO:0005518) |
| 0.1 | 0.6 | GO:0005280 | hydrogen:amino acid symporter activity(GO:0005280) |
| 0.1 | 0.6 | GO:0004931 | extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) |
| 0.1 | 3.9 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.0 | 1.4 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
| 0.0 | 0.3 | GO:0004996 | thyroid-stimulating hormone receptor activity(GO:0004996) |
| 0.0 | 0.3 | GO:0004169 | dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169) |
| 0.0 | 0.2 | GO:0016429 | tRNA (adenine) methyltransferase activity(GO:0016426) tRNA (adenine-N1-)-methyltransferase activity(GO:0016429) |
| 0.0 | 0.2 | GO:1990190 | peptide-glutamate-N-acetyltransferase activity(GO:1990190) |
| 0.0 | 2.1 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.0 | 0.1 | GO:0004108 | citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440) |
| 0.0 | 0.3 | GO:0004689 | phosphorylase kinase activity(GO:0004689) |
| 0.0 | 0.3 | GO:0008568 | microtubule-severing ATPase activity(GO:0008568) |
| 0.0 | 0.6 | GO:0008527 | taste receptor activity(GO:0008527) |
| 0.0 | 0.1 | GO:0010309 | acireductone dioxygenase [iron(II)-requiring] activity(GO:0010309) |
| 0.0 | 0.6 | GO:0004185 | serine-type carboxypeptidase activity(GO:0004185) |
| 0.0 | 0.1 | GO:0004991 | parathyroid hormone receptor activity(GO:0004991) |
| 0.0 | 0.1 | GO:0004906 | interferon-gamma receptor activity(GO:0004906) |
| 0.0 | 5.7 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.0 | 1.9 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.0 | 0.2 | GO:0015185 | gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185) |
| 0.0 | 0.6 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.0 | 1.3 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.0 | 0.9 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.0 | 0.1 | GO:0004852 | uroporphyrinogen-III synthase activity(GO:0004852) |
| 0.0 | 0.3 | GO:0003857 | 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857) |
| 0.0 | 0.0 | GO:0004794 | L-serine ammonia-lyase activity(GO:0003941) L-threonine ammonia-lyase activity(GO:0004794) |
| 0.0 | 0.8 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 0.0 | 0.2 | GO:0032190 | acrosin binding(GO:0032190) |
| 0.0 | 2.5 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 0.4 | GO:0004062 | aryl sulfotransferase activity(GO:0004062) |
| 0.0 | 0.9 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.0 | 0.4 | GO:0004623 | phospholipase A2 activity(GO:0004623) |
| 0.0 | 0.3 | GO:0050700 | CARD domain binding(GO:0050700) |
| 0.0 | 1.0 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 0.4 | GO:0005229 | intracellular calcium activated chloride channel activity(GO:0005229) |
| 0.0 | 0.3 | GO:0042609 | CD4 receptor binding(GO:0042609) |
| 0.0 | 0.7 | GO:0036002 | pre-mRNA binding(GO:0036002) |
| 0.0 | 0.5 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.6 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.1 | 2.4 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 12.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 3.1 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 1.5 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.0 | 2.0 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.0 | 3.2 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 1.6 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 7.6 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 3.1 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 1.8 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 0.6 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 0.0 | 1.2 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.4 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.1 | 2.8 | REACTOME ACYL CHAIN REMODELLING OF PG | Genes involved in Acyl chain remodelling of PG |
| 0.1 | 3.8 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.1 | 2.8 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.1 | 3.8 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.1 | 6.6 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.1 | 1.2 | REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |
| 0.1 | 5.6 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.1 | 0.8 | REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS | Genes involved in Membrane binding and targetting of GAG proteins |
| 0.1 | 0.9 | REACTOME ACYL CHAIN REMODELLING OF PC | Genes involved in Acyl chain remodelling of PC |
| 0.1 | 1.6 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.0 | 2.9 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.0 | 1.1 | REACTOME ALPHA LINOLENIC ACID ALA METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 0.0 | 1.4 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.0 | 1.9 | REACTOME IL RECEPTOR SHC SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.0 | 5.0 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.0 | 0.8 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.0 | 1.9 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 0.6 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.0 | 1.9 | REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | Genes involved in CDK-mediated phosphorylation and removal of Cdc6 |
| 0.0 | 0.6 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.0 | 1.1 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 0.2 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.0 | 2.4 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 0.6 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.0 | 0.7 | REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| 0.0 | 0.3 | REACTOME THE ACTIVATION OF ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
| 0.0 | 1.1 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.0 | 0.3 | REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.0 | 1.3 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 0.3 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.0 | 1.0 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.0 | 0.3 | REACTOME VITAMIN B5 PANTOTHENATE METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.0 | 0.3 | REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE | Genes involved in NGF signalling via TRKA from the plasma membrane |
| 0.0 | 0.4 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.0 | 0.4 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |