ISMARA results: NR1I2

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NR1I2

Z-value: 1.71

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Transcription factors associated with NR1I2

Gene Symbol	Gene ID	Gene Info
NR1I2 Ensembl NCBI GeneCards UniProt	ENSG00000144852.12	nuclear receptor subfamily 1 group I member 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NR1I2	hg19_v2_chr3_+_119499331_119499331	0.25	2.8e-01	Click!

Activity profile of NR1I2 motif

Sorted Z-values of NR1I2 motif

No targets for NR1I2

Network of associatons between targets according to the STRING database.

First level regulatory network of NR1I2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	6.2	GO:0031915	positive regulation of synaptic plasticity(GO:0031915)
0.8	5.6	GO:0060356	leucine import(GO:0060356)
0.5	5.2	GO:0019344	cysteine biosynthetic process(GO:0019344)
0.7	5.1	GO:0061113	pancreas morphogenesis(GO:0061113)
0.2	5.0	GO:0070886	positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.3	4.5	GO:0007144	female meiosis I(GO:0007144)
0.3	3.8	GO:0060050	positive regulation of protein glycosylation(GO:0060050)
0.0	3.6	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.2	3.1	GO:0019532	oxalate transport(GO:0019532)
1.0	3.0	GO:1901202	negative regulation of extracellular matrix assembly(GO:1901202)

Showing 1 to 10 of 192 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	7.3	GO:0045095	keratin filament(GO:0045095)
0.0	7.3	GO:0090575	RNA polymerase II transcription factor complex(GO:0090575)
0.6	6.2	GO:0070033	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.0	6.0	GO:0000922	spindle pole(GO:0000922)
0.0	4.7	GO:0048770	melanosome(GO:0042470) pigment granule(GO:0048770)
0.0	3.2	GO:0030173	integral component of Golgi membrane(GO:0030173)
0.0	3.0	GO:0101003	ficolin-1-rich granule membrane(GO:0101003)
0.2	2.9	GO:0042788	polysomal ribosome(GO:0042788)
0.2	2.5	GO:0070765	gamma-secretase complex(GO:0070765)
0.1	2.5	GO:0044295	axonal growth cone(GO:0044295)

Showing 1 to 10 of 66 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	6.6	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.3	6.3	GO:0036374	glutathione hydrolase activity(GO:0036374)
0.1	6.2	GO:0017075	syntaxin-1 binding(GO:0017075)
0.3	5.6	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	4.9	GO:0004725	protein tyrosine phosphatase activity(GO:0004725)
0.0	4.0	GO:0016278	lysine N-methyltransferase activity(GO:0016278)
0.1	3.8	GO:0000217	DNA secondary structure binding(GO:0000217)
0.2	3.1	GO:0019531	oxalate transmembrane transporter activity(GO:0019531)
0.1	3.1	GO:0005520	insulin-like growth factor binding(GO:0005520)
0.6	3.0	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)

Showing 1 to 10 of 125 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	7.3	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.3	4.5	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1	3.3	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.1	3.1	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling
0.1	3.0	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.1	2.9	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.0	2.8	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.0	2.6	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.1	2.5	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.0	1.9	PID LKB1 PATHWAY	LKB1 signaling events

Showing 1 to 10 of 27 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	9.8	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.1	7.0	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.1	6.3	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.2	4.5	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0	3.6	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.1	3.0	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.2	2.9	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1	2.5	REACTOME REGULATED PROTEOLYSIS OF P75NTR	Genes involved in Regulated proteolysis of p75NTR
0.0	2.0	REACTOME O LINKED GLYCOSYLATION OF MUCINS	Genes involved in O-linked glycosylation of mucins
0.1	1.9	REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN	Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein

Showing 1 to 10 of 36 entries

Results for NR1I2

Z-value: 1.71

Motif logo

Transcription factors associated with NR1I2

Activity-expression correlation:

Activity profile of NR1I2 motif

Sorted Z-values of NR1I2 motif

No targets for NR1I2

Network of associatons between targets according to the STRING database.

First level regulatory network of NR1I2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: