Project

avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

Navigation
Downloads

Results for NR1I2

Z-value: 1.71

Motif logo

Transcription factors associated with NR1I2

Gene Symbol Gene ID Gene Info
ENSG00000144852.12 nuclear receptor subfamily 1 group I member 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NR1I2hg19_v2_chr3_+_119499331_1194993310.252.8e-01Click!

Activity profile of NR1I2 motif

Sorted Z-values of NR1I2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NR1I2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.0 GO:1901202 negative regulation of extracellular matrix assembly(GO:1901202)
0.8 5.6 GO:0060356 leucine import(GO:0060356)
0.7 5.1 GO:0061113 pancreas morphogenesis(GO:0061113)
0.7 2.8 GO:0042369 vitamin D catabolic process(GO:0042369)
0.6 1.9 GO:0006059 hexitol metabolic process(GO:0006059)
0.6 3.0 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.6 1.7 GO:0060827 regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060827) negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060829)
0.5 2.0 GO:0002426 immunoglobulin production in mucosal tissue(GO:0002426)
0.5 2.4 GO:0003289 atrial septum primum morphogenesis(GO:0003289)
0.5 5.2 GO:0019344 cysteine biosynthetic process(GO:0019344)
0.5 2.8 GO:1904674 positive regulation of somatic stem cell population maintenance(GO:1904674)
0.4 1.3 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.4 2.1 GO:0032425 positive regulation of mismatch repair(GO:0032425)
0.4 1.6 GO:0009447 putrescine catabolic process(GO:0009447)
0.4 2.8 GO:0045079 negative regulation of chemokine biosynthetic process(GO:0045079)
0.4 1.2 GO:1903568 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
0.3 1.0 GO:2001112 negative regulation of hepatocyte growth factor receptor signaling pathway(GO:1902203) regulation of cellular response to hepatocyte growth factor stimulus(GO:2001112) negative regulation of cellular response to hepatocyte growth factor stimulus(GO:2001113)
0.3 1.0 GO:0071423 thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) malate transmembrane transport(GO:0071423) oxaloacetate(2-) transmembrane transport(GO:1902356)
0.3 4.5 GO:0007144 female meiosis I(GO:0007144)
0.3 1.3 GO:0018171 peptidyl-cysteine oxidation(GO:0018171)
0.3 1.3 GO:0060032 notochord regression(GO:0060032)
0.3 3.8 GO:0060050 positive regulation of protein glycosylation(GO:0060050)
0.2 1.2 GO:1902378 vestibulocochlear nerve structural organization(GO:0021649) positive regulation of cytokine activity(GO:0060301) ganglion morphogenesis(GO:0061552) VEGF-activated neuropilin signaling pathway involved in axon guidance(GO:1902378) dorsal root ganglion morphogenesis(GO:1904835) otic placode development(GO:1905040)
0.2 0.9 GO:2000230 negative regulation of pancreatic stellate cell proliferation(GO:2000230)
0.2 6.2 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
0.2 1.1 GO:0006447 regulation of translational initiation by iron(GO:0006447)
0.2 2.1 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.2 1.6 GO:0019236 response to pheromone(GO:0019236)
0.2 1.0 GO:0033686 positive regulation of luteinizing hormone secretion(GO:0033686)
0.2 1.0 GO:0034653 diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653)
0.2 0.7 GO:0045208 MAPK phosphatase export from nucleus(GO:0045208) MAPK phosphatase export from nucleus, leptomycin B sensitive(GO:0045209)
0.2 1.6 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.2 0.7 GO:0031133 regulation of axon diameter(GO:0031133)
0.2 2.1 GO:0071321 cellular response to cGMP(GO:0071321)
0.2 5.0 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.2 0.5 GO:0014876 response to injury involved in regulation of muscle adaptation(GO:0014876)
0.2 3.1 GO:0019532 oxalate transport(GO:0019532)
0.2 2.9 GO:0030238 male sex determination(GO:0030238)
0.2 0.6 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.2 2.7 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.2 2.6 GO:0060056 mammary gland involution(GO:0060056)
0.2 2.9 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.2 1.1 GO:0048165 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.2 0.6 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.1 0.7 GO:0018057 peptidyl-lysine oxidation(GO:0018057)
0.1 0.7 GO:0036371 protein localization to T-tubule(GO:0036371)
0.1 0.7 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.1 1.1 GO:0008343 adult feeding behavior(GO:0008343)
0.1 1.1 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.1 0.5 GO:0001878 response to yeast(GO:0001878)
0.1 1.0 GO:0048295 positive regulation of isotype switching to IgE isotypes(GO:0048295)
0.1 1.1 GO:0070560 protein secretion by platelet(GO:0070560)
0.1 1.0 GO:0007256 activation of JNKK activity(GO:0007256)
0.1 0.7 GO:0090131 mesenchyme migration(GO:0090131)
0.1 0.9 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.1 1.3 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.1 0.4 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.1 1.0 GO:1903027 regulation of opsonization(GO:1903027)
0.1 0.3 GO:1903280 negative regulation of calcium:sodium antiporter activity(GO:1903280)
0.1 0.9 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.1 0.6 GO:0036023 limb joint morphogenesis(GO:0036022) embryonic skeletal limb joint morphogenesis(GO:0036023)
0.1 1.4 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.1 2.5 GO:0007220 Notch receptor processing(GO:0007220)
0.1 0.8 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
0.1 1.6 GO:0060242 contact inhibition(GO:0060242)
0.1 0.8 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.1 0.3 GO:0089700 protein kinase D signaling(GO:0089700)
0.1 1.1 GO:1901748 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.1 0.5 GO:0021764 amygdala development(GO:0021764)
0.1 0.2 GO:1904428 negative regulation of tubulin deacetylation(GO:1904428)
0.1 1.0 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.1 0.4 GO:0061687 detoxification of inorganic compound(GO:0061687) stress response to metal ion(GO:0097501)
0.1 1.0 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.1 0.5 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.1 0.7 GO:0061591 calcium activated phospholipid scrambling(GO:0061588) calcium activated phosphatidylcholine scrambling(GO:0061590) calcium activated galactosylceramide scrambling(GO:0061591)
0.1 0.5 GO:0008065 establishment of blood-nerve barrier(GO:0008065)
0.1 2.5 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.1 0.4 GO:2000568 memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
0.1 1.7 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 1.0 GO:0014722 regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
0.1 1.0 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.1 0.2 GO:0072365 regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072365)
0.1 0.6 GO:0072719 copper ion import(GO:0015677) cellular response to cisplatin(GO:0072719)
0.1 0.2 GO:0003331 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.1 0.3 GO:0090070 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
0.1 0.4 GO:0036438 maintenance of lens transparency(GO:0036438)
0.1 0.3 GO:0014826 cellular magnesium ion homeostasis(GO:0010961) vein smooth muscle contraction(GO:0014826)
0.1 0.3 GO:0032571 response to vitamin K(GO:0032571)
0.1 1.1 GO:2000774 positive regulation of cellular senescence(GO:2000774)
0.0 0.4 GO:0002606 positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.0 0.8 GO:1904321 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.0 0.4 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.9 GO:0014029 neural crest formation(GO:0014029)
0.0 0.6 GO:0051660 establishment of centrosome localization(GO:0051660)
0.0 0.2 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.0 2.8 GO:0016601 Rac protein signal transduction(GO:0016601)
0.0 0.4 GO:1904694 negative regulation of vascular smooth muscle contraction(GO:1904694)
0.0 1.1 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 0.7 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 0.2 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
0.0 0.4 GO:0030242 pexophagy(GO:0030242)
0.0 0.5 GO:2001140 regulation of phospholipid transport(GO:2001138) positive regulation of phospholipid transport(GO:2001140)
0.0 0.7 GO:0090292 nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.3 GO:0071484 cellular response to light intensity(GO:0071484)
0.0 1.4 GO:0072348 sulfur compound transport(GO:0072348)
0.0 0.2 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 1.0 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.3 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.0 0.1 GO:1990654 sebum secreting cell proliferation(GO:1990654)
0.0 0.2 GO:0010193 response to ozone(GO:0010193) operant conditioning(GO:0035106)
0.0 0.7 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.0 2.6 GO:0000266 mitochondrial fission(GO:0000266)
0.0 0.2 GO:0060161 positive regulation of dopamine receptor signaling pathway(GO:0060161)
0.0 0.6 GO:0035641 locomotory exploration behavior(GO:0035641)
0.0 0.5 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.0 0.4 GO:1990403 embryonic brain development(GO:1990403)
0.0 0.3 GO:0097105 presynaptic membrane assembly(GO:0097105)
0.0 0.1 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.0 0.2 GO:0010536 positive regulation of activation of Janus kinase activity(GO:0010536) regulation of NK T cell proliferation(GO:0051140) positive regulation of NK T cell proliferation(GO:0051142)
0.0 1.2 GO:0061641 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0 0.5 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.0 0.8 GO:0022011 myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
0.0 0.3 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.0 0.5 GO:0015886 heme transport(GO:0015886)
0.0 0.8 GO:0051023 regulation of immunoglobulin secretion(GO:0051023)
0.0 0.6 GO:1900037 regulation of cellular response to hypoxia(GO:1900037)
0.0 0.1 GO:0030853 negative regulation of granulocyte differentiation(GO:0030853)
0.0 0.9 GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling(GO:0010882)
0.0 0.4 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.0 0.7 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.3 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.0 0.5 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.3 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.1 GO:0060018 astrocyte fate commitment(GO:0060018)
0.0 0.4 GO:0060539 diaphragm development(GO:0060539)
0.0 0.5 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0 1.0 GO:0014904 myotube cell development(GO:0014904)
0.0 0.1 GO:0071420 cellular response to histamine(GO:0071420)
0.0 0.8 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.3 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.0 0.2 GO:0070537 histone H2A K63-linked deubiquitination(GO:0070537)
0.0 1.1 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 0.6 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 1.1 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.2 GO:0098728 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.0 0.4 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.0 1.2 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.0 0.9 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.1 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.0 0.1 GO:0090274 regulation of somatostatin secretion(GO:0090273) positive regulation of somatostatin secretion(GO:0090274)
0.0 0.4 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.3 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.0 0.2 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.7 GO:2000352 negative regulation of endothelial cell apoptotic process(GO:2000352)
0.0 0.1 GO:0002584 negative regulation of antigen processing and presentation of peptide antigen(GO:0002584) regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002586)
0.0 0.8 GO:2000300 regulation of synaptic vesicle exocytosis(GO:2000300)
0.0 0.3 GO:0042832 defense response to protozoan(GO:0042832)
0.0 0.3 GO:0010623 programmed cell death involved in cell development(GO:0010623)
0.0 2.7 GO:0070268 cornification(GO:0070268)
0.0 0.1 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.0 0.6 GO:0032211 negative regulation of telomere maintenance via telomerase(GO:0032211)
0.0 1.5 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.0 0.7 GO:1901224 positive regulation of NIK/NF-kappaB signaling(GO:1901224)
0.0 0.7 GO:0042036 negative regulation of cytokine biosynthetic process(GO:0042036)
0.0 0.5 GO:0030325 adrenal gland development(GO:0030325)
0.0 0.0 GO:0042761 very long-chain fatty acid biosynthetic process(GO:0042761)
0.0 0.1 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.0 0.2 GO:0086069 bundle of His cell to Purkinje myocyte communication(GO:0086069)
0.0 0.3 GO:0015732 prostaglandin transport(GO:0015732)
0.0 0.2 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.0 0.4 GO:0030252 growth hormone secretion(GO:0030252)
0.0 0.8 GO:0001881 receptor recycling(GO:0001881)
0.0 0.2 GO:0010801 negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
0.0 0.3 GO:0043922 negative regulation by host of viral transcription(GO:0043922)
0.0 0.2 GO:0060742 epithelial cell differentiation involved in prostate gland development(GO:0060742)
0.0 0.1 GO:0048619 embryonic hindgut morphogenesis(GO:0048619)
0.0 1.6 GO:0060996 dendritic spine development(GO:0060996)
0.0 0.4 GO:0016048 detection of temperature stimulus(GO:0016048)
0.0 0.5 GO:0015988 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991)
0.0 0.3 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.0 0.1 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0 0.3 GO:0005513 detection of calcium ion(GO:0005513)
0.0 3.6 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.0 0.7 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.0 0.2 GO:0010561 negative regulation of glycoprotein biosynthetic process(GO:0010561)
0.0 0.0 GO:0003164 His-Purkinje system development(GO:0003164) bundle of His development(GO:0003166)
0.0 1.4 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 2.4 GO:0043484 regulation of RNA splicing(GO:0043484)
0.0 0.3 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.2 GO:0007638 mechanosensory behavior(GO:0007638)
0.0 0.1 GO:0030321 transepithelial chloride transport(GO:0030321)
0.0 0.6 GO:0006270 DNA replication initiation(GO:0006270)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 GO:0098855 HCN channel complex(GO:0098855)
0.6 6.2 GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.4 2.1 GO:0042721 mitochondrial inner membrane protein insertion complex(GO:0042721)
0.2 2.9 GO:0042788 polysomal ribosome(GO:0042788)
0.2 2.5 GO:0070765 gamma-secretase complex(GO:0070765)
0.2 1.0 GO:0097058 CRLF-CLCF1 complex(GO:0097058) CNTFR-CLCF1 complex(GO:0097059)
0.2 0.7 GO:0048179 activin receptor complex(GO:0048179)
0.2 1.6 GO:0016012 sarcoglycan complex(GO:0016012)
0.2 1.9 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 0.9 GO:1990584 cardiac Troponin complex(GO:1990584)
0.1 0.6 GO:0097362 MCM8-MCM9 complex(GO:0097362)
0.1 0.3 GO:0031379 RNA-directed RNA polymerase complex(GO:0031379)
0.1 0.9 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.1 1.2 GO:0097443 sorting endosome(GO:0097443)
0.1 1.7 GO:0097427 microtubule bundle(GO:0097427)
0.1 0.7 GO:0097165 nuclear stress granule(GO:0097165)
0.1 7.3 GO:0045095 keratin filament(GO:0045095)
0.1 0.8 GO:0072588 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.1 1.0 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.1 0.2 GO:0043257 laminin-8 complex(GO:0043257)
0.1 1.1 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.1 1.1 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1 1.0 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 0.7 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.1 2.5 GO:0044295 axonal growth cone(GO:0044295)
0.1 2.0 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.1 0.2 GO:0005602 complement component C1 complex(GO:0005602)
0.1 0.5 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 0.3 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.1 1.2 GO:0008385 IkappaB kinase complex(GO:0008385)
0.1 2.5 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 1.1 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 3.2 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 1.1 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 0.6 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.6 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.4 GO:0005869 dynactin complex(GO:0005869)
0.0 7.3 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.6 GO:0032059 bleb(GO:0032059)
0.0 0.7 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 1.9 GO:0097542 ciliary tip(GO:0097542)
0.0 3.0 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.0 6.0 GO:0000922 spindle pole(GO:0000922)
0.0 0.7 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.1 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.0 0.3 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 1.5 GO:0001772 immunological synapse(GO:0001772)
0.0 4.7 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.6 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 0.4 GO:0036038 MKS complex(GO:0036038)
0.0 0.3 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 1.3 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.7 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 0.6 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 1.3 GO:0002102 podosome(GO:0002102)
0.0 0.2 GO:0031906 late endosome lumen(GO:0031906)
0.0 0.3 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.2 GO:0070531 BRCA1-A complex(GO:0070531)
0.0 0.7 GO:0043034 costamere(GO:0043034)
0.0 1.0 GO:0045171 intercellular bridge(GO:0045171)
0.0 2.5 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 2.5 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 0.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 1.1 GO:0043195 terminal bouton(GO:0043195)
0.0 0.4 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 0.6 GO:0008305 integrin complex(GO:0008305)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 2.8 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)
0.9 2.6 GO:0033867 Fas-activated serine/threonine kinase activity(GO:0033867)
0.7 2.9 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.7 2.0 GO:0047225 acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0047225)
0.6 3.0 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
0.5 1.9 GO:0004335 galactokinase activity(GO:0004335)
0.5 1.9 GO:0004583 dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity(GO:0004583)
0.4 2.1 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.4 1.1 GO:0004145 diamine N-acetyltransferase activity(GO:0004145)
0.3 6.3 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.3 1.0 GO:0045155 electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity(GO:0045155)
0.3 1.0 GO:0015117 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131)
0.3 5.6 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.3 2.8 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.3 1.0 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.3 0.8 GO:0005174 CD40 receptor binding(GO:0005174)
0.2 1.2 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.2 1.3 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
0.2 0.6 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.2 1.1 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.2 0.7 GO:0004727 prenylated protein tyrosine phosphatase activity(GO:0004727)
0.2 2.0 GO:0097322 7SK snRNA binding(GO:0097322)
0.2 0.5 GO:0015439 heme-transporting ATPase activity(GO:0015439)
0.2 0.8 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.2 3.1 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 1.6 GO:0070097 delta-catenin binding(GO:0070097)
0.1 1.7 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 0.5 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.1 1.0 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.1 0.4 GO:0050613 delta14-sterol reductase activity(GO:0050613)
0.1 0.9 GO:0050692 DBD domain binding(GO:0050692)
0.1 1.3 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.1 1.0 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.1 0.9 GO:0030172 troponin C binding(GO:0030172)
0.1 0.8 GO:0010858 calcium-dependent protein kinase regulator activity(GO:0010858)
0.1 6.2 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 0.5 GO:0052901 polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)
0.1 0.5 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.1 0.7 GO:0005047 signal recognition particle binding(GO:0005047)
0.1 0.6 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.1 3.8 GO:0000217 DNA secondary structure binding(GO:0000217)
0.1 1.3 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 0.5 GO:0008665 2'-phosphotransferase activity(GO:0008665)
0.1 1.2 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.1 0.7 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.1 1.6 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 0.2 GO:0031783 corticotropin hormone receptor binding(GO:0031780) type 5 melanocortin receptor binding(GO:0031783)
0.1 0.8 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.1 1.0 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.1 0.4 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.1 3.1 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 1.0 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.1 0.7 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.1 0.2 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.1 0.5 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.1 0.4 GO:0023025 MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030)
0.1 0.2 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.1 0.3 GO:0031708 endothelin B receptor binding(GO:0031708)
0.1 0.4 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.1 1.9 GO:0071837 HMG box domain binding(GO:0071837)
0.1 1.4 GO:1901682 sulfur compound transmembrane transporter activity(GO:1901682)
0.1 0.5 GO:0046790 complement component C1q binding(GO:0001849) virion binding(GO:0046790)
0.1 1.7 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.6 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.0 0.9 GO:0046527 glucosyltransferase activity(GO:0046527)
0.0 0.6 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.2 GO:0031013 troponin I binding(GO:0031013)
0.0 0.2 GO:0004995 tachykinin receptor activity(GO:0004995)
0.0 0.5 GO:0035877 death effector domain binding(GO:0035877)
0.0 0.3 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 4.0 GO:0016278 lysine N-methyltransferase activity(GO:0016278)
0.0 0.5 GO:0015288 porin activity(GO:0015288)
0.0 1.1 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.0 0.5 GO:0035497 cAMP response element binding(GO:0035497)
0.0 1.6 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 0.1 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
0.0 0.6 GO:0008301 DNA binding, bending(GO:0008301)
0.0 0.5 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 1.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 6.6 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 1.5 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.2 GO:0031208 POZ domain binding(GO:0031208)
0.0 0.3 GO:0051525 NFAT protein binding(GO:0051525)
0.0 0.7 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 4.9 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 1.9 GO:0030507 spectrin binding(GO:0030507)
0.0 0.4 GO:0042834 peptidoglycan binding(GO:0042834)
0.0 0.3 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.4 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 0.3 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 1.0 GO:0008171 O-methyltransferase activity(GO:0008171)
0.0 0.4 GO:0005024 transforming growth factor beta-activated receptor activity(GO:0005024)
0.0 0.4 GO:0015197 peptide transporter activity(GO:0015197)
0.0 0.2 GO:0016936 galactoside binding(GO:0016936)
0.0 0.9 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.8 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 0.4 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.2 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.0 0.4 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 1.1 GO:0070840 dynein complex binding(GO:0070840)
0.0 0.1 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.0 0.6 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.3 GO:0019966 interleukin-1 binding(GO:0019966)
0.0 1.1 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.6 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.2 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.0 0.6 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 1.0 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.7 GO:0005521 lamin binding(GO:0005521)
0.0 0.3 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.1 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.7 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.6 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.8 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.0 0.1 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.0 0.3 GO:1990239 steroid hormone binding(GO:1990239)
0.0 0.1 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.7 GO:0005158 insulin receptor binding(GO:0005158)
0.0 0.3 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.3 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.3 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.3 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 1.6 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.1 GO:0043237 laminin-1 binding(GO:0043237)
0.0 0.4 GO:0005504 fatty acid binding(GO:0005504)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.5 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 2.9 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 3.0 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.1 7.3 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 3.1 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.1 3.3 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.1 2.5 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 2.8 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.5 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.7 PID ALK2 PATHWAY ALK2 signaling events
0.0 1.3 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 2.6 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.7 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 0.7 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.8 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.7 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 1.9 PID LKB1 PATHWAY LKB1 signaling events
0.0 1.1 PID BMP PATHWAY BMP receptor signaling
0.0 0.7 PID CD40 PATHWAY CD40/CD40L signaling
0.0 0.3 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.4 SIG CHEMOTAXIS Genes related to chemotaxis
0.0 0.2 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.4 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 0.6 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.0 1.8 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.0 0.3 PID GMCSF PATHWAY GMCSF-mediated signaling events
0.0 0.5 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.9 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.2 4.5 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 2.5 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.1 6.3 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 7.0 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 3.0 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.1 9.8 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 0.6 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.1 1.9 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 3.6 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 1.2 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 1.3 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 1.0 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.8 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 1.6 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 0.3 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 1.0 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 1.2 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 1.2 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 1.1 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.6 REACTOME TRNA AMINOACYLATION Genes involved in tRNA Aminoacylation
0.0 1.1 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.9 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.8 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 0.5 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 2.0 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.5 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.0 1.0 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.6 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.5 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.6 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.4 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 0.3 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 0.4 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.3 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.4 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions