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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NR1H4

Z-value: 1.24

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Transcription factors associated with NR1H4

Gene Symbol Gene ID Gene Info
ENSG00000012504.9 nuclear receptor subfamily 1 group H member 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NR1H4hg19_v2_chr12_+_100897130_100897231-0.551.1e-02Click!

Activity profile of NR1H4 motif

Sorted Z-values of NR1H4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NR1H4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0048597 B cell negative selection(GO:0002352) post-embryonic camera-type eye morphogenesis(GO:0048597)
0.7 2.7 GO:0060447 bud outgrowth involved in lung branching(GO:0060447)
0.6 1.9 GO:0006117 acetaldehyde metabolic process(GO:0006117)
0.4 3.3 GO:1902952 positive regulation of dendritic spine maintenance(GO:1902952) regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758)
0.3 2.8 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.3 2.5 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
0.3 1.8 GO:0032571 response to vitamin K(GO:0032571) regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209) bone regeneration(GO:1990523)
0.2 0.7 GO:0060532 bronchus cartilage development(GO:0060532) lung smooth muscle development(GO:0061145)
0.2 0.7 GO:2000118 regulation of sodium-dependent phosphate transport(GO:2000118)
0.2 1.4 GO:0008063 Toll signaling pathway(GO:0008063)
0.2 1.6 GO:1901189 positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.2 3.4 GO:0090361 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.2 1.9 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.1 0.5 GO:0036496 regulation of translational initiation by eIF2 alpha dephosphorylation(GO:0036496)
0.1 1.0 GO:1900242 regulation of synaptic vesicle endocytosis(GO:1900242)
0.1 0.7 GO:2000784 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) positive regulation of barbed-end actin filament capping(GO:2000814)
0.1 0.6 GO:0044034 negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
0.1 2.4 GO:0060716 labyrinthine layer blood vessel development(GO:0060716)
0.1 9.2 GO:0042795 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.1 0.2 GO:0001543 ovarian follicle rupture(GO:0001543)
0.1 0.8 GO:0038031 non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.1 0.6 GO:0098728 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.1 0.2 GO:0046416 alanine metabolic process(GO:0006522) alanine catabolic process(GO:0006524) pyruvate family amino acid metabolic process(GO:0009078) pyruvate family amino acid catabolic process(GO:0009080) D-amino acid metabolic process(GO:0046416)
0.1 2.4 GO:0006491 N-glycan processing(GO:0006491)
0.1 0.3 GO:0002729 positive regulation of natural killer cell cytokine production(GO:0002729)
0.1 0.3 GO:0071603 endothelial cell-cell adhesion(GO:0071603)
0.1 0.4 GO:0090206 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.1 0.8 GO:0030856 regulation of epithelial cell differentiation(GO:0030856)
0.1 1.1 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.1 1.5 GO:1901897 regulation of relaxation of cardiac muscle(GO:1901897)
0.0 0.4 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.0 0.6 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.0 0.1 GO:0050894 determination of affect(GO:0050894)
0.0 1.2 GO:1904776 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.0 1.2 GO:0051531 NFAT protein import into nucleus(GO:0051531) positive regulation of endoplasmic reticulum unfolded protein response(GO:1900103)
0.0 0.3 GO:0043606 histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
0.0 1.0 GO:1903830 magnesium ion transmembrane transport(GO:1903830)
0.0 0.7 GO:1900227 positive regulation of NLRP3 inflammasome complex assembly(GO:1900227)
0.0 0.4 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.0 1.0 GO:0008340 determination of adult lifespan(GO:0008340)
0.0 1.0 GO:0042753 positive regulation of circadian rhythm(GO:0042753)
0.0 0.7 GO:0048243 norepinephrine secretion(GO:0048243)
0.0 1.2 GO:0006706 steroid catabolic process(GO:0006706)
0.0 0.1 GO:1900186 negative regulation of clathrin-mediated endocytosis(GO:1900186)
0.0 1.6 GO:0035767 endothelial cell chemotaxis(GO:0035767)
0.0 0.3 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 1.6 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.0 2.2 GO:0045773 positive regulation of axon extension(GO:0045773)
0.0 1.2 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 11.3 GO:0016197 endosomal transport(GO:0016197)
0.0 2.8 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.9 GO:1902186 regulation of viral release from host cell(GO:1902186)
0.0 1.4 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0 0.1 GO:1904154 positive regulation of retrograde protein transport, ER to cytosol(GO:1904154)
0.0 2.4 GO:0006305 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.0 0.4 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.0 0.7 GO:0015695 organic cation transport(GO:0015695)
0.0 0.3 GO:2000659 regulation of interleukin-1-mediated signaling pathway(GO:2000659)
0.0 2.2 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.9 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.3 GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030949)
0.0 0.2 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.0 0.4 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0 0.1 GO:0006581 acetylcholine catabolic process in synaptic cleft(GO:0001507) acetylcholine catabolic process(GO:0006581)
0.0 0.5 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 1.2 GO:0001510 RNA methylation(GO:0001510)
0.0 0.6 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.0 0.2 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.0 0.1 GO:0035524 proline transmembrane transport(GO:0035524)
0.0 0.0 GO:0071500 cellular response to nitrosative stress(GO:0071500)
0.0 0.2 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 1.1 GO:0071349 interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
0.0 0.1 GO:0055011 atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014)
0.0 0.2 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 8.4 GO:0070876 SOSS complex(GO:0070876)
0.6 1.9 GO:0035525 NF-kappaB p50/p65 complex(GO:0035525)
0.2 2.4 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.2 1.6 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.1 1.2 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.1 1.6 GO:0071986 Ragulator complex(GO:0071986)
0.1 0.3 GO:0005745 m-AAA complex(GO:0005745)
0.1 2.9 GO:0005614 interstitial matrix(GO:0005614)
0.1 0.5 GO:0097513 myosin II filament(GO:0097513)
0.1 0.5 GO:0045272 plasma membrane respiratory chain complex I(GO:0045272)
0.1 0.6 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
0.1 1.0 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.1 0.6 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 2.0 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 1.3 GO:0010369 chromocenter(GO:0010369)
0.0 1.7 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.7 GO:0097427 microtubule bundle(GO:0097427)
0.0 3.3 GO:0043198 dendritic shaft(GO:0043198)
0.0 0.4 GO:0032797 SMN complex(GO:0032797)
0.0 0.8 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.3 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.0 3.2 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 1.9 GO:0002102 podosome(GO:0002102)
0.0 0.3 GO:0008091 spectrin(GO:0008091)
0.0 0.4 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.2 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.0 0.5 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 1.5 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 1.0 GO:0016592 mediator complex(GO:0016592)
0.0 0.2 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 1.8 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 1.3 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.7 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 1.8 GO:0016459 myosin complex(GO:0016459)
0.0 12.0 GO:0031012 extracellular matrix(GO:0031012)
0.0 1.3 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.1 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 11.1 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.3 2.7 GO:0045545 syndecan binding(GO:0045545)
0.2 1.4 GO:0017161 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.2 2.0 GO:0071532 ankyrin repeat binding(GO:0071532)
0.2 2.8 GO:0008199 ferric iron binding(GO:0008199)
0.1 0.7 GO:0010736 serum response element binding(GO:0010736)
0.1 2.4 GO:0051400 BH domain binding(GO:0051400)
0.1 0.6 GO:0019776 Atg8 ligase activity(GO:0019776)
0.1 1.1 GO:0003997 acyl-CoA oxidase activity(GO:0003997)
0.1 0.7 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 0.8 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.1 1.5 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.1 1.2 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1 1.6 GO:0000150 recombinase activity(GO:0000150)
0.1 2.5 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.1 3.3 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 2.7 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 1.4 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.1 0.7 GO:0009881 photoreceptor activity(GO:0009881)
0.0 1.0 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 8.0 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 1.6 GO:0070300 phosphatidic acid binding(GO:0070300)
0.0 0.1 GO:0005298 proline:sodium symporter activity(GO:0005298)
0.0 1.0 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 1.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 1.2 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.0 0.2 GO:0050436 microfibril binding(GO:0050436)
0.0 2.7 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.3 GO:0042731 PH domain binding(GO:0042731)
0.0 0.5 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.8 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.5 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.8 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.7 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.0 0.1 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0 0.6 GO:0070403 NAD+ binding(GO:0070403)
0.0 0.8 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.8 GO:0005109 frizzled binding(GO:0005109)
0.0 0.5 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 1.2 GO:0008173 RNA methyltransferase activity(GO:0008173)
0.0 0.4 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 1.0 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 2.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.3 GO:0016836 hydro-lyase activity(GO:0016836)
0.0 1.4 GO:0032947 protein complex scaffold(GO:0032947)
0.0 0.4 GO:0004181 metallocarboxypeptidase activity(GO:0004181)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.4 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 6.2 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.1 3.1 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 13.3 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.5 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.5 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 0.7 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.8 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 0.7 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 3.4 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.6 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.0 0.7 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 0.8 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 0.4 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.9 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 0.3 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 1.4 PID E2F PATHWAY E2F transcription factor network
0.0 0.4 PID ARF 3PATHWAY Arf1 pathway
0.0 0.8 PID BCR 5PATHWAY BCR signaling pathway
0.0 1.3 PID RHOA REG PATHWAY Regulation of RhoA activity

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.1 2.4 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 1.9 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.1 1.6 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 1.6 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 1.2 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 1.4 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 2.6 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.0 1.2 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 2.4 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 1.1 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 2.8 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.9 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.8 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 1.0 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.7 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.0 2.5 REACTOME LATE PHASE OF HIV LIFE CYCLE Genes involved in Late Phase of HIV Life Cycle
0.0 1.3 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 2.4 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.5 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse